{"id":"https://openalex.org/W2022304168","doi":"https://doi.org/10.1073/pnas.0812191106","title":"Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis","display_name":"Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis","publication_year":2009,"publication_date":"2009-04-22","ids":{"openalex":"https://openalex.org/W2022304168","doi":"https://doi.org/10.1073/pnas.0812191106","mag":"2022304168","pmid":"https://pubmed.ncbi.nlm.nih.gov/19416919","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2678619"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0812191106","doi":"https://doi.org/10.1073/pnas.0812191106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0812191106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2678619/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032368866","display_name":"Pascal Belin","orcid":"https://orcid.org/0000-0001-5033-5931","observed_orcids":["https://orcid.org/0000-0001-5033-5931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pascal Belin","raw_affiliation_strings":["Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012490479","display_name":"Marie\u2010H\u00e9l\u00e8ne Le Du","orcid":"https://orcid.org/0000-0002-4759-3160","observed_orcids":["https://orcid.org/0000-0002-4759-3160"]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]},{"id":"https://openalex.org/I4210152344","display_name":"Institut de Biologie et Technologies","ror":"https://ror.org/052wcqj17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210152344"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie H\u00e9l\u00e8ne Le Du","raw_affiliation_strings":["Service de Bio\u00e9nerg\u00e9tique, Biologie Structurale et M\u00e9canismes, Commissariat \u00e0 l'Energie Atomique (CEA), Institut de Biologie et Technologies de Saclay (IBITECS), F-91191 Gif-sur-Yvette, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Bio\u00e9nerg\u00e9tique, Biologie Structurale et M\u00e9canismes, Commissariat \u00e0 l'Energie Atomique (CEA), Institut de Biologie et Technologies de Saclay (IBITECS), F-91191 Gif-sur-Yvette, France;","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210128565","https://openalex.org/I4210152344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087807433","display_name":"Alistair J. Fielding","orcid":"https://orcid.org/0000-0002-4437-9791","observed_orcids":["https://orcid.org/0000-0002-4437-9791"]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]},{"id":"https://openalex.org/I4210152344","display_name":"Institut de Biologie et Technologies","ror":"https://ror.org/052wcqj17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210152344"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alistair Fielding","raw_affiliation_strings":["Service de Bio\u00e9nerg\u00e9tique, Biologie Structurale et M\u00e9canismes, Commissariat \u00e0 l'Energie Atomique (CEA), Institut de Biologie et Technologies de Saclay (IBITECS), F-91191 Gif-sur-Yvette, France;","School of Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Bio\u00e9nerg\u00e9tique, Biologie Structurale et M\u00e9canismes, Commissariat \u00e0 l'Energie Atomique (CEA), Institut de Biologie et Technologies de Saclay (IBITECS), F-91191 Gif-sur-Yvette, France;","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210128565","https://openalex.org/I4210152344"]},{"raw_affiliation_string":"School of Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009053668","display_name":"Olivier Lequin","orcid":"https://orcid.org/0000-0001-5307-3068","observed_orcids":["https://orcid.org/0000-0001-5307-3068"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Lequin","raw_affiliation_strings":["Synth\u00e8se, Structure et Fonction de Mol\u00e9cules Bioactives, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7613, Universit\u00e9 Pierre et Marie Curie, Universit\u00e9 Paris 06, Case Courrier 45, 4 Place Jussieu, F-75252 Paris Cedex 05, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synth\u00e8se, Structure et Fonction de Mol\u00e9cules Bioactives, Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7613, Universit\u00e9 Pierre et Marie Curie, Universit\u00e9 Paris 06, Case Courrier 45, 4 Place Jussieu, F-75252 Paris Cedex 05, France; and","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028267079","display_name":"Micka\u00ebl Jacquet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Micka\u00ebl Jacquet","raw_affiliation_strings":["Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038479758","display_name":"Jean\u2010Baptiste Charbonnier","orcid":"https://orcid.org/0000-0002-5219-1983","observed_orcids":["https://orcid.org/0000-0002-5219-1983"]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]},{"id":"https://openalex.org/I4210152344","display_name":"Institut de Biologie et Technologies","ror":"https://ror.org/052wcqj17","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210152344"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Baptiste Charbonnier","raw_affiliation_strings":["Service de Bio\u00e9nerg\u00e9tique, Biologie Structurale et M\u00e9canismes, Commissariat \u00e0 l'Energie Atomique (CEA), Institut de Biologie et Technologies de Saclay (IBITECS), F-91191 Gif-sur-Yvette, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Bio\u00e9nerg\u00e9tique, Biologie Structurale et M\u00e9canismes, Commissariat \u00e0 l'Energie Atomique (CEA), Institut de Biologie et Technologies de Saclay (IBITECS), F-91191 