{"id":"https://openalex.org/W2021925807","doi":"https://doi.org/10.1038/sj.gt.3301533","title":"Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector","display_name":"Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2021925807","doi":"https://doi.org/10.1038/sj.gt.3301533","mag":"2021925807","pmid":"https://pubmed.ncbi.nlm.nih.gov/11571584"},"language":"en","primary_location":{"id":"doi:10.1038/sj.gt.3301533","doi":"https://doi.org/10.1038/sj.gt.3301533","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.gt.3301533","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016559292","display_name":"Paola Melotti","orcid":"https://orcid.org/0000-0002-5276-1595","observed_orcids":["https://orcid.org/0000-0002-5276-1595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Melotti","raw_affiliation_strings":["Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076501930","display_name":"Elena Nicolis","orcid":"https://orcid.org/0000-0001-7810-3307","observed_orcids":["https://orcid.org/0000-0001-7810-3307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Nicolis","raw_affiliation_strings":["Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027802626","display_name":"Anna Tamanini","orcid":"https://orcid.org/0000-0002-7427-0981","observed_orcids":["https://orcid.org/0000-0002-7427-0981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Tamanini","raw_affiliation_strings":["Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032783520","display_name":"Rossella Rolfini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Rolfini","raw_affiliation_strings":["Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111962738","display_name":"Andr\u00e9a Pavirani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238723","display_name":"Transgene (France)","ror":"https://ror.org/02d4qpq05","country_code":"FR","type":"company","lineage":["https://openalex.org/I152238723"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Pavirani","raw_affiliation_strings":["Transg\u00e8ne, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transg\u00e8ne, Strasbourg, France","institution_ids":["https://openalex.org/I152238723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004918425","display_name":"Giulio Cabrini","orcid":"https://orcid.org/0000-0003-2720-0742","observed_orcids":["https://orcid.org/0000-0003-2720-0742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Cabrini","raw_affiliation_strings":["Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology, Cystic Fibrosis Center, Verona, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.0709,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.74591225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"18","first_page":"1436","last_page":"1442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.19599999487400055,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.7649999856948853},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.8209999799728394},{"id":"https://openalex.org/keywords/replication-deficient-adenovirus","display_name":"replication-defective adenovirus","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cystic-fibrosis-gene-therapy","display_name":"cystic fibrosis gene therapy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/airway-epithelial-cells","display_name":"airway epithelial cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nf-kappab-inhibitors","display_name":"NF-\u03baB inhibitors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/parthenolide","display_name":"parthenolide","score":0.8050000071525574},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.843999981880188},{"id":"https://openalex.org/keywords/pyrrolidine-dithiocarbamate","display_name":"pyrrolidine dithiocarbamate","score":0.984000027179718},{"id":"https://openalex.org/keywords/proinflammatory-response","display_name":"pro-inflammatory response","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7661653757095337},{"id":"https://openalex.org/C2780983412","wikidata":"https://www.wikidata.org/wiki/Q7263769","display_name":"Pyrrolidine dithiocarbamate","level":4,"score":0.7078590989112854},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6510966420173645},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.5664392113685608},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.5323182940483093},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44820573925971985},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4256199300289154},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.40945783257484436},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.2698938846588135},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26975446939468384},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.21565160155296326},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.20325231552124023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18560418486595154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07102587819099426}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013859","descriptor_name":"Thiocarbamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.gt.3301533","doi":"https://doi.org/10.1038/sj.gt.3301533","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.gt.3301533","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},{"id":"pmid:11571584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11571584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1509901462","https://openalex.org/W1530317014","https://openalex.org/W1535502332","https://openalex.org/W1537855747","https://openalex.org/W1543445053","https://openalex.org/W1558349166","https://openalex.org/W1568529372","https://openalex.org/W1584944565","https://openalex.org/W1676110045","https://openalex.org/W1918990945","https://openalex.org/W1963906419","https://openalex.org/W1965583590","https://openalex.org/W1977348907","https://openalex.org/W1989039738","https://openalex.org/W2010571598","https://openalex.org/W2014019711","https://openalex.org/W2015617337","https://openalex.org/W2018963759","https://openalex.org/W2032870583","https://openalex.org/W2038890616","https://openalex.org/W2047963123","https://openalex.org/W2048366410","https://openalex.org/W2068406884","https://openalex.org/W2072236945","https://openalex.org/W2073516062","https://openalex.org/W2080766098","https://openalex.org/W2082629239","https://openalex.org/W2093082335","https://openalex.org/W2095573430","https://openalex.org/W2102662193","https://openalex.org/W2107021343","https://openalex.org/W2131924126","https://openalex.org/W2135753689","https://openalex.org/W2139031305","https://openalex.org/W2143116542","https://openalex.org/W2143381752","https://openalex.org/W2146261786","https://openalex.org/W2147823227","https://openalex.org/W2156487862","https://openalex.org/W2156829792","https://openalex.org/W2157233081","https://openalex.org/W2159567970","https://openalex.org/W2416631711","https://openalex.org/W2999065750","https://openalex.org/W4232678241","https://openalex.org/W4285719527","https://openalex.org/W4313347901"],"related_works":["https://openalex.org/W2080766098","https://openalex.org/W2082629239","https://openalex.org/W2085206357","https://openalex.org/W2072236945","https://openalex.org/W4313379449","https://openalex.org/W2101684742","https://openalex.org/W2147823227","https://openalex.org/W2121824424","https://openalex.org/W2157233081","https://openalex.org/W2010571598"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
