{"id":"https://openalex.org/W2022405033","doi":"https://doi.org/10.1016/j.ijrobp.2004.01.053","title":"Anti-EGFR\u2013mediated radiosensitization as a result of augmented EGFR expression","display_name":"Anti-EGFR\u2013mediated radiosensitization as a result of augmented EGFR expression","publication_year":2004,"publication_date":"2004-05-12","ids":{"openalex":"https://openalex.org/W2022405033","doi":"https://doi.org/10.1016/j.ijrobp.2004.01.053","mag":"2022405033","pmid":"https://pubmed.ncbi.nlm.nih.gov/15142629"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijrobp.2004.01.053","doi":"https://doi.org/10.1016/j.ijrobp.2004.01.053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2004.01.053","pdf_url":"http://www.redjournal.org/article/S0360301604003323/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.redjournal.org/article/S0360301604003323/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013854802","display_name":"James A. Bonner","orcid":"https://orcid.org/0000-0002-8413-3788","observed_orcids":["https://orcid.org/0000-0002-8413-3788"]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James A Bonner","raw_affiliation_strings":["Department of Radiation Oncology, The University of Alabama School of Medicine, Birmingham, 35294-3300, USA. jabonner@uabmc.edu","Department of Radiation Oncology, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Alabama School of Medicine, Birmingham, 35294-3300, USA. jabonner@uabmc.edu","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Department of Radiation Oncology, Birmingham, Alabama, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013488451","display_name":"Donald J. Buchsbaum","orcid":"https://orcid.org/0000-0003-2797-5847","observed_orcids":["https://orcid.org/0000-0003-2797-5847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald J Buchsbaum","raw_affiliation_strings":["Department of Radiation Oncology, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Birmingham, Alabama, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017355670","display_name":"Suzanne M. Russo","orcid":"https://orcid.org/0000-0002-4144-4711","observed_orcids":["https://orcid.org/0000-0002-4144-4711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne M Russo","raw_affiliation_strings":["Department of Radiation Oncology, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Birmingham, Alabama, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091161682","display_name":"John B. Fiveash","orcid":"https://orcid.org/0000-0002-1129-2884","observed_orcids":["https://orcid.org/0000-0002-1129-2884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John B Fiveash","raw_affiliation_strings":["Department of Radiation Oncology, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Birmingham, Alabama, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069015500","display_name":"Hoa Quang Trummell","orcid":"https://orcid.org/0000-0003-1343-7378","observed_orcids":["https://orcid.org/0000-0003-1343-7378"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hoa Q Trummell","raw_affiliation_strings":["Department of Radiation Oncology and \u2020 Gene Therapy Center , The University of Alabama School of Medicine , Birmingham , AL","Department of Radiation Oncology, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology and \u2020 Gene Therapy Center , The University of Alabama School of Medicine , Birmingham , AL","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Department of Radiation Oncology, Birmingham, Alabama, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T Curiel","raw_affiliation_strings":["Gene Therapy Center, The University of Alabama School of Medicine, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Center, The University of Alabama School of Medicine, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078082133","display_name":"Kevin P. Raisch","orcid":"https://orcid.org/0000-0002-0797-5471","observed_orcids":["https://orcid.org/0000-0002-0797-5471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin P Raisch","raw_affiliation_strings":["Department of Radiation Oncology, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Birmingham, Alabama, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013854802"],"corresponding_institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192","https://openalex.org/I4390039250"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":2.2058,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.86544041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"59","issue":"2","first_page":"S2","last_page":"S10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/anti-egfr-monoclonal-antibody","display_name":"anti-EGFR monoclonal antibody","score":0.8899999856948853},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9810000061988831},{"id":"https://openalex.org/keywords/colon-cancer-cells","display_name":"colon cancer cells","score":0.7160000205039978},{"id":"https://openalex.org/keywords/ls174t-cells","display_name":"LS174T cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/adenoviral-transduction","display_name":"adenoviral transduction","score":0.7789999842643738},{"id":"https://openalex.org/keywords/egfr-overexpression","display_name":"EGFR overexpression","score":0.7129999995231628},{"id":"https://openalex.org/keywords/radiation-response","display_name":"radiation response","score":0.46000000834465027},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.8200764656066895},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7203940153121948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6605697870254517},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.6272537708282471},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.600088357925415},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4785773754119873},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.42396849393844604},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.375987708568573},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34663310647010803},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.20148730278015137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1996590495109558},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18303239345550537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11028504371643066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijrobp.2004.01.053","doi":"https://doi.org/10.1016/j.ijrobp.2004.01.053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2004.01.053","pdf_url":"http://www.redjournal.org/article/S0360301604003323/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},{"id":"pmid:15142629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15142629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation oncology, biology, physics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ijrobp.2004.01.053","doi":"https://doi.org/10.1016/j.ijrobp.2004.01.053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2004.01.053","pdf_url":"http://www.redjournal.org/article/S0360301604003323/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1058759250","display_name":"Radiosensitization with Recombinant Antibodies to EGFr","funder_award_id":"R01CA089297","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4740692570","display_name":"DENDRITIC CELL SPECIFIC VECTOR","funder_award_id":"R01CA086881","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6255563559","display_name":"SPORE in Breast Cancer","funder_award_id":"P50CA089019","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7960482800","display_name":"PRECLINICAL MODELS OF ORGAN & CELL TRANSPLANT TOLERANCE","funder_award_id":"U19DK057958","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8198504426","display_name":null,"funder_award_id":"R01 HL67972","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022405033.pdf","grobid_xml":"https://content.openalex.org/works/W2022405033.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1590794385","https://openalex.org/W1645126533","https://openalex.org/W1804903119","https://openalex.org/W1838340609","https://openalex.org/W1939364580","https://openalex.org/W1945415917","https://openalex.org/W2005204942","https://openalex.org/W2012987137","https://openalex.org/W2024728491","https://openalex.org/W2025313715","https://openalex.org/W2033827633","https://openalex.org/W2038882649","https://openalex.org/W2048454485","https://openalex.org/W2049292021","https://openalex.org/W2053951755","https://openalex.org/W2057409901","https://openalex.org/W2057458801","https://openalex.org/W2129477954","https://openalex.org/W2129944002","https://openalex.org/W2142442804","https://openalex.org/W2144634347","https://openalex.org/W2148011209","https://openalex.org/W2150110662","https://openalex.org/W2155977433","https://openalex.org/W2164686711","https://openalex.org/W2166793232","https://openalex.org/W2171685800","https://openalex.org/W2260028313","https://openalex.org/W2474195763","https://openalex.org/W6635268758","https://openalex.org/W6640518504","https://openalex.org/W6681205928","https://openalex.org/W6683985902","https://openalex.org/W6692250476"],"related_works":["https://openalex.org/W2032382187","https://openalex.org/W1614525425","https://openalex.org/W2262665493","https://openalex.org/W2012987137","https://openalex.org/W2091573051","https://openalex.org/W2110913958","https://openalex.org/W1440303032","https://openalex.org/W3030188508","https://openalex.org/W2142279958","https://openalex.org/W3031621543"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}