{"id":"https://openalex.org/W2021380609","doi":"https://doi.org/10.1186/1476-9255-9-46","title":"Inflammatory events during murine squamous cell carcinoma development","display_name":"Inflammatory events during murine squamous cell carcinoma development","publication_year":2012,"publication_date":"2012-11-23","ids":{"openalex":"https://openalex.org/W2021380609","doi":"https://doi.org/10.1186/1476-9255-9-46","mag":"2021380609","pmid":"https://pubmed.ncbi.nlm.nih.gov/23176085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3542019"},"language":"en","primary_location":{"id":"doi:10.1186/1476-9255-9-46","doi":"https://doi.org/10.1186/1476-9255-9-46","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-9255-9-46","pdf_url":"https://journal-inflammation.biomedcentral.com/counter/pdf/10.1186/1476-9255-9-46","source":{"id":"https://openalex.org/S24701539","display_name":"Journal of Inflammation","issn_l":"1476-9255","issn":["1476-9255"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journal-inflammation.biomedcentral.com/counter/pdf/10.1186/1476-9255-9-46","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010687293","display_name":"Tha\u00eds Helena Gasparoto","orcid":"https://orcid.org/0000-0001-6362-1582","observed_orcids":["https://orcid.org/0000-0001-6362-1582"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thais Helena Gasparoto","raw_affiliation_strings":["Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil. apcampan@usp.br","Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil. apcampan@usp.br","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065585479","display_name":"Carine Ervolino de Oliveira","orcid":"https://orcid.org/0000-0003-3103-090X","observed_orcids":["https://orcid.org/0000-0003-3103-090X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carine Ervolino de Oliveira","raw_affiliation_strings":["Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","Department of Stomatology - Oral Pathology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Stomatology - Oral Pathology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077681616","display_name":"Luisa Thomazini de Freitas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luisa Thomazini de Freitas","raw_affiliation_strings":["Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112363550","display_name":"Cl\u00e1udia Ramos Pinheiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Claudia Ramos Pinheiro","raw_affiliation_strings":["Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036082785","display_name":"Rodrigo Nalio Ramos","orcid":"https://orcid.org/0000-0003-1249-4733","observed_orcids":["https://orcid.org/0000-0003-1249-4733"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo Nalio Ramos","raw_affiliation_strings":["Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004204828","display_name":"Andr\u00e9 Luis Porto da Silva","orcid":"https://orcid.org/0000-0002-5142-6939","observed_orcids":["https://orcid.org/0000-0002-5142-6939"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Luis da Silva","raw_affiliation_strings":["Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020867458","display_name":"Gustavo Pompermaier Garlet","orcid":"https://orcid.org/0000-0002-5071-8382","observed_orcids":["https://orcid.org/0000-0002-5071-8382"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gustavo Pompermaier Garlet","raw_affiliation_strings":["Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439245","display_name":"Jo\u00e3o S. Silva","orcid":"https://orcid.org/0000-0002-3410-3927","observed_orcids":["https://orcid.org/0000-0002-3410-3927"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Santana da Silva","raw_affiliation_strings":["Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Biochemistry and Immunology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036274542","display_name":"Ana Paula Campanelli","orcid":"https://orcid.org/0000-0002-0536-5469","observed_orcids":["https://orcid.org/0000-0002-0536-5469"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Ana Paula Campanelli","raw_affiliation_strings":["Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Biological Sciences - Microbiology and Immunology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036274542"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.7796,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.68031593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"46","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.640999972820282},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.7440000176429749},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.6539999842643738},{"id":"https://openalex.org/keywords/tumour-associated-macrophages","display_name":"tumour-associated