{"id":"https://openalex.org/W2021283737","doi":"https://doi.org/10.1089/ars.2014.6054","title":"Hemodynamic Shear Stress via ROS Modulates PCSK9 Expression in Human Vascular Endothelial and Smooth Muscle Cells and Along the Mouse Aorta","display_name":"Hemodynamic Shear Stress via ROS Modulates PCSK9 Expression in Human Vascular Endothelial and Smooth Muscle Cells and Along the Mouse Aorta","publication_year":2014,"publication_date":"2014-12-09","ids":{"openalex":"https://openalex.org/W2021283737","doi":"https://doi.org/10.1089/ars.2014.6054","mag":"2021283737","pmid":"https://pubmed.ncbi.nlm.nih.gov/25490141","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4361218"},"language":"en","primary_location":{"id":"doi:10.1089/ars.2014.6054","doi":"https://doi.org/10.1089/ars.2014.6054","is_oa":true,"landing_page_url":"https://doi.org/10.1089/ars.2014.6054","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2021283737"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1089/ars.2014.6054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087698430","display_name":"Zufeng Ding","orcid":"https://orcid.org/0000-0001-8643-7059","observed_orcids":["https://orcid.org/0000-0001-8643-7059"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]},{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zufeng Ding","raw_affiliation_strings":["Beihang University","University of Arkansas for Medical Sciences","Zhengzhou University","Central Arkansas Veterans Healthcare System and the Departments of Medicine, and Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas","College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China","Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beihang University","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"University of Arkansas for Medical Sciences","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Zhengzhou University","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"Central Arkansas Veterans Healthcare System and the Departments of Medicine, and Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas","institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"]},{"raw_affiliation_string":"College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424829","display_name":"Shijie Liu","orcid":"https://orcid.org/0000-0002-3673-5194","observed_orcids":["https://orcid.org/0000-0002-3673-5194"]},"institutions":[{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shijie Liu","raw_affiliation_strings":["University of Arkansas for Medical Sciences","Central Arkansas Veterans Healthcare System and the Departments of Medicine, and Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Central Arkansas Veterans Healthcare System and the Departments of Medicine, and Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas","institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638862","display_name":"Xianwei Wang","orcid":"https://orcid.org/0000-0002-1490-8736","observed_orcids":["https://orcid.org/0000-0002-1490-8736"]},"institutions":[{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianwei Wang","raw_affiliation_strings":["University of Arkansas for Medical Sciences","Central Arkansas Veterans Healthcare System and the Departments of Medicine, and Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Central Arkansas Veterans Healthcare System and the Departments of Medicine, and Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas","institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083393177","display_name":"Xiaoyan Deng","orcid":"https://orcid.org/0000-0003-0186-8234","observed_orcids":["https://orcid.org/0000-0003-0186-8234"]},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Deng","raw_affiliation_strings":["Beihang University","Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beihang University","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066943052","display_name":"Yubo Fan","orcid":"https://orcid.org/0000-0002-3480-4395","observed_orcids":["https://orcid.org/0000-0002-3480-4395"]},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yubo Fan","raw_affiliation_strings":["Beihang University","Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beihang University","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088642867","display_name":"Changqing Sun","orcid":"https://orcid.org/0000-0001-5509-9237","observed_orcids":["https://orcid.org/0000-0001-5509-9237"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changqing Sun","raw_affiliation_strings":["Zhengzhou University","College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou University","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071625882","display_name":"Yannian Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yannian Wang","raw_affiliation_strings":["Zhengzhou University","College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou University","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113520521","display_name":"Jawahar L. Mehta","orcid":"https://orcid.org/0000-0003-0384-2097","observed_orcids":["https://orcid.org/0000-0003-0384-2097"]},"institutions":[{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jawahar