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51,4853,4856,4863,4911,4924,4960,5094,5156,5182,5207,5224,5232,5548,5585,5649,5784,5803,5813,5895,5999,6032,6039,6056,6064,6114,6120,6170,6254,6262,6271,6291,6309,6323,6385,6431,6537,6550,6627,6709,6717],"repressor,":[13,84,310,381,2395,4593],"there":[14,311],"has":[15,312,1454,1771,2993,3066,4313,4406,4719,6564],"not":[16,313,1353,1363,1649,2321,3297,3485,3992,4266,4557,4802,5225,5624,5632,5636,5683,5773,5832,5876,5942,6028,6189,6529],"been":[17,314,1424,1456,1772,4314,6623],"an":[18,97,315,394,1581,1891,3463,3600,3637,4101,4532,5193,5556,5750,5835],"example":[19,256,316,553,6595],"where":[20,317,2070],"both":[21,197,318,494,3987,4059,4078,5203,6167],"p53-activating":[22,319],"-repressing":[24,321],"elements":[25,322,2391,3461,4578,5699,6201,6649],"reside":[26,323,6202],"within":[27,245,324,542,2374,2417,5163,5948,6119,6650],"one":[28,325,1879,3261,6196,6618],"target":[29,326,961,2127,4963],"promoter.":[30,60,191,327,357,488,2380,3561,5796,6159,6211,6679],"Previous":[31,328],"work":[32,329],"from":[33,108,330,405,1181,1973,2095,3078,3474,3585,3775,4629,5809,6219,6299],"this":[34,62,251,331,359,548,2341,3617,4172,5764,6014,6241,6331,6682],"laboratory":[35,332,1183],"defined":[36,333],"two":[37,262,334,559,1240,1948,2180,2675,2994,3460,4969,5780,6645],"different":[38,335,4558,4970,6277,6298],"response":[40,290,337,587,1312,1367,1626,3555,5576],"elements,":[41,338],"termed":[42,339,4105],"P1":[43,77,88,92,114,136,142,161,274,340,374,385,389,411,433,439,458,571,2185,2205,2281,2287,2334,2388,3086,3120,3158,3168,3178,3249,3265,3311,3329,3353,3467,3507,3516,3691,3699,4037,4504,4520,4566,4575,4605,4620,4646,4661,4675,4775,4988,5002,5028,5081,5088,5096,5648,6029,6038,6047,6094,6171,6261,6270,6304,6322,6343,6355,6536,6543],"P2,":[45,342,2193,2645,2938,3319,3373],"located":[46,343,2187,2194,2997,3331],"at":[47,344,2188,2195,2482,2500,2728,2750,2847,2998,3088,3478,4290,4376,4583],"nucleotide":[48,345,2189,2999,6206],"positions":[49,346,2190,3000],"\u201370":[50,347,3001,3090],"\u2013707,":[52,349],"respectively,":[53,350,2396,3006],"in":[54,179,280,289,351,476,577,586,632,965,1584,1774,1878,1945,1956,2008,2033,2104,2163,2340,2464,2485,2495,2497,2505,2707,2732,2746,2837,2885,2931,3043,3073,3272,3280,3299,3342,3514,3554,3558,3606,3622,3651,3760,3878,3963,3969,4008,4041,4168,4243,4247,4400,4466,4569,4623,5020,5184,5618,5663,5700,5845,5995,6125,6133,6156,6224,6256,6266,6424,6438,6495,6673],"the":[55,67,102,160,203,220,246,281,352,364,399,457,500,517,543,578,635,1306,1311,1357,1419,1427,1441,1567,1775,1881,1908,1931,1947,1951,1961,1969,2002,2009,2025,2034,2037,2096,2113,2118,2164,2200,2215,2276,2280,2314,2325,2333,2352,2355,2368,2375,2378,2385,2405,2438,2532,2563,2641,2673,2693,2717,2733,2854,2896,2927,2989,3009,3059,3074,3085,3119,3126,3131,3137,3157,3183,3189,3244,3248,3255,3264,3269,3273,3290,3321,3334,3350,3370,3380,3411,3424,3431,3456,3459,3502,3506,3512,3547,3559,3563,3607,3623,3641,3648,3652,3666,3701,3718,3745,3831,3841,3848