{"id":"https://openalex.org/W2021842829","doi":"https://doi.org/10.1152/physrev.00042.2003","title":"Molecular Structure and Function of the Glycine Receptor Chloride Channel","display_name":"Molecular Structure and Function of the Glycine Receptor Chloride Channel","publication_year":2004,"publication_date":"2004-09-21","ids":{"openalex":"https://openalex.org/W2021842829","doi":"https://doi.org/10.1152/physrev.00042.2003","mag":"2021842829","pmid":"https://pubmed.ncbi.nlm.nih.gov/15383648"},"language":"en","primary_location":{"id":"doi:10.1152/physrev.00042.2003","doi":"https://doi.org/10.1152/physrev.00042.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physrev.00042.2003","pdf_url":null,"source":{"id":"https://openalex.org/S203035050","display_name":"Physiological Reviews","issn_l":"0031-9333","issn":["0031-9333","1522-1210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Reviews","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2021842829"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027657793","display_name":"Joseph W. Lynch","orcid":"https://orcid.org/0000-0002-1227-2252","observed_orcids":["https://orcid.org/0000-0002-1227-2252"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Joseph W. Lynch","raw_affiliation_strings":["School of Biomedical Sciences, Univ. of Queensland, Brisbane QLD 4072, Australia. j.lynch@uq.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, Univ. of Queensland, Brisbane QLD 4072, Australia. j.lynch@uq.edu.au","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027657793"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":null,"apc_paid":null,"fwci":3.0368,"has_fulltext":false,"cited_by_count":804,"citation_normalized_percentile":{"value":0.94482396,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"84","issue":"4","first_page":"1051","last_page":"1095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.10329999774694443,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycine-receptor","display_name":"glycine receptor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chloride-channels","display_name":"chloride channels","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ligand-gated-ion-channels","display_name":"ligand-gated ion channels","score":0.9810000061988831},{"id":"https://openalex.org/keywords/alpha-subunit","display_name":"alpha subunit","score":0.7179999947547913},{"id":"https://openalex.org/keywords/beta-subunit","display_name":"beta subunit","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gephyrin","display_name":"gephyrin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/subunit-expression","display_name":"subunit expression","score":0.4090000092983246},{"id":"https://openalex.org/keywords/hyperekplexia","display_name":"hyperekplexia","score":0.8989999890327454},{"id":"https://openalex.org/keywords/startle-disease","display_name":"startle disease","score":0.8090000152587891},{"id":"https://openalex.org/keywords/receptor-mutations","display_name":"receptor mutations","score":0.4909999966621399},{"id":"https://openalex.org/keywords/receptor-modulators","display_name":"receptor modulators","score":0.625},{"id":"https://openalex.org/keywords/muscle-relaxants","display_name":"muscle relaxants","score":0.7940000295639038},{"id":"https://openalex.org/keywords/peripheral-analgesics","display_name":"peripheral analgesics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/inhibitory-neurotransmission","display_name":"inhibitory neurotransmission","score":0.9490000009536743},{"id":"https://openalex.org/keywords/excitatory-neurotransmission","display_name":"excitatory neurotransmission","score":0.6819999814033508},{"id":"https://openalex.org/keywords/embryonic-neurons","display_name":"embryonic neurons","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C35599011","wikidata":"https://www.wikidata.org/wiki/Q426887","display_name":"Glycine receptor","level":4,"score":0.9325545430183411},{"id":"https://openalex.org/C2776104367","wikidata":"https://www.wikidata.org/wiki/Q5891451","display_name":"Homomeric","level":4,"score":0.821271538734436},{"id":"https://openalex.org/C2777969728","wikidata":"https://www.wikidata.org/wiki/Q1270676","display_name":"Gephyrin","level":5,"score":0.6930578351020813},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6311787962913513},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5730832815170288},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5379823446273804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4724683463573456},{"id":"https://openalex.org/C145822097","wikidata":"https://www.wikidata.org/wiki/Q106916978","display_name":"Chloride