{"id":"https://openalex.org/W2021964072","doi":"https://doi.org/10.4161/cbt.27314","title":"MicroRNA expression signatures of stage, grade, and progression in clear cell RCC","display_name":"MicroRNA expression signatures of stage, grade, and progression in clear cell RCC","publication_year":2013,"publication_date":"2013-12-18","ids":{"openalex":"https://openalex.org/W2021964072","doi":"https://doi.org/10.4161/cbt.27314","mag":"2021964072","pmid":"https://pubmed.ncbi.nlm.nih.gov/24351440","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3974834"},"language":"en","primary_location":{"id":"doi:10.4161/cbt.27314","doi":"https://doi.org/10.4161/cbt.27314","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.27314","pdf_url":null,"source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4161/cbt.27314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083658692","display_name":"Banumathy Gowrishankar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Banumathy Gowrishankar","raw_affiliation_strings":["Cancer Epigenetics Program; Fox Chase Cancer Center; Philadelphia, PA USA","Cancer Epigenetics Program","Fox Chase Cancer Center","Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Epigenetics Program; Fox Chase Cancer Center; Philadelphia, PA USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Cancer Epigenetics Program","institution_ids":[]},{"raw_affiliation_string":"Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Philadelphia, PA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062809815","display_name":"Ilsiya Ibragimova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilsiya Ibragimova","raw_affiliation_strings":["Cancer Epigenetics Program; Fox Chase Cancer Center; Philadelphia, PA USA","Cancer Epigenetics Program","Fox Chase Cancer Center","Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Epigenetics Program; Fox Chase Cancer Center; Philadelphia, PA USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Cancer Epigenetics Program","institution_ids":[]},{"raw_affiliation_string":"Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Philadelphia, PA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089209583","display_name":"Yan Zhou","orcid":"https://orcid.org/0000-0002-8698-0040","observed_orcids":["https://orcid.org/0000-0002-8698-0040"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Zhou","raw_affiliation_strings":["Biostatistics and Bioinformatics; Fox Chase Cancer Center; Philadelphia, PA USA","Biostatistics and Bioinformatics","Fox Chase Cancer Center","Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics; Fox Chase Cancer Center; Philadelphia, PA USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Biostatistics and Bioinformatics","institution_ids":[]},{"raw_affiliation_string":"Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Philadelphia, PA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027615447","display_name":"Michael J. Slifker","orcid":"https://orcid.org/0000-0002-9718-5966","observed_orcids":["https://orcid.org/0000-0002-9718-5966"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Slifker","raw_affiliation_strings":["Biostatistics and Bioinformatics; Fox Chase Cancer Center; Philadelphia, PA USA","Biostatistics and Bioinformatics","Fox Chase Cancer Center","Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics; Fox Chase Cancer Center; Philadelphia, PA USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Biostatistics and Bioinformatics","institution_ids":[]},{"raw_affiliation_string":"Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Philadelphia, PA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031081545","display_name":"Karthik Devarajan","orcid":"https://orcid.org/0000-0002-8475-383X","observed_orcids":["https://orcid.org/0000-0002-8475-383X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karthik Devarajan","raw_affiliation_strings":["Biostatistics and Bioinformatics; Fox Chase Cancer Center; Philadelphia, PA USA","Biostatistics and Bioinformatics","Fox Chase Cancer Center","Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics; Fox Chase Cancer Center; Philadelphia, PA USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Biostatistics and Bioinformatics","institution_ids":[]},{"raw_affiliation_string":"Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Philadelphia, PA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111826382","display_name":"Tahseen Al\u2010Saleem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tahseen Al-Saleem","raw_affiliation_strings":["Kidney Cancer Keystone Program; Fox Chase Cancer Center; Philadelphia, PA USA; Department of Pathology; Fox Chase Cancer Center; Philadelphia, PA USA","Department of Pathology","Fox Chase Cancer Center","Kidney Cancer Keystone Program","Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kidney Cancer Keystone Program; Fox Chase Cancer Center; Philadelphia, PA USA; Department of Pathology; Fox Chase Cancer Center; Philadelphia, PA USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Pathology","institution_ids":[]},{"raw_affiliation_string":"Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Kidney