{"id":"https://openalex.org/W2022388562","doi":"https://doi.org/10.4161/cc.3.8.1062","title":"Is There a Link Between DNA Polymerase Beta and Cancer?","display_name":"Is There a Link Between DNA Polymerase Beta and Cancer?","publication_year":2004,"publication_date":"2004-08-21","ids":{"openalex":"https://openalex.org/W2022388562","doi":"https://doi.org/10.4161/cc.3.8.1062","mag":"2022388562","pmid":"https://pubmed.ncbi.nlm.nih.gov/15254423"},"language":"en","primary_location":{"id":"doi:10.4161/cc.3.8.1062","doi":"https://doi.org/10.4161/cc.3.8.1062","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.3.8.1062","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.8.1062?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.8.1062?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008296935","display_name":"Daniela Starcevic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Starcevic","raw_affiliation_strings":["Yale University School of Medicine ; New Haven , Connecticut USA","Yale University School of Medicine, New Haven, Connecticut, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine ; New Haven , Connecticut USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University School of Medicine, New Haven, Connecticut, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112073025","display_name":"Shibani Dalal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shibani Dalal","raw_affiliation_strings":["Yale University School of Medicine ; New Haven , Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine ; New Haven , Connecticut USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031828516","display_name":"Joann Balazs Sweasy","orcid":"https://orcid.org/0000-0002-4503-0284","observed_orcids":["https://orcid.org/0000-0002-4503-0284"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joann B. Sweasy","raw_affiliation_strings":["Departments of Therapeutic Radiology and Genetics ; Yale University School of Medicine ; 333 Cedar Street ; PO Box 208040 ; New Haven , Connecticut 06520 USA;","Yale University School of Medicine ; New Haven , Connecticut USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Therapeutic Radiology and Genetics ; Yale University School of Medicine ; 333 Cedar Street ; PO Box 208040 ; New Haven , Connecticut 06520 USA;","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University School of Medicine ; New Haven , Connecticut USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.6894,"has_fulltext":true,"cited_by_count":239,"citation_normalized_percentile":{"value":0.56028369,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"3","issue":"8","first_page":"996","last_page":"999"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-beta","display_name":"DNA polymerase beta","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.656000018119812},{"id":"https://openalex.org/keywords/mutator-phenotype","display_name":"mutator phenotype","score":0.8519999980926514},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9800000190734863},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9850000143051147},{"id":"https://openalex.org/keywords/telomere-fusion","display_name":"telomere fusion","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tumor-overexpression","display_name":"tumor overexpression","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cancer-etiology","display_name":"cancer etiology","score":0.7699999809265137},{"id":"https://openalex.org/keywords/dna-synthesis-fidelity","display_name":"DNA synthesis fidelity","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2778462844","wikidata":"https://www.wikidata.org/wiki/Q18030641","display_name":"DNA polymerase beta","level":5,"score":0.8852697610855103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8183801174163818},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.7473081350326538},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.649356484413147},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6270111799240112},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5661466717720032},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5433897972106934},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.5118283629417419},{"id":"https://openalex.org/C76535049","wikidata":"https://www.wikidata.org/wiki/Q3487941","display_name":"DNA polymerase delta","level":5,"score":0.44195806980133057},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.4405834972858429},{"id":"https://openalex.org/C116988904","wikidata":"https://www.wikidata.org/wiki/Q18038809","display_name":"DNA polymerase mu","level":5,"score":0.44015246629714966},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3581649363040924},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3455125391483307},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3336537480354309},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3114904761314392},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20122963190078735},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.1673007309436798},{"id":"https://openalex.org/C58167604","wikidata":"https://www.wikidata.org/wiki/Q5121654","display_name":"Circular bacterial chromosome","level":4,"score":0.12103164196014404},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.054189324378967285}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4161/cc.3.8.1062","doi":"https://doi.org/10.4161/cc.3.8.1062","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.3.8.1062","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.8.1062?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:15254423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15254423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmid:15280658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15280658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cc.3.8.1062","doi":"https://doi.org/10.4161/cc.3.8.1062","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.3.8.1062","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.3.8.1062?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8624074680","display_name":"Molecular Basis of Cancer Virus Replication, Transformation, and Innate Defense","funder_award_id":"P01CA016038","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022388562.pdf","grobid_xml":"https://content.openalex.org/works/W2022388562.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2151590716","https://openalex.org/W2090594860","https://openalex.org/W2167423675","https://openalex.org/W2785688469","https://openalex.org/W1921970975","https://openalex.org/W4285271279","https://openalex.org/W2014420068","https://openalex.org/W2085077704","https://openalex.org/W2009900712","https://openalex.org/W2007260748"],"abstract_inverted_index":{"Recent":[0],"small-scale":[1,150],"studies":[2,155],"have":[3],"shown":[4,31,99],"that":[5],"30%":[6],"of":[7,20,106,112,138,159,166],"human":[8,167],"tumors":[9],"examined":[10],"to":[11,32,52,100,121,145],"date":[12],"express":[13],"DNA":[14,22,34,60,93,160],"polymerase":[15,23,61,94,113,139,161],"beta":[16,24,62,95,114,140,162],"variant":[17,63,157],"proteins.":[18],"One":[19],"the":[21,44,53,122,149,164],"colon":[25,66],"cancer-associated":[26],"mutants,":[27],"K289M,":[28],"has":[29,96],"been":[30,98],"synthesize":[33],"with":[35,69,148],"a":[36,49,104,118,142],"lower":[37],"fidelity":[38],"than":[39],"wild-type":[40],"Pol":[41],"beta.":[42],"Thus,":[43,132],"K289M":[45],"protein":[46],"could":[47],"confer":[48,141],"mutator":[50,143],"phenotype":[51,120,144],"cell,":[54],"resulting":[55],"in":[56,65,73,78,90,103,115,129,163],"genomic":[57,91],"instability.":[58,92],"Another":[59],"identified":[64],"carcinoma":[67],"interferes":[68],"base":[70],"excision":[71],"repair":[72],"cells.":[74,123,146],"This":[75],"may":[76],"result":[77,89],"unfilled":[79],"gaps":[80],"which":[81],"can":[82],"serve":[83],"as":[84],"substrates":[85],"for":[86],"recombination":[87],"and":[88],"also":[97],"be":[101],"overexpressed":[102],"variety":[105],"tumors.":[107],"In":[108,124],"some":[109],"cases,":[110,126],"overexpression":[111,127],"cells":[116],"confers":[117],"transformed":[119],"other":[125],"results":[128],"telomere":[130],"fusions.":[131],"mutant":[133],"forms":[134,158],"or":[135],"aberrant":[136],"quantities":[137],"Combined":[147],"tumor":[151],"studies,":[152],"these":[153],"mechanistic":[154],"implicate":[156],"etiology":[165],"cancer.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}