{"id":"https://openalex.org/W2021978125","doi":"https://doi.org/10.1073/pnas.1419399112","title":"Evolutionary pattern in the OXT-OXTR system in primates: Coevolution and positive selection footprints","display_name":"Evolutionary pattern in the OXT-OXTR system in primates: Coevolution and positive selection footprints","publication_year":2014,"publication_date":"2014-12-22","ids":{"openalex":"https://openalex.org/W2021978125","doi":"https://doi.org/10.1073/pnas.1419399112","mag":"2021978125","pmid":"https://pubmed.ncbi.nlm.nih.gov/25535371","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4291646"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1419399112","doi":"https://doi.org/10.1073/pnas.1419399112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1419399112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4291646","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062013480","display_name":"Pedro Vargas\u2010Pinilla","orcid":"https://orcid.org/0000-0003-4622-0941","observed_orcids":["https://orcid.org/0000-0003-4622-0941"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Vargas-Pinilla","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045409751","display_name":"Vanessa Rodrigues Paix\u00e3o\u2010C\u00f4rtes","orcid":"https://orcid.org/0000-0003-2677-0903","observed_orcids":["https://orcid.org/0000-0003-2677-0903"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vanessa Rodrigues Paix\u00e3o-C\u00f4rtes","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":"https://orcid.org/0000-0003-2677-0903","affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029938310","display_name":"P\u00e2mela Par\u00e9","orcid":"https://orcid.org/0000-0001-7881-4360","observed_orcids":["https://orcid.org/0000-0001-7881-4360"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pamela Par\u00e9","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020218271","display_name":"Luciana Tovo\u2010Rodrigues","orcid":"https://orcid.org/0000-0002-8732-6059","observed_orcids":["https://orcid.org/0000-0002-8732-6059"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciana Tovo-Rodrigues","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082361264","display_name":"Carlos Meton de Alencar Gadelha Vieira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos Meton de Alencar Gadelha Vieira","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103449550","display_name":"Agatha Xavier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Agatha Xavier","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017652236","display_name":"David Comas","orcid":"https://orcid.org/0000-0002-5075-0956","observed_orcids":["https://orcid.org/0000-0002-5075-0956"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210135169","display_name":"Institut de Biologia Evolutiva","ror":"https://ror.org/044mj7r89","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I170486558","https://openalex.org/I4210135169"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Comas","raw_affiliation_strings":["Institut de Biologia Evolutiva, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologia Evolutiva, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain;","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210135169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070912815","display_name":"Alcides Pissinatti","orcid":"https://orcid.org/0000-0002-0486-6712","observed_orcids":["https://orcid.org/0000-0002-0486-6712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alcides Pissinatti","raw_affiliation_strings":["Centro de Primatologia do Rio de Janeiro, 20940-200 Rio de Janeiro, RJ, Brazil; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Primatologia do Rio de Janeiro, 20940-200 Rio de Janeiro, RJ, Brazil; and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076004957","display_name":"Marialva Sinigaglia","orcid":"https://orcid.org/0000-0002-8324-6860","observed_orcids":["https://orcid.org/0000-0002-8324-6860"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marialva Sinigaglia","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034774826","display_name":"Maur\u00edcio Rigo","orcid":"https://orcid.org/0000-0002-1584-6194","observed_orcids":["https://orcid.org/0000-0002-1584-6194","https://orcid.org/0009-0004-3279-6143"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maur\u00edcio Menegatti Rigo","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079866895","display_name":"Gustavo Fioravanti Vieira","orcid":"https://orcid.org/0000-0002-2380-8059","observed_orcids":["https://orcid.org/0000-0002-2380-8059"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gustavo Fioravanti Vieira","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067863174","display_name":"Aldo