{"id":"https://openalex.org/W2022158206","doi":"https://doi.org/10.1590/s1415-47572000000400003","title":"Glutathione S-transferase M1 (GSTM1) polymorphism in two Brazilian populations","display_name":"Glutathione S-transferase M1 (GSTM1) polymorphism in two Brazilian populations","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2022158206","doi":"https://doi.org/10.1590/s1415-47572000000400003","mag":"2022158206"},"language":"en","primary_location":{"id":"doi:10.1590/s1415-47572000000400003","doi":"https://doi.org/10.1590/s1415-47572000000400003","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1415-47572000000400003","pdf_url":"https://www.scielo.br/j/gmb/a/Hgc3Bm5Hsm7xcWStP6fQXwb/?lang=en&format=pdf","source":{"id":"https://openalex.org/S151355818","display_name":"Genetics and Molecular Biology","issn_l":"1415-4757","issn":["1415-4757","1678-4685"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312091","host_organization_name":"Brazilian Society of Genetics","host_organization_lineage":["https://openalex.org/P4310312091"],"host_organization_lineage_names":["Brazilian Society of Genetics"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.scielo.br/j/gmb/a/Hgc3Bm5Hsm7xcWStP6fQXwb/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015752146","display_name":"Ana Hatagima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Hatagima","raw_affiliation_strings":["Instituto Oswaldo Cruz, Brasil","Instituto Oswaldo Cruz, Departamento de Genetica, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oswaldo Cruz, Brasil","institution_ids":["https://openalex.org/I4405286966"]},{"raw_affiliation_string":"Instituto Oswaldo Cruz, Departamento de Genetica, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I4405286966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029782080","display_name":"Maria N. Klautau-Guimar\u00e3es","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Nazar\u00e9 Klautau-Guimar\u00e3es","raw_affiliation_strings":["Universidade de Bras\u00edlia, Brasil","UNIVERSIDADE DE BRASILIA, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Bras\u00edlia, Brasil","institution_ids":["https://openalex.org/I150729083"]},{"raw_affiliation_string":"UNIVERSIDADE DE BRASILIA, Brasil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067606206","display_name":"Felizardo Penalva da Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Felizardo Penalva da Silva","raw_affiliation_strings":["Universidade de Bras\u00edlia, Brasil","UNIVERSIDADE DE BRASILIA, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Bras\u00edlia, Brasil","institution_ids":["https://openalex.org/I150729083"]},{"raw_affiliation_string":"UNIVERSIDADE DE BRASILIA, Brasil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007552346","display_name":"Pedro Hern\u00e1n Cabello","orcid":"https://orcid.org/0000-0002-1389-5064","observed_orcids":["https://orcid.org/0000-0002-1389-5064"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Hernan Cabello","raw_affiliation_strings":["Instituto Oswaldo Cruz, Brasil","Instituto Oswaldo Cruz, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oswaldo Cruz, Brasil","institution_ids":["https://openalex.org/I4405286966"]},{"raw_affiliation_string":"Instituto Oswaldo Cruz, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I4405286966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":700,"currency":"USD","value_usd":700},"apc_paid":{"value":700,"currency":"USD","value_usd":700},"fwci":0.1993,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.41457555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"23","issue":"4","first_page":"709","last_page":"713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-s-transferase-m1","display_name":"glutathione S-transferase M1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gstm1-polymorphism","display_name":"GSTM1 polymorphism","score":0.9259999990463257},{"id":"https://openalex.org/keywords/gstm1-null-allele","display_name":"GSTM1 null allele","score":0.8199999928474426},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.5600000023841858},{"id":"https://openalex.org/keywords/hardy-weinberg-equilibrium","display_name":"Hardy-Weinberg equilibrium","score":0.9380000233650208},{"id":"https://openalex.org/keywords/population-genetics","display_name":"population genetics","score":0.574999988079071},{"id":"https://openalex.org/keywords/brazilian-population","display_name":"Brazilian population","score":0.6209999918937683},{"id":"https://openalex.org/keywords/rio-de-janeiro","display_name":"Rio de Janeiro","score":0.7889999747276306},{"id":"https://openalex.org/keywords/brasilia","display_name":"Bras\u00edlia","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8454025387763977},{"id":"https://openalex.org/C106978037","wikidata":"https://www.wikidata.org/wiki/Q967880","display_name":"Panmixia","level":5,"score":0.6678886413574219},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.637678861618042},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4907301664352417},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.4585456848144531},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44878414273262024},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4102155566215515},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3100399672985077},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3091275691986084},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.2571524977684021},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08518853783607483},{"id":"https://openalex.org/C46576788","wikidata":"https://www.wikidata.org/wiki/Q5532925","display_name":"Genetic structure","level":4,"score":0.08046245574951172},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1590/s1415-47572000000400003","doi":"https://doi.org/10.1590/s1415-47572000000400003","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1415-47572000000400003","pdf_url":"https://www.scielo.br/j/gmb/a/Hgc3Bm5Hsm7xcWStP6fQXwb/?lang=en&format=pdf","source":{"id":"https://openalex.org/S151355818","display_name":"Genetics