Gif-sur-Yvette, France;","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210128565","https://openalex.org/I4210152344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089241337","display_name":"Alain Lecoq","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alain Lecoq","raw_affiliation_strings":["Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068577689","display_name":"Robert Tha\u00ef","orcid":"https://orcid.org/0000-0001-9438-4225","observed_orcids":["https://orcid.org/0000-0001-9438-4225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Thai","raw_affiliation_strings":["Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000891319","display_name":"Marie Cour\u00e7on","orcid":"https://orcid.org/0000-0001-7152-1768","observed_orcids":["https://orcid.org/0000-0001-7152-1768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie Cour\u00e7on","raw_affiliation_strings":["Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045624477","display_name":"C\u00e9dric Masson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9dric Masson","raw_affiliation_strings":["Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006028451","display_name":"Christophe Dugave","orcid":"https://orcid.org/0000-0001-5173-8329","observed_orcids":["https://orcid.org/0000-0001-5173-8329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christophe Dugave","raw_affiliation_strings":["Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008199861","display_name":"Roger Genet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger Genet","raw_affiliation_strings":["Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086742631","display_name":"Jean\u2010Luc Pernodet","orcid":"https://orcid.org/0000-0002-6129-7093","observed_orcids":["https://orcid.org/0000-0002-6129-7093"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Luc Pernodet","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique et Microbiologie, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 8621, Universit\u00e9 Paris-Sud 11, F-91405 Orsay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et Microbiologie, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 8621, Universit\u00e9 Paris-Sud 11, F-91405 Orsay, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043828795","display_name":"Muriel Gondry","orcid":"https://orcid.org/0000-0003-0398-3404","observed_orcids":["https://orcid.org/0000-0003-0398-3404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muriel Gondry","raw_affiliation_strings":["Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7147,"has_fulltext":true,"cited_by_count":224,"citation_normalized_percentile":{"value":0.95769165,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"106","issue":"18","first_page":"7426","last_page":"7431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp121","display_name":"CYP121","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/essential-genes","display_name":"essential genes","score":0.44999998807907104},{"id":"https://openalex.org/keywords/intramolecular-c-c-bond-formation","display_name":"intramolecular C\u2013C bond formation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/heme-environment","display_name":"heme environment","score":0.5740000009536743},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.47099998593330383},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6891781091690063},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6822407841682434},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.6328287720680237},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6033065915107727},{"id":"https://openalex.org/C134621786","wikidata":"https://www.wikidata.org/wiki/Q415215","display_name":"Ferredoxin","level":3,"score":0.57136070728302},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.5433399081230164},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.5370333194732666},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5351192951202393},{"id":"https://openalex.org/C63338738","wikidata":"https://www.wikidata.org/wiki/Q287862","display_name":"Catalytic cycle","level":3,"score":0.45828667283058167},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4277631938457489},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.40324920415878296},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3348744511604309},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16661128401756287},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13113495707511902},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11800453066825867},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1073/pnas.0812191106","doi":"https://doi.org/10.1073/pnas.0812191106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0812191106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:19416919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19416919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2678619","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2678619/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:HAL:cea-01997903v1","doi":null,"is_oa":false,"landing_page_url":"https://cea.hal.science/cea-01997903","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (18), pp.7426-7431. &#x27E8;10.1073/pnas.0812191106&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-00382846v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-00382846","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0027-8424","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-04135884v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04135884","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (18), pp.7426-7431. &#x27E8;10.1073/pnas.0812191106&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/83a932ec-15f6-4991-aafa-6f0acf312346","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/83a932ec-15f6-4991-aafa-6f0acf312346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Belin, P, Du, M