{"id":"https://openalex.org/W2021798730","doi":"https://doi.org/10.1016/j.juro.2012.02.1353","title":"1581 ESTROGEN RECEPTORS MEDIATE STROMAL-EPITHELIAL INTERACTIONS IN BPH","display_name":"1581 ESTROGEN RECEPTORS MEDIATE STROMAL-EPITHELIAL INTERACTIONS IN BPH","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2021798730","doi":"https://doi.org/10.1016/j.juro.2012.02.1353","mag":"2021798730"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2012.02.1353","doi":"https://doi.org/10.1016/j.juro.2012.02.1353","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2012.02.1353","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027205779","display_name":"William A. Ricke","orcid":"https://orcid.org/0000-0002-9807-2090","observed_orcids":["https://orcid.org/0000-0002-9807-2090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Ricke","raw_affiliation_strings":["Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madison, WI","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084162340","display_name":"Emily A. Ricke","orcid":"https://orcid.org/0000-0003-3119-0321","observed_orcids":["https://orcid.org/0000-0003-3119-0321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Ricke","raw_affiliation_strings":["Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madison, WI","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1401012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"187","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/epithelial-stromal-interactions","display_name":"stromal-epithelial interactions","score":0.9750000238418579},{"id":"https://openalex.org/keywords/prostatic-stroma","display_name":"prostate stroma","score":0.5759999752044678},{"id":"https://openalex.org/keywords/prostatic-epithelium","display_name":"prostate epithelium","score":0.8420000076293945},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8059999942779541},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/lower-urinary-tract-symptoms","display_name":"lower urinary tract symptoms","score":0.7350000143051147},{"id":"https://openalex.org/keywords/bladder-outlet-obstruction","display_name":"bladder outlet obstruction","score":0.8009999990463257},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.3199999928474426},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.8080554008483887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7194321155548096},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6460662484169006},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.6415442824363708},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6150375008583069},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6014381051063538},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5833345651626587},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.5551314353942871},{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.5395684838294983},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4809533655643463},{"id":"https://openalex.org/C2780070792","wikidata":"https://www.wikidata.org/wiki/Q4923668","display_name":"Bladder outlet obstruction","level":4,"score":0.463284432888031},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.44466203451156616},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38080212473869324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34039998054504395},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.2475849688053131},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07688403129577637},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.05616885423660278}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2012.02.1353","doi":"https://doi.org/10.1016/j.juro.2012.02.1353","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2012.02.1353","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2411999976","https://openalex.org/W1988091239","https://openalex.org/W2376054510","https://openalex.org/W2360532639","https://openalex.org/W2132895311","https://openalex.org/W1979398376","https://openalex.org/W2590997960","https://openalex.org/W1977189077","https://openalex.org/W3015082124","https://openalex.org/W1985665699"],"abstract_inverted_index":{"You":[0],"have":[1],"accessJournal":[2],"of":[3,88,104,126,133,144,154,167,185,202,221,234,251,269,396,424],"UrologyBenign":[4],"Prostatic":[5],"Hyperplasia:":[6],"Basic":[7],"Research1":[8],"Apr":[9],"20121581":[10],"ESTROGEN":[11],"RECEPTORS":[12],"MEDIATE":[13],"STROMAL-EPITHELIAL":[14],"INTERACTIONS":[15],"IN":[16],"BPH":[17,127,152,228,244,425],"William":[18,23,461],"Ricke":[19,22,25,36,462,471],"and":[20,33,68,76,86,124,128,151,156,183,204,219,227,248,378,426,436,457],"Emily":[21,34,470