{"id":"https://openalex.org/W2021890195","doi":"https://doi.org/10.1249/01.mss.0000322533.64969.2e","title":"Dysferlin Deficiency Inhibits Sarcolemmal Repair and Delays Functional Recovery of Skeletal Muscle Injured In Vivo","display_name":"Dysferlin Deficiency Inhibits Sarcolemmal Repair and Delays Functional Recovery of Skeletal Muscle Injured In Vivo","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2021890195","doi":"https://doi.org/10.1249/01.mss.0000322533.64969.2e","mag":"2021890195"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000322533.64969.2e","doi":"https://doi.org/10.1249/01.mss.0000322533.64969.2e","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000322533.64969.2e","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081683404","display_name":"Joseph A. Roche","orcid":"https://orcid.org/0000-0002-9497-6850","observed_orcids":["https://orcid.org/0000-0002-9497-6850"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Roche","raw_affiliation_strings":["Univ of MD Baltimore, Baltimore, MD","(No relationships reported)","(Sponsor: Dr. Edward G. McFarland, M.D., FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of MD Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Dr. Edward G. McFarland, M.D., FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083109409","display_name":"Richard M. Lovering","orcid":"https://orcid.org/0000-0002-9899-5071","observed_orcids":["https://orcid.org/0000-0002-9899-5071"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M. Lovering","raw_affiliation_strings":["Univ of MD Baltimore, Baltimore, MD","(No relationships reported)","(Sponsor: Dr. Edward G. McFarland, M.D., FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of MD Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Dr. Edward G. McFarland, M.D., FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042232757","display_name":"Robert J. Bloch","orcid":"https://orcid.org/0000-0002-4933-3469","observed_orcids":["https://orcid.org/0000-0002-4933-3469"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Bloch","raw_affiliation_strings":["Univ of MD Baltimore, Baltimore, MD","(No relationships reported)","(Sponsor: Dr. Edward G. McFarland, M.D., FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of MD Baltimore, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Dr. Edward G. McFarland, M.D., FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10973299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"5","first_page":"S242","last_page":"S242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12117","display_name":"Muscle and Compartmental Disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11246","display_name":"Sports injuries and prevention","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dysferlin","display_name":"dysferlin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/skeletal-muscle-injury","display_name":"skeletal muscle injury","score":0.9739999771118164},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.7149999737739563},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.75},{"id":"https://openalex.org/keywords/eccentric-contraction","display_name":"eccentric contraction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tibialis-anterior","display_name":"tibialis anterior","score":0.8050000071525574},{"id":"https://openalex.org/keywords/muscle-torque","display_name":"muscle torque","score":0.3230000138282776},{"id":"https://openalex.org/keywords/a-j-mice","display_name":"A/J mice","score":0.5590000152587891},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C37113945","wikidata":"https://www.wikidata.org/wiki/Q14885337","display_name":"Dysferlin","level":3,"score":0.9634848833084106},{"id":"https://openalex.org/C199096232","wikidata":"https://www.wikidata.org/wiki/Q1545001","display_name":"Sarcolemma","level":3,"score":0.7851973176002502},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6377449035644531},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.627951443195343},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4394814074039459},{"id":"https://openalex.org/C2778640784","wikidata":"https://www.wikidata.org/wiki/Q168002","display_name":"Ankle","level":2,"score":0.43266093730926514},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.42714887857437134},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.4216901957988739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40658628940582275},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.37778162956237