,3854,3857,3869,3879,3885,3889,3899,3913,3945,3948,3959,3964,3974,4020,4032,4084,4112,4126,4165,4176,4185,4225,4239,4262,4271,4280,4295,4309,4392,4395,4414,4436,4443,4447,4460,4467,4509,4548,4570,4574,4598,4630,4640,4657,4704,4716,4738,4868,4897,4906,4916,4927,4935,4938,4953,4974,4977,4981,4987,4992,5011,5027,5109,5152,5164,5167,5196,5208,5212,5645,5664,5701,5756,5793,5810,5821,5828,5846,5851,5879,5882,5885,5891,5899,5907,5938,5949,5953,5982,5985,6007,6035,6049,6073,6122,6126,6134,6157,6163,6168,6185,6209,6215,6225,6257,6289,6303,6316,6321,6350,6372,6390,6406,6496,6519,6524,6533,6557,6561,6580,6588,6642,6651,6674,6677,6690,6724],"rat":[56,353,2176,2990,3777,3833,4666,4978,6589],"bradykinin":[57,284,354,581,1603,2119],"B2":[58,285,355,582,1193,2120],"receptor":[59,286,356,583,1606,2121,2159],"In":[61,122,249,358,419,546,1178,1558,1754,1897,1928,2361,2754,3306,3709,4258,4435,4973,5981,6330,6586],"study,":[63,360,2985],"through":[64,361],"manipulation":[65,362],"of":[66,87,125,205,219,225,257,273,283,363,384,422,502,516,522,554,570,580,634,1188,1225,1239,1305,1342,1345,1349,1359,1388,1433,1445,1561,1566,1570,1577,1636,1890,1907,1950,1960,1971,2036,2166,2317,2332,2354,2367,2371,2377,2387,2407,2424,2437,2443,2450,2526,2544,2681,2766,2784,2878,2895,2921,2926,3049,3058,3125,3133,3151,3167,3177,3182,3243,3257,3263,3268,3289,3314,3323,3372,3379,3410,3458,3466,3472,3501,3549,3575,3583,3616,3625,3640,3676,3698,3703,3720,3838,3856,3868,3876,3947,3958,3996,4002,4022,4031,4034,4045,4049,4064,4068,4083,4089,4098,4111,4116,4125,4178,4188,4227,4241,4261,4270,4301,4306,4320,4413,4432,4438,4446,4459,4469,4513,4544,4550,4552,4563,4573,4601,4632,4643,4659,4685,4872,4937,4976,4998,5080,5087,5099,5144,5166,5171,5178,5186,5198,5211,5218,5579,5666,5755,5758,5763,5779,5792,5848,5887,5909,5927,5937,5984,6013,6021,6025,6034,6044,6058,6072,6136,6181,6205,6208,6214,6260,6293,6301,6320,6340,6349,6402,6405,6523,6579,6596,6644,6676,6715,6723],"DNA":[68,365,954,1232,1763,2022,2402,2528,2741,3075,3643,5214,5571,6345,6611,6698],"sequence":[69,366,1307,2068,2099,2218,2326,2353,2783,3266,3650,3661,4718,4900,5150,5206,5230,6052],"context,":[71,368],"we":[72,369,2338,2363,2986,3129,3236,3259,3374,3453,3544,3597,3645,3716,3765,3951,4174,4222,4363,6067,6107,6193],"demonstrate":[73,370,3116],"opposing":[74,371],"roles":[75,372,4589],"for":[76,135,239,373,432,536,1430,1587,2128,2550,2600,2769,2775,2833,2844,3318,4326,4508,4586,4645,4724,4781,4844,4865,4934,5140,5564,5587,5616,5652,5680,5768,6387,6712,6720],"P2":[79,103,126,130,156,171,186,247,276,376,400,423,427,453,468,483,544,573,2207,2285,2336,2390,2408,2427,2642,2727,3191,3362,3412,3438,3469,3473,3509,3520,3550,3626,3635,3642,3649,3677,3712,3721,3733,3747,3753,3770,3859,3904,3920,3936,3955,3999,4023,4035,4060,4079,4501,4517,4534,4577,4607,4622,4651,4663,4717,4739,4758,4780,4838,4869,4877,4883,4993,5112,5121,5135,5145,5158,5190,5199,5650,5667,5694,5874,5986,6018,6045,6059,6080,6098,6123,6137,6169,6272,6313,6324,6363,6391,6538,6552,6573],"respectively.":[85