{"id":"https://openalex.org/W2022415643","doi":"https://doi.org/10.1289/ehp.97105s4883","title":"Epidemiologic Studies of Ionizing Radiation and Cancer: Past Successes and Future Challenges","display_name":"Epidemiologic Studies of Ionizing Radiation and Cancer: Past Successes and Future Challenges","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W2022415643","doi":"https://doi.org/10.1289/ehp.97105s4883","mag":"2022415643","pmid":"https://pubmed.ncbi.nlm.nih.gov/9255575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1470058"},"language":"en","primary_location":{"id":"doi:10.1289/ehp.97105s4883","doi":"https://doi.org/10.1289/ehp.97105s4883","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.97105s4883","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.97105s4883","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.97105s4883","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111915296","display_name":"Jonathan M. Samet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J M Samet","raw_affiliation_strings":["Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21205-2179, USA. jsamet@phnet.sph.jhu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21205-2179, USA. jsamet@phnet.sph.jhu.edu","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111915296"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.398,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.43315508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"105","issue":"suppl 4","first_page":"883","last_page":"883"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6259999871253967,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.32910001277923584,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10946","display_name":"Radioactivity and Radon Measurements","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/3614","display_name":"Radiological and Ultrasound Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/radiation-induced-cancer","display_name":"radiation-induced cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cancer-risk-assessment","display_name":"cancer risk assessment","score":0.8190000057220459},{"id":"https://openalex.org/keywords/low-dose-radiation-exposure","display_name":"low-dose radiation exposure","score":0.753000020980835},{"id":"https://openalex.org/keywords/dose-rate-effects","display_name":"dose rate dependence","score":0.8999999761581421},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9779999852180481},{"id":"https://openalex.org/keywords/occupational-radiation-exposure","display_name":"occupational radiation exposure","score":0.9649999737739563},{"id":"https://openalex.org/keywords/radiological-risk-assessment","display_name":"radiation risk assessment","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.6823470592498779},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.5714151263237},{"id":"https://openalex.org/C2779925993","wikidata":"https://www.wikidata.org/wiki/Q336938","display_name":"Radiation exposure","level":2,"score":0.5595192313194275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49653369188308716},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45054352283477783},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41241922974586487},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.1252908706665039},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1289/ehp.97105s4883","doi":"https://doi.org/10.1289/ehp.97105s4883","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.97105s4883","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.97105s4883","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"doi:10.2307/3433298","doi":"https://doi.org/10.2307/3433298","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3433298","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1470058","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1470058","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environ Health Perspect","raw_type":"Text"},{"id":"pmid:9255575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9255575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health perspectives","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.276.4246","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.4246","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/44/de/Environ_Health_Perspect_1997_Jun_105(Suppl_4)_883-889.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1289/ehp.97105s4883","doi":"https://doi.org/10.1289/ehp.97105s4883","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.97105s4883","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.97105s4883","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022415643.pdf","grobid_xml":"https://content.openalex.org/works/W2022415643.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1953886206","https://openalex.org/W1964510028","https://openalex.org/W1976619415","https://openalex.org/W1978300986","https://openalex.org/W1979560298","https://openalex.org/W1982513951","https://openalex.org/W1984506032","https://openalex.org/W1998174299","https://openalex.org/W2021713732","https://openalex.org/W2025666947","https://openalex.org/W2030810311","https://openalex.org/W2031815267","https://openalex.org/W2035464370","https://openalex.org/W2040465809","https://openalex.org/W2074949790","https://openalex.org/W2075460086","https://openalex.org/W2084775089","https://openalex.org/W2102845070","https://openalex.org/W2155511672","https://openalex.org/W2163592796","https://openalex.org/W2170226799","https://openalex.org/W2332275733","https://openalex.org/W2335515122","https://openalex.org/W2606401427","https://openalex.org/W3149088836","https://openalex.org/W3161627851","https://openalex.org/W4230959474","https://openalex.org/W4231923698","https://openalex.org/W4234375295","https://openalex.org/W4234522982","https://openalex.org/W4248225782","https://openalex.org/W4299901311","https://openalex.org/W4302079195"],"related_works":["https://openalex.org/W2956045939","https://openalex.org/W4407859227","https://openalex.org/W2156398023","https://openalex.org/W4412522802","https://openalex.org/W4400788423","https://openalex.org/W2159780522","https://openalex.org/W2052615338","https://openalex.org/W2028230221","https://openalex.org/W2107801176","https://openalex.org/W2019772976"],"abstract_inverted_index":{"The":[0],"health":[1,72],"effects":[2,73],"of":[3,34,39,53,74,98,107,115,119,122,143,159,169],"radiation":[4,35,76,86,170],"have":[5,91],"been":[6,27],"a":[7,63],"focus":[8],"for":[9,81,162],"research":[10,84],"since":[11],"early":[12],"in":[13],"the":[14,18,31,43,54,66,71,95,105,123,157,167],"20th":[15],"century.":[16],"As":[17],"century":[19],"ends,":[20],"extensive":[21,67],"experimental":[22],"and":[23,46,77,87,117,130,156],"epidemiologic":[24,37,68,83],"evidence":[25,69],"has":[26],"accumulated":[28],"that":[29,147],"addresses":[30],"adverse":[32],"consequences":[33],"exposure;":[36],"studies":[38,90],"radiation-exposed":[40],"groups":[41,49],"from":[42],"general":[44],"population":[45],"specific":[47],"occupational":[48],"provide":[50],"quantitative":[51,96],"estimates":[52],"cancer":[55,100],"risks":[56,97,111,168],"associated":[57],"with":[58],"exposure.":[59,171],"This":[60,134],"report":[61,135],"provides":[62],"perspective":[64],"on":[65,70,78,85,94],"ionizing":[75],"likely":[79],"needs":[80],"further":[82],"health.":[88],"Epidemiologic":[89],"proved":[92],"informative":[93],"radiation-caused":[99],"but":[101],"we":[102],"now":[103],"face":[104],"challenges":[106],"more":[108],"precisely":[109],"characterizing":[110],"at":[112],"lower":[113],"levels":[114],"exposure":[116],"also":[118],"assessing":[120],"modifiers":[121],"risks,":[124],"including":[125],"dose":[126],"rate,":[127],"genetic":[128],"susceptibility,":[129],"other":[131],"environmental":[132],"exposures.":[133],"considers":[136],"investigative":[137],"approaches,":[138],"such":[139],"as":[140],"pooled":[141],"analysis":[142],"multiple":[144],"data":[145],"sets,":[146],"can":[148],"be":[149],"used":[150],"to":[151],"address":[152],"these":[153,160],"complex":[154],"questions":[155],"limitations":[158],"approaches":[161],"addressing":[163],"societal":[164],"concerns":[165],"about":[166]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}