{"id":"https://openalex.org/W2021674853","doi":"https://doi.org/10.1038/oncsis.2013.40","title":"The histone variant MacroH2A regulates Ca2+ influx through TRPC3 and TRPC6 channels","display_name":"The histone variant MacroH2A regulates Ca2+ influx through TRPC3 and TRPC6 channels","publication_year":2013,"publication_date":"2013-10-28","ids":{"openalex":"https://openalex.org/W2021674853","doi":"https://doi.org/10.1038/oncsis.2013.40","mag":"2021674853","pmid":"https://pubmed.ncbi.nlm.nih.gov/24165580","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3816217"},"language":"en","primary_location":{"id":"doi:10.1038/oncsis.2013.40","doi":"https://doi.org/10.1038/oncsis.2013.40","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oncsis.2013.40","pdf_url":"https://www.nature.com/articles/oncsis201340.pdf","source":{"id":"https://openalex.org/S4210239318","display_name":"Oncogenesis","issn_l":"2157-9024","issn":["2157-9024"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/oncsis201340.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052706582","display_name":"J-M Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J-M Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083528430","display_name":"Kyu Heo","orcid":"https://orcid.org/0000-0001-8833-4731","observed_orcids":["https://orcid.org/0000-0001-8833-4731"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210148139","display_name":"Dongnam Institute of Radiological & Medical Sciences","ror":"https://ror.org/055fmxa32","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210148139"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"K Heo","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA","Research Center, Dongnam Institute of Radiological and Medical Sciences, Busan, South Korea","Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Research Center, Dongnam Institute of Radiological and Medical Sciences, Busan, South Korea","institution_ids":["https://openalex.org/I4210148139"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109325586","display_name":"Jinah Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Choi","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA","Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048108625","display_name":"Kyeungpyo Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology , Norris Comprehensive Cancer Center , University of Southern California , Los Angeles , CA , USA and","Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology , Norris Comprehensive Cancer Center , University of Southern California , Los Angeles , CA , USA and","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066038194","display_name":"Woojin An","orcid":"https://orcid.org/0000-0001-8756-595X","observed_orcids":["https://orcid.org/0000-0001-8756-595X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W An","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology , Norris Comprehensive Cancer Center , University of Southern California , 1450 Biggy Street NRT6507 , Los Angeles , CA 90033 , USA","Department of Biochemistry and Molecular Biology , Norris Comprehensive Cancer Center , University of Southern California , Los Angeles , CA , USA and","Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology , Norris Comprehensive Cancer Center , University of Southern California , 1450 Biggy Street NRT6507 , Los Angeles , CA 90033 , USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology , Norris Comprehensive Cancer Center , University of Southern California , Los Angeles , CA , USA and","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066038194"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":1.1954,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.77528484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"2","issue":"10","first_page":"e77","last_page":"e77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.19480000436306,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.10119999945163727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macroh2a1","display_name":"macroH2A1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/histone-variants","display_name":"histone variants","score":0.9470000267028809},{"id":"https://openalex.org/keywords/trpc3","display_name":"TRPC3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/trpc6","display_name":"TRPC6","score":1.0},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.7789999842643738},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.722000002861023},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":0.9729999899864197},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6840000152587891},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C170488646","wikidata":"https://www.wikidata.org/wiki/Q7671459","display_name":"TRPC","level":4,"score":0.9555160403251648},{"id":"https://openalex.org/C2780383360","wikidata":"https://www.wikidata.org/wiki/Q15322900","display_name":"TRPC3","level":5,"score":0.8671212792396545},{"id":"https://openalex.org/C196156954","wikidata":"https://www.wikidata.org/wiki/Q15323059","display_name":"TRPC5","level":5,"score":0.7737720608711243},{"id":"https://openalex.org/C128448793","wikidata":"https://www.wikidata.org/wiki/Q14914578","display_name":"TRPC6","level":4,"score":0.7114322781562805},{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.6778643727302551},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6605648398399353},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6390737295150757},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5508803725242615},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.5465013384819031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5135834217071533},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.5039054751396179},