channel","level":2,"score":0.4619285464286804},{"id":"https://openalex.org/C19876734","wikidata":"https://www.wikidata.org/wiki/Q5201170","display_name":"Cys-loop receptors","level":5,"score":0.45681819319725037},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.45024561882019043},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.43153810501098633},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4250164330005646},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.4223952889442444},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4026111364364624},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.3628003001213074},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.24037787318229675},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1701606810092926},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09858343005180359},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09518095850944519}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018009","descriptor_name":"Receptors, Glycine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018009","descriptor_name":"Receptors, Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/physrev.00042.2003","doi":"https://doi.org/10.1152/physrev.00042.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physrev.00042.2003","pdf_url":null,"source":{"id":"https://openalex.org/S203035050","display_name":"Physiological Reviews","issn_l":"0031-9333","issn":["0031-9333","1522-1210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Reviews","raw_type":"journal-article"},{"id":"pmid:15383648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15383648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological reviews","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.326.8827","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.8827","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.qbi.uq.edu.au/documents/Lynch Lab/Lynch_PhysiolRev.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":447,"referenced_works":["https://openalex.org/W29521164","https://openalex.org/W42223234","https://openalex.org/W69531756","https://openalex.org/W94371480","https://openalex.org/W98874919","https://openalex.org/W118983187","https://openalex.org/W138483743","https://openalex.org/W148303283","https://openalex.org/W149795796","https://openalex.org/W157666778","https://openalex.org/W158293295","https://openalex.org/W159532028","https://openalex.org/W160102508","https://openalex.org/W166408772","https://openalex.org/W182682059","https://openalex.org/W285155939","https://openalex.org/W1484163887","https://openalex.org/W1488934481","https://openalex.org/W1490007128","https://openalex.org/W1490097278","https://openalex.org/W1492943506","https://openalex.org/W1504555080","https://openalex.org/W1504812383","https://openalex.org/W1509513803","https://openalex.org/W1513897459","https://openalex.org/W1519429960","https://openalex.org/W1520948801","https://openalex.org/W1529646650","https://openalex.org/W1533662699","https://openalex.org/W1542694382","https://openalex.org/W1546961682","https://openalex.org/W1548913863","https://openalex.org/W1553149131","https://openalex.org/W1553391791","https://openalex.org/W1562806058","https://openalex.org/W1564990428","https://openalex.org/W1567085508","https://openalex.org/W1567481304","https://openalex.org/W1567869373","https://openalex.org/W1573010690","https://openalex.org/W1574509464","https://openalex.org/W1578375215","https://openalex.org/W1592442520","https://openalex.org/W1596484011","https://openalex.org/W1598864448","https://openalex.org/W1599587228","https://openalex.org/W1606391266","https://openalex.org/W1628508588","https://openalex.org/W1632324362","https://openalex.org/W1633272553","https://openalex.org/W1668093331","https://openalex.org/W1687532913","https://openalex.org/W1710559804","https://openalex.org/W1740455381","https://openalex.org/W1748513738","https://openalex.org/W1760036962","https://openalex.org/W1762877386","