{"id":"https://openalex.org/W2021902859","doi":"https://doi.org/10.3892/or.12.6.1155","title":"Plasminogen activator inhibitor type-1 mutants regulate angiogenesis of human umbilical and lung vascular endothelial cells","display_name":"Plasminogen activator inhibitor type-1 mutants regulate angiogenesis of human umbilical and lung vascular endothelial cells","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2021902859","doi":"https://doi.org/10.3892/or.12.6.1155","mag":"2021902859","pmid":"https://pubmed.ncbi.nlm.nih.gov/15547731"},"language":"en","primary_location":{"id":"doi:10.3892/or.12.6.1155","doi":"https://doi.org/10.3892/or.12.6.1155","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.12.6.1155","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080173835","display_name":"Joanna Chorostowska\u2010Wynimko","orcid":"https://orcid.org/0000-0003-1743-2961","observed_orcids":["https://orcid.org/0000-0003-1743-2961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Chorostowska-Wynimko","raw_affiliation_strings":["Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland. j.chorostowska@igichp.edu.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland. j.chorostowska@igichp.edu.pl","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037959815","display_name":"Rafal Swiercz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafal Swiercz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026381921","display_name":"Ewa Skrzypczak\u2010Jankun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewa Skrzypczak-Jankun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081142231","display_name":"Steven H. Selman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Selman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079636370","display_name":"Jerzy Jankun","orcid":"https://orcid.org/0000-0003-2354-4046","observed_orcids":["https://orcid.org/0000-0003-2354-4046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerzy Jankun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1953,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.42435817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"12","issue":"6","first_page":"1155","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.08889999985694885,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.8180000185966492},{"id":"https://openalex.org/keywords/upar","display_name":"uPAR","score":0.6510000228881836},{"id":"https://openalex.org/keywords/sprout-formation","display_name":"sprout formation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lung-microvascular-endothelial-cells","display_name":"lung microvascular endothelial cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/vitronectin-binding","display_name":"vitronectin binding","score":0.7089999914169312},{"id":"https://openalex.org/keywords/integrin-binding","display_name":"integrin binding","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.41499999165534973},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.8872066140174866},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7630033493041992},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.6791084408760071},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.6172745227813721},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.5953861474990845},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5372037887573242},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5307690501213074},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5214425921440125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4871461093425751},{"id":"https://openalex.org/C2777834122","wikidata":"https://www.wikidata.org/wiki/Q5939177","display_name":"Human umbilical vein endothelial cell","level":4,"score":0.45793581008911133},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4063095152378082},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3910561800003052},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3888680040836334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3378097712993622},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27466991543769836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24898135662078857},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17470860481262207},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09579715132713318},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07120704650878906}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.12.6.1155","doi":"https://doi.org/10.3892/or.12.6.1155","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.12.6.1155","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:15547731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15547731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5159172935","display_name":"Genetically