,382,4594],"Deletion":[86,383,3064,3409,4110],"abrogates":[89,386,3170,5082],"p53-mediated":[90,387,1223,1350,1431,1585,1884,1934,2344,2422,3171,3180,3487,3571,3593,3632,3704,3728,4012,4046,4065,4123,4268,4382,4421,4457,4538,5083,5092,5130,5219,5673,5691,5743,5790,5871,5935,6229,6403,6692],"activation.":[91,129,388,426,3442,3684,5674,5745,5776,6230],"maintains":[93,390,5091,5159],"its":[94,391,2359,2415,2418,2638,3475,4284,5160,5179,5204,5805,5814,6061],"role":[95,392,1583,3256,3371,4021,5197,5615,6132],"upon":[99,396],"relocation":[100,397,5086],"site":[104,177,401,474,1953,1963,1967,2186,2282,3012,3087,3121,3159,3413,4000,4843,5030,5886,6124,6621],"activates":[106,188,403,485,2275,6054,6668],"transcription":[107,132,259,404,429,556,1226,1341,1421,2201,3010,3057,3207,4288,4711,4846,4954,5137,5552,5591,5808,6055,6381,6607,6672],"heterologous":[110,190,407,487,3291,5101],"promoter":[111,408,1759,1910,2035,2178,2269,2278,2345,2420,2700,2779,2992,3185,3246,3292,3336,4006,4129,4232,4310,5014,5024,5169,6023,6075,6128,6164,6653],"construct.":[112,409,2735,3293,3966,5104],"Thus,":[113,192,410,489,5195,5612,6515],"bona":[117,414,3356,5005],"fide":[118,415,3357,5006],"positive":[119,416,3070,3358,3602,5007],"p53-response":[120,417,2010,2356,3071,3359,5008,6154],"element.":[121,248,418,545,1368,3360,4995,6244],"contrast,":[123,420,4248,5021],"deletion":[124,421,3400,3565,3697,3713,5079,5947,6213],"enhances":[127,424,6065],"P1-induced":[128,425],"represses":[131,428,1340,1376,2101,3440,5136,6081,6670],"when":[133,138,155,430,435,452,3316,3328,5138,6283],"substituted":[134,158,431,455,3317,3518,5139],"or":[137,162,217,434,459,514,656,1443,1564,2080,2085,2092,2211,2530,2603,2772,2797,3387,3714,3724,4114,4181,4274,4621,5127,5560,5562,5620,5946,6027,6048,6197,6353,6669],"relocated":[139,436],"midway":[140,437],"between":[141,438,3505,3609,6037,6535,6547],"P2.":[144,441,4686,4709,6040,6263],"P2-mediated":[145,193,206,442,490,503,2372,3497,3929,4094,4169,4327,4411,5610,5825,5841,6070,6085,6110,6397],"repression":[146,195,207,222,443,492,504,519,1351,1432,1461,1634,1760,1885,1906,1935,1974,2348,2373,2423,2440,3498,3553,3633,3682,3930,4016,4124,4269,4319,4328,4412,4422,5153,5221,5544,5568,5692,5738,5791,5842,5872,5910,5916,5923,5936,6020,6071,6086,6111],"sequence-dependent,":[148,445],"because":[149,446,1356,3444,3696,5635,5770,6042,6079,6097,6162],"it":[150,210,447,507,5771,6333],"reversed":[152,449],"activation":[154,181,451,478,1224,1903,1976,2346,3172,3181,3242,3288,3295,3325,3417,3572,3594,3687,3705,4013,4458,4539,4551,4985,5098,5131,6578],"by":[159,215,456,512,1243,1572,2351,2430,2592,2716,2725,3519,3527,3688,3884,3888,4311,4426,4506,4540,4618,4770,4789,4797,4803,4811,4822,4828,5123,5146,5202,5697,5890,5912,5944,6177,6191,6371,6604],"consensus":[164,461,1235,1366,2097,2217,3659,4899,5148,6051],"sequences.":[165,462],"Moreover,":[166,463,2404,3994],"site-directed":[167,464,2695],"mutagenesis":[168,465,2696,2703,2785,3722,3924,4038,4115,4229,5128,6057],"that":[169,209,232,266,466,506