{"id":"https://openalex.org/W2022016504","doi":"https://doi.org/10.1074/jbc.272.34.21654","title":"Native and Modified Low Density Lipoproteins Increase the Functional Expression of the Macrophage Class B Scavenger Receptor, CD36","display_name":"Native and Modified Low Density Lipoproteins Increase the Functional Expression of the Macrophage Class B Scavenger Receptor, CD36","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2022016504","doi":"https://doi.org/10.1074/jbc.272.34.21654","mag":"2022016504","pmid":"https://pubmed.ncbi.nlm.nih.gov/9261189"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.34.21654","doi":"https://doi.org/10.1074/jbc.272.34.21654","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.34.21654","pdf_url":"http://www.jbc.org/article/S0021925819658047/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819658047/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007205089","display_name":"Jihong Han","orcid":"https://orcid.org/0000-0001-5837-0897","observed_orcids":["https://orcid.org/0000-0001-5837-0897"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihong Han","raw_affiliation_strings":["Department of Pathology, Cornell University Medical College, New York, New York 10021, USA","Department of Pathology, Cornell-University Medical College, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Cornell University Medical College, New York, New York 10021, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Pathology, Cornell-University Medical College, New York, New York 10021, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108660778","display_name":"David P. Hajjar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Hajjar","raw_affiliation_strings":["Department of Pathology and Division of Hematology and Oncology/Department of Medicine, Cornell University Medical College, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Division of Hematology and Oncology/Department of Medicine, Cornell University Medical College, New York, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065729262","display_name":"Maria Febbraio","orcid":"https://orcid.org/0000-0001-7142-8440","observed_orcids":["https://orcid.org/0000-0001-7142-8440"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Febbraio","raw_affiliation_strings":["Department of Pathology and Division of Hematology and Oncology/Department of Medicine, Cornell University Medical College, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Division of Hematology and Oncology/Department of Medicine, Cornell University Medical College, New York, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061554211","display_name":"ANDREW C. NICHOLSON","orcid":"https://orcid.org/0000-0002-3307-5207","observed_orcids":["https://orcid.org/0000-0002-3307-5207"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew C. Nicholson","raw_affiliation_strings":["Department of Pathology and Division of Hematology and Oncology/Department of Medicine, Cornell University Medical College, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Division of Hematology and Oncology/Department of Medicine, Cornell University Medical College, New York, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061554211"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.1101,"has_fulltext":true,"cited_by_count":264,"citation_normalized_percentile":{"value":0.96808927,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"272","issue":"34","first_page":"21654","last_page":"21659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.3334999978542328,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.9900000095367432},{"id":"https://openalex.org/keywords/scavenger-receptor-class-b","display_name":"scavenger receptor class B","score":0.7239999771118164},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8259999752044678},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.949999988079071},{"id":"https://openalex.org/keywords/acetylated-ldl","display_name":"acetylated LDL","score":0.8640000224113464},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.9309999942779541},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/apolipoprotein-b-100","display_name":"apolipoprotein B-100","score":0.8259999752044678},{"id":"https://openalex.org/keywords/macrophage-scavenger-receptor","display_name":"macrophage scavenger receptor","score":0.652999997138977},{"id":"https://openalex.org/keywords/j774-cells","display_name":"J774 