{"id":"https://openalex.org/W2021096771","doi":"https://doi.org/10.1074/jbc.m111.290825","title":"Inhibitors of Src and Focal Adhesion Kinase Promote Endocrine Specification","display_name":"Inhibitors of Src and Focal Adhesion Kinase Promote Endocrine Specification","publication_year":2011,"publication_date":"2011-08-19","ids":{"openalex":"https://openalex.org/W2021096771","doi":"https://doi.org/10.1074/jbc.m111.290825","mag":"2021096771","pmid":"https://pubmed.ncbi.nlm.nih.gov/21852242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3195622"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.290825","doi":"https://doi.org/10.1074/jbc.m111.290825","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.290825","pdf_url":"http://www.jbc.org/article/S0021925820738111/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820738111/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069696615","display_name":"Ivka Afrikanova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivka Afrikanova","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","Department of Pediatrics, University of California San Diego, San Diego, California 92121","Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003994815","display_name":"Mayra Yebra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayra Yebra","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","Department of Pediatrics, University of California San Diego, San Diego, California 92121","Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037068464","display_name":"Megan Simpkinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Simpkinson","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","Department of Pediatrics, University of California San Diego, San Diego, California 92121","Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100779940","display_name":"Yang Xu","orcid":"https://orcid.org/0000-0001-5574-921X","observed_orcids":["https://orcid.org/0000-0001-5574-921X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Xu","raw_affiliation_strings":["Division of Biological Science, University of California San Diego, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Science, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090226966","display_name":"Alberto Hayek","orcid":"https://orcid.org/0009-0009-7736-5503","observed_orcids":["https://orcid.org/0009-0009-7736-5503"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alberto Hayek","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","Department of Pediatrics, University of California San Diego, San Diego, California 92121","Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109282882","display_name":"Anthony M.P. Montgomery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony Montgomery","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121. Electronic address: ammontgo@ucsd.edu","Department of Pediatrics, University of California San Diego, San Diego, California 92121","Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121; Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121. Electronic address: ammontgo@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Pediatric Diabetes Research Center, University of California San Diego, San Diego, California 92121","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109282882"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.1827,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.86728876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"286","issue":"41","first_page":"36042","last_page":"36052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-cell-differentiation","display_name":"beta cell differentiation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.8730000257492065},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pp2","display_name":"PP2","score":0.9089999794960022},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ngn3","display_name":"Ngn3","score":0.8960000276565552},{"id":"https://openalex.org/keywords/neurod1","display_name":"NeuroD1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nkx2-2","display_name":"Nkx2.2","score":1.0},{"id":"https://openalex.org/keywords/pax4","display_name":"Pax4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tgf-beta-smad2-3-signaling","display_name":"TGF-\u03b2/Smad2/3 signaling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/p57kip2","display_name":"p57KIP2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/id1","display_name":"Id1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/id2","display_name":"Id2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-producing-cells","display_name":"insulin-producing cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/diabetes-cell-therapy","display_name":"diabetes cell therapy","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5789743661880493},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5564516186714172},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5392277836799622},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5340961813926697},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.49024897813796997},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4565254747867584},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.45609888434410095},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4539806544780731},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36745959520339966},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33993762731552124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32766515016555786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15638011693954468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08082479238510132},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090322","descriptor_name":"Homeobox Protein Nkx-2.2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050761","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p57","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051797","descriptor_name":"Inhibitor of Differentiation Protein 