,529,563,1373,1384,2005,2160,2273,2284,2384,2988,3047,3118,3150,3165,3199,3238,3352,3437,3455,3496,3546,3599,3674,3867,3898,3928,3973,4420,4429,4456,4499,4543,4715,4837,4858,4952,5001,5111,5600,5647,5678,5741,5840,5870,5992,6017,6069,6109,6117,6195,6338,6354,6368,6376,6560,6600],"converts":[170,467,3680,5151],"higher":[174,471,3327,3738,3836,3865,3979,4649,6307,6437],"affinity":[175,472,2226,4572,4642,6308],"p53-binding":[176,473,1236,1768,1943,1952,2182,2995,3250,3961,5029,5149,6062,6620,6648],"results":[178,475,2382,3163,3346,3850,4033,5598,5838,5868,5989,6374],"rather":[182,479,1904,4014,6100],"than":[183,480,1905,3451,3744,3840,3866,3912,3982,4015,4294,4529,4650,4683,5860,5929,6101,6312,6440,6617],"repression.":[184,481,3729,4170,4384,5611,5932,6398],"Surprisingly,":[185,482],"strongly":[187,484,3439,6053],"sequence-":[198,268,495,565],"context-dependent.":[200,270,497,567],"Investigations":[201,498],"into":[202,499,4695,5800],"mechanisms":[204,501,1348,2316,2370,5217,5234],"indicate":[208,505,2383,4836,4926,5599],"trichostatin-insensitive":[212,509],"unaffected":[214,511,2429],"CBP":[216,513,4536,5661,5681],"mutation":[218,515,2436,5945],"minimal":[221,518,1633,2439,4005,5012,5102,5737,6104],"C-terminal":[223,520,2441,4096,5757,5950],"domain":[224,521,1635,2442,5739,5765],"p53.":[226,523,4358,5760],"However,":[227,524,2313,3443,4547,5174,5659,6096],"gel":[228,525,1617,6267],"shift":[229,526,1619,6268],"assays":[230,527,3041,3896,4390],"suggest":[231,528,4857,5000,5869,6068,6115],"competes":[234,531,4777,4860,6378],"with":[235,532,1418,1440,1574,1964,2224,2489,2523,2529,2828,2830,2850,3149,3302,3340,3399,3406,3531,3657,3678,3755,3771,4368,4391,4404,4503,4531,4702,4861,4881,4887,5120,5550,5589,5593,5925,6006,6046,6093,6276,6359,6379,6422,6615],"other":[236,533,4697,4816,5590,6380],"activators":[238,535,1448],"binding":[240,243,537,540,1442,1628,1764,1939,2855,3739,3855,4571,4599,4658,4722,4842,4866,4875,4967,5546,5554,5572,5588,5595,5889,6339,6388],"overlapping":[242,539,1893,4721,5594],"sequences":[244,541,2208,2925,2996,4936,6118],"conclusion,":[250,547],"study":[252,549,2342,4950,6015],"provides":[253,550],"rare":[255,552,6594],"factor":[260,557,650,2041,4712,4955,6608],"having":[261,558,4519],"divergent":[263,560,6647,6691],"functional":[264,561,2015,2181,6258,6619],"effects":[265,562,2319,3719,4177,5806],"are":[267,564,630,1352,1954,2349,2397,2705,2933,3524,3906,5222,5640,6287,6296,6327,6435,6444,6695],"The":[271,568,594,1234,1347,2175,2204,2381,2699,2710,2720,2839,2924,2974,3162,3361,3614,3685,3874,4612,4670,4757,4948,5216,5746,5761,5837,6142,6399],"interplay":[272,569,6534],"may":[277,574,2446,4355,5917,6394,6517,6684],"be":[278,575,3694,3758,3942,5627,5918,6089,6236,6413],"important":[279,576,1582,3464,6011,6247],"regulation":[282,579,633,999,2165,6404],"gene":[287,584,1607,2043,4908,4964,5940,6408,6563,6582,6591,6599,6671],"expression":[288,585,3048,4240,5662,6494,6522],"inflammatory":[292,589],"stress":[293,590,971],"during":[295,592,6417,6570,6583],"development