{"id":"https://openalex.org/W2021987221","doi":"https://doi.org/10.1126/science.1186743","title":"Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting","display_name":"Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting","publication_year":2010,"publication_date":"2010-05-06","ids":{"openalex":"https://openalex.org/W2021987221","doi":"https://doi.org/10.1126/science.1186743","mag":"2021987221","pmid":"https://pubmed.ncbi.nlm.nih.gov/20448185","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3760334"},"language":"en","primary_location":{"id":"doi:10.1126/science.1186743","doi":"https://doi.org/10.1126/science.1186743","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1186743","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3760334","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028224364","display_name":"Xinning Zhang","orcid":"https://orcid.org/0000-0003-2763-1526","observed_orcids":["https://orcid.org/0000-0003-2763-1526","https://orcid.org/0009-0004-3236-1158","https://orcid.org/0009-0005-6888-6842"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Zhang","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Rashid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Rashid","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA","California  Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"California  Institute of Technology","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Wang","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA","California Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"California Institute of Technology","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000584662","display_name":"Shu\u2010ou Shan","orcid":"https://orcid.org/0000-0002-6526-1733","observed_orcids":["https://orcid.org/0000-0002-6526-1733"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. o. Shan","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA","California  Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"California  Institute of Technology","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000584662"],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":null,"apc_paid":null,"fwci":4.6864,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.95981084,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"328","issue":"5979","first_page":"757","last_page":"760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.28299999237060547,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signal-recognition-particle","display_name":"signal recognition particle","score":0.7170000076293945},{"id":"https://openalex.org/keywords/co-translational-protein-targeting","display_name":"co-translational protein targeting","score":0.9660000205039978},{"id":"https://openalex.org/keywords/substrate-selection","display_name":"substrate selection","score":0.871999979019165},{"id":"https://openalex.org/keywords/signal-sequence-recognition","display_name":"signal sequence recognition","score":0.5630000233650208},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bacterial-inner-membrane","display_name":"bacterial inner membrane","score":0.7300000190734863},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.5820000171661377},{"id":"https://openalex.org/keywords/protein-translocation","display_name":"protein translocation","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C186175293","wikidata":"https://www.wikidata.org/wiki/Q424665","display_name":"Signal recognition particle","level":5,"score":0.9139654636383057},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5802416801452637},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5509249567985535},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.48995915055274963},{"id":"https://openalex.org/C203900970","wikidata":"https://www.wikidata.org/wiki/Q21125262","display_name":"Signal recognition particle receptor","level":5,"score":0.4732801616191864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4702550172805786},{"id":"https://openalex.org/C2776459999","wikidata":"https://www.wikidata.org/wiki/Q2119376","display_name":"Fidelity","level":2,"score":0.45036551356315613},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4448462128639221},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.43390604853630066},{"id":"https://openalex.org/C2908821069","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli Proteins","level":4,"score":0.4218364953994751},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4195246398448944},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40839841961860657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.396321177482605},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.3931240439414978},{"id":"https://openalex.org/C559089031","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein targeting","level":4,"score":0.37174782156944275},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.30410686135292053},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24966102838516235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23046141862869263},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.19502690434455872},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1861574947834015},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.1554224193096161},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.146367609500885},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.082844078540802},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018271","descriptor_name":"Signal Recognition Particle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021382","descriptor_name":"Protein Sorting Signals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1126/science.1186743","doi":"https://doi.org/10.1126/science.1186743","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1186743","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:20448185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20448185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2754302","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3760334","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3760334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3760334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:18403","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20100521-152717223","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2754302","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3760334","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4097402463","display_name":null,"funder_award_id":"GM078024","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4985439405","display_name":"Molecular