Cancer Keystone Program","institution_ids":[]},{"raw_affiliation_string":"Philadelphia, PA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043554307","display_name":"Robert G. Uzzo","orcid":"https://orcid.org/0000-0003-2398-6530","observed_orcids":["https://orcid.org/0000-0003-2398-6530"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G Uzzo","raw_affiliation_strings":["Kidney Cancer Keystone Program; Fox Chase Cancer Center; Philadelphia, PA USA; Department of Surgery; Fox Chase Cancer Center; Philadelphia, PA USA","Department of Surgery","Fox Chase Cancer Center","Kidney Cancer Keystone Program","Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kidney Cancer Keystone Program; Fox Chase Cancer Center; Philadelphia, PA USA; Department of Surgery; Fox Chase Cancer Center; Philadelphia, PA USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Surgery","institution_ids":[]},{"raw_affiliation_string":"Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Kidney Cancer Keystone Program","institution_ids":[]},{"raw_affiliation_string":"Philadelphia, PA USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109103979","display_name":"Paul Cairns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Cairns","raw_affiliation_strings":["Cancer Epigenetics Program; Fox Chase Cancer Center; Philadelphia, PA USA; Kidney Cancer Keystone Program; Fox Chase Cancer Center; Philadelphia, PA USA","Cancer Epigenetics Program","Fox Chase Cancer Center","Kidney Cancer Keystone Program","Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Epigenetics Program; Fox Chase Cancer Center; Philadelphia, PA USA; Kidney Cancer Keystone Program; Fox Chase Cancer Center; Philadelphia, PA USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Cancer Epigenetics Program","institution_ids":[]},{"raw_affiliation_string":"Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Kidney Cancer Keystone Program","institution_ids":[]},{"raw_affiliation_string":"Philadelphia, PA USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109103979"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":{"value":2710,"currency":"EUR","value_usd":2970},"fwci":2.7189,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.90688113,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"15","issue":"3","first_page":"329","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microrna-signature","display_name":"microRNA signature","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nuclear-grade","display_name":"nuclear grade","score":0.8309999704360962},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7850000262260437},{"id":"https://openalex.org/keywords/let-7-family","display_name":"let-7 family","score":0.7210000157356262},{"id":"https://openalex.org/keywords/mir-21-5p","display_name":"miR-21-5p","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mir-142-3p","display_name":"miR-142-3p","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mir-204-5p","display_name":"miR-204-5p","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mir-424-5p","display_name":"miR-424-5p","score":0.9160000085830688},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8309999704360962},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.811184823513031},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.7275820970535278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6940088868141174},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.6406391263008118},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6077088713645935},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6011596322059631},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5517822504043579},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.487842321395874},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4396911859512329},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35994288325309753},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.19625574350357056},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17719170451164246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17362603545188904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09519371390342712}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/cbt.27314","doi":"https://doi.org/10.4161/cbt.27314","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.27314","pdf_url":null,"source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2959707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3974834","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24351440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24351440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3974834","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3974834/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biol Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4161/cbt.27314","doi":"https://doi.org/10.4161/cbt.27314","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.27314","pdf_url":null,"source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1480905771","display_name":"Methylation & Proteomics-Based Detection of Renal Cancer","funder_award_id":"U01CA111242","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1548453476","https://openalex.org/W1648301895","https://openalex.org/W1966347977","https://openalex.org/W1967576554","https://openalex.org/W1970178087","https://openalex.org/W1980718338","https://openalex.org/W1992272392","https://openalex.org/W1992499158","https://openalex.org/W1997196734","https://openalex.org/W2001258296","https://openalex.org/W2002995168","https://openalex.org/W2008438358","https://openalex.org/W2010231082","https://openalex.org/W2026570544","https://openalex.org/W2033892848","https://openalex.org/W2034269086","https://openalex.org/W2034561062","https://openalex.org/W2039340234","https://openalex.org/W2039545078","https://openalex.org/W2062385231","https://openalex.org/W2069136947","https://openalex.org/W2070161604","https://openalex.org/W2071300544","https://openalex.org/W2074059417","https://openalex.org/W2080679809","https://openalex.org/W2081098333","https://openalex.org/W2081113032","https://openalex.org/W2088161934","https://openalex.org/W2092050888","https://openalex.org/W2110362508","https://openalex.org/W2111608545","https://openalex.org/W2111687673","https://openalex.org/W2111990378","https://openalex.org/W2119492915","https://openalex.org/W2122899297","https://openalex.org/W2130154562","https://openalex.org/W2130281728","https://openalex.org/W2135204782","https://openalex.org/W2136109165","https://openalex.org/W2139834510","https://openalex.org/W2141371533","https://openalex.org/W2142489285","https://openalex.org/W2148929244","https://openalex.org/W2152874907","https://openalex.org/W2153238348","https://openalex.org/W2158102364","https://openalex.org/W2161222316","https://openalex.org/W2161817637","https://openalex.org/W2162128049","https://openalex.org/W2170514882","https://openalex.org/W2335012284","https://openalex.org/W4232510591"],"related_works":["https://openalex.org/W4363675934","https://openalex.org/W2090629367","https://openalex.org/W3035081670","https://openalex.org/W6925096055","https://openalex.org/W2907709130","https://openalex.org/W1483026516","https://openalex.org/W2341201056","https://openalex.org/W4286486931","https://openalex.org/W2052071642","https://openalex.org/W2353095951"],"abstract_inverted_index":{"Clear":[0],"cell":[1],"RCC":[2],"is":[3,22,78],"the":[4,13,23,66,85,92,100,191,210,231,234],"most":[5,24,193,211],"common,":[6],"and":[7,28,49,58,75,94,117,142,220,238],"more":[8],"likely":[9],"to":[10,43,91,150,222,228],"metastasize,":[11],"of":[12,18,36,47,68,87,96,105,112,125,137,148,155,168,190,209,236],"three":[14],"main":[15],"histological":[16],"types":[17],"RCC.":[19,38],"Pathologic":[20],"stage":[21],"important":[25],"prognostic":[26],"indicator":[27],"nuclear":[29],"grade":[30],"can":[31],"predict":[32],"outcome":[33],"within":[34],"stages":[35],"localized":[37],"Epithelial":[39],"tumors":[40],"are":[41,63],"thought":[42],"accumulate":[44],"a":[45,110,122,130],"series":[46,111,124],"genetic":[48],"epigenetic":[50],"changes":[51],"as":[52,144,146,207],"they":[53],"progress":[54],"through":[55,109],"well-defined":[56],"clinical":[57],"histopathological":[59],"changes.":[60],"MicroRNAs":[61],"(miRNAs)":[62],"involved":[64],"in":[65,80,102,121,182],"regulation":[67],"mRNA":[69],"expression":[70,77,90,103],"from":[71],"many":[72],"human":[73,107],"genes":[74],"miRNA":[76,89],"dysregulated":[79,88,213],"cancer.":[81],"To":[82],"better":[83],"understand":[84],"contribution":[86],"progression":[93,119,172,235],"biology":[95,232],"ccRCC,":[97],"we":[98],"examined":[99],"differences":[101],"levels":[104],"723":[106],"miRNAs":[108,197,214,240],"analyses":[113],"by":[114,202],"stage,":[115,157,169],"grade,":[116,160,170],"disease":[118],"status":[120],"large":[123],"94":[126],"ccRCC.":[127],"We":[128],"found":[129],"consistent":[131],"signature":[132],"that":[133],"included":[134,215],"significant":[135],"upregulation":[136],"miR-21-5p,":[138],"142-3p,":[139],"let-7g-5p,":[140],"let-7i-5p":[141],"424-5p,":[143],"well":[145],"downregulation":[147],"miR-204-5p,":[149],"be":[151],"associated":[152,165],"with":[153,166,185],"ccRCC":[154,183,199,237],"high":[156,159],"or":[158,161,171],"progression.":[162],"Discrete":[163],"signatures":[164],"each":[167],"were":[173],"also":[174],"identified.":[175],"The":[176],"let-7":[177],"family":[178],"was":[179,200],"significantly":[180,194,212],"downregulated":[181],"compared":[184],"normal":[186],"renal":[187],"parenchyma.":[188],"Expression":[189],"6":[192],"differentially":[195],"expressed":[196],"between":[198],"verified":[201],"stem-loop":[203],"qRT-PCR.":[204],"Pathways":[205],"predicted":[206],"targets":[208],"signaling,":[216],"epithelial":[217,221],"cancers,":[218],"metabolism,":[219],"mesenchymal":[223],"transition.":[224],"Our":[225],"studies":[226],"help":[227],"further":[229],"elucidate":[230],"underlying":[233],"identify":[239],"for":[241],"potential":[242],"translational":[243],"application.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}