{"id":"https://openalex.org/W2021292018","doi":"https://doi.org/10.1162/15353500200202124","title":"Microarray Gene Expression Analysis of Murine Tumor Heterogeneity Defined by Dynamic Contrast-Enhanced MRI","display_name":"Microarray Gene Expression Analysis of Murine Tumor Heterogeneity Defined by Dynamic Contrast-Enhanced MRI","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2021292018","doi":"https://doi.org/10.1162/15353500200202124","mag":"2021292018","pmid":"https://pubmed.ncbi.nlm.nih.gov/12920855"},"language":"en","primary_location":{"id":"doi:10.1162/15353500200202124","doi":"https://doi.org/10.1162/15353500200202124","is_oa":true,"landing_page_url":"https://doi.org/10.1162/15353500200202124","pdf_url":null,"source":{"id":"https://openalex.org/S55147621","display_name":"Molecular Imaging","issn_l":"1535-3508","issn":["1535-3508","1536-0121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Imaging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1162/15353500200202124","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027556954","display_name":"Nick G. Costouros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nick G. Costouros","raw_affiliation_strings":["National Cancer Institute","National Cancer Institute, Bethesda, Md., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, Md., USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067941858","display_name":"Dominique Lorang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominique Lorang","raw_affiliation_strings":["National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032376390","display_name":"Yantian Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yantian Zhang","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109917838","display_name":"Marshall S. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marshall S. Miller","raw_affiliation_strings":["National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064519201","display_name":"Felix E. Diehn","orcid":"https://orcid.org/0000-0001-9458-8017","observed_orcids":["https://orcid.org/0000-0001-9458-8017"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felix E. Diehn","raw_affiliation_strings":["National Institutes of Health","National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011055578","display_name":"Stephen M. Hewitt","orcid":"https://orcid.org/0000-0001-8283-1788","observed_orcids":["https://orcid.org/0000-0001-8283-1788"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen M. Hewitt","raw_affiliation_strings":["National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016175407","display_name":"Michael Vinzenz Knopp","orcid":"https://orcid.org/0000-0001-9543-2962","observed_orcids":["https://orcid.org/0000-0001-9543-2962"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael V. Knopp","raw_affiliation_strings":["Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063975699","display_name":"King C. Li","orcid":"https://orcid.org/0000-0002-6473-2687","observed_orcids":["https://orcid.org/0000-0002-6473-2687"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"King C. P. Li","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082080836","display_name":"Peter L. Choyke","orcid":"https://orcid.org/0000-0003-1086-8826","observed_orcids":["https://orcid.org/0000-0003-1086-8826"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter L. Choyke","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081233015","display_name":"Henry Richard Alexander","orcid":"https://orcid.org/0000-0003-0687-9434","observed_orcids":["https://orcid.org/0000-0003-0687-9434"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Richard Alexander","raw_affiliation_strings":["National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003655999","display_name":"Steven K. Libutti","orcid":"https://orcid.org/0000-0003-2313-9809","observed_orcids":["https://orcid.org/0000-0003-2313-9809"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven K. Libutti","raw_affiliation_strings":["National Cancer Institute","National Institutes of Health","Ohio State University","Surgery Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Surgery Branch","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003655999"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I52357470"],"apc_list":{"value":2175,"currency":"USD","value_usd":2175},"apc_paid":{"value":2175,"currency":"USD","value_usd":2175},"fwci":1.9373,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.8448746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"3","first_page":"301","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.11190000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dynamic-contrast-enhanced-mri","display_name":"dynamic contrast-enhanced MRI","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pharmacokinetic-modeling","display_name":"pharmacokinetic modeling","score":0.8510000109672546},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ribosomal-proteins","display_name":"ribosomal proteins","score":0.8830000162124634},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/subcutaneous-tumor","display_name":"subcutaneous tumor","score":0.6299999952316284},{"id":"https://openalex.org/keywords/contrast-washout","display_name":"contrast washout","score":0.5230000019073486},{"id":"https://openalex.org/keywords/mrna-translation","display_name":"mRNA translation","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6019222140312195},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.5218623876571655},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4988517761230469},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.49097850918769836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4858962893486023},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4679369330406189},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44732967019081116},{"id":"https://openalex.org/C41727105","wikidata":"https://www.wikidata.org/wiki/Q17009718","display_name":"Dynamic contrast-enhanced MRI","level":3,"score":0.44054025411605835},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43988996744155884},{"id":"https://openalex.org/C2994142346","wikidata":"https://www.wikidata.org/wiki/Q353268","display_name":"Dynamic