cells","score":0.6869999766349792},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.8569999933242798},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2779828298","wikidata":"https://www.wikidata.org/wiki/Q4035577","display_name":"CD36","level":3,"score":0.9896137118339539},{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.9745706915855408},{"id":"https://openalex.org/C2777895019","wikidata":"https://www.wikidata.org/wiki/Q1425962","display_name":"Foam cell","level":4,"score":0.786171555519104},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5945392847061157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.500892162322998},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4567694365978241},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4267578125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3998253643512726},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3908522427082062},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.31593239307403564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20854341983795166},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09737715125083923}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018110","descriptor_name":"Receptors, Lipoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018110","descriptor_name":"Receptors, Lipoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018110","descriptor_name":"Receptors, Lipoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051122","descriptor_name":"Scavenger Receptors, Class B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051122","descriptor_name":"Scavenger Receptors, Class B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051122","descriptor_name":"Scavenger Receptors, Class B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.34.21654","doi":"https://doi.org/10.1074/jbc.272.34.21654","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.34.21654","pdf_url":"http://www.jbc.org/article/S0021925819658047/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9261189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9261189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.34.21654","doi":"https://doi.org/10.1074/jbc.272.34.21654","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.34.21654","pdf_url":"http://www.jbc.org/article/S0021925819658047/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7825562263","display_name":"Cardiovascular Biology and Atherosclerosis","funder_award_id":"T32HL007423","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8479859515","display_name":null,"funder_award_id":"T32-HL-07423-17","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8727795127","display_name":null,"funder_award_id":"K01 RR00085","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G931469540","display_name":"REGULATION OF LIPOPROTEIN RECEPTORS IN ATHEROSCLEROSIS","funder_award_id":"5k01rr000085-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022016504.pdf","grobid_xml":"https://content.openalex.org/works/W2022016504.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W2069558","https://openalex.org/W104029063","https://openalex.org/W152815097","https://openalex.org/W317487423","https://openalex.org/W1512516272","https://openalex.org/W1529376098","https://openalex.org/W1547338001","https://openalex.org/W1551379024","https://openalex.org/W1558637003","https://openalex.org/W1562774051","https://openalex.org/W1566477377","https://openalex.org/W1568755186","https://openalex.org/W1574380753","https://openalex.org/W1581806217","https://openalex.org/W1596816338","https://openalex.org/W1653408396","https://openalex.org/W1775749144","https://openalex.org/W1857052429","https://openalex.org/W1973979172","https://openalex.org/W1977778060","https://openalex.org/W1985170971","https://openalex.org/W2004657626","https://openalex.org/W2005175065","https://openalex.org/W2006738360","https://openalex.org/W2009141354","https://openalex.org/W2024131238","https://openalex.org/W2036852690","https://openalex.org/W2037599912","https://openalex.org/W2038484123","https://openalex.org/W2040219415","https://openalex.org/W2043713555","https://openalex.org/W2046181597","https://openalex.org/W2049401036","https://openalex.org/W2050705339","https://openalex.org/W2051048068","https://openalex.org/W2051825180","https://openalex.org/W2063813098","https://openalex.org/W2065766518","https://openalex.org/W2072764799","https://openalex.org/W2080486016","https://openalex.org/W2083267747","https://openalex.org/W2084744450","https://openalex.org/W2093782393","https://openalex.org/W2099992849","https://openalex.org/W2107953123","https://openalex.org/W2112807003","https://openalex.org/W2113682801","https://openalex.org/W2117864941","https://openalex.org/W2119432184","https://openalex.org/W2136572409","