{"id":"https://openalex.org/W2021407435","doi":"https://doi.org/10.1074/jbc.r800083200","title":"ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases","display_name":"ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases","publication_year":2009,"publication_date":"2009-04-29","ids":{"openalex":"https://openalex.org/W2021407435","doi":"https://doi.org/10.1074/jbc.r800083200","mag":"2021407435","pmid":"https://pubmed.ncbi.nlm.nih.gov/19401469","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2742807"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.r800083200","doi":"https://doi.org/10.1074/jbc.r800083200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r800083200","pdf_url":"http://www.jbc.org/article/S0021925817483657/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925817483657/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088195948","display_name":"Thomas R. Kleyman","orcid":"https://orcid.org/0000-0002-2413-5415","observed_orcids":["https://orcid.org/0000-0002-2413-5415"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Kleyman","raw_affiliation_strings":["Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA","Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053328495","display_name":"Marcelo D. Carattino","orcid":"https://orcid.org/0000-0003-1901-1618","observed_orcids":["https://orcid.org/0000-0003-1901-1618"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marcelo D. Carattino","raw_affiliation_strings":["Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077733949","display_name":"Rebecca P. Hughey","orcid":"https://orcid.org/0000-0002-8388-3720","observed_orcids":["https://orcid.org/0000-0002-8388-3720"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca P. Hughey","raw_affiliation_strings":["Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261","Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053328495"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.3272,"has_fulltext":true,"cited_by_count":292,"citation_normalized_percentile":{"value":0.91814159,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"284","issue":"31","first_page":"20447","last_page":"20451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enac","display_name":"epithelial sodium channel","score":0.9919999837875366},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.746999979019165},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.9670000076293945},{"id":"https://openalex.org/keywords/channel-activation","display_name":"channel activation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/open-probability","display_name":"open probability","score":0.6589999794960022},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.7710000276565552},{"id":"https://openalex.org/keywords/sodium-transport","display_name":"sodium transport","score":0.652999997138977},{"id":"https://openalex.org/keywords/epithelium","display_name":"epithelium","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.888997495174408},{"id":"https://openalex.org/C6507245","wikidata":"https://www.wikidata.org/wiki/Q424948","display_name":"Epithelial sodium channel","level":3,"score":0.8571308851242065},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.598936140537262},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5956397652626038},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5869407057762146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.553696870803833},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5323125720024109},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4149395823478699},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3540838062763214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32476139068603516},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.15434563159942627},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15319982171058655},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05622506141662598},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053503","descriptor_name":"Epithelial Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053503","descriptor_name":"Epithelial Sodium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.r800083200","doi":"https://doi.org/10.1074/jbc.r800083200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r800083200","pdf_url":"http://www.jbc.org/article/S0021925817483657/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2002462","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2742807","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:19401469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19401469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2742807","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2742807/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.r800083200","doi":"https://doi.org/10.1074/jbc.r800083200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r800083200","pdf_url":"http://www.jbc.org/article/S0021925817483657/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6817805763","display_name":"Sodium Channel Biogenesis","funder_award_id":"R56DK065161","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000257744","display_name":null,"funder_award_id":"DK065161","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306605","display_name":"American Society of Nephrology","ror":"https://ror.org/014pcm848"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2021407435.pdf","grobid_xml":"https://content.openalex.org/works/W2021407435.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W160369686","https://openalex.org/W1486524131","https://openalex.org/W1505008375","https://openalex.org/W1820962178","https://openalex.org/W1964217202","https://openalex.org/W1969898475","https://openalex.org/W1972543530","https://openalex.org/W1974043792","https://openalex.org/W1976728586","https://openalex.org/W1985372182","https://openalex.org/W1999535387","https://openalex.org/W2002563649","https://openalex.org/W2004049927","https://openalex.org/W2006363853","https://openalex.org/W2013711061","https://openalex.org/W2018202678","https://openalex.org/W2018978933","https://openalex.org/W2020056111","https://openalex.org/W2022941489","https://openalex.org/W2034728504","https://openalex.org/W2039558969","https://openalex.org/W2043134189","https://openalex.org/W2043191266","https://openalex.org/W2043728729","https://openalex.org/W2058058212","https://openalex.org/W2062889240","https://openalex.org/W2070196411","https://openalex.org/W2071112171","https://openalex.org/W2077330224","https://openalex.org/W2078043014","https://openalex.org/W2079851211","https://openalex.org/W2083326116","https://openalex.org/W2096878801","https://openalex.org/W2100532971","https://openalex.org/W2109328478","https://openalex.org/W2111397256","https://openalex.org/W2118823673","https://openalex.org/W2138550890","https://openalex.org/W2140830639","https://openalex.org/W2148474634","https://openalex.org/W2149949073","https://openalex.org/W2151510057","https://openalex.org/W2151770768","https://openalex.org/W2155720515","https://openalex.org/W2157369948","https://openalex.org/W2171279232","https://openalex.org/W2410344667"],"related_works":["https://openalex.org/W2039558969","https://openalex.org/W1999535387","https://openalex.org/W2000358364","https://openalex.org/W2018978933","https://openalex.org/W4389918343","https://openalex.org/W2050551137","https://openalex.org/W2099136268","https://openalex.org/W1486524131","https://openalex.org/W2155720515","https://openalex.org/W2156926612"],"abstract_inverted_index":{"Epithelial":[0],"Na+":[1,7,38],"channels":[2,24,39],"facilitate":[3],"the":[4,20,54,63],"transport":[5],"of":[6,22,65,73],"across":[8],"high":[9],"resistance":[10],"epithelia.":[11],"Proteolytic":[12],"cleavage":[13],"has":[14,68],"an":[15],"important":[16],"role":[17],"in":[18],"regulating":[19],"activity":[21],"these":[23],"by":[25,40,56],"increasing":[26],"their":[27,48],"open":[28],"probability.":[29],"Specific":[30],"proteases":[31,58],"have":[32],"been":[33],"shown":[34],"to":[35],"activate":[36,59],"epithelial":[37],"cleaving":[41],"channel":[42,61,74],"subunits":[43],"at":[44],"defined":[45],"sites":[46],"within":[47],"extracellular":[49],"domains.":[50],"This":[51],"minireview":[52],"addresses":[53],"mechanisms":[55],"which":[57],"this":[60],"and":[62],"question":[64],"why":[66],"proteolysis":[67],"evolved":[69],"as":[70],"a":[71],"mechanism":[72],"activation.":[75]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":37}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}