Engineered PAI1 for Anti-cancer Therapy","funder_award_id":"R21CA109625","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6901862125","display_name":"Computer Directed Photodynamic Therapy of Prostate Ca","funder_award_id":"R01CA090524","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W173015816","https://openalex.org/W2137400219","https://openalex.org/W2145489671","https://openalex.org/W2125865842","https://openalex.org/W2096487443","https://openalex.org/W7074254785","https://openalex.org/W2166676774","https://openalex.org/W1892118861","https://openalex.org/W1604221154","https://openalex.org/W2136794886"],"abstract_inverted_index":{"Plasminogen":[0],"activator":[1],"inhibitor":[2],"type-1":[3],"(PAI-1)":[4],"is":[5],"considered":[6],"one":[7],"of":[8,12,47,53,96,119,132,237,240,249,261,274,284,301],"the":[9,94,176,235,246,254,267,281],"key":[10],"regulators":[11],"tumor":[13],"invasion,":[14],"metastasis,":[15],"as":[16,18],"well":[17],"cancer-related":[19],"angiogenesis.":[20],"The":[21,186],"literature":[22],"suggests":[23],"that":[24,279],"PAI-1":[25,56,59,139,146,285],"plays":[26],"a":[27,169,211],"dual":[28],"role":[29],"in":[30,192,219,223,228,242],"these":[31,54,289],"processes":[32],"because":[33],"it":[34],"inhibits":[35],"plasmin-originated":[36],"proteolysis":[37],"and":[38,67,77,122,145,161,183,197,245,293],"binds":[39,74],"to":[40,75,86,234,269],"vitronectin":[41,76],"or":[42,45],"integrins.":[43,78],"Stimulation":[44],"inhibition":[46,99,187],"angiogenesis":[48,275,292],"largely":[49],"depends":[50],"on":[51,102,178],"which":[52],"elements":[55],"interacts.":[57],"Wild":[58],"converts":[60],"quickly":[61],"into":[62],"its":[63,69],"latent,":[64],"inactive":[65],"form":[66],"loses":[68],"anti-proteolytic":[70,89,213,282],"activity,":[71],"but":[72,221],"still":[73],"Thus":[79],"we":[80],"constructed":[81],"PAI-1s":[82,101],"with":[83,204,210,271],"extended":[84],"half-life":[85,154,214],"prolong":[87],"their":[88,152],"activity.":[90],"We":[91,135,166,277],"have":[92,136,167],"analyzed":[93],"effects":[95,300],"sprout":[97,179,217],"formation":[98,180,218],"by":[100,151,175,181],"two":[103],"functionally":[104],"different":[105],"endothelial":[106,113,126],"cell":[107,195,255],"(EC)":[108],"systems,":[109],"human":[110,123],"umbilical":[111],"vein":[112],"cells":[114,127,244,263],"(HUVEC),":[115],"expressing":[116,129],"moderate":[117],"amounts":[118,131,239],"urokinase":[120],"(uPA),":[121],"lung":[124,193],"microvascular":[125],"(HLMVEC),":[128],"high":[130],"this":[133],"enzyme.":[134],"used":[137],"wild-type":[138],"(wPAI-1)":[140],"(t(1/2)":[141,157],"=":[142,158,163],"1.6":[143],"h)":[144],"cysteine":[147],"mutants":[148,203],"(CysPAI-1)":[149],"characterized":[150],"prolonged":[153],"time":[155],"(hDbetaT)":[156],"63.6":[159],"h":[160],"t(1/2)":[162],"7,000":[164],"h).":[165],"observed":[168],"significant":[170],"inhibitory":[171,294],"dose-dependent":[172],"effect":[173],"exerted":[174],"CysPAI-1s":[177],"HUVEC":[182,262],"HLMVEC":[184,224,243],"cells.":[185],"rate":[188],"was":[189,230],"considerably":[190],"stronger":[191],"capillary":[194],"cultures":[196],"significantly":[198],"more":[199],"pronounced":[200],"for":[201],"CysPAI-1":[202],"longer":[205],"anti-uPA":[206],"activity":[207,295],"(betaT).":[208],"wPAI-1":[209,266],"short":[212],"has":[215],"induced":[216],"HUVEC,":[220],"not":[222],"cultures.":[225],"This":[226],"difference":[227],"behavior":[229],"most":[231],"likely":[232],"related":[233],"presence":[236],"excessive":[238],"uPA":[241],"known":[247],"mechanism":[248],"clearing":[250],"PAI-1/uPA/uPAR":[251],"complexes":[252],"from":[253],"surface.":[256],"A":[257],"less":[258],"efficient":[259],"system":[260],"might":[264],"give":[265],"chance":[268],"interact":[270],"non-proteolytic":[272],"pathways":[273],"stimulation.":[276],"conclude":[278],"while":[280],"properties":[283],"constructs":[286],"are":[287],"preserved,":[288],"proteins":[290],"inhibit":[291],"dominates":[296],"over":[297],"any":[298],"stimulatory":[299],"PAI-1.":[302]},"counts_by_year":[{"year":2018,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