https://openalex.org/W1770930219","https://openalex.org/W1788430178","https://openalex.org/W1808020363","https://openalex.org/W1817006636","https://openalex.org/W1839965102","https://openalex.org/W1852345676","https://openalex.org/W1859985147","https://openalex.org/W1862870409","https://openalex.org/W1879293587","https://openalex.org/W1895925127","https://openalex.org/W1901708675","https://openalex.org/W1905325352","https://openalex.org/W1925303519","https://openalex.org/W1931542423","https://openalex.org/W1937345133","https://openalex.org/W1957270349","https://openalex.org/W1959467500","https://openalex.org/W1964044900","https://openalex.org/W1964897006","https://openalex.org/W1965996399","https://openalex.org/W1966203252","https://openalex.org/W1966552570","https://openalex.org/W1967225412","https://openalex.org/W1967233387","https://openalex.org/W1967536482","https://openalex.org/W1968031887","https://openalex.org/W1969154943","https://openalex.org/W1969749311","https://openalex.org/W1971238170","https://openalex.org/W1971281799","https://openalex.org/W1971422019","https://openalex.org/W1972287815","https://openalex.org/W1972679607","https://openalex.org/W1972994417","https://openalex.org/W1974910619","https://openalex.org/W1975382331","https://openalex.org/W1975624561","https://openalex.org/W1977835147","https://openalex.org/W1978884918","https://openalex.org/W1979001025","https://openalex.org/W1979126279","https://openalex.org/W1981030868","https://openalex.org/W1981111905","https://openalex.org/W1982009183","https://openalex.org/W1982135535","https://openalex.org/W1982186905","https://openalex.org/W1982504085","https://openalex.org/W1982815592","https://openalex.org/W1983799682","https://openalex.org/W1985315727","https://openalex.org/W1985640796","https://openalex.org/W1985984620","https://openalex.org/W1986293017","https://openalex.org/W1986315354","https://openalex.org/W1987519756","https://openalex.org/W1989901564","https://openalex.org/W1990189870","https://openalex.org/W1990343602","https://openalex.org/W1990535637","https://openalex.org/W1990546626","https://openalex.org/W1990924196","https://openalex.org/W1991183604","https://openalex.org/W1991647860","https://openalex.org/W1993361450","https://openalex.org/W1993673269","https://openalex.org/W1993816915","https://openalex.org/W1994042329","https://openalex.org/W1994090837","https://openalex.org/W1994288348","https://openalex.org/W1994397958","https://openalex.org/W1994522080","https://openalex.org/W1995268545","https://openalex.org/W1995727805","https://openalex.org/W1997437840","https://openalex.org/W1997505926","https://openalex.org/W1999490342","https://openalex.org/W1999530354","https://openalex.org/W1999879346","https://openalex.org/W2000255506","https://openalex.org/W2000664999","https://openalex.org/W2000727165","https://openalex.org/W2001255162","https://openalex.org/W2001397936","https://openalex.org/W2002822665","https://openalex.org/W2003051555","https://openalex.org/W2003127982","https://openalex.org/W2004349398","https://openalex.org/W2004368544","https://openalex.org/W2005349051","https://openalex.org/W2005392755","https://openalex.org/W2005843451","https://openalex.org/W2006428029","https://openalex.org/W2006538429","https://openalex.org/W2007147751","https://openalex.org/W2007212380","https://openalex.org/W2007262222","https://openalex.org/W2007418564","https://openalex.org/W2007659653","https://openalex.org/W2008089110","https://openalex.org/W2008713052","https://openalex.org/W2010247503","https://openalex.org/W2010288352","https://openalex.org/W2010361818","https://openalex.org/W2010379824","https://openalex.org/W2011785924","https://openalex.org/W2012249011","https://openalex.org/W2012282425","https://openalex.org/W2012538511","https://openalex.org/W2012724805","https://openalex.org/W2013025891","https://openalex.org/W2013034672","https://openalex.org/W2013161023","https://openalex.org/W2013887321","https://openalex.org/W2014905519","https://openalex.org/W2015120705","https://openalex.org/W2015290558","https://openalex.org/W2015405439","https://openalex.org/W2015417958","https://openalex.org/W2015625017","https://openalex.org/W2015940242","https://openalex.org/W2016202743","https://openalex.org/W2016864174","https://openalex.org/W2016979211","https://openalex.org