{"id":"https://openalex.org/W2022017500","doi":"https://doi.org/10.1182/blood-2013-02-482539","title":"Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease","display_name":"Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease","publication_year":2013,"publication_date":"2013-07-02","ids":{"openalex":"https://openalex.org/W2022017500","doi":"https://doi.org/10.1182/blood-2013-02-482539","mag":"2022017500","pmid":"https://pubmed.ncbi.nlm.nih.gov/23818545"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2013-02-482539","doi":"https://doi.org/10.1182/blood-2013-02-482539","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2013-02-482539","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038216864","display_name":"Shen Dong","orcid":"https://orcid.org/0000-0001-8839-7046","observed_orcids":["https://orcid.org/0000-0001-8839-7046"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Shen Dong","raw_affiliation_strings":["Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016915312","display_name":"Sylvie Maiella","orcid":"https://orcid.org/0009-0004-0950-0658","observed_orcids":["https://orcid.org/0009-0004-0950-0658"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Maiella","raw_affiliation_strings":["Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044449649","display_name":"Ali\u00e9nor Xhaard","orcid":"https://orcid.org/0000-0002-4449-989X","observed_orcids":["https://orcid.org/0000-0002-4449-989X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali\u00e9nor Xhaard","raw_affiliation_strings":["Service d'H\u00e9matologie-Greffe, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9matologie-Greffe, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000390499","display_name":"Yuanyu Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yuanyu Pang","raw_affiliation_strings":["Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010091423","display_name":"Lynn Wenandy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lynn Wenandy","raw_affiliation_strings":["Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069149045","display_name":"J\u00e9r\u00f4me Larghero","orcid":"https://orcid.org/0000-0003-2086-7448","observed_orcids":["https://orcid.org/0000-0003-2086-7448"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4405259871","display_name":"Institut Universitaire d'H\u00e9matologie","ror":"https://ror.org/02w653772","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4405259871"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u00e9rome Larghero","raw_affiliation_strings":["Cell Therapy Unit and Clinical Investigation Center in Biotherapies, H\u00f4pital Saint-Louis, Assistance Publique-Hopitaux de Paris, Universit\u00e9 Paris VII Denis-Diderot, Paris, France;","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U940, Institut Universitaire d'H\u00e9matologie, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy Unit and Clinical Investigation Center in Biotherapies, H\u00f4pital Saint-Louis, Assistance Publique-Hopitaux de Paris, Universit\u00e9 Paris VII Denis-Diderot, Paris, France;","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610","https://openalex.org/I4387154366"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U940, Institut Universitaire d'H\u00e9matologie, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405259871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038846106","display_name":"Christophe B\u00e9cavin","orcid":"https://orcid.org/0000-0003-1555-3153","observed_orcids":["https://orcid.org/0000-0003-1555-3153"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I277688954","https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Becavin","raw_affiliation_strings":["Institut des Hautes \u00c9tudes Scientifiques and Centre National de la Recherche Scientifique Unit\u00e9s de Services et de Recherche, Bures sur Yvette, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques and Centre National de la Recherche Scientifique Unit\u00e9s de Services et de Recherche, Bures sur Yvette, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I84909340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054769886","display_name":"Arndt Benecke","orcid":"https://orcid.org/0000-0002-7121-823X","observed_orcids":["https://orcid.org/0000-0002-7121-823X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I277688954","https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arndt Benecke","raw_affiliation_strings":["Institut des Hautes \u00c9tudes Scientifiques and Centre National de la Recherche Scientifique Unit\u00e9s de Services et de Recherche, Bures sur Yvette, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques and Centre National de la Recherche Scientifique Unit\u00e9s de Services et de Recherche, Bures sur Yvette, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I84909340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068975132","display_name":"Elisabetta Bianchi","orcid":"https://orcid.org/0000-0001-6612-8881","observed_orcids":["https://orcid.org/0000-0001-6612-8881"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elisabetta Bianchi","raw_affiliation_strings":["Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012691135","display_name":"G\u00e8rard Soci\u00e9","orcid":"https://orcid.org/0000-0002-2114-7533","observed_orcids":["https://orcid.org/0000-0002-2114-7533","https://orcid.org/0000-0003-3819-8641"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405259871","display_name":"Institut Universitaire d'H\u00e9matologie","ror":"https://ror.org/02w653772","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4405259871"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G\u00e9rard Soci\u00e9","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U940, Institut Universitaire d'H\u00e9matologie, Paris, France;","Service d'H\u00e9matologie-Greffe, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U940, Institut Universitaire d'H\u00e9matologie, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405259871"]},{"raw_affiliation_string":"Service d'H\u00e9matologie-Greffe, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044143952","display_name":"Lars Rogge","orcid":"https://orcid.org/0000-0003-1262-9204","observed_orcids":["https://orcid.org/0000-0003-1262-9204"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lars Rogge","raw_affiliation_strings":["Center for Human Immunology, Institut Pasteur, Paris, France; and","Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Service, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Immunology, Institut Pasteur, Paris, France; and","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Immunoregulation Unit, Institut Pasteur, and Centre National de la Recherche Scientifique, Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Service, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":5.0308,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.95628029,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"122","issue":"10","first_page":"1802","last_page":"1812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cd4-foxp3-t-cells","display_name":"CD4+ Foxp3+ T cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/treg-heterogeneity","display_name":"Treg heterogeneity","score":0.953000009059906},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9169999957084656},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treg-homeostasis","display_name":"Treg homeostasis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.6549999713897705},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.9079999923706055},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.7570000290870667},{"id":"https://openalex.org/keywords/treg-suppressive-function","display_name":"Treg suppressive function","score":0.746999979019165},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7559999823570251},{"id":"https://openalex.org/keywords/homing-receptors","display_name":"homing receptors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6519834995269775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6314132213592529},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6213845014572144},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5722270011901855},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5290915966033936},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4957062005996704},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43771249055862427},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.42510849237442017},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4161384403705597},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40137386322021484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25697094202041626},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.255663126707077},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.23903748393058777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17078456282615662},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15023410320281982},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09924578666687012}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2013-02-482539","doi":"https://doi.org/10.1182/blood-2013-02-482539","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2013-02-482539","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:23818545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23818545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01544151v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01544151","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood, 2013, 122 (10), pp.1802-1812. ⟨10.1182/blood-2013-02-482539⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1567420244","https://openalex.org/W1965052809","https://openalex.org/W1969162956","https://openalex.org/W1974728044","https://openalex.org/W1979594892","https://openalex.org/W1981102729","https://openalex.org/W1981690705","https://openalex.org/W1985516890","https://openalex.org/W1986730103","https://openalex.org/W1989516288","https://openalex.org/W1991748190","https://openalex.org/W1993310853","https://openalex.org/W2007631222","https://openalex.org/W2012628829","https://openalex.org/W2016191219","https://openalex.org/W2017467835","https://openalex.org/W2027627024","https://openalex.org/W2034430001","https://openalex.org/W2036383793","https://openalex.org/W2042227130","https://openalex.org/W2042586707","https://openalex.org/W2042952613","https://openalex.org/W2043776488","https://openalex.org/W2044035130","https://openalex.org/W2054710330","https://openalex.org/W2059452586","https://openalex.org/W2060735279","https://openalex.org/W2073045132","https://openalex.org/W2081360252","https://openalex.org/W2085704445","https://openalex.org/W2088046822","https://openalex.org/W2088570448","https://openalex.org/W2098970896","https://openalex.org/W2100088787","https://openalex.org/W2102857641","https://openalex.org/W2105970563","https://openalex.org/W2105983154","https://openalex.org/W2111329034","https://openalex.org/W2123166427","https://openalex.org/W2134591209","https://openalex.org/W2141649011","https://openalex.org/W2145030204","https://openalex.org/W2150645158","https://openalex.org/W2150901150","https://openalex.org/W2152642587","https://openalex.org/W2157325100","https://openalex.org/W2160700813","https://openalex.org/W2162261192","https://openalex.org/W2162819001","https://openalex.org/W2167297937","https://openalex.org/W2564152524","https://openalex.org/W4296296481","https://openalex.org/W4313324526"],"related_works":["https://openalex.org/W1631979401","https://openalex.org/W2395945797","https://openalex.org/W2129470469","https://openalex.org/W2368295610","https://openalex.org/W1543102035","https://openalex.org/W1497716427","https://openalex.org/W2946692299","https://openalex.org/W3014941007","https://openalex.org/W2183075003","https://openalex.org/W1529708509"],"abstract_inverted_index":{"Understanding":[0],"the":[1,25,34,72,85,122,161,177,189],"heterogeneity":[2,35,175],"of":[3,17,39,60,74,84,95,99,105,136,184,195],"human":[4,40,196],"CD4+FOXP3+":[5,157,185],"regulatory":[6],"T":[7,67,158,186],"cells":[8,68,103,159],"(Tregs)":[9],"and":[10,36,45,79,104,117,166,192],"their":[11],"potential":[12],"for":[13,20],"lineage":[14,182],"reprogramming":[15,183],"is":[16,112],"critical":[18],"importance":[19],"moving":[21],"Treg":[22,87,110,123,137,162],"therapy":[23],"into":[24],"clinics.":[26],"Using":[27],"multiparameter":[28],"single-cell":[29,153,178],"analysis":[30,131],"techniques,":[31],"we":[32,120],"explored":[33],"functional":[37,193],"diversity":[38,194],"Tregs":[41,56],"in":[42,46,125,142],"healthy":[43],"donors":[44],"patients":[47,126,143],"after":[48,128],"allogeneic":[49],"hematopoietic":[50],"stem":[51],"cell":[52],"transplantation":[53],"(alloHSCT).":[54],"Human":[55],"displayed":[57],"a":[58,133,139],"level":[59],"complexity":[61,191],"similar":[62],"to":[63,71],"conventional":[64],"CD4+":[65],"effector":[66],"with":[69,138,149],"respect":[70],"expression":[73,97,164],"transcription":[75],"factors,":[76],"homing":[77],"receptors":[78],"inflammatory":[80,116],"cytokines.":[81],"Single-cell":[82],"profiling":[83,154],"rare":[86],"producing":[88],"interleukin-17A":[89],"or":[90,101],"interferon-\u03b3":[91],"showed":[92,155],"an":[93,115],"overlap":[94],"gene":[96,163],"signatures":[98],"Th17":[100],"Th1":[102],"Tregs.":[106,197],"To":[107],"assess":[108],"whether":[109],"homeostasis":[111],"affected":[113],"by":[114],"lymphopenic":[118],"environment,":[119],"characterized":[121],"compartment":[124],"early":[127],"alloHSCT.":[129],"This":[130],"suggested":[132],"marked":[134],"depletion":[135],"naive":[140],"phenotype":[141],"developing":[144],"acute":[145],"graft-versus-host":[146],"disease,":[147],"compared":[148],"tolerant":[150],"patients.":[151],"However,":[152],"that":[156,174],"maintain":[160],"signature":[165],"Treg-suppressive":[167],"activity":[168],"was":[169],"preserved.":[170],"Our":[171],"study":[172],"establishes":[173],"at":[176],"level,":[179],"rather":[180],"than":[181],"cells,":[187],"explains":[188],"remarkable":[190]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2025-10-10T00:00:00"}