{"id":"https://openalex.org/W2021181739","doi":"https://doi.org/10.1371/journal.pmed.1000166","title":"Potential Role of Decoy B7-H4 in the Pathogenesis of Rheumatoid Arthritis: A Mouse Model Informed by Clinical Data","display_name":"Potential Role of Decoy B7-H4 in the Pathogenesis of Rheumatoid Arthritis: A Mouse Model Informed by Clinical Data","publication_year":2009,"publication_date":"2009-10-19","ids":{"openalex":"https://openalex.org/W2021181739","doi":"https://doi.org/10.1371/journal.pmed.1000166","mag":"2021181739","pmid":"https://pubmed.ncbi.nlm.nih.gov/19841745","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2760136"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pmed.1000166","doi":"https://doi.org/10.1371/journal.pmed.1000166","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1000166","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000166&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000166&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020434543","display_name":"Takeshi Azuma","orcid":"https://orcid.org/0000-0002-4921-2122","observed_orcids":["https://orcid.org/0000-0002-4921-2122"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takeshi Azuma","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102507722","display_name":"Gefeng Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gefeng Zhu","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103739466","display_name":"Haiying Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiying Xu","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Cecilia Rietz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Cecilia Rietz","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031310463","display_name":"Charles G. Drake","orcid":"https://orcid.org/0000-0001-9610-3677","observed_orcids":["https://orcid.org/0000-0001-9610-3677"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles G. Drake","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052273654","display_name":"Eric L. Matteson","orcid":"https://orcid.org/0000-0002-9866-0124","observed_orcids":["https://orcid.org/0000-0002-9866-0124"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Matteson","raw_affiliation_strings":["Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035295243","display_name":"Lieping Chen","orcid":"https://orcid.org/0000-0002-6825-3069","observed_orcids":["https://orcid.org/0000-0002-6825-3069"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lieping Chen","raw_affiliation_strings":["Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035295243"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":6460,"currency":"USD","value_usd":6460},"apc_paid":{"value":6460,"currency":"USD","value_usd":6460},"fwci":1.8852,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.84681312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"6","issue":"10","first_page":"e1000166","last_page":"e1000166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.949999988079071},{"id":"https://openalex.org/keywords/b7-h4","display_name":"B7-H4","score":0.996999979019165},{"id":"https://openalex.org/keywords/decoy-receptor","display_name":"decoy receptor","score":0.781000018119812},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/t-cell-mediated-inflammation","display_name":"T cell-mediated inflammation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/b-cell-autoimmunity","display_name":"B cell-mediated autoimmunity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.921999990940094},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.699999988079071},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6466464996337891},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6286743879318237},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6246119737625122},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5688114166259766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5324757099151611},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.49427103996276855},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49268466234207153},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4860835373401642},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4337095022201538},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34361013770103455}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018122","descriptor_name":"B7-1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060907","descriptor_name":"V-Set Domain-Containing T-Cell Activation Inhibitor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pmed.1000166","doi":"https://doi.org/10.1371/journal.pmed.1000166","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1000166","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000166&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2760136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2760136","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Med","raw_type":"Text"},{"id":"pmid:19841745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19841745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.9549","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.9549","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0a/8c/pmed.1000166.PMC2760136.