{"id":"https://openalex.org/W2022018134","doi":"https://doi.org/10.1161/01.hyp.26.6.1177","title":"Regulation of Neuronal Calcitonin Gene\u2013Related Peptide Expression","display_name":"Regulation of Neuronal Calcitonin Gene\u2013Related Peptide Expression","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2022018134","doi":"https://doi.org/10.1161/01.hyp.26.6.1177","mag":"2022018134","pmid":"https://pubmed.ncbi.nlm.nih.gov/7498991"},"language":"en","primary_location":{"id":"doi:10.1161/01.hyp.26.6.1177","doi":"https://doi.org/10.1161/01.hyp.26.6.1177","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.hyp.26.6.1177","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011379118","display_name":"Scott C. Supowit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott C. Supowit","raw_affiliation_strings":["From the Departments of Internal Medicine (Division of General Internal Medicine and Hypertension Section) and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine (Division of General Internal Medicine and Hypertension Section) and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033317259","display_name":"Huawei Zhao","orcid":"https://orcid.org/0000-0003-3688-6694","observed_orcids":["https://orcid.org/0000-0003-3688-6694"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huawei Zhao","raw_affiliation_strings":["From the Departments of Internal Medicine (Division of General Internal Medicine and Hypertension Section) and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine (Division of General Internal Medicine and Hypertension Section) and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004553768","display_name":"Donna H. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna H. Wang","raw_affiliation_strings":["From the Departments of Internal Medicine (Division of General Internal Medicine and Hypertension Section) and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine (Division of General Internal Medicine and Hypertension Section) and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087239740","display_name":"Donald J. DiPette","orcid":"https://orcid.org/0000-0002-5762-9104","observed_orcids":["https://orcid.org/0000-0002-5762-9104","https://orcid.org/0009-0008-9446-7942"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald J. DiPette","raw_affiliation_strings":["From the Departments of Internal Medicine (Division of General Internal Medicine and Hypertension Section) and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine (Division of General Internal Medicine and Hypertension Section) and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":null,"apc_paid":null,"fwci":0.2667,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.45369369,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"6","first_page":"1177","last_page":"1180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide","display_name":"calcitonin gene-related peptide","score":1.0},{"id":"https://openalex.org/keywords/cgrp-mrna-expression","display_name":"CGRP mRNA expression","score":0.8640000224113464},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8769999742507935},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.6610000133514404},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C163170386","wikidata":"https://www.wikidata.org/wiki/Q419432","display_name":"Calcitonin gene-related peptide","level":4,"score":0.9447267651557922},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8563581705093384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8354694843292236},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.6760733127593994},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5984746813774109},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.598110020160675},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5709149837493896},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5680484771728516},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5269585251808167},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.49741318821907043},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.459661602973938},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4031464159488678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3510347008705139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2723079323768616},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14256030321121216},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0878467857837677}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015347","descriptor_name":"RNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.hyp.26.6.1177","doi":"https://doi.org/10.1161/01.hyp.26.6.1177","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.hyp.26.6.1177","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:7498991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7498991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7099999785423279}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1579911359","display_name":"CALCITONIN