{"id":"https://openalex.org/W2021702829","doi":"https://doi.org/10.2471/blt.07.043802","title":"Anti-tuberculosis medication side-effects constitute major factor for poor adherence to tuberculosis treatment","display_name":"Anti-tuberculosis medication side-effects constitute major factor for poor adherence to tuberculosis treatment","publication_year":2008,"publication_date":"2008-01-07","ids":{"openalex":"https://openalex.org/W2021702829","doi":"https://doi.org/10.2471/blt.07.043802","mag":"2021702829","pmid":"https://pubmed.ncbi.nlm.nih.gov/18368191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647396"},"language":"en","primary_location":{"id":"doi:10.2471/blt.07.043802","doi":"https://doi.org/10.2471/blt.07.043802","is_oa":true,"landing_page_url":"https://doi.org/10.2471/blt.07.043802","pdf_url":"https://doi.org/10.2471/blt.07.043802","source":{"id":"https://openalex.org/S22004576","display_name":"Bulletin of the World Health Organization","issn_l":"0042-9686","issn":["0042-9686","1564-0604"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ddh","doaj","dongbi-b","doyens","fnege-4","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319663","host_organization_name":"World Health Organization","host_organization_lineage":["https://openalex.org/P4310319663","https://openalex.org/P4310321776"],"host_organization_lineage_names":["World Health Organization","United Nations"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the World Health Organization","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.2471/blt.07.043802","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082239487","display_name":"Niyi Awofeso","orcid":"https://orcid.org/0000-0001-5748-2969","observed_orcids":["https://orcid.org/0000-0001-5748-2969"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Niyi Awofeso","raw_affiliation_strings":["University of New South wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New South wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082239487"],"corresponding_institution_ids":["https://openalex.org/I31746571"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":157,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"3","first_page":"240","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-treatment-adherence","display_name":"tuberculosis treatment adherence","score":0.8529999852180481},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dots-strategy","display_name":"DOTS strategy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/hepatitis","display_name":"hepatitis","score":0.31200000643730164},{"id":"https://openalex.org/keywords/hiv-coinfection","display_name":"HIV coinfection","score":0.5770000219345093},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/second-line-drugs","display_name":"second-line drugs","score":0.8600000143051147},{"id":"https://openalex.org/keywords/patient-counseling","display_name":"patient counseling","score":0.656000018119812},{"id":"https://openalex.org/keywords/adverse-drug-reaction-management","display_name":"adverse drug reaction management","score":0.5820000171661377},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.640999972820282},{"id":"https://openalex.org/keywords/patient-centered-care","display_name":"patient-centered care","score":0.5519999861717224},{"id":"https://openalex.org/keywords/health-system-factors","display_name":"health system factors","score":0.3569999933242798},{"id":"https://openalex.org/keywords/patient-autonomy","display_name":"patient autonomy","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8969926834106445},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7827625274658203},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.7602719068527222},{"id":"https://openalex.org/C2909923361","wikidata":"https://www.wikidata.org/wiki/Q2339584","display_name":"Directly Observed Therapy","level":3,"score":0.6365543603897095},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.560189425945282},{"id":"https://openalex.org/C2778173179","wikidata":"https://www.wikidata.org/wiki/Q25339289","display_name":"Attendance","level":2,"score":0.523809552192688},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.4681921899318695},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.46518319845199585},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4364578425884247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34147635102272034},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010349","descriptor_name":"Patient Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D023801","descriptor_name":"Directly