/W2016988692","https://openalex.org/W2017193677","https://openalex.org/W2018187963","https://openalex.org/W2018336011","https://openalex.org/W2018501377","https://openalex.org/W2018547231","https://openalex.org/W2018572283","https://openalex.org/W2020078505","https://openalex.org/W2022198005","https://openalex.org/W2022731078","https://openalex.org/W2022764897","https://openalex.org/W2023938933","https://openalex.org/W2024364777","https://openalex.org/W2024674054","https://openalex.org/W2024852738","https://openalex.org/W2026332460","https://openalex.org/W2027002330","https://openalex.org/W2027426248","https://openalex.org/W2027465915","https://openalex.org/W2027609895","https://openalex.org/W2027807510","https://openalex.org/W2028351881","https://openalex.org/W2028592856","https://openalex.org/W2029596063","https://openalex.org/W2030047965","https://openalex.org/W2030945785","https://openalex.org/W2031134561","https://openalex.org/W2031152100","https://openalex.org/W2031296192","https://openalex.org/W2032321386","https://openalex.org/W2032493626","https://openalex.org/W2032945522","https://openalex.org/W2032967272","https://openalex.org/W2034007433","https://openalex.org/W2035263031","https://openalex.org/W2035620075","https://openalex.org/W2036151217","https://openalex.org/W2037028966","https://openalex.org/W2037060386","https://openalex.org/W2037358308","https://openalex.org/W2037413915","https://openalex.org/W2037496847","https://openalex.org/W2039598777","https://openalex.org/W2039881330","https://openalex.org/W2039890389","https://openalex.org/W2040105394","https://openalex.org/W2041358678","https://openalex.org/W2041389546","https://openalex.org/W2042286191","https://openalex.org/W2042437053","https://openalex.org/W2043296500","https://openalex.org/W2043428108","https://openalex.org/W2043697771","https://openalex.org/W2044912570","https://openalex.org/W2046390092","https://openalex.org/W2046423382","https://openalex.org/W2046884724","https://openalex.org/W2046952822","https://openalex.org/W2047232497","https://openalex.org/W2048070160","https://openalex.org/W2048463939","https://openalex.org/W2048530738","https://openalex.org/W2049400749","https://openalex.org/W2049879893","https://openalex.org/W2049958331","https://openalex.org/W2050785203","https://openalex.org/W2051094953","https://openalex.org/W2051308032","https://openalex.org/W2051852738","https://openalex.org/W2052100140","https://openalex.org/W2053002528","https://openalex.org/W2053507928","https://openalex.org/W2054243250","https://openalex.org/W2055500166","https://openalex.org/W2055690117","https://openalex.org/W2056037856","https://openalex.org/W2056186806","https://openalex.org/W2056778461","https://openalex.org/W2056980153","https://openalex.org/W2057139355","https://openalex.org/W2057264061","https://openalex.org/W2057299327","https://openalex.org/W2058883143","https://openalex.org/W2058896100","https://openalex.org/W2059971190","https://openalex.org/W2060287150","https://openalex.org/W2061464671","https://openalex.org/W2062928716","https://openalex.org/W2063313299","https://openalex.org/W2063446111","https://openalex.org/W2063701158","https://openalex.org/W2064066585","https://openalex.org/W2066412710","https://openalex.org/W2066841787","https://openalex.org/W2067718897","https://openalex.org/W2068212118","https://openalex.org/W2068315659","https://openalex.org/W2068600362","https://openalex.org/W2070675609","https://openalex.org/W2071042339","https://openalex.org/W2071647919","https://openalex.org/W2071662051","https://openalex.org/W2071780344","https://openalex.org/W2072218526","https://openalex.org/W2072378908","https://openalex.org/W2072465203","https://openalex.org/W2073031109","https://openalex.org/W2073208119","https://openalex.org/W2073224027","https://openalex.org/W2073286007","https://openalex.org/W2073456996","https://openalex.org/W2073830296","https://openalex.org/W2073898713","https://openalex.org/W2074034535","https://openalex.org/W2074196811","https://openalex.org/W2075633632","https://openalex.org/W2075853825","https://openalex.org/W2075977677","https://openalex.org/W2076171494","https://openalex.org/W2076481913","https://openalex.org/W2076829990","https://openalex.org/W2077212686","https://openalex.org/W2078037173","https://openalex.org/W2078686035","https://