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051798","descriptor_name":"Inhibitor of Differentiation Protein 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051899","descriptor_name":"Smad2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m111.290825","doi":"https://doi.org/10.1074/jbc.m111.290825","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.290825","pdf_url":"http://www.jbc.org/article/S0021925820738111/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2461137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3195622","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3195622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3195622","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21852242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21852242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.290825","doi":"https://doi.org/10.1074/jbc.m111.290825","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.290825","pdf_url":"http://www.jbc.org/article/S0021925820738111/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320306380","display_name":"Larry L. Hillblom Foundation","ror":"https://ror.org/00br6vq85"},{"id":"https://openalex.org/F4320309885","display_name":"California Institute of Regenerative Medicine","ror":"https://ror.org/033m8b439"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2021096771.pdf","grobid_xml":"https://content.openalex.org/works/W2021096771.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W37370853","https://openalex.org/W1586680337","https://openalex.org/W1824239451","https://openalex.org/W1964480894","https://openalex.org/W1965878299","https://openalex.org/W1969342647","https://openalex.org/W1979452780","https://openalex.org/W1980415923","https://openalex.org/W1981960957","https://openalex.org/W1984477435","https://openalex.org/W1989167529","https://openalex.org/W2003023514","https://openalex.org/W2006637593","https://openalex.org/W2007951709","https://openalex.org/W2010513479","https://openalex.org/W2023029824","https://openalex.org/W2025839193","https://openalex.org/W2031569048","https://openalex.org/W2033552769","https://openalex.org/W2034540804","https://openalex.org/W2044903738","https://openalex.org/W2047732446","https://openalex.org/W2050432303","https://openalex.org/W2053837765","https://openalex.org/W2054361177","https://openalex.org/W2069180517","https://openalex.org/W2073603121","https://openalex.org/W2086692735","https://openalex.org/W2093103652","https://openalex.org/W2095298909","https://openalex.org/W2097233438","https://openalex.org/W2097281134","https://openalex.org/W2098798309","https://openalex.org/W2102019072","https://openalex.org/W2106219965","https://openalex.org/W2120440477","https://openalex.org/W2126412386","https://openalex.org/W2132670099","https://openalex.org/W2134202966","https://openalex.org/W2135604793","https://openalex.org/W2136465065","https://openalex.org/W2137987484","https://openalex.org/W2138726422","https://openalex.org/W2140662194","https://openalex.org/W2145615770","https://openalex.org/W2151224963","https://openalex.org/W2157820793","https://openalex.org/W2158769524","https://openalex.org/W2169191544","https://openalex.org/W2170781656","https://openalex.org/W4390472953"],"related_works":["https://openalex.org/W3099956245","https://openalex.org/W2545599580","https://openalex.org/W2611644318","https://openalex.org/W7205709233","https://openalex.org/W4396606907","https://openalex.org/W2318822064","https://openalex.org/W1872821774","https://openalex.org/W4379055968","https://openalex.org/W3138238652","https://openalex.org/W6939479740"],"abstract_inverted_index":{"Stepwise":[0],"approaches":[1],"for":[2,135,194,199],"the":[3,22,34,44,59,74,86,156,171,174,183,195,200,210],"derivation":[4,196],"of":[5,18,25,47,61,77,88,96,111,145,155,164,173,185,197,203],"\u03b2-cells":[6,198],"from":[7],"human":[8,48,124],"embryonic":[9,49],"stem":[10,50],"cells":[11],"have":[12],"been":[13],"described.":[14],"However,":[15],"low":[16],"levels":[17],"endocrine":[19,45,105,138,150,216],"specification":[20,46,151],"limit":[21],"final":[23,75],"yield":[24,76],"insulin-producing":[26],"\u03b2-cells.":[27],"In":[28],"this":[29,97],"study,":[30],"we":[31,141,160],"show":[32,161],"that":[33,83,128,143,162,213],"pyrrolo-pyrimidine":[35],"Src":[36],"family":[37],"kinase":[38,91,98,177],"(SFK)":[39],"inhibitor":[40,178],"PP2":[41,84],"effectively":[42],"promotes":[43],"cell":[51,168],"derivatives":[52],"based":[53,107],"on":[54,108,209],"its":[55],"capacity":[56],"to":[57,71,102],"induce":[58,103],"expression":[60,110,172,184],"proendocrine":[62],"transcription":[63],"factors":[64],"(NGN3,":[65],"NEUROD1,":[66,113],"NKX2.2,":[67],"and":[68,70,93,114,122,180,187,205],"PAX4)":[69],"significantly":[72],"increase":[73],"insulin-positive":[78],"cells.":[79],"We":[80],"further":[81],"demonstrate":[82],"inhibits":[85],"activation":[87,154],"focal":[89],"adhesion":[90],"(FAK),":[92],"selective":[94],"inhibition":[95,144,163],"is":[99,130],"also":[100],"sufficient":[101],"early":[104,137,215],"commitment":[106],"increased":[109],"NGN3,":[112],"NKX2.2.":[115],"Additional":[116],"studies":[117],"using":[118],"dominant":[119],"negative":[120],"constructs":[121],"isolated":[123],"fetal":[125],"pancreata":[126],"suggest":[127],"c-Src":[129],"at":[131],"least":[132],"partially":[133],"responsible":[134],"inhibiting":[136],"specification.":[139,217],"Mechanistically,":[140],"propose":[142],"SFK/FAK":[146,165],"signaling":[147,166,211],"can":[148],"promote":[149],"by":[152],"limiting":[153],"TGF\u03b2R/Smad2/3":[157],"pathway.":[158],"Moreover,":[159],"suppresses":[167,182],"growth,":[169],"increases":[170],"\u03b2-cell-associated":[175],"cyclin-dependent":[176],"p57kip2,":[179],"simultaneously":[181],"Id1":[186],"Id2.":[188],"This":[189],"study":[190],"has":[191],"important":[192],"implications":[193],"cell-based":[201],"therapy":[202],"diabetes":[204],"sheds":[206],"new":[207],"light":[208],"events":[212],"regulate":[214]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