contrast","level":3,"score":0.4355373978614807},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3836672306060791},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3780186176300049},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34553173184394836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21757137775421143},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2019338607788086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19638049602508545},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12410661578178406},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08541291952133179},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1162/15353500200202124","doi":"https://doi.org/10.1162/15353500200202124","is_oa":true,"landing_page_url":"https://doi.org/10.1162/15353500200202124","pdf_url":null,"source":{"id":"https://openalex.org/S55147621","display_name":"Molecular Imaging","issn_l":"1535-3508","issn":["1535-3508","1536-0121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Imaging","raw_type":"journal-article"},{"id":"doi:10.1162/153535002760235481","doi":"https://doi.org/10.1162/153535002760235481","is_oa":true,"landing_page_url":"https://doi.org/10.1162/153535002760235481","pdf_url":null,"source":{"id":"https://openalex.org/S55147621","display_name":"Molecular Imaging","issn_l":"1535-3508","issn":["1535-3508","1536-0121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Imaging","raw_type":"journal-article"},{"id":"pmid:12920855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12920855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular imaging","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3bbbd0f539d3485aad41e77c46d27a52","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3bbbd0f539d3485aad41e77c46d27a52","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Imaging, Vol 1 (2002)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1162/15353500200202124","doi":"https://doi.org/10.1162/15353500200202124","is_oa":true,"landing_page_url":"https://doi.org/10.1162/15353500200202124","pdf_url":null,"source":{"id":"https://openalex.org/S55147621","display_name":"Molecular Imaging","issn_l":"1535-3508","issn":["1535-3508","1536-0121"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W120565579","https://openalex.org/W1483828791","https://openalex.org/W1484784716","https://openalex.org/W1495287184","https://openalex.org/W1573363574","https://openalex.org/W1910297873","https://openalex.org/W1982509041","https://openalex.org/W1987610971","https://openalex.org/W2003608913","https://openalex.org/W2015145164","https://openalex.org/W2017679962","https://openalex.org/W2022307144","https://openalex.org/W2027192494","https://openalex.org/W2027406000","https://openalex.org/W2036913456","https://openalex.org/W2043507448","https://openalex.org/W2059597289","https://openalex.org/W2066321210","https://openalex.org/W2071715597","https://openalex.org/W2072770862","https://openalex.org/W2085840728","https://openalex.org/W2090117920","https://openalex.org/W2099388441","https://openalex.org/W2101160504","https://openalex.org/W2147415913","https://openalex.org/W2161650475","https://openalex.org/W2163936025","https://openalex.org/W2403648956","https://openalex.org/W2404506793"],"related_works":["https://openalex.org/W1983994322","https://openalex.org/W2998765584","https://openalex.org/W2053053668","https://openalex.org/W2415025170","https://openalex.org/W74695042","https://openalex.org/W1531528770","https://openalex.org/W3032874291","https://openalex.org/W2900947575","https://openalex.org/W2364061485","https://openalex.org/W2006024165"],"abstract_inverted_index":{"Current":[0],"methods":[1],"of":[2,50,58,93,97,110,130,133,159,188,199],"studying":[3],"angiogenesis":[4,60,192,207],"are":[5,69,74],"limited":[6],"in":[7,13,71,79,140,165,191,205],"their":[8],"ability":[9],"to":[10,88,184,203],"serially":[11],"evaluate":[12,204],"vivo":[14,206],"function":[15],"throughout":[16],"a":[17,30,80,94,120,209],"target":[18],"tissue.":[19],"Dynamic":[20],"contrast-enhanced":[21],"magnetic":[22],"resonance":[23],"imaging":[24,118],"(DCE-MRI)":[25],"and":[26,41,54,61,107,153,168,175,193],"pharmacokinetic":[27,90,115,143],"modeling":[28],"provide":[29],"useful":[31],"method":[32],"for":[33,122,196],"evaluating":[34],"tissue":[35],"vasculature":[36],"based":[37,113],"on":[38,114,151],"contrast":[39,52,201],"accumulation":[40],"washout.":[42],"While":[43],"it":[44],"is":[45],"often":[46],"assumed":[47],"that":[48,68],"areas":[49,57,73],"high":[51,166],"enhancement":[53,167],"washout":[55,169],"comprise":[56],"increased":[59,131,164,172,177],"tumor":[62,83,111],"activity,":[63],"the":[64,137,157,185,194,197],"actual":[65],"molecular":[66,210],"pathways":[67],"active":[70],"such":[72],"poorly":[75],"understood.":[76],"Using":[77,117],"DCE-MRI":[78],"murine":[81],"subcutaneous":[82],"model,":[84],"we":[85,125],"were":[86],"able":[87],"perform":[89],"functional":[91],"analysis":[92],"tumor,":[95],"coregistration":[96],"MRI":[98],"images":[99],"with":[100],"histological":[101],"cross-sections,":[102],"immunohistochemistry,":[103],"laser":[104],"capture":[105],"microdissection,":[106],"genetic":[108],"profiling":[109],"heterogeneity":[112],"parameters.":[116],"as":[119],"template":[121],"biologic":[123],"investigation,":[124],"have":[126],"not":[127],"found":[128],"evidence":[129],"expression":[132,158],"proangiogenic":[134],"modulators":[135],"at":[136,208],"transcriptional":[138],"level":[139],"either":[141],"distinct":[142],"region.":[144],"Furthermore,":[145],"these":[146,181],"regions":[147],"show":[148],"no":[149],"difference":[150],"histology":[152],"CD31":[154],"immunohistochemistry.":[155],"However,":[156],"ribosomal":[160],"proteins":[161],"was":[162],"greatly":[163],"regions,":[170],"implying":[171],"protein":[173],"translation":[174],"consequent":[176],"cellular":[178],"activity.":[179],"Together,":[180],"findings":[182],"point":[183],"potential":[186],"importance":[187],"posttranscriptional":[189],"regulation":[190],"need":[195],"development":[198],"angiogenesis-specific":[200],"agents":[202],"level.":[211]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}