https://openalex.org/W2146675158","https://openalex.org/W2153041000","https://openalex.org/W2161165626","https://openalex.org/W2170564808","https://openalex.org/W2326202471","https://openalex.org/W2396195587","https://openalex.org/W3139808032","https://openalex.org/W4318972697"],"related_works":["https://openalex.org/W2016442940","https://openalex.org/W2126408606","https://openalex.org/W1990149642","https://openalex.org/W2038445236","https://openalex.org/W2162456146","https://openalex.org/W2002812554","https://openalex.org/W4288080673","https://openalex.org/W2107835036","https://openalex.org/W2115017173","https://openalex.org/W2059457394"],"abstract_inverted_index":{"The":[0,81],"uptake":[1],"of":[2,20,56,84,95,106,121,139,169,181,208,212,243,249,270,280,294,297,312,316,357],"oxidized":[3],"low":[4],"density":[5],"lipoprotein":[6,250],"(OxLDL)":[7],"by":[8,187,195,202,232,238,301,322,378],"macrophages":[9,213,271,304],"is":[10,63,92,343],"a":[11,126,136,284,380],"key":[12],"event":[13],"implicated":[14],"in":[15,58,60,87,98,123,135,190,283,291,327,376],"the":[16,34,47,67,93,104,119,199,206,236,247,290,295,338,344,358],"initiation":[17],"and":[18,33,52,78,110,116,159,165,351],"development":[19,375],"atherosclerotic":[21],"lesions.":[22],"Two":[23],"macrophage":[24,35,128],"surface":[25],"receptors,":[26],"CD36":[27,57,100,122,140,170,182,191,222,227,244,253,259,281,298,317],"(a":[28,38],"class":[29,39,359],"B":[30,360],"scavenger":[31,36,41,361],"receptor)":[32],"receptor":[37,86],"A":[40],"receptor),":[42],"have":[43],"been":[44],"identified":[45],"as":[46,70,72,91,193],"major":[48,381],"receptors":[49],"that":[50,148,226,347,367],"bind":[51],"internalize":[53],"OxLDL.":[54,166],"Expression":[55],"monocyte/macrophages":[59],"tissue":[61],"culture":[62],"dependent":[64],"both":[65],"on":[66,118,252],"differentiation":[68],"state":[69],"well":[71],"exposure":[73,348],"to":[74,132,288,329,349,372],"soluble":[75],"mediators":[76],"(cytokines":[77],"growth":[79],"factors).":[80],"regulatory":[82],"mechanisms":[83],"this":[85],"vivo":[88,292],"are":[89],"undetermined":[90],"role":[94],"lipoproteins":[96,133,240,368],"themselves":[97],"modulating":[99],"expression.":[101,255],"We":[102],"studied":[103],"effect":[105],"lipoproteins,":[107,302],"native":[108],"LDL":[109,112,114,164],"modified":[111],"(acetylated":[113],"(AcLDL)":[115],"OxLDL)":[117],"expression":[120,142,168,184,242,261,279,300,315,356],"J774":[124],"cells,":[125],"murine":[127],"cell":[129,374],"line.":[130],"Exposure":[131],"resulted":[134],"marked":[137],"induction":[138,150,201,296,340],"mRNA":[141,171,183,223,228,254,260,282,299,318],"(4-8-fold).":[143],"Time":[144],"course":[145],"studies":[146],"showed":[147],"maximum":[149],"was":[151,185,229,319],"observed":[152],"2":[153],"h":[154,162,175],"after":[155],"treatment":[156,178,211],"with":[157,163,176,198,214,272,332,335],"AcLDL":[158],"at":[160],"4":[161],"Increased":[167],"persisted":[172],"for":[173],"24":[174],"each":[177],"group.":[179],"Induction":[180],"paralleled":[186],"an":[188],"increase":[189],"protein":[192],"determined":[194],"Western":[196],"blot":[197],"greatest":[200,339],"OxLDL":[203,218,326,336,382],"(4-fold).":[204],"In":[205],"presence":[207],"actinomycin":[209],"D,":[210],"LDL,":[215,323],"AcLDL,":[216,324],"or":[217,276,325],"did":[219],"not":[220],"affect":[221],"stability,":[224],"implying":[225],"transcriptionally":[230],"regulated":[231],"lipoproteins.":[233,313],"To":[234],"determine":[235],"mechanism(s)":[237],"which":[239],"increased":[241,258,321],"we":[245],"evaluated":[246],"effects":[248],"components":[251],"ApoB":[256],"100":[257],"significantly,":[262],"whereas":[263],"phospholipid/cholesterol":[264],"liposomes":[265],"had":[266],"less":[267],"effect.":[268],"Incubation":[269],"bovine":[273],"serum":[274],"albumin":[275],"HDL":[277],"reduced":[278],"dose-dependent":[285],"manner.":[286],"Finally,":[287],"evaluate":[289],"relevance":[293],"peritoneal":[303],"were":[305],"isolated":[306],"from":[307],"mice":[308,330],"following":[309],"intraperitoneal":[310],"injection":[311],"Macrophage":[314],"significantly":[320],"relation":[328],"infused":[331],"phosphate-buffered":[333],"saline,":[334],"causing":[337],"(8-fold).":[341],"This":[342],"first":[345],"demonstration":[346],"free":[350],"esterified":[352],"lipids":[353],"augments":[354],"functional":[355],"receptor,":[362],"CD36.":[363],"These":[364],"data":[365],"imply":[366],"can":[369],"further":[370],"contribute":[371],"foam":[373],"atherosclerosis":[377],"up-regulating":[379],"receptor.":[383]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}