{"id":"https://openalex.org/W2021965692","doi":"https://doi.org/10.1002/eji.1830030716","title":"Hapten\u2010specific tolerance: unresponsiveness in the t celldepleted population","display_name":"Hapten\u2010specific tolerance: unresponsiveness in the t celldepleted population","publication_year":1973,"publication_date":"1973-07-01","ids":{"openalex":"https://openalex.org/W2021965692","doi":"https://doi.org/10.1002/eji.1830030716","mag":"2021965692","pmid":"https://pubmed.ncbi.nlm.nih.gov/4586172"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830030716","doi":"https://doi.org/10.1002/eji.1830030716","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830030716","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. A. Hamilton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"J. A. Hamilton","raw_affiliation_strings":["Walter and Eliza Hall Institute of Medical Research, Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, Melbourne","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110033583","display_name":"J. F. A. P. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. F. A. P. Miller","raw_affiliation_strings":["Walter and Eliza Hall Institute of Medical Research, Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, Melbourne","institution_ids":["https://openalex.org/I196021976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I196021976"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":5.385,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.96097837,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"7","first_page":"457","last_page":"460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hapten-specific-tolerance","display_name":"hapten-specific tolerance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adoptive-transfer","display_name":"adoptive transfer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.6399999856948853},{"id":"https://openalex.org/keywords/unresponsiveness","display_name":"unresponsiveness","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C182420344","wikidata":"https://www.wikidata.org/wiki/Q17144130","display_name":"NIP","level":2,"score":0.8646313548088074},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.7545594573020935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6767019033432007},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6585903167724609},{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.6253207921981812},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5536398887634277},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5195906162261963},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.42137232422828674},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41509127616882324},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3750832676887512},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.32195550203323364},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.27874642610549927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10382691025733948},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001386","descriptor_name":"Azides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006241","descriptor_name":"Haptens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006462","descriptor_name":"Hemolytic Plaque Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008806","descriptor_name":"Mice, Inbred AKR","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009596","descriptor_name":"Nitrophenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011828","descriptor_name":"Radiation Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017710","descriptor_name":"Lymphocyte Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.1830030716","doi":"https://doi.org/10.1002/eji.1830030716","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830030716","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:4586172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4586172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W197781038","https://openalex.org/W1972935960","https://openalex.org/W1973624503","https://openalex.org/W2019238190","https://openalex.org/W2040345119","https://openalex.org/W2046368166","https://openalex.org/W2056194756","https://openalex.org/W2061871917","https://openalex.org/W2072948401","https://openalex.org/W2095488982","https://openalex.org/W2110756629","https://openalex.org/W2132255277","https://openalex.org/W2133164292","https://openalex.org/W2168395383","https://openalex.org/W2168425266","https://openalex.org/W2170175055","https://openalex.org/W2414360874"],"related_works":["https://openalex.org/W1980558634","https://openalex.org/W2120805766","https://openalex.org/W2027831148","https://openalex.org/W1978196337","https://openalex.org/W1480152774","https://openalex.org/W2050573067","https://openalex.org/W1569352579","https://openalex.org/W1670715419","https://openalex.org/W1797110664","https://openalex.org/W1985199697"],"abstract_inverted_index":{"Abstract":[0],"Complete":[1],"and":[2,35],"specific":[3],"suppression":[4,28],"of":[5,41,49,75],"the":[6,69,73,76],"anti\u2010NIP":[7],"[(4\u2010hydroxy\u20105\u2010iodo\u20103\u2010nitro\u2010phenyl)acetyl]":[8],"indirect":[9],"plaque\u2010forming":[10],"cell":[11],"response":[12],"to":[13,32],"NIP\u2010fowl":[14],"IgG":[15],"was":[16,36,51],"obtained":[17],"in":[18],"mice":[19],"by":[20,54,58],"pretreatment":[21],"with":[22,60],"NIP\u2010coated":[23],"syngeneic":[24],"erythrocytes.":[25],"The":[26,47],"complete":[27],"occurred":[29,71],"within":[30],"5":[31],"7":[33],"days":[34],"evident":[37],"after":[38],"adoptive":[39],"transfer":[40],"spleen":[42,64],"cells":[43],"into":[44],"irradiated":[45],"mice.":[46],"state":[48],"unresponsiveness":[50,70],"reversed,":[52],"not":[53],"thymus":[55],"cells,":[56],"but":[57],"supplementing":[59],"T":[61],"cell\u2010depleted":[62],"normal":[63],"cells.":[65],"This":[66],"suggests":[67],"that":[68],"at":[72],"level":[74],"B":[77],"lymphocyte":[78],"population.":[79]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}