L. Mehta","raw_affiliation_strings":["University of Arkansas for Medical Sciences","Central Arkansas Veterans Healthcare System and the Departments of Medicine, and Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Central Arkansas Veterans Healthcare System and the Departments of Medicine, and Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas","institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100424829","https://openalex.org/A5113520521"],"corresponding_institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"],"apc_list":null,"apc_paid":null,"fwci":3.7179,"has_fulltext":false,"cited_by_count":226,"citation_normalized_percentile":{"value":0.94044546,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"22","issue":"9","first_page":"760","last_page":"771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.1005999967455864,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcsk9","display_name":"PCSK9","score":0.902999997138977},{"id":"https://openalex.org/keywords/hemodynamic-shear-stress","display_name":"hemodynamic shear stress","score":0.9290000200271606},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8949999809265137},{"id":"https://openalex.org/keywords/lox-1","display_name":"LOX-1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.828000009059906},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.7940000295639038},{"id":"https://openalex.org/keywords/gp91phox","display_name":"gp91phox","score":0.8899999856948853},{"id":"https://openalex.org/keywords/diphenyleneiodonium","display_name":"diphenyleneiodonium","score":0.6909999847412109},{"id":"https://openalex.org/keywords/apocynin","display_name":"apocynin","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.6837127804756165},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.5959950685501099},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5024793148040771},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49039125442504883},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.48932498693466187},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4885457456111908},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4703148901462555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4262259602546692},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4079892635345459},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3715277910232544},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.26401466131210327},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.2364577054977417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19522178173065186},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.15482673048973083},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071449","descriptor_name":"Proprotein Convertase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074662","descriptor_name":"NADPH Oxidase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098","descriptor_name":"Acetophenones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009861","descriptor_name":"Onium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043484","descriptor_name":"Proprotein Convertases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051127","descriptor_name":"Scavenger Receptors, Class E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/ars.2014.6054","doi":"https://doi.org/10.1089/ars.2014.6054","is_oa":true,"landing_page_url":"https://doi.org/10.1089/ars.2014.6054","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3340433","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4361218","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25490141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25490141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & redox signaling","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4361218","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4361218/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxid Redox Signal","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1089/ars.2014.6054","doi":"https://doi.org/10.1089/ars.2014.6054","is_oa":true,"landing_page_url":"https://doi.org/10.1089/ars.2014.6054","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1027067274","display_name":null,"funder_award_id":"61190123","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1836309646","display_name":null,"funder_award_id":"I01 