Bolten Lucion","orcid":"https://orcid.org/0000-0003-3329-1118","observed_orcids":["https://orcid.org/0000-0003-3329-1118"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Aldo B. Lucion","raw_affiliation_strings":["Departamento de Fisiologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064637421","display_name":"Francisco M. Salzano","orcid":"https://orcid.org/0000-0002-4753-3184","observed_orcids":["https://orcid.org/0000-0002-4753-3184"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco Mauro Salzano","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045949136","display_name":"Mar\u00eda C\u00e1tira Bortolini","orcid":"https://orcid.org/0000-0003-0598-3854","observed_orcids":["https://orcid.org/0000-0003-0598-3854"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria C\u00e1tira Bortolini","raw_affiliation_strings":["Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica, Instituto de Bioci\u00eancias, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil;","institution_ids":["https://openalex.org/I130442723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.3334,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.98728382,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"112","issue":"1","first_page":"88","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10699","display_name":"Primate Behavior and Ecology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxytocin-receptor","display_name":"oxytocin receptor","score":1.0},{"id":"https://openalex.org/keywords/primate-evolution","display_name":"primate evolution","score":0.8550000190734863},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.8180000185966492},{"id":"https://openalex.org/keywords/coevolution","display_name":"coevolution","score":0.9729999899864197},{"id":"https://openalex.org/keywords/new-world-monkeys","display_name":"New World monkeys","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cebidae","display_name":"Cebidae","score":0.9200000166893005},{"id":"https://openalex.org/keywords/litter-size","display_name":"litter size","score":0.8679999709129333},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.8360000252723694},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.8500000238418579},{"id":"https://openalex.org/keywords/male-parental-care","display_name":"male parental care","score":0.824999988079071},{"id":"https://openalex.org/keywords/placental-mammals","display_name":"placental mammals","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C181612422","wikidata":"https://www.wikidata.org/wiki/Q14908140","display_name":"Oxytocin receptor","level":3,"score":0.8154159784317017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6603062748908997},{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.631822407245636},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6078745722770691},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.589866578578949},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5612030625343323},{"id":"https://openalex.org/C33009525","wikidata":"https://www.wikidata.org/wiki/Q208841","display_name":"Coevolution","level":2,"score":0.4740971028804779},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.46414366364479065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2729083299636841},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16607555747032166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15852084755897522},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0754764974117279},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07268103957176208},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018045","descriptor_name":"Receptors, Oxytocin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1419399112","doi":"https://doi.org/10.1073/pnas.1419399112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1419399112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3456054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4291646","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4291646","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4291646","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:25535371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25535371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3456054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4291646","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1216461804","https://openalex.org/W1501877799","https://openalex.org/W1589339136","https://openalex.org/W1718009280","https://openalex.org/W1866285812","https://openalex.org/W1897035253","https://openalex.org/W1907806866","https://openalex.org/W1963931493","https://openalex.org/W1967195968","https://openalex.org/W1969375325