{"id":"https://openalex.org/W2021458699","doi":"https://doi.org/10.1016/j.radonc.2009.12.019","title":"A comparison of dose\u2013volume constraints derived using peak and longitudinal definitions of late rectal toxicity","display_name":"A comparison of dose\u2013volume constraints derived using peak and longitudinal definitions of late rectal toxicity","publication_year":2010,"publication_date":"2010-01-25","ids":{"openalex":"https://openalex.org/W2021458699","doi":"https://doi.org/10.1016/j.radonc.2009.12.019","mag":"2021458699","pmid":"https://pubmed.ncbi.nlm.nih.gov/20096945"},"language":"en","primary_location":{"id":"doi:10.1016/j.radonc.2009.12.019","doi":"https://doi.org/10.1016/j.radonc.2009.12.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.radonc.2009.12.019","pdf_url":null,"source":{"id":"https://openalex.org/S144507673","display_name":"Radiotherapy and Oncology","issn_l":"0167-8140","issn":["0167-8140","1879-0887"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiotherapy and Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045062892","display_name":"S. Gulliford","orcid":"https://orcid.org/0000-0002-1768-2904","observed_orcids":["https://orcid.org/0000-0002-1768-2904"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sarah L. Gulliford","raw_affiliation_strings":["Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK. sarahg@icr.ac.uk","Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK. sarahg@icr.ac.uk","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]},{"raw_affiliation_string":"Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016263500","display_name":"Mike Partridge","orcid":"https://orcid.org/0000-0002-8876-8190","observed_orcids":["https://orcid.org/0000-0002-8876-8190"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mike Partridge","raw_affiliation_strings":["Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059261043","display_name":"Matthew Robert Sydes","orcid":"https://orcid.org/0000-0002-9323-1371","observed_orcids":["https://orcid.org/0000-0002-9323-1371"]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew R. Sydes","raw_affiliation_strings":["Cancer Group, Medical Research Council Clinical Trials Unit, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Group, Medical Research Council Clinical Trials Unit, London, UK","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029255628","display_name":"Jervoise N. Andreyev","orcid":"https://orcid.org/0000-0002-7165-6352","observed_orcids":["https://orcid.org/0000-0002-7165-6352"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jervoise Andreyev","raw_affiliation_strings":["Department of Medicine, Royal Marsden NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Royal Marsden NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025921361","display_name":"David Paul Dearnaley","orcid":"https://orcid.org/0000-0002-3954-2806","observed_orcids":["https://orcid.org/0000-0002-3954-2806"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David P. Dearnaley","raw_affiliation_strings":["Academic Urology Unit, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Urology Unit, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045062892"],"corresponding_institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"],"apc_list":{"value":3770,"currency":"USD","value_usd":3770},"apc_paid":null,"fwci":4.2893,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.93630077,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"94","issue":"2","first_page":"241","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dose-volume-constraints","display_name":"dose-volume constraints","score":0.8759999871253967},{"id":"https://openalex.org/keywords/late-rectal-toxicity","display_name":"late rectal toxicity","score":0.984000027179718},{"id":"https://openalex.org/keywords/prostate-cancer-radiotherapy","display_name":"prostate cancer radiotherapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/stool-frequency","display_name":"stool frequency","score":0.7120000123977661},{"id":"https://openalex.org/keywords/late-radiation-effects","display_name":"late radiation effects","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.9055580496788025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5842134952545166},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5148531794548035},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5050521492958069},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.4251210689544678},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4074777662754059},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.36511796712875366},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3178575038909912},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25626540184020996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24502679705619812},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08711394667625427},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023381","descriptor_name":"Endpoint Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.radonc.2009.12.019","doi":"https://doi.org/10.1016/j.radonc.2009.12.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.radonc.2009.12.019","pdf_url":null,"source":{"id":"https://openalex.org/S144507673","display_name":"Radiotherapy and Oncology","issn_l":"0167-8140","issn":["0167-8140","1879-0887"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiotherapy and Oncology","raw_type":"journal-article"},{"id":"pmid:20096945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20096945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology","raw_type":"Comparative Study"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1304926","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1304926/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"RADIOTHER ONCOL , 94 (2) 241 - 247. (2010)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2843189317","display_name":null,"funder_award_id":"C46/A2131.","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W34534769","https://openalex.org/W1964942666","https://openalex.org/W1968626722","https://openalex.org/W1969110490","https://openalex.org/W1971199850","https://openalex.org/W1978906140","https://openalex.org/W1979914233","https://openalex.org/W1980789427","https://openalex.org/W1992823803","https://openalex.org/W2008203815","https://openalex.org/W2016899305","https://openalex.org/W2017298571","https://openalex.org/W2020967568","https://openalex.org/W2031434408","https://openalex.org/W2031657014","https://openalex.org/W2043945205","https://openalex.org/W2056643793","https://openalex.org/W2061444197","https://openalex.org/W2065158281","https://openalex.org/W2068796302","https://openalex.org/W2071238711","https://openalex.org/W2074386077","https://openalex.org/W2076280910","https://openalex.org/W2129584252","https://openalex.org/W2136257552","https://openalex.org/W2146021001","https://openalex.org/W2152182740","https://openalex.org/W2156579478","https://openalex.org/W2160504756","https://openalex.org/W4253473049"],"related_works":["https://openalex.org/W2146021001","https://openalex.org/W2109001489","https://openalex.org/W2073291129","https://openalex.org/W1977382534","https://openalex.org/W2337023045","https://openalex.org/W1481912170","https://openalex.org/W1971199850","https://openalex.org/W2596588799","https://openalex.org/W2076280910","https://openalex.org/W2040204466"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
