{"id":"https://openalex.org/W2021283318","doi":"https://doi.org/10.1016/j.bmcl.2015.03.035","title":"Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2","display_name":"Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2","publication_year":2015,"publication_date":"2015-04-05","ids":{"openalex":"https://openalex.org/W2021283318","doi":"https://doi.org/10.1016/j.bmcl.2015.03.035","mag":"2021283318","pmid":"https://pubmed.ncbi.nlm.nih.gov/25838147"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2015.03.035","doi":"https://doi.org/10.1016/j.bmcl.2015.03.035","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2015.03.035","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065836546","display_name":"Thierry Sifferlen","orcid":"https://orcid.org/0009-0004-8073-9434","observed_orcids":["https://orcid.org/0009-0004-8073-9434"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Thierry Sifferlen","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082267449","display_name":"Amandine Boller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Amandine Boller","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082894361","display_name":"Audrey Chardonneau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Audrey Chardonneau","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003457095","display_name":"Emmanuelle Cottreel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emmanuelle Cottreel","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079713627","display_name":"John Gatfield","orcid":"https://orcid.org/0000-0003-1617-8500","observed_orcids":["https://orcid.org/0000-0003-1617-8500"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"John Gatfield","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084451359","display_name":"Alexander Treiber","orcid":"https://orcid.org/0000-0002-2380-2538","observed_orcids":["https://orcid.org/0000-0002-2380-2538"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexander Treiber","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021529062","display_name":"Catherine Roch","orcid":"https://orcid.org/0000-0002-0260-2756","observed_orcids":["https://orcid.org/0000-0002-0260-2756"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Catherine Roch","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110091737","display_name":"F. Jenck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Francois Jenck","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061130041","display_name":"Hamed Aissaoui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hamed Aissaoui","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016596853","display_name":"Jodi T. Williams","orcid":"https://orcid.org/0000-0002-1392-1349","observed_orcids":["https://orcid.org/0000-0002-1392-1349"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jodi T. Williams","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004827037","display_name":"Christine Brotschi","orcid":"https://orcid.org/0000-0002-7362-3167","observed_orcids":["https://orcid.org/0000-0002-7362-3167"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christine Brotschi","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086508550","display_name":"Bibia Heidmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bibia Heidmann","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007667222","display_name":"Romain Siegrist","orcid":"https://orcid.org/0009-0009-7590-7786","observed_orcids":["https://orcid.org/0009-0009-7590-7786"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Romain Siegrist","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000076674","display_name":"Christoph Boss","orcid":"https://orcid.org/0000-0001-8838-8190","observed_orcids":["https://orcid.org/0000-0001-8838-8190"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Christoph Boss","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland. Electronic address: christoph.boss@actelion.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, Drug Discovery and Preclinical Research & Development, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland. Electronic address: christoph.boss@actelion.com","institution_ids":["https://openalex.org/I95056601"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000076674","https://openalex.org/A5065836546"],"corresponding_institution_ids":["https://openalex.org/I95056601"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":2.6023,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.8853818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"9","first_page":"1884","last_page":"1891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orexin-receptor-antagonists","display_name":"orexin receptor antagonists","score":0.968999981880188},{"id":"https://openalex.org/keywords/pyrrolidin-2-one","display_name":"pyrrolidin-2-one","score":0.9150000214576721},{"id":"https://openalex.org/keywords/orexin-2-receptor","display_name":"orexin receptor 2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/sleep-promotion","display_name":"sleep promotion","score":0.7080000042915344},{"id":"https://openalex.org/keywords/c-3-substitution","display_name":"C-3 substitution","score":0.7570000290870667},{"id":"https://openalex.org/keywords/p-glycoprotein-efflux","display_name":"P-glycoprotein efflux","score":0.8429999947547913},{"id":"https://openalex.org/keywords/brain-exposure","display_name":"brain exposure","score":0.5389999747276306},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8100000023841858},{"id":"https://openalex.org/keywords/metabolic-stability","display_name":"metabolic stability","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.880380392074585},{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.7743103504180908},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6155436038970947},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6102885603904724},{"id":"https://openalex.org/C2991874392","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Metabolic stability","level":3,"score":0.5500723719596863},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5439465045928955},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5083231329917908},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.48720306158065796},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4553126096725464},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3964797556400299},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34844765067100525},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3370986580848694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3251159191131592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21583634614944458},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.2063823640346527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068796","descriptor_name":"Orexin Receptor Antagonists","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000068796","descriptor_name":"Orexin Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000068796","descriptor_name":"Orexin Receptor Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011760","descriptor_name":"Pyrrolidinones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011760","descriptor_name":"Pyrrolidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011760","descriptor_name":"Pyrrolidinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064446","descriptor_name":"Orexin Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2015.03.035","doi":"https://doi.org/10.1016/j.bmcl.2015.03.035","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2015.03.035","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:25838147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25838147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1966481627","https://openalex.org/W1984747983","https://openalex.org/W1992000457","https://openalex.org/W1992708712","https://openalex.org/W1993291214","https://openalex.org/W1996610435","https://openalex.org/W2010642502","https://openalex.org/W2013666521","https://openalex.org/W2015116773","https://openalex.org/W2016329740","https://openalex.org/W2016433222","https://openalex.org/W2018441208","https://openalex.org/W2027740042","https://openalex.org/W2033473705","https://openalex.org/W2035018594","https://openalex.org/W2041702402","https://openalex.org/W2042244182","https://openalex.org/W2049520178","https://openalex.org/W2051712994","https://openalex.org/W2066374958","https://openalex.org/W2069036367","https://openalex.org/W2074379521","https://openalex.org/W2080123342","https://openalex.org/W2080324686","https://openalex.org/W2080574751","https://openalex.org/W2086770490","https://openalex.org/W2101362443","https://openalex.org/W2108982217","https://openalex.org/W2110791596","https://openalex.org/W2117685090","https://openalex.org/W2131263310","https://openalex.org/W2135874952","https://openalex.org/W2140599926","https://openalex.org/W2147187503","https://openalex.org/W2150172934","https://openalex.org/W2152211310","https://openalex.org/W2182593958","https://openalex.org/W2950657421","https://openalex.org/W2952318484"],"related_works":["https://openalex.org/W2582957278","https://openalex.org/W4388983269","https://openalex.org/W293642904","https://openalex.org/W3015290109","https://openalex.org/W2944107830","https://openalex.org/W2033581027","https://openalex.org/W2180588909","https://openalex.org/W2001415299","https://openalex.org/W1967523006","https://openalex.org/W2441268639"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