","https://openalex.org/W1975008822","https://openalex.org/W1989850098","https://openalex.org/W1992991337","https://openalex.org/W1995989434","https://openalex.org/W2004444667","https://openalex.org/W2004948333","https://openalex.org/W2005750609","https://openalex.org/W2006327345","https://openalex.org/W2012051436","https://openalex.org/W2014441770","https://openalex.org/W2014854982","https://openalex.org/W2016082001","https://openalex.org/W2024066961","https://openalex.org/W2033855766","https://openalex.org/W2036668049","https://openalex.org/W2039714243","https://openalex.org/W2041756668","https://openalex.org/W2044573154","https://openalex.org/W2045659750","https://openalex.org/W2053349628","https://openalex.org/W2053820259","https://openalex.org/W2060536455","https://openalex.org/W2061141022","https://openalex.org/W2062583603","https://openalex.org/W2078641132","https://openalex.org/W2083334427","https://openalex.org/W2083831789","https://openalex.org/W2093176106","https://openalex.org/W2096250412","https://openalex.org/W2104244040","https://openalex.org/W2104306559","https://openalex.org/W2110335151","https://openalex.org/W2114374730","https://openalex.org/W2120498344","https://openalex.org/W2125202809","https://openalex.org/W2127396309","https://openalex.org/W2129819610","https://openalex.org/W2132632499","https://openalex.org/W2133194321","https://openalex.org/W2135509505","https://openalex.org/W2135720675","https://openalex.org/W2142642753","https://openalex.org/W2144820135","https://openalex.org/W2146132811","https://openalex.org/W2146976480","https://openalex.org/W2153187042","https://openalex.org/W2155108881","https://openalex.org/W2157375137","https://openalex.org/W2160544821","https://openalex.org/W2162203550","https://openalex.org/W2164004777","https://openalex.org/W2168161193","https://openalex.org/W2170172095","https://openalex.org/W2170298557","https://openalex.org/W2495065424","https://openalex.org/W3156807887"],"related_works":["https://openalex.org/W7047091354","https://openalex.org/W406767003","https://openalex.org/W2113631199","https://openalex.org/W7009650677","https://openalex.org/W4387419438","https://openalex.org/W7100661195","https://openalex.org/W4398780999","https://openalex.org/W2804317358","https://openalex.org/W7204941787","https://openalex.org/W3107044690"],"abstract_inverted_index":{"Oxytocin":[0],"is":[1],"a":[2,6,64,69,115],"nonapeptide":[3],"involved":[4],"in":[5,26,35,44,56,85,94,106],"wide":[7],"range":[8],"of":[9,46,68,101,131,137,187],"physiologic":[10],"and":[11,39,110,147,157,159],"behavioral":[12],"functions.":[13],"Until":[14],"recently,":[15],"it":[16],"was":[17,24,104],"believed":[18],"that":[19,170],"an":[20],"unmodified":[21],"oxytocin":[22,33,41],"sequence":[23],"present":[25],"all":[27],"placental":[28],"mammals.":[29],"This":[30],"study":[31],"analyzed":[32],"(OXT)":[34],"29":[36],"primate":[37],"species":[38],"the":[40,57,80,107,185],"receptor":[42,145],"(OXTR)":[43],"21":[45],"these":[47,77],"species.":[48],"We":[49,168],"report":[50],"here":[51],"three":[52,82],"novel":[53],"OXT":[54,111,164],"forms":[55,176],"New":[58,172],"World":[59,173],"monkeys,":[60],"as":[61,63],"well":[62],"more":[65],"extensive":[66],"distribution":[67],"previously":[70],"described":[71],"variant":[72],"(Leu8Pro).":[73],"In":[74],"structural":[75],"terms,":[76],"OXTs":[78],"share":[79],"same":[81],"low-energy":[83],"conformations":[84],"solution":[86],"during":[87],"molecular":[88],"dynamic":[89],"simulations,":[90],"with":[91,122,141,163,189],"subtle":[92],"differences":[93],"their":[95],"side":[96],"chains.":[97],"A":[98],"consistent":[99],"signal":[100],"positive":[102,155],"selection":[103],"detected":[105],"Cebidae":[108],"family,":[109],"position":[112],"8":[113],"showed":[114],"statistically":[116],"significant":[117],"(P":[118],"=":[119],"0.013)":[120],"correlation":[121],"litter":[123],"size.":[124],"Several":[125],"OXTR":[126,149],"changes":[127],"were":[128,165],"identified,":[129],"some":[130,171],"them":[132],"promoting":[133],"gain":[134],"or":[135],"loss":[136],"putative":[138],"phosphorylation":[139],"sites,":[140],"possible":[142],"consequences":[143],"for":[144],"internalization":[146],"desensitization.":[148],"amino":[150],"acid":[151],"sites":[152],"are":[153],"under":[154],"selection,":[156],"intramolecular":[158],"intermolecular":[160],"coevolutionary":[161],"processes":[162],"also":[166],"detected.":[167],"suggest":[169],"monkey":[174],"OXT-OXTR":[175],"can":[177],"be":[178],"correlated":[179,191],"to":[180],"male":[181],"parental":[182],"care":[183],"through":[184],"increase":[186],"cross-reactivity":[188],"its":[190],"vasopressin":[192],"system.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}