{"id":"https://openalex.org/W2021289971","doi":"https://doi.org/10.1016/j.bone.2005.12.013","title":"Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells","display_name":"Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells","publication_year":2006,"publication_date":"2006-02-20","ids":{"openalex":"https://openalex.org/W2021289971","doi":"https://doi.org/10.1016/j.bone.2005.12.013","mag":"2021289971","pmid":"https://pubmed.ncbi.nlm.nih.gov/16487757"},"language":"en","primary_location":{"id":"doi:10.1016/j.bone.2005.12.013","doi":"https://doi.org/10.1016/j.bone.2005.12.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2005.12.013","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057184063","display_name":"Lisa M. Masiello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa M. Masiello","raw_affiliation_strings":["Cell Biology and Biochemistry Group, Pacific Northwest National Laboratory, P.O. Box 999, MS P7-56, Richland, WA 99352, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Biochemistry Group, Pacific Northwest National Laboratory, P.O. Box 999, MS P7-56, Richland, WA 99352, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076638638","display_name":"Joseph S. Fotos","orcid":"https://orcid.org/0000-0001-8888-5592","observed_orcids":["https://orcid.org/0000-0001-8888-5592"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph S. Fotos","raw_affiliation_strings":["Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081857171","display_name":"Deni S. Galileo","orcid":"https://orcid.org/0000-0002-0089-2198","observed_orcids":["https://orcid.org/0000-0002-0089-2198"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deni S. Galileo","raw_affiliation_strings":["Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111527464","display_name":"Norman J. Karin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Norman J. Karin","raw_affiliation_strings":["Cell Biology and Biochemistry Group, Pacific Northwest National Laboratory, P.O. Box 999, MS P7-56, Richland, WA 99352, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Biochemistry Group, Pacific Northwest National Laboratory, P.O. Box 999, MS P7-56, Richland, WA 99352, USA","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111527464"],"corresponding_institution_ids":["https://openalex.org/I142606810"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":2.3093,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.87109848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"39","issue":"1","first_page":"72","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"lysophosphatidic acid","score":1.0},{"id":"https://openalex.org/keywords/osteoblast-migration","display_name":"osteoblast migration","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/lpa1-receptor","display_name":"LPA1 receptor","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lpa2-receptor","display_name":"LPA2 receptor","score":0.6299999952316284},{"id":"https://openalex.org/keywords/lpa3-receptor","display_name":"LPA3 receptor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9620000123977661},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9150000214576721},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.9589999914169312},{"id":"https://openalex.org/keywords/intracellular-calcium-signaling","display_name":"intracellular calcium signaling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ki16425","display_name":"Ki16425","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cell-shape","display_name":"cell shape","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2776661833","wikidata":"https://www.wikidata.org/wiki/Q2823281","display_name":"Lysophosphatidic acid","level":3,"score":0.9770277738571167},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.8074078559875488},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.7602596282958984},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.6830122470855713},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6764042973518372},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6638315320014954},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.6562728881835938},{"id":"https://openalex.org/C2779866169","wikidata":"https://www.wikidata.org/wiki/Q724875","display_name":"Chemotaxis assay","level":4,"score":0.5768197178840637},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5439380407333374},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.4526611566543579},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.450580358505249},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4338603615760803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3787384331226349},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.36523666977882385},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2621568739414215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20883366465568542},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.1850065290927887},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08483240008354187}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037342","descriptor_name":"Pertussis Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bone.2005.12.013","doi":"https://doi.org/10.1016/j.bone.2005.12.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2005.12.013","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},{"id":"pmid:16487757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16487757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2746606765","display_name":"NgCAM/L1 misexpression in developing brain","funder_award_id":"R21NS040317","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3913756190","display_name":"Regulation of Osteoblast Function /Lysophosphatidic Acid","funder_award_id":"R03HD042066","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W149144940","https://openalex.org/W1580286725","https://openalex.org/W1776576701","https://openalex.org/W1836594018","https://openalex.org/W1963786764","https://openalex.org/W1977998332","https://openalex.org/W1992365461","https://openalex.org/W1994850027","https://openalex.org/W2000712251","https://openalex.org/W2014140239","https://openalex.org/W2018511244","https://openalex.org/W2023266494","https://openalex.org/W2031240706","https://openalex.org/W2037783676","https://openalex.org/W2046939994","https://openalex.org/W2059318962","https://openalex.org/W2061649562","https://openalex.org/W2063845703","https://openalex.org/W2075108741","https://openalex.org/W2082211144","https://openalex.org/W2085108731","https://openalex.org/W2085559561","https://openalex.org/W2089520150","https://openalex.org/W2090540774","https://openalex.org/W2094074840","https://openalex.org/W2098615703","https://openalex.org/W2107007984","https://openalex.org/W2117519868","https://openalex.org/W2117781884","https://openalex.org/W2120639213","https://openalex.org/W2124440700","https://openalex.org/W2131715982","https://openalex.org/W2143975749","https://openalex.org/W2144742443","https://openalex.org/W2145221446","https://openalex.org/W2149310803","https://openalex.org/W2149833461","https://openalex.org/W2170636321","https://openalex.org/W2402711967","https://openalex.org/W4235309145"],"related_works":["https://openalex.org/W12480718","https://openalex.org/W2118709577","https://openalex.org/W7067371447","https://openalex.org/W2014140239","https://openalex.org/W2009602163","https://openalex.org/W2131717780","https://openalex.org/W7099431966","https://openalex.org/W2000485424","https://openalex.org/W2230714896","https://openalex.org/W3117178771"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}