Observed Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2471/blt.07.043802","doi":"https://doi.org/10.2471/blt.07.043802","is_oa":true,"landing_page_url":"https://doi.org/10.2471/blt.07.043802","pdf_url":"https://doi.org/10.2471/blt.07.043802","source":{"id":"https://openalex.org/S22004576","display_name":"Bulletin of the World Health Organization","issn_l":"0042-9686","issn":["0042-9686","1564-0604"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ddh","doaj","dongbi-b","doyens","fnege-4","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319663","host_organization_name":"World Health Organization","host_organization_lineage":["https://openalex.org/P4310319663","https://openalex.org/P4310321776"],"host_organization_lineage_names":["World Health Organization","United Nations"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the World Health Organization","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1450962","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2647396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:18368191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18368191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the World Health Organization","raw_type":"Comment"},{"id":"pmh:oai:pubmedcentral.nih.gov:2647396","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2647396/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bull World Health Organ","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:36456d9a926440beb8a8632f4fbec291","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/36456d9a926440beb8a8632f4fbec291","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bulletin of the World Health Organization, Vol 86, Iss 3, Pp B-D (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2471/blt.07.043802","doi":"https://doi.org/10.2471/blt.07.043802","is_oa":true,"landing_page_url":"https://doi.org/10.2471/blt.07.043802","pdf_url":"https://doi.org/10.2471/blt.07.043802","source":{"id":"https://openalex.org/S22004576","display_name":"Bulletin of the World Health Organization","issn_l":"0042-9686","issn":["0042-9686","1564-0604"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ddh","doaj","dongbi-b","doyens","fnege-4","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319663","host_organization_name":"World Health Organization","host_organization_lineage":["https://openalex.org/P4310319663","https://openalex.org/P4310321776"],"host_organization_lineage_names":["World Health Organization","United Nations"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the World Health Organization","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2021702829.pdf","grobid_xml":"https://content.openalex.org/works/W2021702829.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W100013862","https://openalex.org/W1590576387","https://openalex.org/W1878744777","https://openalex.org/W1899176177","https://openalex.org/W1966243392","https://openalex.org/W1975623572","https://openalex.org/W1976643553","https://openalex.org/W1997853602","https://openalex.org/W2013916408","https://openalex.org/W2017924912","https://openalex.org/W2077319066","https://openalex.org/W2108451559","https://openalex.org/W2115011764","https://openalex.org/W2131679208","https://openalex.org/W2133688319","https://openalex.org/W2135184715","https://openalex.org/W2149691825","https://openalex.org/W2152029320","https://openalex.org/W2154396724","https://openalex.org/W2154752052","https://openalex.org/W2155651109","https://openalex.org/W2161849138","https://openalex.org/W2185350617","https://openalex.org/W2186379012","https://openalex.org/W2414647901","https://openalex.org/W2729541202","https://openalex.org/W4301248396"],"related_works":["https://openalex.org/W2919993191","https://openalex.org/W2322097001","https://openalex.org/W2083159789","https://openalex.org/W3003909151","https://openalex.org/W3126653819","https://openalex.org/W7217989184","https://openalex.org/W4416270171","https://openalex.org/W4293013434","https://openalex.org/W4412185476","https://openalex.org/W7217137801"],"abstract_inverted_index":{"Two":[0],"significant":[1,52,277],"issues":[2],"that":[3,191,224,513,673,747,809],"require":[4],"further":[5],"clarification":[6],"in":[7,68,100,129,143,184,269,310,320,335,361,410,435,440,505,699,792,801],"Garner":[8],"et":[9],"al.