openalex.org/W2078752328","https://openalex.org/W2079066138","https://openalex.org/W2079319779","https://openalex.org/W2079748100","https://openalex.org/W2081025398","https://openalex.org/W2081246829","https://openalex.org/W2081446858","https://openalex.org/W2081556250","https://openalex.org/W2081825219","https://openalex.org/W2083106679","https://openalex.org/W2085008093","https://openalex.org/W2085025778","https://openalex.org/W2086080088","https://openalex.org/W2086759672","https://openalex.org/W2087025010","https://openalex.org/W2087271908","https://openalex.org/W2088814430","https://openalex.org/W2088909919","https://openalex.org/W2089741147","https://openalex.org/W2090058279","https://openalex.org/W2090552744","https://openalex.org/W2091419520","https://openalex.org/W2091751135","https://openalex.org/W2091766450","https://openalex.org/W2093238079","https://openalex.org/W2093413520","https://openalex.org/W2094392893","https://openalex.org/W2094426376","https://openalex.org/W2095947640","https://openalex.org/W2098742258","https://openalex.org/W2099629252","https://openalex.org/W2102780743","https://openalex.org/W2103335119","https://openalex.org/W2103800908","https://openalex.org/W2104004306","https://openalex.org/W2106000608","https://openalex.org/W2106006747","https://openalex.org/W2107253022","https://openalex.org/W2108265031","https://openalex.org/W2108754858","https://openalex.org/W2109018046","https://openalex.org/W2111622691","https://openalex.org/W2111858740","https://openalex.org/W2113112171","https://openalex.org/W2113565256","https://openalex.org/W2115717442","https://openalex.org/W2116774903","https://openalex.org/W2117449859","https://openalex.org/W2117474212","https://openalex.org/W2118202827","https://openalex.org/W2118419531","https://openalex.org/W2119051861","https://openalex.org/W2119790118","https://openalex.org/W2121110904","https://openalex.org/W2121480306","https://openalex.org/W2122283371","https://openalex.org/W2123742256","https://openalex.org/W2124102028","https://openalex.org/W2124250485","https://openalex.org/W2124419019","https://openalex.org/W2128934600","https://openalex.org/W2129687735","https://openalex.org/W2129779698","https://openalex.org/W2130583664","https://openalex.org/W2130630814","https://openalex.org/W2131378880","https://openalex.org/W2131925023","https://openalex.org/W2133083344","https://openalex.org/W2133249378","https://openalex.org/W2134068133","https://openalex.org/W2134331961","https://openalex.org/W2134616658","https://openalex.org/W2136035575","https://openalex.org/W2136733746","https://openalex.org/W2138937351","https://openalex.org/W2139773174","https://openalex.org/W2140556250","https://openalex.org/W2140899588","https://openalex.org/W2142368722","https://openalex.org/W2145087907","https://openalex.org/W2148598721","https://openalex.org/W2149403200","https://openalex.org/W2152052384","https://openalex.org/W2152452579","https://openalex.org/W2152959849","https://openalex.org/W2153482551","https://openalex.org/W2153876630","https://openalex.org/W2154304660","https://openalex.org/W2154379019","https://openalex.org/W2155483891","https://openalex.org/W2155795824","https://openalex.org/W2157403216","https://openalex.org/W2158224529","https://openalex.org/W2159006731","https://openalex.org/W2159163399","https://openalex.org/W2161495721","https://openalex.org/W2163119877","https://openalex.org/W2164903594","https://openalex.org/W2165502098","https://openalex.org/W2165524988","https://openalex.org/W2166674578","https://openalex.org/W2168079133","https://openalex.org/W2169699681","https://openalex.org/W2191585768","https://openalex.org/W2226187382","https://openalex.org/W2245630575","https://openalex.org/W2246659591","https://openalex.org/W2261499467","https://openalex.org/W2266129269","https://openalex.org/W2283899000","https://openalex.org/W2289222529","https://openalex.org/W2314222561","https://openalex.org/W2317425620","https://openalex.org/W2333135202","https://openalex.org/W2337162497","https://openalex.org/W2342124397","https://openalex.org/W2342190829","https://openalex.org/W2346429022","https://openalex.org/W2346482202","https://openalex.org/W2377678051","https://openalex.org/W2397903919","https://openalex.org/W2404061401","https://openalex.org/W2407659316","https://openalex.org/W2407969