{"id":"https://openalex.org/W2021966241","doi":"https://doi.org/10.1111/j.1365-3083.1979.tb01339.x","title":"Establishment of Anti\u2010TNP Antibody\u2010producing Human Lymphoid Lines by Preselection for Hapten Binding followed by EBV Transformation","display_name":"Establishment of Anti\u2010TNP Antibody\u2010producing Human Lymphoid Lines by Preselection for Hapten Binding followed by EBV Transformation","publication_year":1979,"publication_date":"1979-09-01","ids":{"openalex":"https://openalex.org/W2021966241","doi":"https://doi.org/10.1111/j.1365-3083.1979.tb01339.x","mag":"2021966241","pmid":"https://pubmed.ncbi.nlm.nih.gov/230581"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-3083.1979.tb01339.x","doi":"https://doi.org/10.1111/j.1365-3083.1979.tb01339.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-3083.1979.tb01339.x","pdf_url":null,"source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019050712","display_name":"Danuta Kozbor","orcid":"https://orcid.org/0000-0003-1927-096X","observed_orcids":["https://orcid.org/0000-0003-1927-096X"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"D. KOZBOR","raw_affiliation_strings":["Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113532578","display_name":"Michael O Steinitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"M. STEINITZ","raw_affiliation_strings":["Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109158685","display_name":"George Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":true,"raw_author_name":"G. KLEIN","raw_affiliation_strings":["Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110058174","display_name":"S. Koskimies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"S. KOSKIMIES","raw_affiliation_strings":["Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063528963","display_name":"O. M\u00e4kel\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"O. M\u00c3KEL\u00c4","raw_affiliation_strings":["Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden, and Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109158685"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I28166907"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":4.3009,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.94928367,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"10","issue":"3","first_page":"187","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.49540001153945923,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.49540001153945923,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-tnp-antibodies","display_name":"anti-TNP antibodies","score":0.6539999842643738},{"id":"https://openalex.org/keywords/trinitrophenyl","display_name":"trinitrophenyl","score":0.9729999899864197},{"id":"https://openalex.org/keywords/epstein-barr-virus-transformation","display_name":"Epstein-Barr virus transformation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lymphoblastoid-cell-lines","display_name":"lymphoblastoid cell lines","score":0.9520000219345093},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.7630000114440918},{"id":"https://openalex.org/keywords/antibody-specificity","display_name":"antibody specificity","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.8862550258636475},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7728233337402344},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.6655412912368774},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6336814761161804},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.5908137559890747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48990315198898315},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4545412063598633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4021967351436615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3267815113067627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13111764192581177},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006241","descriptor_name":"Haptens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010948","descriptor_name":"Viral Plaque Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012397","descriptor_name":"Rosette Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014301","descriptor_name":"Trinitrobenzenes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-3083.1979.tb01339.x","doi":"https://doi.org/10.1111/j.1365-3083.1979.tb01339.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-3083.1979.tb01339.x","pdf_url":null,"source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:230581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/230581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W197781038","https://openalex.org/W1538475960","https://openalex.org/W1591208477","https://openalex.org/W1970748912","https://openalex.org/W1985148567","https://openalex.org/W1986046536","https://openalex.org/W1991450017","https://openalex.org/W2013556409","https://openalex.org/W2030522563","https://openalex.org/W2044326018","https://openalex.org/W2089276240","https://openalex.org/W2089517154","https://openalex.org/W2128663983","https://openalex.org/W2154226690","https://openalex.org/W2157768631","https://openalex.org/W2158240651","https://openalex.org/W2282755628","https://openalex.org/W2402730709","https://openalex.org/W2403054154","https://openalex.org/W2405256866","https://openalex.org/W2414360874","https://openalex.org/W4302442086"],"related_works":["https://openalex.org/W2409757190","https://openalex.org/W2346337489","https://openalex.org/W2170298774","https://openalex.org/W2076121781","https://openalex.org/W2049367233","https://openalex.org/W1505520677","https://openalex.org/W2044326018","https://openalex.org/W1673456927","https://openalex.org/W2086187197","https://openalex.org/W2304099950"],"abstract_inverted_index":{"Human":[0],"lymphoblastoid":[1],"cell":[2,138],"lines":[3,34],"that":[4],"produce":[5],"specific":[6,45],"antibody":[7,79,113],"against":[8,50],"the":[9,56,68,82,111,117,127,130,144,150],"hapten":[10,118,146,152],"trinitrophenyl":[11],"(TNP)":[12],"have":[13],"been":[14],"established":[15],"by":[16,22,28,96,116],"selecting":[17],"TNP-binding":[18],"human":[19],"B":[20],"lymphocytes":[21],"TNP-rosetting":[23],"and":[24,39,47,89,99,123],"Ficoll-Isopaque":[25],"separation,":[26],"followed":[27],"Epstein-Barr":[29],"virus":[30],"(EBV)":[31],"immortalization.":[32],"Derived":[33],"secreted":[35],"polyclonal":[36],"anti-TNP":[37,112],"antibodies":[38,104,141],"contained":[40],"relatively":[41],"small":[42],"numbers":[43],"of":[44,58,70,110,129],"rosette-":[46],"plaque-forming":[48,71],"cells":[49,60,72],"TNP-RBC.":[51],"Following":[52],"rerosetting":[53],"with":[54,126],"TNP-RBC,":[55],"frequency":[57,69],"rosette-forming":[59],"increased":[61,73,84],"from":[62,74,85,90],"2%":[63],"to":[64,76,87,92],"75%.":[65],"In":[66],"parallel,":[67],"0.4%":[75],"30%.":[77],"The":[78,103,108],"titres":[80],"in":[81,121],"supernatants":[83],"64":[86],"512":[88],"48":[91],"192,":[93],"as":[94],"measured":[95],"TNP":[97],"agglutination":[98],"haemolytic":[100],"assays,":[101],"respectively.":[102],"were":[105,142],"19S,":[106],"IgM.":[107],"specificity":[109],"was":[114],"confirmed":[115],"inhibition":[119],"test,":[120],"comparison":[122],"cross-reactivity":[124],"tests":[125],"supernatant":[128],"previously":[131],"established,":[132],"EBV-transformed":[133],"anti-4-hydroxy-3,5-dinitrophenacetic":[134],"acid":[135],"(NNP)":[136],"antibody-producing":[137],"line.":[139],"Both":[140],"specific:":[143],"homologous":[145],"inhibited":[147],"them":[148],"but":[149],"heterologous":[151],"did":[153],"not.":[154]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