\u2019s":[10],"stimulating":[11],"paper":[12],"(Promoting":[13],"adherence":[14,26,31,253,374,443,455,697,714,741,762,780],"to":[15,32,70,83,208,213,239,286,289,318,384,412,464,474,509,545,571,579,587,604,612,623,638,693,713],"tuberculosis":[16,33],"treatment1)":[17],"are":[18,195,264,397,438,471,479,621,636],"the":[19,46,75,93,107,133,178,234,287,333,340,445,450,495,573,619,634,668,723,758,768,804,814],"impact":[20,180,812],"of":[21,66,72,138,152,170,181,218,236,245,252,304,332,343,372,416,453,497,536,552,575,618,633,667,704,757,776,789,807,816],"medication":[22,103,174,182,395,482,554,614],"side-effects":[23,79,104,136,183,217,228,396,483],"on":[24,198,215,501,813],"treatment":[25,42,148,186,244,373,413,442,469,500,537,648,654,705,726,791],"as":[27,29,56,96,166,168,323,349,428,430,583,601,615,650],"well":[28,429],"how":[30,207],"(TB)":[34],"chemotherapy":[35,140,238,345,590],"should":[36,205,229],"be":[37,84,230,376,569,599,764],"defined":[38],"and":[39,60,122,154,201,242,254,263,301,329,352,358,363,391,420,425,432,470,530,671,702],"monitored.":[40],"The":[41,117,135,279,370],"regimen":[43],"recommended":[44],"within":[45],"DOTS":[47,115,248,446,451],"approach":[48,452,712],"is":[49,141,189,221,315,405,539,709,752,800],"associated":[50,86],"with":[51,87,145,158,233,307,418,562,683,803],"side-effects.":[53],"Side-effects":[54],"such":[55,246,582],"hepatitis,":[57],"dyspepsia,":[58],"exanthema":[59],"arthralgia":[61],"were":[62,80,105,259,516],"responsible":[63],"for":[64,111,161,226,366,468,631,657,679,727,739,760,778],"termination":[65],"therapy":[67,687],"up":[69],"23%":[71],"patients":[73,128,144,214,291,305,348,462,515,586,609,628],"during":[74,132,164],"intensive":[76],"phase.2":[77],"Medication":[78],"also":[81,222],"found":[82],"significantly":[85],"defaulting.3":[88],"At":[89],"Kyrgyzstan":[90,493,769],"prisons,":[91,494],"where":[92],"author":[94,118],"worked":[95],"a":[97,293,298,326,402,406,547,602,646,651,665,710,748,782,793],"TB":[98,127,139,185,192,270,344,436,520,589,613,647,686,771],"doctor":[99],"early":[101],"2007,":[102],"among":[106,125],"most":[108,533],"common":[109],"reasons":[110,759,777],"patient":[112,334,431,528,652,724,783],"non-attendance":[113,121],"at":[114,526,754,767,785],"clinics.":[116],"observed":[119],"similar":[120],"defaulting":[123],"trends":[124],"community-based":[126],"northern":[130],"Nigeria":[131],"1990s.":[134],"profile":[137],"magnified":[142],"concurrent":[146],"HIV":[147,684],"and/or":[149],"prior":[150],"history":[151],"hepatitis,4":[153],"those":[155],"being":[156],"treated":[157],"second-line":[159],"drugs":[160],"multidrug-resistant":[162],"TB,":[163,419],"which":[165,290,546,755],"many":[167,514],"86%":[169],"patents":[171],"may":[172,375,568,598],"develop":[173],"side-effects.5,6":[175],"To":[176],"minimize":[177],"adverse":[179],"adherence,":[187],"it":[188,324,597,717],"important":[190,223,439],"health":[193,385,565,577],"staff":[194],"adequately":[196],"trained":[197],"their":[199,312,367,518],"recognition":[200],"management.":[202,337],"Such":[203],"training":[204],"include":[206],"provide":[209,738],"concise":[210],"pretreatment":[211],"counselling":[212],"possible":[216],"treatment.7":[219],"It":[220,296,338,663],"medications":[225],"managing":[227,311],"ordered":[231],"concurrently":[232],"ordering":[235],"anti-TB":[237,499,790],"facilitate":[240,694],"timely":[241],"adequate":[243],"side-effects.