BX000282","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G504739924","display_name":"\u8840\u7ba1\u5185\u8102\u8d28\u7684\u6d53\u5ea6\u6781\u5316\u4e0e\u8840\u7ba1\u642d\u6865\u672f\u540e\u9759\u8109\u8840\u7ba1\u8001\u5316\uff08\u52a0\u901f\u7ca5\u6837\u786c\u5316\uff09\u73b0\u8c61\u7684\u76f8\u5173\u6027\u7814\u7a76","funder_award_id":"31170904","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6088952646","display_name":null,"funder_award_id":"20121102110031","funder_id":"https://openalex.org/F4320336024","funder_display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China"},{"id":"https://openalex.org/G6834513838","display_name":null,"funder_award_id":"11228205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336024","display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1555746577","https://openalex.org/W1966373116","https://openalex.org/W1967296654","https://openalex.org/W1967765358","https://openalex.org/W1972938168","https://openalex.org/W1975051403","https://openalex.org/W1991416826","https://openalex.org/W1991970275","https://openalex.org/W1998641623","https://openalex.org/W2002957986","https://openalex.org/W2007981595","https://openalex.org/W2008303171","https://openalex.org/W2024335159","https://openalex.org/W2029459374","https://openalex.org/W2030106766","https://openalex.org/W2041762633","https://openalex.org/W2042160477","https://openalex.org/W2055396192","https://openalex.org/W2055792109","https://openalex.org/W2057430111","https://openalex.org/W2067539811","https://openalex.org/W2068933494","https://openalex.org/W2071154679","https://openalex.org/W2073361685","https://openalex.org/W2084621368","https://openalex.org/W2090845578","https://openalex.org/W2099868609","https://openalex.org/W2106295346","https://openalex.org/W2113111549","https://openalex.org/W2113361833","https://openalex.org/W2117011155","https://openalex.org/W2117320262","https://openalex.org/W2118033940","https://openalex.org/W2118364454","https://openalex.org/W2118814154","https://openalex.org/W2120942558","https://openalex.org/W2128880476","https://openalex.org/W2133422448","https://openalex.org/W2140380288","https://openalex.org/W2146769790","https://openalex.org/W2155056314","https://openalex.org/W2157836756","https://openalex.org/W2159087408","https://openalex.org/W2159161252","https://openalex.org/W2160301642","https://openalex.org/W2160637851","https://openalex.org/W2163625494","https://openalex.org/W2313018934","https://openalex.org/W2765549060"],"related_works":["https://openalex.org/W2640456656","https://openalex.org/W2194274372","https://openalex.org/W4406798644","https://openalex.org/W2769728123","https://openalex.org/W2979839831","https://openalex.org/W3217690404","https://openalex.org/W7161113699","https://openalex.org/W2160637851","https://openalex.org/W2322588319","https://openalex.org/W4220911423"],"abstract_inverted_index":{"AIMS:":[0],"To":[1,117],"investigate":[2],"a":[3,25,119,186],"possible":[4],"link":[5],"between":[6,121,145],"hemodynamic":[7],"shear":[8,49,62,104,201,221,260],"stress,":[9],"reactive":[10],"oxygen":[11],"species":[12],"(ROS)":[13],"generation,":[14],"and":[15,40,53,94,123,127,136,138,147,154,167,182,234],"proprotein":[16],"convertase":[17],"subtilisin/kexin":[18],"type":[19],"9":[20],"(PCSK9)":[21],"expression.":[22,91,143,241],"RESULTS:":[23],"Using":[24],"parallel-plate":[26],"flow":[27],"chamber,":[28],"we":[29],"observed":[30],"that":[31,101,180,219,244],"PCSK9":[32,64,73,90,112,124,142,146,163,190,204,224,240],"expression":[33,65,74,113,191,225],"in":[34,61,78,81,152,165,170,189,226,231,250,255],"vascular":[35,232],"smooth":[36],"muscle":[37],"cells":[38,42,68],"(SMCs)":[39],"endothelial":[41],"(ECs)":[43],"reached":[44],"maximal":[45],"value":[46],"at":[47],"low":[48,103,162,220,259],"stress":[50,105,202,222],"(3-6":[51],"dynes/cm(2)),":[52],"then":[54],"began":[55],"to":[56,109,238],"decline":[57],"with":[58,71,131,228,258],"an":[59],"increase":[60],"stress.":[63,261],"increased":[66],"when":[67],"were":[69,106,129],"treated":[70,130],"lipopolysaccharide.":[72],"was":[75,149],"always":[76],"greater":[77,111],"SMCs":[79,128],"than":[80],"ECs.":[82],"ROS":[83,122,132,148,181,212,229,236],"generation":[84,230],"followed":[85],"the":[86,251],"same":[87],"pattern":[88],"as":[89],"Aortic":[92],"branching":[93],"aorta-iliac":[95,171],"bifurcation":[96,172],"regions":[97,173],"of":[98,253],"mouse":[99],"aorta":[100],"express":[102],"also":[107],"found":[108],"have":[110],"(vs.":[114,174],"other":[115],"regions).":[116],"determine":[118],"relationship":[120],"expression,":[125,205],"ECs":[126,233],"inhibitors":[133],"diphenylene-iodonium":[134],"chloride":[135],"apocynin,":[137],"both":[139,158],"markedly":[140],"reduced":[141],"Relationship":[144],"further":[150],"studied":[151],"p47(phox)":[153],"gp91(phox)":[155],"knockout":[156],"mice;":[157],"mice":[159],"strains":[160],"revealed":[161],"levels":[164,169],"serum":[166],"mRNA":[168],"wild-type":[175],"mice).":[176],"Other":[177],"studies":[178],"showed":[179],"NF-\u03baB":[183],"activation":[184],"plays":[185],"bridging":[187],"role":[188],"via":[192],"lectin-like":[193],"oxidized":[194],"low-density":[195],"lipoprotein":[196],"receptor-1":[197],"(LOX-1).":[198],"INNOVATION:":[199],"Low":[200],"induces":[203],"which":[206],"is":[207],"mediated":[208],"by":[209],"NADPH":[210],"oxidase-dependent":[211],"production.":[213],"CONCLUSIONS:":[214],"This":[215],"study":[216],"provides":[217],"evidence":[218],"enhances":[223],"concert":[227],"SMCs.":[235],"seem":[237],"regulate":[239],"We":[242],"propose":[243],"PCSK9-ROS":[245],"interaction":[246],"may":[247],"be":[248],"important":[249],"development":[252],"atherosclerosis":[254],"arterial":[256],"channels":[257]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