and Molecular Biology","issn_l":"1415-4757","issn":["1415-4757","1678-4685"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312091","host_organization_name":"Brazilian Society of Genetics","host_organization_lineage":["https://openalex.org/P4310312091"],"host_organization_lineage_names":["Brazilian Society of Genetics"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:scielo:S1415-47572000000400003","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&amp;pid=S1415-47572000000400003","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Biology v.23 n.4 2000","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:1822647","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=1822647","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UnB","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:americanae.aecid.es:2478046","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2478046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genetics and Molecular Biology v.23 n.4 2000","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:94ca44182d8c4d7492ccf5c653bbdbf6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/94ca44182d8c4d7492ccf5c653bbdbf6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genetics and Molecular Biology, Vol 23, Iss 4, Pp 709-713 (2000)","raw_type":"article"},{"id":"pmh:oai:repositorio.unb.br:10482/31915","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unb.br/handle/10482/31915","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UnB","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1590/s1415-47572000000400003","doi":"https://doi.org/10.1590/s1415-47572000000400003","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s1415-47572000000400003","pdf_url":"https://www.scielo.br/j/gmb/a/Hgc3Bm5Hsm7xcWStP6fQXwb/?lang=en&format=pdf","source":{"id":"https://openalex.org/S151355818","display_name":"Genetics and Molecular Biology","issn_l":"1415-4757","issn":["1415-4757","1678-4685"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312091","host_organization_name":"Brazilian Society of Genetics","host_organization_lineage":["https://openalex.org/P4310312091"],"host_organization_lineage_names":["Brazilian Society of Genetics"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322749","display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","ror":"https://ror.org/03kk0s825"},{"id":"https://openalex.org/F4320323917","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022158206.pdf","grobid_xml":"https://content.openalex.org/works/W2022158206.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W596118951","https://openalex.org/W1493036774","https://openalex.org/W1753058125","https://openalex.org/W1970901098","https://openalex.org/W1973275034","https://openalex.org/W1989327131","https://openalex.org/W1989549235","https://openalex.org/W2013770643","https://openalex.org/W2014813076","https://openalex.org/W2015161126","https://openalex.org/W2016469048","https://openalex.org/W2032118018","https://openalex.org/W2033852172","https://openalex.org/W2035586283","https://openalex.org/W2043091666","https://openalex.org/W2046807457","https://openalex.org/W2052447033","https://openalex.org/W2052864573","https://openalex.org/W2060079158","https://openalex.org/W2069296209","https://openalex.org/W2070032218","https://openalex.org/W2075734115","https://openalex.org/W2076589905","https://openalex.org/W2078990611","https://openalex.org/W2107428252","https://openalex.org/W2108796332","https://openalex.org/W2126848032","https://openalex.org/W2131786855","https://openalex.org/W2150487766","https://openalex.org/W2155128827","https://openalex.org/W2160883809","https://openalex.org/W2327071703","https://openalex.org/W2399974113","https://openalex.org/W2417663303"],"related_works":["https://openalex.org/W2022948837","https://openalex.org/W7028787552","https://openalex.org/W7094051740","https://openalex.org/W2105508346","https://openalex.org/W2018859353","https://openalex.org/W2138164378","https://openalex.org/W2028417502","https://openalex.org/W2141982419","https://openalex.org/W2368707517","https://openalex.org/W2378065687"],"abstract_inverted_index":{"The":[0,30,49,65,82],"distribution":[1],"of":[2,13,19,34,136],"GSTM1":[3,50,66,83],"phenotype":[4,68,84,131],"frequencies":[5],"was":[6,70],"studied":[7],"in":[8,23,88,93,129],"two":[9],"Brazilian":[10,138],"samples":[11],"composed":[12],"healthy":[14],"and":[15,41,57,72,78,106,147],"unrelated":[16],"blood":[17],"donors":[18],"both":[20],"sexes":[21],"ranging":[22],"age":[24],"from":[25,37,47,117],"18":[26],"to":[27,123],"61":[28],"years.":[29],"first":[31],"sample":[32],"consisted":[33],"658":[35],"individuals":[36,46],"Rio":[38,75,103],"de":[39,76,104],"Janeiro,":[40],"the":[42,61,130,137],"second":[43],"included":[44],"179":[45],"Bras\u00edlia.":[48,114],"phenotypes":[51],"were":[52,86],"detected":[53],"using":[54],"PCR":[55],"reactions":[56],"subsequent":[58],"digestion":[59],"by":[60],"restriction":[62],"enzyme":[63],"HaeII.":[64],"null":[67],"frequency":[69],"46%":[71],"49%":[73],"for":[74,102,113],"Janeiro":[77,105],"Bras\u00edlia":[79],"samples,":[80],"respectively.":[81],"distributions":[85],"not":[87],"agreement":[89],"with":[90],"Hardy-Weinberg":[91,118],"equilibrium":[92,119],"either":[94],"sample,":[95],"chi\u00b21":[96,107],"=":[97,108],"11.49":[98],"(P":[99,110],"<":[100,111],"0.001)":[101],"6.77":[109],"0.01)":[112],"This":[115],"deviation":[116],"may":[120],"be":[121],"due":[122],"factors":[124],"such":[125],"as":[126],"selection,":[127],"errors":[128],"determination":[132],"or":[133],"incomplete":[134],"panmixia":[135],"population,":[139],"whose":[140],"main":[141],"racial":[142],"components":[143],"are":[144],"Caucasians,":[145],"Africans":[146],"Indians.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}