{"id":"https://openalex.org/W2022310463","doi":"https://doi.org/10.2174/1381210203706716128","title":"Current and Future Therapeutic Strategies in NAFLD","display_name":"Current and Future Therapeutic Strategies in NAFLD","publication_year":2010,"publication_date":"2010-04-23","ids":{"openalex":"https://openalex.org/W2022310463","doi":"https://doi.org/10.2174/1381210203706716128","mag":"2022310463","pmid":"https://pubmed.ncbi.nlm.nih.gov/20370671"},"language":"en","primary_location":{"id":"doi:10.2174/1381210203706716128","doi":"https://doi.org/10.2174/1381210203706716128","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381210203706716128","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34116546","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020807613","display_name":"Nimantha Mark Wilfred de Alwis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nimantha Mark Wilfred de Alwis","raw_affiliation_strings":["Faculty of Medical Sciences, Faculty Office, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Faculty Office, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101918789","display_name":"Christopher Paul Day","orcid":"https://orcid.org/0000-0001-7161-0293","observed_orcids":["https://orcid.org/0000-0001-7161-0293","https://orcid.org/0000-0003-1458-0045"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher Paul Day","raw_affiliation_strings":["Faculty of Medical Sciences, Faculty Office, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH. United Kingdom.,United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Faculty Office, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH. United Kingdom.,United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101918789"],"corresponding_institution_ids":["https://openalex.org/I84884186"],"apc_list":null,"apc_paid":null,"fwci":0.7523,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.748003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"17","first_page":"1","last_page":"1962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7889999747276306},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.675000011920929},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.8884764909744263},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.8098069429397583},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7585406303405762},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.7342356443405151},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7293910384178162},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7200464010238647},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.664281964302063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5849036574363708},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5429979562759399},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.490242063999176},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4723328649997711},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.35354742407798767},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.339080274105072}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/1381210203706716128","doi":"https://doi.org/10.2174/1381210203706716128","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381210203706716128","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"doi:10.2174/138161210791208901","doi":"https://doi.org/10.2174/138161210791208901","is_oa":false,"landing_page_url":"https://doi.org/10.2174/138161210791208901","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:20370671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20370671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"},{"id":"doi:10.25405/ncl.34116546","doi":"https://doi.org/10.25405/ncl.34116546","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34116546","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34116546","doi":"https://doi.org/10.25405/ncl.34116546","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34116546","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1548087902","https://openalex.org/W1973493210","https://openalex.org/W1552988097","https://openalex.org/W3217571156","https://openalex.org/W82388168","https://openalex.org/W1499407397","https://openalex.org/W1712745076","https://openalex.org/W2291546216","https://openalex.org/W2724776928","https://openalex.org/W2013682112"],"abstract_inverted_index":{"Non":[0],"alcoholic":[1],"fatty":[2],"liver":[3,16,63,86,111],"disease":[4,24,112],"(NAFLD)":[5],"is":[6,45,70,81],"increasingly":[7],"diagnosed":[8],"worldwide":[9],"and":[10,40,48,57,65,78,80,100,124],"considered":[11],"to":[12,36,61,119,138],"be":[13],"the":[14,85,89,95,104,107,130],"commonest":[15],"disorder":[17],"in":[18,98,122,127],"Western":[19],"countries.":[20],"It":[21],"comprises":[22],"a":[23],"spectrum":[25],"ranging":[26],"from":[27],"simple":[28],"steatosis":[29,44],"(fatty":[30],"liver),":[31],"through":[32],"non-alcoholic":[33],"steatohepatitis":[34],"(NASH)":[35],"fat":[37],"with":[38,73,103,144],"fibrosis":[39,58],"ultimately":[41],"cirrhosis.":[42],"Simple":[43],"largely":[46],"benign":[47],"non-progressive,":[49],"whereas":[50],"NASH,":[51],"characterized":[52],"by":[53],"hepatocyte":[54],"injury,":[55],"inflammation":[56],"can":[59],"lead":[60],"cirrhosis,":[62],"failure":[64],"hepatocellular":[66],"carcinoma":[67],"(HCC).":[68],"NAFLD":[69,128],"strongly":[71],"associated":[72],"obesity,":[74],"insulin":[75],"resistance,":[76],"hypertension":[77],"dyslipidaemia":[79],"now":[82,136],"regarded":[83],"as":[84],"manifestation":[87],"of":[88,94,109],"metabolic":[90],"syndrome.":[91],"Rapid":[92],"spread":[93],"obesity":[96],"'pandemic'":[97],"adults":[99],"children,":[101],"coupled":[102],"realisation":[105],"that":[106],"outcomes":[108],"obesity-related":[110],"are":[113,135],"not":[114],"entirely":[115],"benign,":[116],"has":[117],"led":[118],"rapid":[120],"growth":[121],"clinical":[123],"basic":[125],"studies":[126,134],"over":[129],"past":[131],"decade.":[132],"These":[133],"beginning":[137],"inform":[139],"management":[140],"strategies":[141],"for":[142],"patients":[143],"NAFLD.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