GENE RELATED PEPTIDE IN HYPERTENSION","funder_award_id":"5r01hl044277-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5491851558","display_name":null,"funder_award_id":"HL44277-0141","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1506673182","https://openalex.org/W1584722453","https://openalex.org/W1594921867","https://openalex.org/W1618176959","https://openalex.org/W1986647797","https://openalex.org/W1989145539","https://openalex.org/W2013724508","https://openalex.org/W2031306451","https://openalex.org/W2035581625","https://openalex.org/W2040306557","https://openalex.org/W2048183890","https://openalex.org/W2053277833","https://openalex.org/W2055353756","https://openalex.org/W2060333964","https://openalex.org/W2065008933","https://openalex.org/W2079277054","https://openalex.org/W2104212576","https://openalex.org/W2111528243","https://openalex.org/W2125356206","https://openalex.org/W2144634347","https://openalex.org/W2199264035","https://openalex.org/W2224676279","https://openalex.org/W2396195122"],"related_works":["https://openalex.org/W2111528243","https://openalex.org/W1991952151","https://openalex.org/W2046056056","https://openalex.org/W7096454120","https://openalex.org/W2168505959","https://openalex.org/W2095288177","https://openalex.org/W2044486912","https://openalex.org/W1987950011","https://openalex.org/W2325927901","https://openalex.org/W1988001076"],"abstract_inverted_index":{"Calcitonin":[0],"gene-related":[1],"peptide":[2],"(CGRP)":[3],"is":[4,27,69,82,88],"a":[5,66,70,117,160,223],"potent":[6,67,118],"vasodilator":[7,68],"neuropeptide.":[8],"We":[9],"have":[10],"previously":[11],"demonstrated":[12],"that":[13,222],"CGRP":[14,25,43,87,123,206,235],"mRNA":[15,207,236],"levels":[16],"are":[17],"increased":[18,63],"in":[19,29,33,58,77,99,109,163,184,226],"dorsal":[20,203],"root":[21,37,204],"ganglia,":[22],"and":[23,44,51,182],"immunoreactive":[24],"content":[26,208],"elevated":[28,93],"the":[30,75,92,114,152,155,214],"spinal":[31,54],"cord":[32,55],"mineralocorticoid-salt":[34],"hypertension.":[35],"Dorsal":[36],"ganglia":[38,205],"neuronal":[39,86,122,234],"cell":[40],"bodies":[41],"synthesize":[42],"send":[45],"axons":[46],"peripherally":[47],"to":[48,53,73],"blood":[49,59,78,94,107,165,227],"vessels":[50],"centrally":[52],"sites":[56],"involved":[57],"pressure":[60,95,108,166],"regulation.":[61],"This":[62],"synthesis":[64],"of":[65,106,116,217],"compensatory":[71],"response":[72],"attenuate":[74],"increase":[76,121,162,225,233],"pressure;":[79],"however,":[80],"it":[81],"not":[83,210,232],"known":[84],"if":[85,104],"regulated":[89],"simply":[90],"by":[91,97,113,146,229],"or":[96,141],"changes":[98],"other":[100],"parameters.":[101],"To":[102],"determine":[103],"elevation":[105],"normal":[110],"rats":[111,128,158],"induced":[112],"administration":[115],"vasoconstrictor":[119],"can":[120],"mRNA,":[124],"7-week-old":[125],"male":[126],"Sprague-Dawley":[127],"were":[129],"treated":[130],"for":[131],"2":[132],"weeks":[133],"with":[134],"either":[135],"angiotensin":[136,156],"II":[137],"(n":[138,143],"=":[139,144],"6)":[140,145],"vehicle":[142],"using":[147],"implanted":[148],"osmotic":[149],"minipumps.":[150],"After":[151],"treatment":[153],"period,":[154],"II-treated":[157],"displayed":[159],"marked":[161,224],"systolic":[164],"(angiotensin":[167,188],"II,":[168,189],"217":[169],"+/-":[170,175,191,196],"18":[171],"versus":[172,193],"control,":[173,194],"131":[174],"3":[176],"mm":[177],"Hg,":[178],"P":[179,199],"<":[180,200],".001),":[181],"decrease":[183],"plasma":[185],"renin":[186],"activity":[187],"3.7":[190],"3.5":[192],"35.9":[195],"14.2":[197],"ng.mL-1.h-1,":[198],".05).":[201],"However,":[202],"did":[209],"significantly":[211],"differ":[212],"between":[213],"two":[215],"groups":[216],"rats.":[218],"These":[219],"results":[220],"demonstrate":[221],"pressure,":[228],"itself,":[230],"does":[231],"accumulation.(ABSTRACT":[237],"TRUNCATED":[238],"AT":[239],"250":[240],"WORDS)":[241]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
