{"id":"https://openalex.org/W20218741","doi":null,"title":"What Clinical Observations on the Epidemiology of Antiepileptic Drug Intractability Tell Us About the Mechanisms of Pharmacoresistance","display_name":"What Clinical Observations on the Epidemiology of Antiepileptic Drug Intractability Tell Us About the Mechanisms of Pharmacoresistance","publication_year":2008,"publication_date":"2008-07-17","ids":{"openalex":"https://openalex.org/W20218741","mag":"20218741"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt1z28v0dq","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1z28v0dq","pdf_url":"https://escholarship.org/uc/item/1z28v0dq","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/1z28v0dq","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004551722","display_name":"Michael A. Rogawski","orcid":"https://orcid.org/0000-0002-3296-8193","observed_orcids":["https://orcid.org/0000-0002-3296-8193"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael A. Rogawski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3296-8193","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004551722"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00309621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiepileptic-drug-resistance","display_name":"antiepileptic drug resistance","score":0.9459999799728394},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8040000200271606},{"id":"https://openalex.org/keywords/clinical-epidemiology","display_name":"clinical epidemiology","score":0.6850000023841858},{"id":"https://openalex.org/keywords/seizure-control","display_name":"seizure control","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C2994127763","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Antiepileptic drug","level":3,"score":0.6217943429946899},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5455554723739624},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4666196405887604},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.4539882242679596},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43309569358825684},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.3154943585395813},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.27234458923339844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt1z28v0dq","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1z28v0dq","pdf_url":"https://escholarship.org/uc/item/1z28v0dq","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:qt1z28v0dq","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/1z28v0dq","pdf_url":"http://www.escholarship.org/uc/item/1z28v0dq","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rogawski, Michael A.(2008). What Clinical Observations on the Epidemiology of Antiepileptic Drug Intractability Tell Us About the Mechanisms of Pharmacoresistance. Department of Neurology, UC Davis School of Medicine. UC Davis: Department of Neurology, UC Davis School of Medicine. Retrieved from: http://www.escholarship.org/uc/item/1z28v0dq","raw_type":"article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.886.835","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.886.835","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://works.bepress.com/michael_rogawski/2/download/","raw_type":"text"},{"id":"mag:20218741","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt1z28v0dq/qt1z28v0dq.pdf?t=krnbr4","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt1z28v0dq","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1z28v0dq","pdf_url":"https://escholarship.org/uc/item/1z28v0dq","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3406176328","display_name":"IMRT Dose Optimization","funder_award_id":"R01CA104205","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G787420206","display_name":"IMRT Guided by Magnetic Resonance Spectroscopic Imaging","funder_award_id":"R01CA098523","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W20218741.pdf","grobid_xml":"https://content.openalex.org/works/W20218741.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1943887740","https://openalex.org/W1974622048","https://openalex.org/W1977595701","https://openalex.org/W1979467944","https://openalex.org/W1983282754","https://openalex.org/W1985906464","https://openalex.org/W1987398739","https://openalex.org/W1991097570","https://openalex.org/W1994040773","https://openalex.org/W1994572997","https://openalex.org/W2000357710","https://openalex.org/W2001509490","https://openalex.org/W2004976650","https://openalex.org/W2021489157","https://openalex.org/W2027717108","https://openalex.org/W2028500192","https://openalex.org/W2031483215","https://openalex.org/W2034638577","https://openalex.org/W2042915207","https://openalex.org/W2044989922","https://openalex.org/W2048244833","https://openalex.org/W2061928059","https://openalex.org/W2065214055","https://openalex.org/W2065620933","https://openalex.org/W2069118421","https://openalex.org/W2071198083","https://openalex.org/W2074603333","https://openalex.org/W2077164497","https://openalex.org/W2083785141","https://openalex.org/W2086759170","https://openalex.org/W2090562151","https://openalex.org/W2092781259","https://openalex.org/W2094420080","https://openalex.org/W2094977553","https://openalex.org/W2099263404","https://openalex.org/W2107104883","https://openalex.org/W2114499550","https://openalex.org/W2114776162","https://openalex.org/W2120091670","https://openalex.org/W2121613199","https://openalex.org/W2122503098","https://openalex.org/W2126487804","https://openalex.org/W2134365734","https://openalex.org/W2138521331","https://openalex.org/W2147974822","https://openalex.org/W2152491568","https://openalex.org/W2154582753","https://openalex.org/W2158681127","https://openalex.org/W2160882954","https://openalex.org/W2166332376","https://openalex.org/W2605864756"],"related_works":["https://openalex.org/W2526967460","https://openalex.org/W2353466729","https://openalex.org/W2130375794","https://openalex.org/W2021489157","https://openalex.org/W128280079","https://openalex.org/W2023544660","https://openalex.org/W1536140107","https://openalex.org/W2323652053","https://openalex.org/W4252436204","https://openalex.org/W2104566059"],"abstract_inverted_index":{"In":[0,105],"the":[1,11,35,48,63,99,110,113,120],"past":[2],"several":[3],"years,":[4],"there":[5],"have":[6,79],"been":[7],"important":[8,96],"advances":[9],"in":[10,67],"clinical":[12,93,115],"epidemiology":[13],"of":[14,34,37,53,87,112,123],"antiepileptic":[15,38],"drug":[16,39,65],"resistance,":[17],"as":[18],"reviewed":[19],"by":[20,28],"Mohanraj":[21],"and":[22,29],"Brodie.":[23],"It":[24],"would":[25],"appear":[26],"that":[27,74],"large,":[30],"intractability":[31],"is":[32,72,89],"independent":[33],"choice":[36],"(AED).":[40],"Many":[41],"patients":[42],"will":[43,76],"become":[44],"seizure":[45],"free":[46],"on":[47,98,119],"first":[49,64],"agent":[50],"tried,":[51],"irrespective":[52],"which":[54,83],"one":[55],"their":[56],"physician":[57],"decides":[58],"to":[59,62,78],"pick.":[60],"Nonresponders":[61],"are":[66],"a":[68],"different":[69],"category:":[70],"it":[71],"likely":[73],"they":[75],"continue":[77],"seizures":[80],"no":[81],"matter":[82],"medicine":[84],"or":[85],"combination":[86],"medicines":[88],"tried.":[90],"This":[91],"simple":[92],"observation":[94],"puts":[95],"constraints":[97],"possible":[100],"biological":[101],"mechanisms":[102,122],"for":[103,117],"pharmacoresistance.":[104],"this":[106],"essay,":[107],"I":[108],"consider":[109],"implications":[111],"new":[114],"research":[116],"studies":[118],"neurobiological":[121],"AED":[124],"intractability.":[125]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}