{"id":"https://openalex.org/W2022019816","doi":"https://doi.org/10.1016/j.jns.2010.09.030","title":"Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease","display_name":"Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease","publication_year":2010,"publication_date":"2010-11-02","ids":{"openalex":"https://openalex.org/W2022019816","doi":"https://doi.org/10.1016/j.jns.2010.09.030","mag":"2022019816","pmid":"https://pubmed.ncbi.nlm.nih.gov/21040931"},"language":"en","primary_location":{"id":"doi:10.1016/j.jns.2010.09.030","doi":"https://doi.org/10.1016/j.jns.2010.09.030","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jns.2010.09.030","pdf_url":null,"source":{"id":"https://openalex.org/S169054600","display_name":"Journal of the Neurological Sciences","issn_l":"0022-510X","issn":["0022-510X","1878-5883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Neurological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046472539","display_name":"Hiroyasu Akatsu","orcid":"https://orcid.org/0000-0002-0089-6033","observed_orcids":["https://orcid.org/0000-0002-0089-6033"]},"institutions":[{"id":"https://openalex.org/I4210102080","display_name":"Fukushimura Hospital","ror":"https://ror.org/0180ay989","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102080"]},{"id":"https://openalex.org/I4210142016","display_name":"Choju Medical Institute","ror":"https://ror.org/044rmp068","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210142016"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroyasu Akatsu","raw_affiliation_strings":["Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan. akatu@chojuken.net","Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan. akatu@chojuken.net","institution_ids":["https://openalex.org/I4210102080","https://openalex.org/I4210142016"]},{"raw_affiliation_string":"Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan","institution_ids":["https://openalex.org/I4210102080","https://openalex.org/I4210142016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091446794","display_name":"Norihiro Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102080","display_name":"Fukushimura Hospital","ror":"https://ror.org/0180ay989","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102080"]},{"id":"https://openalex.org/I4210142016","display_name":"Choju Medical Institute","ror":"https://ror.org/044rmp068","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210142016"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norihiro Ogawa","raw_affiliation_strings":["Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan","institution_ids":["https://openalex.org/I4210102080","https://openalex.org/I4210142016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085365961","display_name":"Takeshi Kanesaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102080","display_name":"Fukushimura Hospital","ror":"https://ror.org/0180ay989","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102080"]},{"id":"https://openalex.org/I4210142016","display_name":"Choju Medical Institute","ror":"https://ror.org/044rmp068","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210142016"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Kanesaka","raw_affiliation_strings":["Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan","institution_ids":["https://openalex.org/I4210102080","https://openalex.org/I4210142016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109854215","display_name":"Akira Hori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102080","display_name":"Fukushimura Hospital","ror":"https://ror.org/0180ay989","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102080"]},{"id":"https://openalex.org/I4210142016","display_name":"Choju Medical Institute","ror":"https://ror.org/044rmp068","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210142016"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Hori","raw_affiliation_strings":["Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan","institution_ids":["https://openalex.org/I4210102080","https://openalex.org/I4210142016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071958820","display_name":"Takayuki Yamamoto","orcid":"https://orcid.org/0000-0001-7551-5568","observed_orcids":["https://orcid.org/0000-0001-7551-5568"]},"institutions":[{"id":"https://openalex.org/I4210102080","display_name":"Fukushimura Hospital","ror":"https://ror.org/0180ay989","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102080"]},{"id":"https://openalex.org/I4210142016","display_name":"Choju Medical Institute","ror":"https://ror.org/044rmp068","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210142016"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Yamamoto","raw_affiliation_strings":["Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan","institution_ids":["https://openalex.org/I4210102080","https://openalex.org/I4210142016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002007939","display_name":"Noriyuki Matsukawa","orcid":"https://orcid.org/0000-0002-6638-4516","observed_orcids":["https://orcid.org/0000-0002-6638-4516"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriyuki Matsukawa","raw_affiliation_strings":["Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008709206","display_name":"Makoto Michikawa","orcid":"https://orcid.org/0000-0001-5397-2709","observed_orcids":["https://orcid.org/0000-0001-5397-2709"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Michikawa","raw_affiliation_strings":["'","Department of