{"id":"https://openalex.org/W2022147482","doi":"https://doi.org/10.1016/0304-3940(90)90604-8","title":"d-CPP-ene (SDZ EAA 494), a potent and competitive (NMDA) antagonist: Effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801","display_name":"d-CPP-ene (SDZ EAA 494), a potent and competitive (NMDA) antagonist: Effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W2022147482","doi":"https://doi.org/10.1016/0304-3940(90)90604-8","mag":"2022147482","pmid":"https://pubmed.ncbi.nlm.nih.gov/2166255"},"language":"en","primary_location":{"id":"doi:10.1016/0304-3940(90)90604-8","doi":"https://doi.org/10.1016/0304-3940(90)90604-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3940(90)90604-8","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083915382","display_name":"David Lowe","orcid":"https://orcid.org/0000-0002-1441-0065","observed_orcids":["https://orcid.org/0000-0002-1441-0065"]},"institutions":[{"id":"https://openalex.org/I4388891806","display_name":"Sandoz Group AG (Switzerland)","ror":"https://ror.org/02rse7p59","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4388891806"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David A. Lowe","raw_affiliation_strings":["Sandoz Research Institute Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Research Institute Bern, Switzerland","institution_ids":["https://openalex.org/I4388891806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113871291","display_name":"Hans C. Neijt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891806","display_name":"Sandoz Group AG (Switzerland)","ror":"https://ror.org/02rse7p59","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4388891806"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hans C. Neijt","raw_affiliation_strings":["Sandoz Research Institute Bern, Bern Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Research Institute Bern, Bern Switzerland","institution_ids":["https://openalex.org/I4388891806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108574466","display_name":"B. AEBISCHER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891806","display_name":"Sandoz Group AG (Switzerland)","ror":"https://ror.org/02rse7p59","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4388891806"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bernard Aebischer","raw_affiliation_strings":["Sandoz Research Institute Bern, Bern Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Research Institute Bern, Bern Switzerland","institution_ids":["https://openalex.org/I4388891806"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4388891806"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":1.5578,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.81868003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"113","issue":"3","first_page":"315","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8029999732971191},{"id":"https://openalex.org/keywords/spontaneous-neuronal-activity","display_name":"spontaneous neuronal activity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cerebral-cortex-slices","display_name":"cerebral cortex slices","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.889405369758606},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.7682331800460815},{"id":"https://openalex.org/C86811712","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Competitive antagonist","level":4,"score":0.7250164747238159},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.6387925744056702},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.603219211101532},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5829181671142578},{"id":"https://openalex.org/C42533223","wikidata":"https://www.wikidata.org/wiki/Q1378064","display_name":"ED50","level":3,"score":0.45563051104545593},{"id":"https://openalex.org/C2909833455","wikidata":"https://www.wikidata.org/wiki/Q209309","display_name":"2-Amino-5-phosphonovalerate","level":5,"score":0.43049079179763794},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.42323383688926697},{"id":"https://openalex.org/C2911067986","wikidata":"https://www.wikidata.org/wiki/Q5419644","display_name":"Excitatory Amino Acid Antagonists","level":4,"score":0.3090282082557678},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2718208432197571},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23133566975593567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22835510969161987},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22276750206947327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2221892774105072}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003986","descriptor_name":"Dibenzocycloheptenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005071","descriptor_name":"Evoked Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0304-3940(90)90604-8","doi":"https://doi.org/10.1016/0304-3940(90)90604-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3940(90)90604-8","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:2166255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2166255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1540713802","https://openalex.org/W1773332605","https://openalex.org/W1966751481","https://openalex.org/W1968956259","https://openalex.org/W1995056605","https://openalex.org/W2034598759","https://openalex.org/W2047916166","https://openalex.org/W2056826168","https://openalex.org/W2073757300","https://openalex.org/W2095173719","https://openalex.org/W2135723161","https://openalex.org/W2137079796","https://openalex.org/W2152058439","https://openalex.org/W2163815564","https://openalex.org/W2417803326","https://openalex.org/W6638215122","https://openalex.org/W6648966281"],"related_works":["https://openalex.org/W2135723161","https://openalex.org/W1468260985","https://openalex.org/W2025523086","https://openalex.org/W1968956259","https://openalex.org/W2084960545","https://openalex.org/W2008637582","https://openalex.org/W2032216760","https://openalex.org/W2066514372","https://openalex.org/W1971145067","https://openalex.org/W2094126290"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}