353","https://openalex.org/W2412205269","https://openalex.org/W2418309771","https://openalex.org/W2418547604","https://openalex.org/W2427054186","https://openalex.org/W2474430303","https://openalex.org/W2602548552","https://openalex.org/W2605123890","https://openalex.org/W2991190608","https://openalex.org/W3107008105","https://openalex.org/W4231781093","https://openalex.org/W4237959052","https://openalex.org/W4246020673","https://openalex.org/W4295682975","https://openalex.org/W4317639427","https://openalex.org/W4390473188","https://openalex.org/W4405989249","https://openalex.org/W4406057120","https://openalex.org/W4406059073","https://openalex.org/W4407109614"],"related_works":["https://openalex.org/W166109311","https://openalex.org/W2098742258","https://openalex.org/W1964352423","https://openalex.org/W9718795","https://openalex.org/W1487689711","https://openalex.org/W4239148732","https://openalex.org/W2024217354","https://openalex.org/W2088638836","https://openalex.org/W2493247612","https://openalex.org/W2021086824"],"abstract_inverted_index":{"The":[0,34,80,108,124],"glycine":[1],"receptor":[2,13],"chloride":[3],"channel":[4],"(GlyR)":[5],"is":[6,36,98,110],"a":[7,86,130,138,182],"member":[8],"of":[9,15,21,83,140,152,165,201,222,243],"the":[10,44,106,116,120,153,163,166,223,241],"nicotinic":[11],"acetylcholine":[12],"family":[14,23],"ligand-gated":[16],"ion":[17],"channels.":[18],"Functional":[19],"receptors":[20],"this":[22,212],"comprise":[24],"five":[25],"subunits":[26,84,168],"and":[27,47,74,149,226,246],"are":[28,216],"important":[29],"targets":[30],"for":[31,39,112,240],"neuroactive":[32],"drugs.":[33,249],"GlyR":[35,89,146,177],"best":[37],"known":[38],"mediating":[40],"inhibitory":[41,228],"neurotransmission":[42,63],"in":[43,64,88,105,132,134,194,218],"spinal":[45,224],"cord":[46,225],"brain":[48],"stem,":[49],"although":[50],"recent":[51],"evidence":[52],"suggests":[53],"it":[54],"may":[55,236],"also":[56,192],"have":[57,77,128],"other":[58,167,195],"physiological":[59],"roles,":[60],"including":[61],"excitatory":[62],"embryonic":[65],"neurons.":[66],"To":[67],"date,":[68],"four":[69],"alpha-subunits":[70],"(alpha1":[71],"to":[72,96,115,175,181,206],"alpha4)":[73],"one":[75],"beta-subunit":[76,109],"been":[78,156,204],"identified.":[79],"differential":[81],"expression":[82],"underlies":[85],"diversity":[87],"pharmacology.":[90],"A":[91,197],"developmental":[92],"switch":[93],"from":[94,158],"alpha2":[95],"alpha1beta":[97],"completed":[99],"by":[100],"around":[101],"postnatal":[102],"day":[103],"20":[104],"rat.":[107],"responsible":[111],"anchoring":[113],"GlyRs":[114,215],"subsynaptic":[117],"cytoskeleton":[118],"via":[119],"cytoplasmic":[121],"protein":[122],"gephyrin.":[123],"last":[125],"few":[126],"years":[127],"seen":[129],"surge":[131],"interest":[133],"these":[135,234],"receptors.":[136],"Consequently,":[137],"wealth":[139],"information":[141,154],"has":[142,155,203],"recently":[143],"emerged":[144],"concerning":[145],"molecular":[147],"structure":[148],"function.":[150],"Most":[151],"obtained":[157],"homomeric":[159],"alpha1":[160],"GlyRs,":[161],"with":[162],"roles":[164],"receiving":[169],"relatively":[170],"little":[171],"attention.":[172],"Heritable":[173],"mutations":[174],"human":[176],"genes":[178],"give":[179],"rise":[180],"rare":[183],"neurological":[184],"disorder,":[185],"hyperekplexia":[186],"(or":[187],"startle":[188],"disease).":[189],"Similar":[190],"syndromes":[191],"occur":[193],"species.":[196],"rapidly":[198],"growing":[199],"list":[200],"compounds":[202,239],"shown":[205],"exert":[207],"potent":[208],"modulatory":[209],"effects":[210],"on":[211],"receptor.":[213],"Since":[214],"involved":[217],"motor":[219],"reflex":[220],"circuits":[221],"provide":[227,237],"synapses":[229],"onto":[230],"pain":[231],"sensory":[232],"neurons,":[233],"agents":[235],"lead":[238],"development":[242],"muscle":[244],"relaxant":[245],"peripheral":[247],"analgesic":[248]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":39},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":45},{"year":2018,"cited_by_count":33},{"year":2017,"cited_by_count":45},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":36},{"year":2013,"cited_by_count":36},{"year":2012,"cited_by_count":40}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