793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2746334373950958},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000322533.64969.2e","doi":"https://doi.org/10.1249/01.mss.0000322533.64969.2e","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000322533.64969.2e","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1984360124","https://openalex.org/W2296519014","https://openalex.org/W2009318006","https://openalex.org/W2294518859","https://openalex.org/W2077983212","https://openalex.org/W2063107894","https://openalex.org/W2097880588","https://openalex.org/W7098678623","https://openalex.org/W2013627478","https://openalex.org/W1972100707"],"abstract_inverted_index":{"Dysferlin":[0,296],"is":[1,297,314],"a":[2,39,275,287,353],"237":[3],"kDa":[4],"protein":[5],"of":[6,12,48,69,96,159,224,243,265,293,337],"the":[7,34,60,81,99,121,291,322,335,346],"sarcolemma":[8],"and":[9,46,63,66,108,112,115,134,143,161,173,191,253,260,270,360],"cytoplasmic":[10],"vesicles":[11],"skeletal":[13],"muscle.":[14],"A":[15],"role":[16,40,354],"for":[17,299,330],"dysferlin":[18,37,127,351],"in":[19,25,29,41,43,77,98,229,247,251,290,311,334,355,357,361],"sarcolemmal":[20,44,132,358],"repair":[21,45,333,359],"has":[22],"been":[23],"demonstrated":[24],"vitro,":[26],"but":[27,210,283,341],"not":[28,273],"vivo.":[30],"PURPOSE:":[31],"To":[32],"test":[33],"hypothesis":[35],"that":[36,350],"plays":[38,352],"vivo":[42,356],"recovery":[47,203,301,310,362],"function":[49],"after":[50,110,198,208,220,236,281],"injury":[51,303],"induced":[52],"by":[53,80,129,136,147,157,305,321],"large-strain":[54,306],"lengthening":[55,86,307],"contractions.":[56,308],"METHODS:":[57],"We":[58,83,119],"studied":[59],"dysferlin-deficient,":[61],"A/J,":[62],"control,":[64],"A/WySnJ":[65,174,254,271],"C57Bl/6J":[67,252,269],"strains":[68],"mice":[70,212,285,313],"(40":[71],"per":[72],"strain;":[73],"male,":[74],"12-14":[75],"wks)":[76],"protocols":[78],"approved":[79],"IACUC.":[82],"used":[84],"15":[85],"contractions":[87],"(90-170\u00b0":[88],"plantarflexion":[89],"at":[90],"900\u00b0/s)":[91],"to":[92,178,182,216,324],"induce":[93],"~40%":[94],"loss":[95],"torque":[97,104,176],"ankle":[100],"dorsiflexors.":[101],"Maximal":[102],"tetanic":[103],"was":[105,155,204],"recorded":[106],"before":[107],"immediately":[109,197],"injury,":[111,209,221,237,282],"3,":[113],"7":[114],"14":[116],"days":[117],"later.":[118],"analyzed":[120],"tibialis":[122],"anterior":[123],"muscle":[124,145],"for:":[125],"a)":[126],"levels,":[128],"immunoblotting;":[130],"b)":[131],"damage":[133],"repair,":[135,319],"injecting":[137],"fluorescein":[138],"dextran":[139],"(F-Dx;":[140],"10kDa,":[141],"fixable);":[142],"c)":[144],"regeneration,":[146],"counting":[148],"centrally":[149],"nucleated":[150],"fibers":[151,225,244,266],"(CNFs).":[152],"Statistical":[153],"significance":[154],"determined":[156],"analyses":[158],"variance":[160],"Tukey's":[162],"post-hoc":[163],"tests,":[164],"with":[165,316],"p<0.05":[166],"considered":[167],"significant.":[168],"RESULTS:":[169],"In":[170,200],"C57Bl/6J,":[171],"A/J":[172,248,284],"mice,":[175,202,249,255],"normalized":[177],"pre-injury":[179],"levels":[180],"decreased":[181],"62":[183,192],"\u00b1":[184,188,193,240,257,262],"8":[185],"%,":[186,195],"61":[187],"4":[189],"%":[190,223,242,259,264],"6":[194],"respectively,":[196],"injury.":[199,365],"control":[201],"complete":[205,340],"one":[206],"week":[207],"dysferlin-deficient":[211,312],"required":[213],"two":[214,234,279],"weeks":[215,235,280],"recover":[217],"completely.":[218],"Immediately":[219],"~30":[222],"took":[226],"up":[227],"F-Dx":[228,246],"all":[230],"three":[231],"strains.":[232],"However,":[233],"only":[238],"3":[239,263],"2":[241,258],"retained":[245,267],"while":[250],"31":[256],"33":[261],"F-Dx.":[268,326],"did":[272],"show":[274],"significant":[276],"regenerative":[277],"response":[278],"showed":[286],"five-fold":[288],"increase":[289],"number":[292],"CNFs.":[294],"CONCLUSIONS:":[295],"necessary":[298],"normal":[300],"from":[302,363],"caused":[304],"Delayed":[309],"associated":[315],"defective":[317,331],"membrane":[318,332],"evidenced":[320],"failure":[323],"retain":[325],"Myofiber":[327],"regeneration":[328],"compensates":[329],"absence":[336],"dysferlin,":[338],"enabling":[339],"slower":[342],"recovery.":[343],"This":[344],"constitutes":[345],"first":[347],"direct":[348],"evidence":[349],"eccentric":[364]},"counts_by_year":[],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2016-06-24T00:00:00"}