{"id":"https://openalex.org/W2021576512","doi":"https://doi.org/10.1161/01.res.30.1.23","title":"Endothelial Nuclear Patterns in the Canine Arterial Tree with Particular Reference to Hemodynamic Events","display_name":"Endothelial Nuclear Patterns in the Canine Arterial Tree with Particular Reference to Hemodynamic Events","publication_year":1972,"publication_date":"1972-01-01","ids":{"openalex":"https://openalex.org/W2021576512","doi":"https://doi.org/10.1161/01.res.30.1.23","mag":"2021576512","pmid":"https://pubmed.ncbi.nlm.nih.gov/5007525"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.30.1.23","doi":"https://doi.org/10.1161/01.res.30.1.23","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.30.1.23","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052250085","display_name":"John T. Flaherty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN T. FLAHERTY","raw_affiliation_strings":["Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112152316","display_name":"Joseph E. Pierce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOSEPH E. PIERCE","raw_affiliation_strings":["Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110238153","display_name":"Victor J. Ferrans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"VICTOR J. FERRANS","raw_affiliation_strings":["Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111991279","display_name":"Dali J. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DALI J. PATEL","raw_affiliation_strings":["Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W. Kirk TUCKER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Kirk TUCKER","raw_affiliation_strings":["Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083817742","display_name":"Donald L. Fry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DONALD L. FRY","raw_affiliation_strings":["Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Experimental Atherosclerosis, the Section on Laboratory Animal Medicine and Surgery, and the Section on Pathology, Cardiology Branch, the National Heart and Lung Institute, National Institutes of Health Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5884,"has_fulltext":false,"cited_by_count":346,"citation_normalized_percentile":{"value":0.8087886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"30","issue":"1","first_page":"23","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-orientation","display_name":"nuclear orientation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/arterial-endothelium","display_name":"arterial endothelium","score":0.6850000023841858},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.7419999837875366},{"id":"https://openalex.org/keywords/thoracic-aorta","display_name":"thoracic aorta","score":0.8259999752044678},{"id":"https://openalex.org/keywords/arterial-branching","display_name":"arterial branching","score":0.36899998784065247},{"id":"https://openalex.org/keywords/nuclear-morphology","display_name":"nuclear morphology","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6801728010177612},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6226074695587158},{"id":"https://openalex.org/C2780663194","wikidata":"https://www.wikidata.org/wiki/Q3270170","display_name":"Descending aorta","level":3,"score":0.5984421372413635},{"id":"https://openalex.org/C2776864027","wikidata":"https://www.wikidata.org/wiki/Q615993","display_name":"Thoracic aorta","level":3,"score":0.5872364044189453},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.5448451638221741},{"id":"https://openalex.org/C2776619873","wikidata":"https://www.wikidata.org/wiki/Q3623006","display_name":"Arterial tree","level":2,"score":0.5350614190101624},{"id":"https://openalex.org/C2778249958","wikidata":"https://www.wikidata.org/wiki/Q2349469","display_name":"Ascending aorta","level":3,"score":0.5179892778396606},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5136072635650635},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4571118652820587},{"id":"https://openalex.org/C2988186910","wikidata":"https://www.wikidata.org/wiki/Q29588829","display_name":"Long axis","level":2,"score":0.45044130086898804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3472132682800293},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2979127764701843},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.11266404390335083},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1012611985206604},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.res.30.1.23","doi":"https://doi.org/10.1161/01.res.30.1.23","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.30.1.23","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:5007525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5007525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1986161881","https://openalex.org/W2035008153","https://openalex.org/W2049072541","https://openalex.org/W2088039453","https://openalex.org/W2155950748","https://openalex.org/W2564149533","https://openalex.org/W4238504247"],"related_works":["https://openalex.org/W1988250653","https://openalex.org/W3176829295","https://openalex.org/W294788940","https://openalex.org/W2001132215","https://openalex.org/W1982836978","https://openalex.org/W2027983756","https://openalex.org/W2021769718","https://openalex.org/W2095121591","https://openalex.org/W2077563228","https://openalex.org/W3139667726"],"abstract_inverted_index":{"The":[0,81,90,153],"objective":[1],"of":[2,16,19,47,55,107,136,143,148,171,181,208],"the":[3,10,20,56,77,128,134,137,141,149,187,196,201,206],"study":[4],"was":[5,60,84,151,199],"(1)":[6,116],"to":[7,30,66,133,145,160,173],"measure":[8],"systematically":[9],"orientation,":[11],"morphology,":[12],"and":[13,24,28,64,123,140,185],"population":[14],"density":[15],"endothelial":[17],"nuclei":[18,129],"canine":[21],"thoracic":[22,58,126],"aorta":[23,59],"its":[25],"major":[26,144,172,183],"branches":[27],"(2)":[29,163],"obtain":[31],"evidence":[32],"in":[33,36,88,155,178,186,194,205],"a":[34,53,68,71],"chronic":[35,192],"vivo":[37],"preparation":[38],"that":[39],"altered":[40],"flow":[41,154,197,209],"patterns":[42,46,100],"do":[43],"indeed":[44],"change":[45],"nuclear":[48,99,166,202],"orientation.":[49],"For":[50],"this":[51],"purpose,":[52],"segment":[54,83],"descending":[57,125],"removed,":[61],"opened":[62],"longitudinally,":[63],"reclosed":[65],"form":[67],"tube":[69],"with":[70,110,168],"new":[72,82],"longitudinal":[73],"axis":[74,135],"90\u00b0":[75],"from":[76,103],"original":[78],"vessel":[79,119],"axis.":[80],"then":[85],"sutured":[86],"back":[87],"place.":[89],"animals":[91],"were":[92,101,130,176],"killed":[93],"at":[94],"suitable":[95],"postoperative":[96],"periods.":[97],"Endothelial":[98],"studied":[102],"en":[104],"face":[105],"photomicrographs":[106],"preparations":[108],"stained":[109],"Evans":[111],"blue":[112],"dye.":[113],"Results":[114],"indicated:":[115],"In":[117,191],"uniform":[118],"segments,":[120],"e.g.,":[121],"middle":[122],"lower":[124],"aorta,":[127],"oriented":[131],"parallel":[132],"blood":[138],"vessel,":[139],"ratio":[142],"minor":[146,174],"axes":[147,175],"nucleus":[150],"large.":[152],"these":[156],"regions":[157,180],"is":[158],"known":[159],"be":[161],"stable.":[162],"Nonaxial,":[164],"less-ordered":[165],"orientation":[167],"smaller":[169],"ratios":[170],"found":[177],"entrance":[179],"many":[182],"arteries":[184],"ascending":[188],"aorta.":[189],"(3)":[190],"studies":[193],"which":[195],"pattern":[198,203],"altered,":[200],"realigned":[204],"direction":[207],"within":[210],"10":[211],"days":[212],"after":[213],"surgery.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}