{"id":"https://openalex.org/W2022332003","doi":"https://doi.org/10.1126/science.6105709","title":"Evidence for L-glutamate as the Neurotransmitter of Baroreceptor Afferent Nerve Fibers","display_name":"Evidence for L-glutamate as the Neurotransmitter of Baroreceptor Afferent Nerve Fibers","publication_year":1980,"publication_date":"1980-08-15","ids":{"openalex":"https://openalex.org/W2022332003","doi":"https://doi.org/10.1126/science.6105709","mag":"2022332003","pmid":"https://pubmed.ncbi.nlm.nih.gov/6105709"},"language":"en","primary_location":{"id":"doi:10.1126/science.6105709","doi":"https://doi.org/10.1126/science.6105709","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.6105709","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018222752","display_name":"William T. Talman","orcid":"https://orcid.org/0000-0001-7805-711X","observed_orcids":["https://orcid.org/0000-0001-7805-711X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T. Talman","raw_affiliation_strings":["Laboratory of Neurobiology, Cornell University Medical College, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology, Cornell University Medical College, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101723","display_name":"Mark H. Perrone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark H. Perrone","raw_affiliation_strings":["Laboratory of Neurobiology, Cornell University Medical College, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology, Cornell University Medical College, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109986398","display_name":"Donald J. Reis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald J. Reis","raw_affiliation_strings":["Laboratory of Neurobiology, Cornell University Medical College, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology, Cornell University Medical College, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":null,"apc_paid":null,"fwci":12.9789,"has_fulltext":false,"cited_by_count":451,"citation_normalized_percentile":{"value":0.99055982,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"209","issue":"4458","first_page":"813","last_page":"815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.375,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neurotransmitter-identification","display_name":"neurotransmitter identification","score":0.7229999899864197},{"id":"https://openalex.org/keywords/arterial-baroreceptors","display_name":"arterial baroreceptors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/nucleus-tractus-solitarius","display_name":"nucleus tractus solitarius","score":0.8600000143051147},{"id":"https://openalex.org/keywords/nodose-ganglion","display_name":"nodose ganglion","score":0.7960000038146973},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.6909999847412109},{"id":"https://openalex.org/keywords/baroreflex","display_name":"baroreflex","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8379999995231628},{"id":"https://openalex.org/keywords/bradycardia","display_name":"bradycardia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/apnea","display_name":"apnea","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C79752029","wikidata":"https://www.wikidata.org/wiki/Q808732","display_name":"Baroreceptor","level":4,"score":0.9208066463470459},{"id":"https://openalex.org/C2909127448","wikidata":"https://www.wikidata.org/wiki/Q6029330","display_name":"Nodose Ganglion","level":4,"score":0.8422690629959106},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6600097417831421},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.5599102973937988},{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.5362365245819092},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.4898809790611267},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.4638161063194275},{"id":"https://openalex.org/C2779929655","wikidata":"https://www.wikidata.org/wiki/Q119744","display_name":"Solitary nucleus","level":3,"score":0.45939064025878906},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.4337652623653412},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4278922975063324},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4254564940929413},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3759456276893616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34337830543518066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33839818835258484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3131706714630127},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.1964823603630066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19451645016670227},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.18248483538627625},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14890339970588684},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.10521316528320312},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09474843740463257}],"mesh":[{"descriptor_ui":"D000344","descriptor_name":"Afferent Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007608","descriptor_name":"Kainic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011311","descriptor_name":"Pressoreceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.6105709","doi":"https://doi.org/10.1126/science.6105709","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.6105709","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:6105709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6105709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W996500346","https://openalex.org/W1431244970","https://openalex.org/W1903250037","https://openalex.org/W1939037149","https://openalex.org/W1967950071","https://openalex.org/W1980595683","https://openalex.org/W1981604210","https://openalex.org/W1987289944","https://openalex.org/W1992549052","https://openalex.org/W2044240340","https://openalex.org/W2060707121","https://openalex.org/W2070153895","https://openalex.org/W2077907524","https://openalex.org/W2089710352","https://openalex.org/W2153087708","https://openalex.org/W2403238292","https://openalex.org/W2430103740","https://openalex.org/W2499295491","https://openalex.org/W4211185952"],"related_works":["https://openalex.org/W1994572353","https://openalex.org/W2283065289","https://openalex.org/W4237021353","https://openalex.org/W2219306657","https://openalex.org/W2473236155","https://openalex.org/W2064584926","https://openalex.org/W4255991442","https://openalex.org/W2110952780","https://openalex.org/W2035892816","https://openalex.org/W1972627200"],"abstract_inverted_index":{"Microinjection":[0],"of":[1,21,29,32,44],"L-glutamate":[2],"into":[3],"the":[4,22,35,42],"intermediate":[5],"nucleus":[6,36],"tractus":[7,37],"solitarii":[8],"in":[9,26,34],"anesthetized":[10],"rats":[11],"elicits":[12],"hypotension,":[13],"bradycardia,":[14],"and":[15],"apnea,":[16],"simulating":[17],"baroreceptor":[18],"reflexes.":[19],"Ablation":[20],"nodose":[23],"ganglion":[24],"results":[25],"selective":[27],"reduction":[28],"high-affinity":[30],"uptake":[31],"L-glutanate":[33],"solitarii.":[38],"L-Glutamate":[39],"may":[40],"be":[41],"neurotransmitter":[43],"afferent":[45],"nerve":[46],"fibers":[47],"from":[48],"arterial":[49],"baroreceptors.":[50]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}