],"RickeWilliam":[24],"Madison,":[26,37,463,472],"WI":[27,38,464,473],"More":[28,39,465,474],"articles":[29,40,466,475],"by":[30,41,172,431,452,467,476],"this":[31,42,134,468,477],"author":[32,43,469,478],"RickeEmily":[35],"View":[44],"All":[45,480],"Author":[46],"Informationhttps://doi.org/10.1016/j.juro.2012.02.1353AboutPDF":[47],"ToolsAdd":[48],"to":[49,111,137,163,246,375],"favoritesDownload":[50],"CitationsTrack":[51],"CitationsPermissionsReprints":[52],"ShareFacebookTwitterLinked":[53],"InEmail":[54],"INTRODUCTION":[55],"AND":[56],"OBJECTIVES":[57],"Benign":[58],"prostatic":[59,168],"hyperplasia":[60],"(BPH)":[61],"is":[62,96],"highly":[63,112],"prevalent":[64],"among":[65],"aging":[66],"men":[67],"can":[69,108],"result":[70],"in":[71,101,121,148,179,187,209,216,243,260,278,289,306,328,341,369,403,421],"bladder":[72],"outlet":[73],"obstruction":[74],"(BOO)":[75],"lower":[77,259],"urinary":[78],"tract":[79],"symptoms":[80],"(LUTS)":[81],"that":[82,115,368,393],"significantly":[83,240,257,266,301,349],"impact":[84],"health":[85],"quality":[87],"life.":[89],"Currently":[90],"the":[91,102,122,139,193,249,331,387,397,404,413,422],"androgen":[92],"receptor":[93,177],"signaling":[94],"cascade":[95],"a":[97,400,417],"chief":[98],"pathway":[99,415,420],"targeted":[100],"treatment":[103,423],"BPH.":[105,261,408],"However,":[106,296],"androgens":[107],"be":[109],"metabolized":[110],"potent":[113],"estrogens":[114,173],"may":[116],"play":[117],"an":[118,199],"important":[119],"role":[120,402],"manifestation":[123],"progression":[125],"associated":[129,427],"LUTS.":[130,428],"The":[131,232],"purpose":[132],"project":[135],"was":[136,170,190,214,239,256,300,334],"determine":[138,164],"stromal":[140,252,271,284,309,317,344,357],"versus":[141],"epithelial":[142,155,158,235,273,292,297,337,352],"localization":[143,372],"estrogen":[145,176,394,414],"receptors":[146],"(ER)":[147],"normal":[149,247],"prostate":[150,188,270],"specimens":[153,189],"mixed":[157],"subtypes.":[159],"Additionally":[160],"we":[161],"wanted":[162],"if":[165],"proliferation":[166,268,286,354,406],"cells":[169,223,238,255,274,338],"affected":[171],"or":[174,272],"selective":[175],"modulators":[178],"vitro.":[180],"METHODS":[181],"Detection":[182],"quantification":[184],"ERs":[186],"performed":[191],"using":[192],"Vectra":[194],"analysis":[195],"system,":[196],"which":[197],"provides":[198],"unbiased":[200],"detection":[201],"chromogen":[203],"hence":[205,379],"objective":[206],"ER":[207,213,236,253,371,380],"recognition":[208],"tissue":[210,376],"specimens.":[211],"RESULTS":[212],"detected":[215],"approximately":[217],"12%":[218],"8.5%":[220],"total":[222],"from":[224],"benign":[225],"(n=45)":[226],"(n=25)":[229],"specimens,":[230],"respectively.":[231],"percentage":[233,250],"positive":[237,254],"(P<0.05)":[241,258,302,350],"increased":[242,303],"compared":[245],"Estradiol":[262],"(E2)":[263],"did":[264,281],"not":[265],"affect":[267],"directly":[275],"when":[276,287,304],"grown":[277,288,305,340],"culture,":[279],"nor":[280],"E2":[282,290,307],"increase":[283],"cell":[285,293,298,310,318,345,353,358],"treated":[291,308,343],"conditioned":[294,311,319,346,359],"media.":[295],"growth":[299],"media":[312,320,360],"(OD=":[313,322],"0.39)":[314],"vs":[315,355],"untreated":[316,356],"controls":[321],"0.25).":[323],"Similar":[324],"results":[325],"were":[326,339],"obtained":[327],"experiments":[329],"where":[330],"antiestrogen,":[332],"Raloxifene,":[333],"used.":[335],"When":[336],"Raloxifene":[342],"media,":[347],"it":[348],"decreased":[351],"(OD=0.21vs":[361],"0.33,":[362],"respectively).":[363],"CONCLUSIONS":[364],"These":[365],"data":[366,411],"suggest":[367,392],"BPH,":[370],"changes":[373],"according":[374],"layer":[377],"regulated":[381],"events":[382],"are":[383],"increasingly":[384],"mediated":[385],"via":[386],"epithelium.":[388],"Interestingly,":[389],"functional":[390],"assays":[391],"regulation":[395],"stroma":[398],"plays":[399],"key":[401],"overall":[405],"during":[407],"Generally,":[409],"these":[410],"implicate":[412],"as":[416],"potential":[418],"therapeutic":[419],"\u00a9":[429],"2012":[430,451],"American":[432,453],"Urological":[433,454],"Association":[434,455],"Education":[435,456],"Research,":[437,458],"Inc.FiguresReferencesRelatedDetails":[438],"Volume":[439],"187Issue":[440],"4SApril":[441],"2012Page:":[442],"e640":[443],"Peer":[444],"Review":[445],"Report":[446],"Advertisement":[447,481,482],"Copyright":[448],"&":[449],"Permissions\u00a9":[450],"Inc.MetricsAuthor":[459],"Information":[460],"Expand":[479],"PDF":[483],"downloadLoading":[484],"...":[485]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