.":[296,593],"tumor":[595],"suppressor":[596],"protein,":[597,1609,5901],"p53,":[598,2912,3430,3853,4439,4849,5769,5862,6192],"sequence-specific":[601,1231,4966,5115,5233,5931,5997,6610],"DNA-binding":[602,3201,4699],"protein":[603,993,1629,2601,4874,5703,5894],"(1Kern":[604],"S.E.":[605,1285,2944],"Kinzler":[606,684,1288,2947],"K.W.":[607,685,1289,1982,2948,5503],"Bruskin":[608],"A.":[609,712,730,795,1024,1076,1253,1515,1521,2058,5288,5294,5534,6631,6633],"Jarosz":[610],"D.":[611,681,847,1114,1144,1511,1816,5284,5438],"Friedman":[612],"P.":[613,722,724,859,1074,1080,1251,1257,1529,5302],"Prives":[614],"C.":[615,1399,1525,5298],"Vogelstein":[616,686,1290,2949,6711],"B.":[617,687,1291,1546,1692,1790,2950,5319,5369,6710],"Science.":[618,910],"1991;":[619],"252:":[620],"1708-1711Crossref":[621],"PubMed":[622,695,716,738,757,787,808,871,887,914,933,946,1009,1028,1064,1100,1128,1149,1173,1218,1277,1297,1333,1411,1483,1505,1534,1678,1706,1725,1749,1804,1828,1845,1871,1923,1994,2062,2149,2239,2263,2308,2625,2667,2817,2956,3032,3110,3227,3805,3826,4151,4217,4348,4492,5049,5073,5256,5278,5307,5355,5383,5402,5426,5450,5467,5493,5515,5538,5729,5976,6459,6480,6510],"Scopus":[623,696,717,739,758,788,809,872,888,915,934,947,1010,1029,1065,1101,1129,1150,1174,1219,1278,1298,1334,1412,1484,1506,1535,1679,1707,1726,1750,1805,1829,1846,1872,1924,1995,2063,2150,2240,2264,2309,2626,2668,2818,2957,3033,3111,3228,3806,3827,4152,4218,4349,4493,5050,5074,5257,5279,5308,5356,5384,5403,5427,5451,5468,5494,5516,5539,5730,5977,6460,6481,6511],"(941)":[624],"Google":[625,698,719,741,760,790,811,827,844,874,890,917,936,949,1012,1031,1067,1103,1131,1152,1176,1221,1280,1300,1336,1414,1486,1508,1537,1556,1681,1709,1728,1752,1807,1831,1848,1874,1926,1997,2065,2152,2242,2266,2311,2628,2670,2820,2959,3035,3113,3230,3808,3829,4154,4220,4351,4495,5052,5076,5259,5281,5310,5329,5358,5386,5405,5429,5453,5470,5496,5518,5541,5732,5979,6462,6483,6513,6640],"Scholar).":[626,950,1177,1222,1301,1337,1415,1557,1753,1875,1927,1998,2066,2153,2267,2312,2629,2671,2821,3114,3231,4155,4352,4496,5542,5980,6484,6514],"Classic":[627],"p53-target":[628],"genes":[629,962,1191,1205,1361,1651,1780,5639],"involved":[631,964,2162],"cell":[636,641,654,2575],"cycle":[637],"(e.g.":[638,658,1589,1652,5089,5558,5582,6383,6625,6697],"p21Waf-1/Cip-1,":[639],"proliferating":[640],"nuclear":[642,2799,2851,3772,3862,3880,4668,4698,4873,4890,6285,6432],"antigen,":[643],"Reprimo,":[644],"Gadd45,":[645],"14-3-3,":[646],"p22/PRG1,":[647],"epidermal":[648],"growth":[649,2040],"receptor)":[651],"programmed":[653],"death":[655],"apoptosis":[657],"Bax,":[659],"Fas,":[660],"p53AIP1,":[661],"Pidd,":[662],"Noxa,":[663],"Caspase-1,":[664],"Apaf-1,":[665],"PUMA,":[666],"KILLER/DR5)":[667],"(2el-Deiry":[668],"W.S.":[669,941,1283,2942],"Tokino":[670,904],"T.":[671,775,797,901,903,905,907],"Velculescu":[672],"V.E.":[673],"Levy":[674],"D.B.":[675,1544,5317],"Parsons":[676],"R.":[677,763,849,89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