{"id":"https://openalex.org/W2021367388","doi":"https://doi.org/10.1021/jm010191w","title":"Methylene\u2212gem-Difluorocyclopropane Analogues of Nucleosides: Synthesis, Cyclopropene\u2212Methylenecyclopropane Rearrangement, and Biological Activity","display_name":"Methylene\u2212gem-Difluorocyclopropane Analogues of Nucleosides: Synthesis, Cyclopropene\u2212Methylenecyclopropane Rearrangement, and Biological Activity","publication_year":2001,"publication_date":"2001-10-10","ids":{"openalex":"https://openalex.org/W2021367388","doi":"https://doi.org/10.1021/jm010191w","mag":"2021367388","pmid":"https://pubmed.ncbi.nlm.nih.gov/11689090"},"language":"en","primary_location":{"id":"doi:10.1021/jm010191w","doi":"https://doi.org/10.1021/jm010191w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm010191w","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100769142","display_name":"Ruifang Wang","orcid":"https://orcid.org/0000-0002-3849-9914","observed_orcids":["https://orcid.org/0000-0002-3849-9914"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruifang Wang","raw_affiliation_strings":["Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27837315","https://openalex.org/I32389192","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007051212","display_name":"Mohamad B. Ksebati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamad B. Ksebati","raw_affiliation_strings":["Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27837315","https://openalex.org/I32389192","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113456083","display_name":"Thomas H. Corbett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas H. Corbett","raw_affiliation_strings":["Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27837315","https://openalex.org/I32389192","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109070397","display_name":"Earl R. Kern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Earl R. Kern","raw_affiliation_strings":["Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27837315","https://openalex.org/I32389192","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110073621","display_name":"John C. Drach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Drach","raw_affiliation_strings":["Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27837315","https://openalex.org/I32389192","https://openalex.org/I4210090317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006348104","display_name":"Ji\u0159\u00ed \u017demli\u010dka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiri Zemlicka","raw_affiliation_strings":["Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, Michigan 48201-1379, Central Instrumentation Facility, Department of Chemistry, Wayne State University, Detroit, Michigan 48202, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Biological and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48019-1078","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27837315","https://openalex.org/I32389192","https://openalex.org/I4210090317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006348104"],"corresponding_institution_ids":["https://openalex.org/I185443292","https://openalex.org/I27837315","https://openalex.org/I32389192","https://openalex.org/I4210090317"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.5153,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.58478998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"44","issue":"23","first_page":"4019","last_page":"4022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11611","display_name":"Cyclopropane Reaction Mechanisms","score":0.17910000681877136,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gem-difluorocyclopropanes","display_name":"gem-difluorocyclopropanes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.8569999933242798},{"id":"https://openalex.org/keywords/adenine-derivatives","display_name":"adenine derivatives","score":0.7080000042915344},{"id":"https://openalex.org/keywords/2-amino-6-chloropurine","display_name":"2-amino-6-chloropurine","score":0.972000002861023},{"id":"https://openalex.org/keywords/guanine-analogues","display_name":"guanine analogues","score":0.8479999899864197},{"id":"https://openalex.org/keywords/debenzoylation","display_name":"debenzoylation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/thermodynamic-control","display_name":"thermodynamic control","score":0.5910000205039978},{"id":"https://openalex.org/keywords/leukemia-l1210","display_name":"leukemia L1210","score":0.8999999761581421},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9589062333106995},{"id":"https://openalex.org/C2780815526","wikidata":"https://www.wikidata.org/wiki/Q3333713","display_name":"Methylenecyclopropane","level":3,"score":0.9309526681900024},{"id":"https://openalex.org/C2777320604","wikidata":"https://www.wikidata.org/wiki/Q414101","display_name":"Cyclopropene","level":2,"score":0.9127013683319092},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.788347601890564},{"id":"https://openalex.org/C2777454769","wikidata":"https://www.wikidata.org/wiki/Q11172462","display_name":"Methylene","level":2,"score":0.6008195877075195},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.589525043964386},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5709605813026428},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.5001790523529053},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.343265175819397},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24186167120933533},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1807878613471985},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.17675262689590454},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.15127187967300415},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.11750322580337524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm010191w","doi":"https://doi.org/10.1021/jm010191w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm010191w","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:11689090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11689090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1620397531","display_name":null,"funder_award_id":"N01-AI35177","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3503499778","display_name":null,"funder_award_id":"R01CA46560","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G364970380","display_name":"IN VITRO ANTIVIRAL SCREEN FOR HERPESVIRUSES","funder_award_id":"n01ai035177-007","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8552458023","display_name":"Antitumor and Antiviral Nucleoside Analogues","funder_award_id":"R01CA032779","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8722106665","display_name":"NEW INHIBITORS AND NEW TARGETS TO DEVELOP HCMV DRUGS","funder_award_id":"U19AI031718","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W153395274","https://openalex.org/W618238210","https://openalex.org/W1482896844","https://openalex.org/W1977423563","https://openalex.org/W2093169421","https://openalex.org/W2951160406","https://openalex.org/W2953371971","https://openalex.org/W4235752277","https://openalex.org/W4238917801"],"related_works":["https://openalex.org/W2091997636","https://openalex.org/W2039458539","https://openalex.org/W2055535477","https://openalex.org/W2007917184","https://openalex.org/W2949490873","https://openalex.org/W2029043829","https://openalex.org/W2174223530","https://openalex.org/W2009656721","https://openalex.org/W2084394543","https://openalex.org/W1988832737"],"abstract_inverted_index":{"Alkylation-elimination":[0],"of":[1,24,41,54],"adenine":[2],"and":[3,11,16,18,21,29,33,38,45,51,75,86],"2-amino-6-chloropurine":[4,42],"with":[5,77],"gem-difluorocyclopropane":[6],"dibromide":[7],"10":[8],"gave":[9],"E-":[10,32],"Z-methylene-gem-difluorocyclopropanes":[12],"11a,":[13,26],"11b,":[14,27],"12a,":[15,28],"12b":[17,30],"gem-difluorocyclopropenes":[19],"13a":[20],"13b.":[22],"Debenzylation":[23],"intermediates":[25],"afforded":[31,47],"Z-methylenecyclopropanes":[34],"4a,":[35],"4b,":[36],"5a,":[37],"5b.":[39],"Hydrolysis":[40],"derivatives":[43],"4b":[44],"5b":[46],"guanine":[48],"analogues":[49],"4c":[50],"5c.":[52],"Composition":[53],"products":[55],"(except":[56],"14b)":[57],"obtained":[58],"from":[59],"alkylation-elimination":[60],"reflects":[61],"thermodynamically":[62],"controlled":[63],"cyclopropene-methylenecyclopropene":[64],"rearrangement.":[65],"The":[66],"E-isomer":[67],"4a":[68],"was":[69,81],"moderately":[70],"active":[71,82],"against":[72,83],"human":[73],"cytomegalovirus":[74],"along":[76],"the":[78],"Z-isomer":[79],"5a":[80],"leukemia":[84],"L1210":[85],"solid":[87],"tumors":[88],"in":[89],"vitro.":[90]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