Mechanism of Protein Targeting by the Signal Recognition Particle","funder_award_id":"R01GM078024","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":112,"referenced_works":["https://openalex.org/W117684456","https://openalex.org/W171398818","https://openalex.org/W1525157376","https://openalex.org/W1590472235","https://openalex.org/W1597762634","https://openalex.org/W1970107043","https://openalex.org/W1971195614","https://openalex.org/W1972167068","https://openalex.org/W1973035845","https://openalex.org/W1973792741","https://openalex.org/W1975217090","https://openalex.org/W1975567952","https://openalex.org/W1977598234","https://openalex.org/W1980856759","https://openalex.org/W1981790879","https://openalex.org/W1982313409","https://openalex.org/W1994095191","https://openalex.org/W1995153766","https://openalex.org/W1995686466","https://openalex.org/W1996489229","https://openalex.org/W1997391192","https://openalex.org/W1997477098","https://openalex.org/W1997914060","https://openalex.org/W1998564815","https://openalex.org/W2002785901","https://openalex.org/W2003178039","https://openalex.org/W2004538909","https://openalex.org/W2006102455","https://openalex.org/W2006816153","https://openalex.org/W2009119310","https://openalex.org/W2010004274","https://openalex.org/W2015039690","https://openalex.org/W2023870517","https://openalex.org/W2025658961","https://openalex.org/W2029582401","https://openalex.org/W2030128644","https://openalex.org/W2030764144","https://openalex.org/W2032392220","https://openalex.org/W2032549034","https://openalex.org/W2033083162","https://openalex.org/W2033164699","https://openalex.org/W2034849841","https://openalex.org/W2037780433","https://openalex.org/W2040894016","https://openalex.org/W2042047503","https://openalex.org/W2042674021","https://openalex.org/W2042955816","https://openalex.org/W2045032671","https://openalex.org/W2048813428","https://openalex.org/W2050154932","https://openalex.org/W2054017406","https://openalex.org/W2054707540","https://openalex.org/W2055466584","https://openalex.org/W2056145435","https://openalex.org/W2056502129","https://openalex.org/W2058273091","https://openalex.org/W2062492647","https://openalex.org/W2063029946","https://openalex.org/W2063078491","https://openalex.org/W2063810968","https://openalex.org/W2065232854","https://openalex.org/W2066636585","https://openalex.org/W2067237172","https://openalex.org/W2069516894","https://openalex.org/W2071273803","https://openalex.org/W2072559002","https://openalex.org/W2073723844","https://openalex.org/W2075046123","https://openalex.org/W2076710572","https://openalex.org/W2076787023","https://openalex.org/W2079064092","https://openalex.org/W2079114119","https://openalex.org/W2080821333","https://openalex.org/W2082270046","https://openalex.org/W2082285195","https://openalex.org/W2084156924","https://openalex.org/W2087129510","https://openalex.org/W2091905411","https://openalex.org/W2094291868","https://openalex.org/W2095509404","https://openalex.org/W2099562375","https://openalex.org/W2101255026","https://openalex.org/W2105105619","https://openalex.org/W2106098125","https://openalex.org/W2106768806","https://openalex.org/W2108708484","https://openalex.org/W2117761303","https://openalex.org/W2119555549","https://openalex.org/W2122550753","https://openalex.org/W2123529526","https://openalex.org/W2123612435","https://openalex.org/W2127753323","https://openalex.org/W2128207929","https://openalex.org/W2129995310","https://openalex.org/W2138438888","https://openalex.org/W2138563074","https://openalex.org/W2139132736","https://openalex.org/W2140139924","https://openalex.org/W2144764975","https://openalex.org/W2153134143","https://openalex.org/W2157331768","https://openalex.org/W2157377535","https://openalex.org/W2164282000","https://openalex.org/W2165289894","https://openalex.org/W2167300514","https://openalex.org/W2167702721","https://openalex.org/W2169284526","https://openalex.org/W2170813053","https://openalex.org/W2243212101","https://openalex.org/W2347230326","https://openalex.org/W2411984669","https://openalex.org/W2952384259"],"related_works":["https://openalex.org/W2136899447","https://openalex.org/W6958905979","https://openalex.org/W4200253823","https://openalex.org/W2091439201","https://openalex.org/W2153242873","https://openalex.org/W2096086492","https://openalex.org/W1704087982","https://openalex.org/W2089039378","https://openalex.org/W2792349330","https://openalex.org/W2064351381"],"abstract_inverted_index":{"Proper":[0],"protein":[1],"localization":[2],"is":[3,16,18,101],"essential":[4],"for":[5,22],"all":[6],"cells.":[7],"However,":[8],"the":[9,33,46,64,104],"precise":[10],"mechanism":[11],"by":[12],"which":[13,42],"high":[14,96],"fidelity":[15,97],"achieved":[17,102],"not":[19],"well":[20],"understood":[21],"any":[23],"protein-targeting":[24],"pathway.":[25],"To":[26],"address":[27],"this":[28,110],"fundamental":[29],"question,":[30],"we":[31,77],"investigated":[32],"signal":[34,53,121],"recognition":[35,51],"particle":[36],"(SRP)":[37],"pathway":[38],"in":[39],"Escherichia":[40],"coli,":[41],"delivers":[43],"proteins":[44],"to":[45,61,68,71,116],"bacterial":[47],"inner":[48],"membrane":[49],"through":[50,85,103],"of":[52,66,88,93,98,107],"sequences":[54],"on":[55],"cargo":[56],"proteins.":[57],"Fidelity":[58],"was":[59],"thought":[60],"arise":[62],"from":[63],"inability":[65],"SRP":[67],"bind":[69],"strongly":[70],"incorrect":[72,80],"cargos.":[73],"Using":[74],"biophysical":[75],"assays,":[76],"found":[78],"that":[79],"cargos":[81],"were":[82],"also":[83],"rejected":[84],"a":[86],"series":[87],"checkpoints":[89],"during":[90],"subsequent":[91],"steps":[92],"targeting.":[94],"Thus,":[95],"substrate":[99],"selection":[100],"cumulative":[105],"effect":[106],"multiple":[108],"checkpoints;":[109],"principle":[111],"may":[112],"be":[113],"generally":[114],"applicable":[115],"other":[117],"pathways":[118],"involving":[119],"selective":[120],"recognition.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