H L, Fielding, A, Lequin, O, Jacquet, M, Charbonnier, J B, Lecoq, A, Thai, R, Cour\u00e7on, M, Masson, C, Dugave, C, Genet, R, Pernodet, J L & Gondry, M 2009, 'Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 18, pp. 7426-7431. https://doi.org/10.1073/pnas.0812191106","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2678619","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2678619/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W112306890","https://openalex.org/W1777183573","https://openalex.org/W1970847421","https://openalex.org/W1975716269","https://openalex.org/W1985019749","https://openalex.org/W1985815325","https://openalex.org/W1988402636","https://openalex.org/W1989587215","https://openalex.org/W1995110989","https://openalex.org/W1998656159","https://openalex.org/W2001641653","https://openalex.org/W2003105919","https://openalex.org/W2003766180","https://openalex.org/W2006421614","https://openalex.org/W2012755676","https://openalex.org/W2022306285","https://openalex.org/W2028061849","https://openalex.org/W2038840577","https://openalex.org/W2046729559","https://openalex.org/W2059045499","https://openalex.org/W2077621515","https://openalex.org/W2080544622","https://openalex.org/W2082632980","https://openalex.org/W2086559674","https://openalex.org/W2092452637","https://openalex.org/W2093384465","https://openalex.org/W2095254482","https://openalex.org/W2097493124","https://openalex.org/W2120409655","https://openalex.org/W2120956519","https://openalex.org/W2125112523","https://openalex.org/W2141046318","https://openalex.org/W2141632349","https://openalex.org/W2144010669","https://openalex.org/W2149383303","https://openalex.org/W2158023121","https://openalex.org/W2162591274","https://openalex.org/W2164877979","https://openalex.org/W2165280507","https://openalex.org/W2315690155","https://openalex.org/W2952208998","https://openalex.org/W4211167365","https://openalex.org/W6604598156","https://openalex.org/W6822635993"],"related_works":["https://openalex.org/W2085478776","https://openalex.org/W1587828592","https://openalex.org/W2731664411","https://openalex.org/W4225428166","https://openalex.org/W3013401249","https://openalex.org/W3168553147","https://openalex.org/W3018281260","https://openalex.org/W4400129730","https://openalex.org/W2765954027","https://openalex.org/W2980432510"],"abstract_inverted_index":{"The":[0,81],"gene":[1],"encoding":[2],"the":[3,13,23,54,61,101,110,127,147,151,154,160,165,176,197],"cytochrome":[4],"P450":[5],"CYP121":[6,14,41,59,142,215],"is":[7,31,186],"essential":[8],"for":[9,210],"Mycobacterium":[10],"tuberculosis.":[11],"However,":[12],"catalytic":[15,198],"activity":[16,42],"remains":[17],"unknown.":[18],"Here,":[19],"we":[20,181],"show":[21],"that":[22,58,183],"cyclodipeptide":[24],"cyclo(l-Tyr-l-Tyr)":[25],"(cYY)":[26],"binds":[27],"to":[28,175],"CYP121,":[29,86],"and":[30,47,112,122,201],"efficiently":[32],"converted":[33],"into":[34,196],"a":[35,40,77,114,144],"single":[36],"major":[37],"product":[38,56],"in":[39,76,100,146,164],"assay":[43],"containing":[44],"spinach":[45],"ferredoxin":[46,48],"reductase.":[49],"NMR":[50],"spectroscopy":[51],"analysis":[52],"of":[53,63,73,84,140,153,204,213],"reaction":[55],"shows":[57],"catalyzes":[60],"formation":[62],"an":[64],"intramolecular":[65],"C-C":[66,167,184],"bond":[67],"between":[68],"2":[69],"tyrosyl":[70,108,190],"carbon":[71,161],"atoms":[72,162],"cYY":[74,95,107],"resulting":[75],"novel":[78],"chemical":[79],"entity.":[80],"X-ray":[82],"structure":[83],"cYY-bound":[85,141],"solved":[87],"at":[88],"high":[89],"resolution":[90],"(1.4":[91],"A),":[92],"reveals":[93],"one":[94],"molecule":[96],"with":[97,118,135,150,188],"full":[98],"occupancy":[99],"large":[102],"active":[103],"site":[104],"cavity.":[105],"One":[106],"approaches":[109],"heme":[111,148,156],"establishes":[113],"specific":[115],"H-bonding":[116],"network":[117],"Ser-237,":[119],"Gln-385,":[120],"Arg-386,":[121],"3":[123],"water":[124],"molecules,":[125],"including":[126],"sixth":[128,155],"iron":[129,157],"ligand.":[130,158],"These":[131],"observations":[132],"are":[133,169],"consistent":[134],"low":[136],"temperature":[137],"EPR":[138],"spectra":[139],"showing":[143],"change":[145],"environment":[149],"persistence":[152],"As":[159],"involved":[163],"final":[166],"coupling":[168,185],"located":[170],"5.4":[171],"A":[172],"apart":[173],"according":[174],"CYP121-cYY":[177],"complex":[178],"crystal":[179],"structure,":[180],"propose":[182],"concomitant":[187],"substrate":[189],"movements.":[191],"This":[192],"study":[193],"provides":[194,208],"insight":[195],"activity,":[199],"mechanism,":[200],"biological":[202],"function":[203],"CYP121.":[205],"Also,":[206],"it":[207],"clues":[209],"rational":[211],"design":[212],"putative":[214],"substrate-based":[216],"antimycobacterial":[217],"agents.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
