{"id":"https://openalex.org/W2021187511","doi":"https://doi.org/10.1093/infdis/165-supplement_1-s103","title":"Iron Acquisition in Haemophilus influenzae: Receptors for Human Transferrin","display_name":"Iron Acquisition in Haemophilus influenzae: Receptors for Human Transferrin","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W2021187511","doi":"https://doi.org/10.1093/infdis/165-supplement_1-s103","mag":"2021187511","pmid":"https://pubmed.ncbi.nlm.nih.gov/1588135"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/165-supplement_1-s103","doi":"https://doi.org/10.1093/infdis/165-supplement_1-s103","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/165-supplement_1-s103","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048328229","display_name":"Anthony Bernard Schryvers","orcid":"https://orcid.org/0000-0002-4029-3296","observed_orcids":["https://orcid.org/0000-0002-4029-3296"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. B. Schryvers","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051736448","display_name":"Scott D. Gray\u2010Owen","orcid":"https://orcid.org/0000-0002-1477-3616","observed_orcids":["https://orcid.org/0000-0002-1477-3616"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S. Gray-Owen","raw_affiliation_strings":["Department ofMicrobiology and Infectious Diseases, Faculty of Medicine, University ofCalgary, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMicrobiology and Infectious Diseases, Faculty of Medicine, University ofCalgary, Canada","institution_ids":["https://openalex.org/I168635309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I168635309"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":1.7476,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.83468293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"165","issue":"Supplement 1","first_page":"S103","last_page":"S104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7235999703407288,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.1453000009059906,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/iron-acquisition","display_name":"iron acquisition","score":0.8640000224113464},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/human-transferrin","display_name":"human transferrin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.7229999899864197},{"id":"https://openalex.org/keywords/transferrin-binding-protein","display_name":"transferrin-binding protein","score":0.8339999914169312},{"id":"https://openalex.org/keywords/iron-regulation","display_name":"iron regulation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/host-range","display_name":"host range","score":0.6620000004768372},{"id":"https://openalex.org/keywords/nontypeable-haemophilus-influenzae","display_name":"nontypeable Haemophilus influenzae","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.9254923462867737},{"id":"https://openalex.org/C108319773","wikidata":"https://www.wikidata.org/wiki/Q424747","display_name":"Siderophore","level":3,"score":0.8067464828491211},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.7766427993774414},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.737971305847168},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.6413100361824036},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6314178705215454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6062262058258057},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5784918665885925},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4960390031337738},{"id":"https://openalex.org/C2779369046","wikidata":"https://www.wikidata.org/wiki/Q6072234","display_name":"Iron-binding proteins","level":3,"score":0.42883503437042236},{"id":"https://openalex.org/C2776402342","wikidata":"https://www.wikidata.org/wiki/Q311275","display_name":"Haemophilus","level":3,"score":0.42821192741394043},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.42686256766319275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39665207266807556},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3109309673309326},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.23425862193107605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20048555731773376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10428866744041443},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/infdis/165-supplement_1-s103","doi":"https://doi.org/10.1093/infdis/165-supplement_1-s103","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/165-supplement_1-s103","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:1588135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1588135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W356514199","https://openalex.org/W1542045638","https://openalex.org/W1701141768","https://openalex.org/W1845325179","https://openalex.org/W1953496394","https://openalex.org/W1968068948","https://openalex.org/W2013740990","https://openalex.org/W2018909260","https://openalex.org/W2054587928","https://openalex.org/W2068939314","https://openalex.org/W2079372552","https://openalex.org/W2095979534","https://openalex.org/W2102612647","https://openalex.org/W2107696455","https://openalex.org/W2113562122","https://openalex.org/W2122934351","https://openalex.org/W2166154848","https://openalex.org/W2169032126","https://openalex.org/W2175449496"],"related_works":["https://openalex.org/W2113562122","https://openalex.org/W1775613041","https://openalex.org/W2068939314","https://openalex.org/W6940682069","https://openalex.org/W7096011368","https://openalex.org/W2107696455","https://openalex.org/W7100362562","https://openalex.org/W2107993674","https://openalex.org/W1968068948","https://openalex.org/W1892238392"],"abstract_inverted_index":{"As":[0],"an":[1],"adaptation":[2],"to":[3],"the":[4,8,37,55,70,80,98,112],"iron-limited":[5],"environment":[6],"of":[7,17,32,39,45,83,92,116],"host,":[9],"Haemophilus":[10],"influenzae":[11,51],"has":[12],"a":[13,43],"transferrin":[14,40,122],"receptor-mediated":[15],"mechanism":[16,56],"iron":[18,25,90],"acquisition":[19],"such":[20],"that":[21,54,69,89],"it":[22],"can":[23],"acquire":[24],"directly":[26],"from":[27],"human":[28,75],"transferrin.":[29],"The":[30],"absence":[31],"detectable":[33],"siderophore":[34],"production":[35],"and":[36,48,63,126],"presence":[38],"binding":[41,64,123],"in":[42,59],"collection":[44],"type":[46],"b":[47],"nontypeable":[49],"H.":[50],"strains":[52],"indicate":[53,88,104],"is":[57,72,95,114],"widespread":[58],"this":[60,84],"species.":[61],"Growth":[62],"studies":[65],"have":[66],"consistently":[67],"shown":[68],"receptor":[71,93,113],"specific":[73],"for":[74],"transferrin,":[76],"which":[77],"correlates":[78],"with":[79,108],"host":[81],"range":[82],"pathogen.":[85],"Inhibitor":[86],"experiments":[87,103],"regulation":[91],"activity":[94],"mediated":[96],"at":[97],"gene":[99],"level.":[100],"Affinity":[101],"isolation":[102],"that,":[105],"as":[106],"observed":[107],"other":[109],"bacterial":[110],"pathogens,":[111],"composed":[115],"two":[117],"iron-repressible":[118],"outer":[119],"membrane":[120],"proteins,":[121],"proteins":[124],"1":[125],"2.":[127]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}