\r\n\r\nThe":[247],"strategy":[249],"contains":[250],"elements":[251],"compliance.":[255],"While":[256],"these":[257],"terms":[258,551],"initially":[260],"used":[261,267,570,600],"synonymously":[262],"still":[265],"commonly":[266],"interchangeably":[268],"literature,":[271],"they":[272,478],"have":[273],"subtle":[274],"but":[275],"noteworthy":[276],"differences.":[278],"term":[280],"\u201cadherence\u201d":[281],"(or":[282],"\u201cpatient-centred":[283],"compliance\u201d8)":[284],"refers":[285],"extent":[288,371,544],"follow":[292],"prescribed":[294,616],"regimen.":[295],"implies":[297],"more":[299,327,730],"active":[300,330,357],"collaborative":[302],"involvement":[303],"working":[306],"health-care":[308],"providers":[309],"treatment.":[313,369],"\u201cAdherence\u201d":[314],"currently":[316],"preferred":[317],"\u201ccompliance\u201d":[319],"medical":[321,368,563],"literature":[322],"portrays":[325],"respectful":[328],"role":[331],"disease":[336],"captures":[339],"increasing":[341],"complexity":[342],"by":[346,378,540,584],"characterizing":[347],"independent,":[350],"intelligent":[351],"autonomous":[353],"people":[354,417],"who":[355,610,629],"take":[356,588],"voluntary":[359],"roles":[360],"defining":[362],"pursuing":[364],"goals":[365],"facilitated":[377],"positive":[379,407],"or":[380,484,490,557,564,661,729],"negative":[381,398],"attributes":[382,400],"related":[383],"system,":[386],"social/family":[387],"issues,":[388],"personal":[389],"factors,":[390],"drug":[392,399,408,487],"factors":[393],"(e.g.":[394],"while":[401,627],"fixed-dose":[403],"combination":[404],"attribute":[409],"relation":[411],"adherence).":[414],"Empowerment":[415],"communities,":[421],"through":[422],"advocacy,":[423],"communication":[424],"social":[426],"mobilization":[427],"community":[433],"participation":[434],"care":[437],"facilitating":[441,454],"using":[444,591],"approach.9\r\n\r\nIn":[447],"exceptional":[448],"situations,":[449],"might":[456],"not":[457,719],"achieve":[458],"its":[459],"objectives,":[460],"since":[461,716],"need":[463],"make":[465],"themselves":[466],"available":[467],"less":[472],"likely":[473],"do":[475],"so":[476,680],"if":[477,781],"imprisoned,":[480],"suffer":[481],"experience":[485],"homelessness,":[486],"addiction,":[488],"unemployment":[489],"alcoholism.4,10":[491],"In":[492],"practice":[496],"self-administered":[498],"weekends":[502],"was":[503,655],"discontinued":[504],"March":[506],"2007":[507],"due":[508],"repeated":[510],"documented":[511],"evidence":[512],"trafficking":[517],"weekend":[519],"medications,":[521],"despite":[522],"concerted":[523],"efforts":[524],"aimed":[525],"enhancing":[527],"empowerment":[529],"peer":[531],"support.\r\n\r\nThe":[532],"cited":[534],"definition":[535],"compliance":[538,675,692,701,735,750],"Haynes":[541],"\u2013":[542],"\u201cthe":[543],"person\u2019s":[548],"behaviour":[549],"(in":[550],"taking":[553],"following":[555],"diets,":[556],"executing":[558],"lifestyle":[559],"changes)":[560],"coincides":[561],"advice\u201d.11":[566],"\u201cCompliance\u201d":[567],"describe":[572],"\u201cright":[574],"public":[576],"authorities":[578],"demand":[580],"adherence\u201d1":[581],"compelling":[585],"Public":[592],"Health":[593,643],"Detention":[594],"Orders.12":[595],"Or":[596],"framework":[603],"evaluate":[605],"adherence.":[606],"For":[607],"example,":[608],"adhere":[611,630],"95%":[617],"time":[620,635],"said":[622,637],"demonstrate":[624,639],"high":[625,689,700],"compliance,":[626],"40%":[632],"low":[640],"compliance.\r\n\r\nThe":[641],"World":[642],"Organization":[644],"defines":[645],"defaulter":[649,744],"whose":[653],"interrupted":[656,725],"two":[658,787],"consecutive":[659,731],"months":[660],"more.":[662],"indicates":[664],"closure":[666],"current":[669],"treatment,":[670,685],"documents":[672],"patients\u2019":[674],"has":[676],"been":[677],"0%":[678],"long.":[681],"As":[682],"requires":[688],"(>":[690],"90%)":[691],"cure.":[695],"Good":[696],"results":[698],"absence":[703],"default.":[706],"Default":[707],"rate":[708],"crude":[711],"monitoring,":[715],"does":[718],"really":[720],"reveal":[721],"why":[722],"2":[728],"months.":[732],"Promptly":[733],"implementing":[734],"assurance":[736],"measures":[737],"better":[740],"monitoring":[742],"than":[743],"tracing,":[745],"provided":[746],"baseline":[749,798],"level":[751],"set":[753],"investigation":[756,775],"poor":[761,779],"can":[763],"undertaken.":[765],"Currently":[766],"prison":[770],"project,":[772],"we":[773],"undertake":[774],"misses":[784],"least":[786],"doses":[788],"week.":[794],"This":[795],"\u201cpatient":[796],"contact\u201d":[797],"period":[799],"line":[802],"maximum":[805],"duration":[806],"non-adherence":[808],"will":[810],"adversely":[811],"efficacy":[815],"treatment.13":[817],"\u25a0":[818]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}