{"id":"https://openalex.org/W2021390563","doi":"https://doi.org/10.1212/wnl.52.5.991","title":"MRI evidence of past cerebral microbleeds in a healthy elderly population","display_name":"MRI evidence of past cerebral microbleeds in a healthy elderly population","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2021390563","doi":"https://doi.org/10.1212/wnl.52.5.991","mag":"2021390563","pmid":"https://pubmed.ncbi.nlm.nih.gov/10102418"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.52.5.991","doi":"https://doi.org/10.1212/wnl.52.5.991","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.52.5.991","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2021390563"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057782010","display_name":"Gudrun Roob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G. Roob","raw_affiliation_strings":["From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112264364","display_name":"Reinhold Schmidt","orcid":"https://orcid.org/0000-0002-6406-7584","observed_orcids":["https://orcid.org/0000-0002-6406-7584"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"R. Schmidt","raw_affiliation_strings":["From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047626152","display_name":"Peter Kapeller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"P. Kapeller","raw_affiliation_strings":["From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089944333","display_name":"Anita Lechner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Lechner","raw_affiliation_strings":["From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063615479","display_name":"Hans\u2010Peter Hartung","orcid":"https://orcid.org/0000-0002-0614-6989","observed_orcids":["https://orcid.org/0000-0002-0614-6989"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"H.-P. Hartung","raw_affiliation_strings":["From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057796353","display_name":"Franz Fazekas","orcid":"https://orcid.org/0000-0001-8155-7799","observed_orcids":["https://orcid.org/0000-0001-8155-7799"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"F. Fazekas","raw_affiliation_strings":["From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (Drs. RoobSchmidt, Kapeller, Lechner, Hartung, and Fazekas) and the MR Institute (Drs. Schmidt, Kapeller, and Fazekas), Karl-Franzens University, Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I15766117"],"apc_list":null,"apc_paid":null,"fwci":8.1022,"has_fulltext":false,"cited_by_count":368,"citation_normalized_percentile":{"value":0.98097356,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"52","issue":"5","first_page":"991","last_page":"991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-microbleeds","display_name":"cerebral microbleeds","score":0.9940000176429749},{"id":"https://openalex.org/keywords/asymptomatic-elderly","display_name":"asymptomatic elderly","score":0.5799999833106995},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7929999828338623},{"id":"https://openalex.org/keywords/lacunes","display_name":"lacunes","score":0.8539999723434448},{"id":"https://openalex.org/keywords/white-matter-injury","display_name":"white matter injury","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cerebral-small-vessel-disease","display_name":"cerebral small vessel disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/intracerebral-hemorrhage-risk","display_name":"intracerebral hemorrhage risk","score":0.9049999713897705},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6669072508811951},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4947063624858856},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4379897117614746},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.39755645394325256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32949161529541016},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.22639793157577515},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.06908202171325684}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002543","descriptor_name":"Cerebral Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.52.5.991","doi":"https://doi.org/10.1212/wnl.52.5.991","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.52.5.991","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:10102418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10102418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1522694313","https://openalex.org/W1865808209","https://openalex.org/W1975879668","https://openalex.org/W1981892624","https://openalex.org/W2002097520","https://openalex.org/W2025313184","https://openalex.org/W2035293676","https://openalex.org/W2036100058","https://openalex.org/W2047316865","https://openalex.org/W2053265279","https://openalex.org/W2061549913","https://openalex.org/W2062763327","https://openalex.org/W2077375901","https://openalex.org/W2081106827","https://openalex.org/W2082496690","https://openalex.org/W2104080769","https://openalex.org/W2140769219","https://openalex.org/W2143060791","https://openalex.org/W2143253844","https://openalex.org/W2171402594"],"related_works":["https://openalex.org/W3193479306","https://openalex.org/W2381888886","https://openalex.org/W2039017413","https://openalex.org/W2338948950","https://openalex.org/W2113770731","https://openalex.org/W7098386125","https://openalex.org/W974460425","https://openalex.org/W2159823093","https://openalex.org/W2509968570","https://openalex.org/W2165209297"],"abstract_inverted_index":{"BACKGROUND:":[0],"Incidental":[1],"foci":[2,116],"of":[3,7,18,68,77,88,97,105,117,170,185,206,213,219],"signal":[4,118],"loss":[5,119],"suggestive":[6],"past":[8,186],"microbleeds":[9,110,174,187],"are":[10],"a":[11,74],"frequent":[12],"finding":[13,215],"on":[14],"gradient-echo":[15],"T2-weighted":[16,66],"MRI":[17,67,183],"patients":[19],"with":[20,28,130,157,173],"nontraumatic":[21],"intracerebral":[22,220],"hemorrhage":[23],"and":[24,32,56,62,134,139,164,197],"have":[25],"been":[26],"associated":[27,129],"bleeding-prone":[29],"microangiopathy.":[30],"If":[31],"to":[33,59,86,114,176,203],"what":[34],"extent":[35],"such":[36],"lesions":[37],"may":[38,188],"also":[39],"occur":[40],"in":[41,52,73,122,154,160,167,192],"the":[42,69,89,161,217],"normal":[43,194],"population":[44],"is":[45,198],"unclear.":[46],"OBJECTIVE:":[47],"To":[48],"determine":[49],"focal":[50,158],"hypointensities":[51,159],"asymptomatic":[53],"elderly":[54,195],"individuals":[55,100,156,196],"their":[57],"relation":[58],"other":[60,204],"clinical":[61],"morphologic":[63],"variables.":[64],"METHODS:":[65],"brain":[70],"was":[71,144,152],"performed":[72],"consecutive":[75],"series":[76],"280":[78],"participants":[79],"(mean":[80],"age":[81],"60":[82],"years,":[83],"range":[84],"44":[85],"79)":[87],"Austrian":[90],"Stroke":[91],"Prevention":[92],"Study.":[93],"This":[94],"cohort":[95],"consisted":[96],"randomly":[98],"selected":[99],"without":[101],"history":[102],"or":[103],"signs":[104],"neuropsychiatric":[106],"disorder.":[107],"RESULTS:":[108],"Past":[109],"ranging":[111],"from":[112],"one":[113],"five":[115],"were":[120,127],"seen":[121],"18":[123],"(6.4%)":[124],"individuals.":[125],"They":[126],"strongly":[128],"higher":[131],"age,":[132],"hypertension,":[133],"lacunes":[135],"(p":[136,148,179],"<":[137],"0.001),":[138],"extensive":[140],"white":[141],"matter":[142],"damage":[143],"more":[145],"frequently":[146],"noted":[147],"=":[149,180],"0.02).":[150],"Hypertension":[151],"present":[153],"all":[155],"basal":[162],"ganglia":[163],"infratentorially":[165],"but":[166,200],"only":[168],"5":[169],"10":[171],"volunteers":[172],"limited":[175],"cortico-subcortical":[177],"sites":[178],"0.04).":[181],"CONCLUSIONS:":[182],"evidence":[184],"be":[189],"found":[190],"even":[191],"neurologically":[193],"related,":[199],"not":[201],"restricted,":[202],"indicators":[205],"small":[207],"vessel":[208],"disease.":[209],"The":[210],"predictive":[211],"potential":[212],"this":[214],"regarding":[216],"risk":[218],"bleeding":[221],"requires":[222],"further":[223],"investigation.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}