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6f4c1172a35f4784abaaadfb126c0a69","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6f4c1172a35f4784abaaadfb126c0a69","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Medicine, Vol 6, Iss 10, p e1000166 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/145981","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Potential_Role_of_Decoy_B7_H4_in_the_Pathogenesis_of_Rheumatoid_Arthritis_A_Mouse_Model_Informed_by_Clinical_Data/145981","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pmed.1000166","doi":"https://doi.org/10.1371/journal.pmed.1000166","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1000166","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000166&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1353640427","display_name":"Therapeutic Manipulation of the B7-like Molecules","funder_award_id":"R01CA098731","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5078696110","display_name":null,"funder_award_id":"CA98731","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2021181739.pdf","grobid_xml":"https://content.openalex.org/works/W2021181739.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W201632791","https://openalex.org/W1491865343","https://openalex.org/W1522007640","https://openalex.org/W1561950821","https://openalex.org/W1602277155","https://openalex.org/W1638726768","https://openalex.org/W1873874031","https://openalex.org/W1881116487","https://openalex.org/W1945743078","https://openalex.org/W1968836499","https://openalex.org/W1970443937","https://openalex.org/W1976665020","https://openalex.org/W1990811183","https://openalex.org/W1992184534","https://openalex.org/W1997488342","https://openalex.org/W1999843687","https://openalex.org/W2000905503","https://openalex.org/W2020250668","https://openalex.org/W2021293284","https://openalex.org/W2023982750","https://openalex.org/W2029140584","https://openalex.org/W2029631026","https://openalex.org/W2029987893","https://openalex.org/W2044808340","https://openalex.org/W2047904172","https://openalex.org/W2056605430","https://openalex.org/W2061252374","https://openalex.org/W2065419533","https://openalex.org/W2072796605","https://openalex.org/W2075804595","https://openalex.org/W2075819066","https://openalex.org/W2075836508","https://openalex.org/W2103137174","https://openalex.org/W2103612126","https://openalex.org/W2105620133","https://openalex.org/W2110836981","https://openalex.org/W2121934915","https://openalex.org/W2134141915","https://openalex.org/W2134523831","https://openalex.org/W2143050297","https://openalex.org/W2146404779","https://openalex.org/W2152348310","https://openalex.org/W2156150500","https://openalex.org/W2166433840","https://openalex.org/W2169579591","https://openalex.org/W2172160382","https://openalex.org/W2287943396","https://openalex.org/W2328587823","https://openalex.org/W2417180220","https://openalex.org/W4214589643","https://openalex.org/W4236183098"],"related_works":["https://openalex.org/W2023780869","https://openalex.org/W2345421091","https://openalex.org/W2209948191","https://openalex.org/W2225614405","https://openalex.org/W4225575534","https://openalex.org/W2172160382","https://openalex.org/W158675144","https://openalex.org/W2100811742","https://openalex.org/W2089095516","https://openalex.org/W2355635700"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,31],"pathogenic":[2],"hallmark":[3],"of":[4,40,43,58,70,79,95,99,105,107,117,142,146,151,156,173,178,212,218],"rheumatoid":[5],"arthritis":[6],"(RA)":[7],"is":[8,37],"persistent":[9],"inflammatory":[10],"responses":[11,18,167],"in":[12,67,102,134,176,190,197,231,255],"target":[13,248],"tissues":[14],"and":[15,23,163,228],"organs.":[16],"Immune":[17],"mediated":[19],"by":[20,160],"T":[21,162],"cells":[22],"autoantibodies":[24],"are":[25],"known":[26],"to":[27,49,207,216,238],"play":[28,64],"pivotal":[29],"roles.":[30],"possible":[32],"interpretation":[33],"for":[34,249,258],"this":[35],"observation":[36],"a":[38,53,65,76,80,135,139,181,204,240,246],"loss":[39],"negative":[41],"regulation":[42],"autoimmune":[44,166],"responses.":[45],"Here":[46],"we":[47,91],"sought":[48],"investigate":[50],"whether":[51],"B7-H4,":[52,214],"cell":[54],"surface":[55],"inhibitory":[56,210],"molecule":[57,206],"the":[59,68,96,103,154,191,209,222,256,259],"B7-CD28":[60],"signaling":[61],"pathway,":[62],"may":[63],"role":[66],"pathogenesis":[69],"RA.":[71],"METHODS":[72],"AND":[73],"FINDINGS:":[74],"In":[75,138],"cross-sectional":[77,136],"study":[78],"clinical":[81],"convenience":[82],"sample":[83],"using":[84],"monoclonal":[85],"antibodies":[86],"against":[87],"human":[88],"B7-H4":[89,100,152],"molecules,":[90],"detected":[92],"high":[93],"levels":[94,227],"soluble":[97],"form":[98],"(sH4)":[101],"sera":[104],"65%":[106],"patients":[108,232],"with":[109,127,233],"RA":[110,234],"(n":[111,120],"=":[112,121],"68)":[113],"versus":[114],"only":[115],"13%":[116],"healthy":[118],"donors":[119],"24).":[122],"Elevated":[123],"sH4":[124,147,201,226],"was":[125],"associated":[126],"an":[128,179],"increased":[129,171],"disease":[130,188,229],"severity":[131],"score":[132],"(DAS28)":[133],"analysis.":[137],"mouse":[140,192],"model":[141],"RA,":[143],"transgenic":[144],"expression":[145],"or":[148],"genetic":[149],"deletion":[150],"accelerated":[153],"progression":[155,189],"collagen-induced":[157,219],"arthritis,":[158],"accompanied":[159],"enhanced":[161],"B":[164],"cell-mediated":[165],"as":[168,170,203],"well":[169],"activity":[172,230],"neutrophils.":[174],"Expression":[175],"vivo":[177],"agonist,":[180],"B7-H4-immunoglobulin":[182],"Fc":[183],"fusion":[184],"protein,":[185],"profoundly":[186],"suppressed":[187],"model.":[193],"CONCLUSIONS:":[194],"Our":[195],"findings":[196,244],"mice":[198],"indicate":[199],"that":[200],"acts":[202],"decoy":[205],"block":[208],"functions":[211],"cell-surface":[213],"leading":[215],"exacerbation":[217],"arthritis.":[220],"If":[221],"preliminary":[223],"correlation":[224],"between":[225],"can":[235],"be":[236],"confirmed":[237],"reflect":[239],"similar":[241],"mechanism,":[242],"these":[243],"suggest":[245],"novel":[247],"treatment":[250],"approaches.":[251],"Please":[252],"see":[253],"later":[254],"article":[257],"Editors'":[260],"Summary.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}