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.489866703748703},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.47126102447509766},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.43329450488090515},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4118783175945282},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3159645199775696},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2957172989845276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24322479963302612},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17063307762145996},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.15342476963996887}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/oncsis.2013.40","doi":"https://doi.org/10.1038/oncsis.2013.40","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oncsis.2013.40","pdf_url":"https://www.nature.com/articles/oncsis201340.pdf","source":{"id":"https://openalex.org/S4210239318","display_name":"Oncogenesis","issn_l":"2157-9024","issn":["2157-9024"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2805698","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3816217","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3816217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3816217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"Text"},{"id":"pmid:24165580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24165580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/oncsis.2013.40","doi":"https://doi.org/10.1038/oncsis.2013.40","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oncsis.2013.40","pdf_url":"https://www.nature.com/articles/oncsis201340.pdf","source":{"id":"https://openalex.org/S4210239318","display_name":"Oncogenesis","issn_l":"2157-9024","issn":["2157-9024"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogenesis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6692871275","display_name":"ROLE OF HISTONE H4 N-TERMINAL TAIL IN TRANSCRIPTION REGULATION","funder_award_id":"R01GM084209","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8334273651","display_name":null,"funder_award_id":"DMC-1005001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2021674853.pdf","grobid_xml":"https://content.openalex.org/works/W2021674853.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1967994974","https://openalex.org/W1968637358","https://openalex.org/W1983522412","https://openalex.org/W1987400169","https://openalex.org/W2002401551","https://openalex.org/W2005725366","https://openalex.org/W2010795846","https://openalex.org/W2019637656","https://openalex.org/W2025525406","https://openalex.org/W2030592870","https://openalex.org/W2032594275","https://openalex.org/W2037231961","https://openalex.org/W2038356000","https://openalex.org/W2055322019","https://openalex.org/W2065055088","https://openalex.org/W2071427251","https://openalex.org/W2072699494","https://openalex.org/W2074998492","https://openalex.org/W2076788485","https://openalex.org/W2081100502","https://openalex.org/W2083308605","https://openalex.org/W2095921496","https://openalex.org/W2096235102","https://openalex.org/W2101179323","https://openalex.org/W2101716183","https://openalex.org/W2104271783","https://openalex.org/W2122813253","https://openalex.org/W2126469092","https://openalex.org/W2134377563","https://openalex.org/W2157569563","https://openalex.org/W2162812593","https://openalex.org/W2167083524","https://openalex.org/W2169567788","https://openalex.org/W2170872601","https://openalex.org/W4255760236"],"related_works":["https://openalex.org/W7099199960","https://openalex.org/W2018863876","https://openalex.org/W2063463104","https://openalex.org/W2002670570","https://openalex.org/W6903812547","https://openalex.org/W1967994974","https://openalex.org/W7134492822","https://openalex.org/W2139811812","https://openalex.org/W2926947162","https://openalex.org/W7151412606"],"abstract_inverted_index":{"The":[0,26,47],"histone":[1,92,108,120],"variant":[2],"macroH2A":[3],"replaces":[4],"canonical":[5,30],"H2A":[6],"in":[7,42,86,104,148],"the":[8,17,43,62,111],"designated":[9],"region":[10],"of":[11,36,50,64,107,152],"chromatin":[12,24,55],"where":[13],"its":[14,100],"incorporation":[15],"has":[16],"potential":[18,29],"to":[19,98,126],"establish":[20],"a":[21,34,105,143],"functionally":[22],"distinct":[23],"domain.":[25],"transient":[27],"receptor":[28],"(TRPC)":[31],"channels":[32,39],"are":[33],"family":[35,76],"Ca(2+)-permeable":[37],"cationic":[38],"controlling":[40],"changes":[41],"cytosolic":[44],"Ca(2+)":[45,123,139],"concentration.":[46],"proper":[48],"regulation":[49],"Trpc":[51,75],"gene":[52],"expression":[53],"requires":[54],"remodeling,":[56],"but":[57],"little":[58],"is":[59],"known":[60],"about":[61],"nature":[63],"these":[65],"regulatory":[66],"processes.":[67],"Here,":[68],"we":[69],"show":[70],"that":[71],"macroH2A1":[72,117,147],"represses":[73],"two":[74],"genes,":[77],"Trpc3":[78,112,153],"and":[79,81,96,113,122,130,141,154],"Trpc6,":[80],"attenuates":[82],"Ca(2+)-dependent":[83],"proliferative":[84],"responses":[85],"bladder":[87],"cancer":[88],"cells.":[89],"MacroH2A1":[90],"recruits":[91],"deacetylase":[93],"1":[94],"(HDAC1)":[95],"HDAC2":[97],"facilitate":[99],"persistent":[101],"action,":[102],"resulting":[103],"compromise":[106],"acetylation":[109,121],"across":[110],"Trpc6":[114,155],"loci.":[115],"Further,":[116],"depletion":[118],"augments":[119],"influx,":[124],"leading":[125],"increased":[127],"cell":[128],"growth":[129],"invasion.":[131],"Our":[132],"data":[133],"provide":[134],"new":[135],"insights":[136],"into":[137],"TRPC3/TRPC6-mediated":[138],"signaling":[140],"indicate":[142],"central":[144],"role":[145],"for":[146],"regulating":[149],"transcriptional":[150],"competence":[151],"genes.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}