macrophages","score":0.9419999718666077},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/elastase","display_name":"elastase","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8109999895095825},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8830000162124634},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6959999799728394},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9520000219345093},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9399999976158142},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dmba-induced-carcinogenesis","display_name":"DMBA-induced carcinogenesis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gr-1","display_name":"Gr-1","score":0.5669999718666077},{"id":"https://openalex.org/keywords/f4-80","display_name":"F4/80","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.750003457069397},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.6417348384857178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4129691421985626},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4116992950439453},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3260710835456848},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32137972116470337}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1186/1476-9255-9-46","doi":"https://doi.org/10.1186/1476-9255-9-46","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-9255-9-46","pdf_url":"https://journal-inflammation.biomedcentral.com/counter/pdf/10.1186/1476-9255-9-46","source":{"id":"https://openalex.org/S24701539","display_name":"Journal of Inflammation","issn_l":"1476-9255","issn":["1476-9255"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3542019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3542019","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Inflamm (Lond)","raw_type":"Text"},{"id":"pmid:23176085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23176085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of inflammation (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/34777","doi":null,"is_oa":true,"landing_page_url":"http://www.producao.usp.br/handle/BDPI/34777","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP","raw_type":"publishedVersion"},{"id":"pmh:oai:www.producao.usp.br:BDPI/47076","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1186/1476-9255-9-46","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP","raw_type":"publishedVersion"},{"id":"pmh:oai:www.producao.usp.br:BDPI/47843","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1186/1476-9255-9-46","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP","raw_type":"publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.411.8170","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.411.8170","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/49/66/1476-9255-9-46.PMC3542019.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:84c966ace93e4761b42d4668356c3b3d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/84c966ace93e4761b42d4668356c3b3d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Inflammation, Vol 9, Iss 1, p 46 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1476-9255-9-46","doi":"https://doi.org/10.1186/1476-9255-9-46","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-9255-9-46","pdf_url":"https://journal-inflammation.biomedcentral.com/counter/pdf/10.1186/1476-9255-9-46","source":{"id":"https://openalex.org/S24701539","display_name":"Journal of Inflammation","issn_l":"1476-9255","issn":["1476-9255"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4264184289","display_name":"The role of inflammasomes in chemically induced tumor","funder_award_id":"11/03195-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2021380609.pdf","grobid_xml":"https://content.openalex.org/works/W2021380609.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W189711494","https://openalex.org/W1521885247","https://openalex.org/W1536009735","https://openalex.org/W1568485804","https://openalex.org/W1582074887","https://openalex.org/W1592043559","https://openalex.org/W1597643123","https://openalex.org/W1652153701","https://openalex.org/W1690102379","https://openalex.org/W1889896208","https://openalex.org/W1913007537","https://openalex.org/W1959256317","https://openalex.org/W1971985122","https://openalex.org/W1972234366","https://openalex.org/W1984921826","https://openalex.org/W1988924112","https://openalex.org/W2000102677","https://openalex.org/W2000479440","https://openalex.org/W2002147029","https://openalex.org/W2006353845","https://openalex.org/W2010435531","https://openalex.org/W2018255335","https://openalex.org/W2019969899","https://openalex.org/W2020830322","https://openalex.org/W2025141680","https://openalex.org/W2025193872","https://openalex.org/W2031291993","https://openalex.org/W2032368145","https://openalex.org/W2049527513","https://openalex.org/W2059125139","https://openalex.org/W2059149560","https://openalex.org/W2061958868","https://openalex.org/W2063259891","https://openalex.org/W2066004242","https://openalex.org/W2069718808","https://openalex.org/W2071867803","https://openalex.org/W2076881902","https://openalex.org/W2077224253","https://openalex.org/W2091637866","https://openalex.org/W2093683863","https://openalex.org/W2093915452","https://openalex.org/W2095677734","https://openalex.org/W2106787323","https://openalex.org/W2107989579","https://openalex.org/W2110567472","https://openalex.org/W2111014913","https://openalex.org/W2112212243","https://openalex.org/W2116378201","https://openalex.org/W2118278569","https://openalex.org/W2119896120","https://openalex.org/W2122368175","https://openalex.org/W2124913747","https://openalex.org/W2125063590","https://openalex.org/W2126994971","https://openalex.org/W2128100003","https://openalex.org/W2133439754","https://openalex.org/W2133547601","https://openalex.org/W2137522692","https://openalex.org/W2139240734","https://openalex.org/W2139391701","https://openalex.org/W2139754661","https://openalex.org/W2141089839","https://openalex.org/W2142484934","https://openalex.org/W2145108148","https://openalex.org/W2149979963","https://openalex.org/W2154400632","https://openalex.org/W2157797076","https://openalex.org/W2162069632","https://openalex.org/W2164613158","https://openalex.org/W2172097071","https://openalex.org/W2315613727","https://openalex.org/W2402326353","https://openalex.org/W2411706012","https://openalex.org/W2415316576","https://openalex.org/W2419429403","https://openalex.org/W2439374163"],"related_works":["https://openalex.org/W7100988868","https://openalex.org/W2333038909","https://openalex.org/W1996605608","https://openalex.org/W3042024410","https://openalex.org/W2011137048","https://openalex.org/W2989615649","https://openalex.org/W2606678887","https://openalex.org/W3097457749","https://openalex.org/W4416320090","https://openalex.org/W2058173364"],"abstract_inverted_index":{"BACKGROUND:":[0],"Squamous":[1],"cell":[2],"carcinoma":[3],"(SCC)":[4],"is":[5,18],"one":[6],"of":[7,39,70,76,141,146,159,178,198,220,250],"the":[8,74,115,135,164,176,228,242],"most":[9],"common":[10],"human":[11],"cancers":[12],"worldwide.":[13],"In":[14],"SCC,":[15],"tumour":[16,28,97],"development":[17],"accompanied":[19],"by":[20,30,257],"an":[21,207,248],"immune":[22],"response":[23],"that":[24,53],"leads":[25],"to":[26,72],"massive":[27],"infiltration":[29],"inflammatory":[31,57,251],"cells,":[32],"and":[33,36,42,49,90,92,94,100,103,109,120,123,129,143,181,189,194,205,224,227,238,259,261],"consequently,":[34],"local":[35,265],"systemic":[37],"production":[38],"cytokines,":[40],"chemokines":[41],"other":[43],"mediators.":[44],"Studies":[45],"in":[46,55,96,114,134,163,175,185,241,253,263],"both":[47,203],"humans":[48],"animal":[50],"models":[51],"indicate":[52,247],"imbalances":[54],"these":[56],"mediators":[58,252],"are":[59],"associated":[60],"with":[61,168,236],"cancer":[62],"development.":[63,98],"METHODS:":[64],"We":[65,171,213],"used":[66],"a":[67,195,215],"multistage":[68],"model":[69],"SCC":[71,255],"examine":[73],"involvement":[75],"elastase":[77],"(ELA),":[78],"myeloperoxidase":[79],"(MPO),":[80],"nitric":[81],"oxide":[82],"(NO),":[83],"cytokines":[84],"(IL-6,":[85],"IL-10,":[86,105,125,221],"IL-13,":[87],"IL-17,":[88,222],"TGF-\u03b2":[89,110,130],"TNF-\u03b1),":[91],"neutrophils":[93,180,258],"macrophages":[95,200,260],"ELA":[99,119],"MPO":[101,121,237],"activity":[102,122],"NO,":[104,124],"IL":[106,126],"-17,":[107,127],"TNF-\u03b1":[108,128],"levels":[111,131,140,145,158,219,240],"were":[112,132,148,161],"increased":[113,133],"precancerous":[116,136,165,254],"microenvironment.":[117,137],"RESULTS:":[118],"Significantly":[138],"higher":[139,196],"IL-6":[142],"lower":[144],"IL-10":[147],"detected":[149,162],"at":[150,187,210],"4":[151,188],"weeks":[152,191],"following":[153,192],"7,12-Dimethylbenz(a)anthracene":[154],"(DMBA)":[155],"treatment.":[156],"Similar":[157],"IL-13":[160],"microenvironment":[166],"compared":[167],"control":[169],"tissue.":[170],"identified":[172],"significant":[173,216],"increases":[174],"number":[177],"GR-1+":[179],"F4/80+/GR-1-":[182],"infiltrating":[183],"cells":[184],"tissues":[186],"8":[190],"treatment":[193],"percentage":[197],"tumour-associated":[199],"(TAM)":[201],"expressing":[202],"GR-1":[204],"F4/80,":[206],"activated":[208,225],"phenotype,":[209],"16":[211],"weeks.":[212],"found":[214],"correlation":[217],"between":[218],"ELA,":[223],"TAMs":[226],"lesions.":[229,243],"Additionally,":[230],"neutrophil":[231],"infiltrate":[232],"was":[233],"positively":[234],"correlated":[235],"NO":[239],"CONCLUSION:":[244],"Our":[245],"results":[246],"imbalance":[249],"caused":[256],"culminating":[262],"pro-tumour":[264],"tissue":[266],"alterations.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}