Alzheimer","s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"'","institution_ids":[]},{"raw_affiliation_string":"Department of Alzheimer","institution_ids":[]},{"raw_affiliation_string":"s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan","institution_ids":["https://openalex.org/I4210160102"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5046472539"],"corresponding_institution_ids":["https://openalex.org/I4210102080","https://openalex.org/I4210142016"],"apc_list":{"value":3640,"currency":"USD","value_usd":3640},"apc_paid":null,"fwci":2.2885,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.86937686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"300","issue":"1-2","first_page":"67","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9309999942779541},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.9950000047683716},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.49799999594688416},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7889999747276306},{"id":"https://openalex.org/keywords/amyloid-beta-40","display_name":"A\u03b240","score":0.8999999761581421},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":1.0},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.8830000162124634},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.7289999723434448},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.5879999995231628},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.7240764498710632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6984404921531677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5582942962646484},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5529195070266724},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.545246958732605},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.5222216844558716},{"id":"https://openalex.org/C2988731192","wikidata":"https://www.wikidata.org/wiki/Q7410159","display_name":"Blood sampling","level":2,"score":0.4770749807357788},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.4245380163192749},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37067466974258423},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10773086547851562}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jns.2010.09.030","doi":"https://doi.org/10.1016/j.jns.2010.09.030","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jns.2010.09.030","pdf_url":null,"source":{"id":"https://openalex.org/S169054600","display_name":"Journal of the Neurological Sciences","issn_l":"0022-510X","issn":["0022-510X","1878-5883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Neurological Sciences","raw_type":"journal-article"},{"id":"pmid:21040931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21040931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the neurological sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.49000000953674316,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000287696","display_name":"Studies on the role(s) of renin-angiotensin system in the pathogenesis of Alzheimer disease","funder_award_id":"21300145","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309773","display_name":"Japan Health Sciences Foundation","ror":"https://ror.org/04z7xfj55"},{"id":"https://openalex.org/F4320324144","display_name":"National Institute of Biomedical Innovation","ror":"https://ror.org/001rkbe13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W44848436","https://openalex.org/W151444980","https://openalex.org/W1556008598","https://openalex.org/W1569630040","https://openalex.org/W1582334575","https://openalex.org/W1876279475","https://openalex.org/W1969501720","https://openalex.org/W1978231609","https://openalex.org/W1981772222","https://openalex.org/W1987271810","https://openalex.org/W1998750669","https://openalex.org/W1999061258","https://openalex.org/W2001976078","https://openalex.org/W2002731861","https://openalex.org/W2007566464","https://openalex.org/W2007769449","https://openalex.org/W2009178052","https://openalex.org/W2010528085","https://openalex.org/W2025514142","https://openalex.org/W2028403300","https://openalex.org/W2030011352","https://openalex.org/W2044936845","https://openalex.org/W2051565339","https://openalex.org/W2052321977","https://openalex.org/W2054812065","https://openalex.org/W2060926663","https://openalex.org/W2061763839","https://openalex.org/W2069677719","https://openalex.org/W2075651951","https://openalex.org/W2076517751","https://openalex.org/W2077398422","https://openalex.org/W2077595053","https://openalex.org/W2080123209","https://openalex.org/W2081998222","https://openalex.org/W2088608159","https://openalex.org/W2095745901","https://openalex.org/W2097532633","https://openalex.org/W2098817493","https://openalex.org/W2123826799","https://openalex.org/W2145488319","https://openalex.org/W2150999725","https://openalex.org/W2151359071","https://openalex.org/W2156653951","https://openalex.org/W2170430546","https://openalex.org/W2287382550","https://openalex.org/W2315249223","https://openalex.org/W2329525838","https://openalex.org/W4298498024","https://openalex.org/W6601841037","https://openalex.org/W6634903354","https://openalex.org/W6695879525"],"related_works":["https://openalex.org/W2186768350","https://openalex.org/W2415614104","https://openalex.org/W1998672586","https://openalex.org/W2160709476","https://openalex.org/W2398445761","https://openalex.org/W2790461664","https://openalex.org/W1997518038","https://openalex.org/W2013706992","https://openalex.org/W2068435782","https://openalex.org/W2015679682"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}