{"id":"https://openalex.org/W2021061","doi":null,"title":"The effect of the bicarbonate anion on serum ionized calcium concentration in vitro.","display_name":"The effect of the bicarbonate anion on serum ionized calcium concentration in vitro.","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2021061","mag":"2021061","pmid":"https://pubmed.ncbi.nlm.nih.gov/6317778"},"language":"en","primary_location":{"id":"pmid:6317778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6317778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110609817","display_name":"William S. Hughes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W S Hughes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020484711","display_name":"Gerald D. Aurbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G D Aurbach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050967567","display_name":"Mark Sharp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Sharp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103038670","display_name":"Stephen J. Marx","orcid":"https://orcid.org/0000-0001-9317-332X","observed_orcids":["https://orcid.org/0000-0001-9317-332X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Marx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4865,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.60584316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"103","issue":"1","first_page":"93","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bicarbonate","display_name":"bicarbonate","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ionized-calcium","display_name":"ionized calcium","score":0.9279999732971191},{"id":"https://openalex.org/keywords/serum-calcium","display_name":"serum calcium","score":0.8669999837875366},{"id":"https://openalex.org/keywords/acid-base-balance","display_name":"acid-base balance","score":0.7599999904632568},{"id":"https://openalex.org/keywords/ph","display_name":"pH","score":0.3479999899864197},{"id":"https://openalex.org/keywords/partial-pressure-of-co2","display_name":"partial pressure of CO2","score":0.8399999737739563},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.5659999847412109},{"id":"https://openalex.org/keywords/respiratory-acid-base-disorders","display_name":"respiratory acid-base disorders","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.9250245094299316},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.855846643447876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8236192464828491},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.5597206354141235},{"id":"https://openalex.org/C2777140959","wikidata":"https://www.wikidata.org/wiki/Q10343041","display_name":"pCO2","level":2,"score":0.5095722675323486},{"id":"https://openalex.org/C115900902","wikidata":"https://www.wikidata.org/wiki/Q378751","display_name":"Acid\u2013base reaction","level":2,"score":0.4301326274871826},{"id":"https://openalex.org/C530467964","wikidata":"https://www.wikidata.org/wiki/Q1997","display_name":"Carbon dioxide","level":2,"score":0.4247297942638397},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.4197431802749634},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34512102603912354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3011053204536438},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.04700163006782532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000137","descriptor_name":"Acid-Base Imbalance","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006934","descriptor_name":"Hypercalcemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017693","descriptor_name":"Sodium Bicarbonate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6317778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6317778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2021061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6317778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1998438526","https://openalex.org/W2004913891","https://openalex.org/W2012435565","https://openalex.org/W2043002242","https://openalex.org/W2082626835","https://openalex.org/W2087629637","https://openalex.org/W2111425597","https://openalex.org/W2342126793","https://openalex.org/W2410070583","https://openalex.org/W2790245058"],"related_works":["https://openalex.org/W2026478486","https://openalex.org/W2163128910","https://openalex.org/W89848122","https://openalex.org/W1996888106","https://openalex.org/W1992837708","https://openalex.org/W2147929384","https://openalex.org/W2046607827","https://openalex.org/W2083884259","https://openalex.org/W2077185125","https://openalex.org/W2406869006"],"abstract_inverted_index":{"The":[0,21],"effect":[1,151,156,168,173],"of":[2,29,38,58,62,83,94],"changes":[3],"in":[4,14,16,23,40,48,77,91,105,113,142],"bicarbonate":[5,95,126,150,167],"ion":[6,10,159,176],"concentration":[7,11],"on":[8,157,174],"calcium":[9,133,140,158,175],"was":[12,56],"examined":[13],"vitro":[15],"serum":[17,50,67,97],"and":[18,51],"protein-free":[19,41,52],"solution.":[20,42,53],"findings":[22,122],"this":[24],"study":[25],"support":[26],"the":[27,59,117,149,154,166,171],"formation":[28],"a":[30,36,81,101,111],"calcium-bicarbonate":[31],"complex":[32],"(CaHCO3+)":[33],"that":[34,108,124],"has":[35],"KA":[37],"5.20":[39],"[Ca++]":[43,63,68,106],"varied":[44,69],"inversely":[45],"with":[46,64,80],"[HCO3-]":[47,78],"both":[49],"This":[54],"variation":[55,61,82],"independent":[57],"known":[60],"pH.":[65,92],"In":[66,145,161],"0.0036":[70],"mM":[71,75,85],"Ca++":[72,86],"per":[73,87],"1":[74],"change":[76,90],"compared":[79],"0.0060":[84],"0.01":[88],"unit":[89],"Addition":[93],"to":[96,153],"(Pco2":[98],"constant)":[99],"produced":[100,109],"50%":[102],"greater":[103],"decrease":[104],"than":[107],"by":[110],"reduction":[112],"Pco2":[114],"which":[115],"gave":[116],"same":[118],"pH":[119,155,172],"change.":[120],"These":[121],"indicate":[123],"abnormal":[125],"concentrations":[127,134],"should":[128],"be":[129],"considered":[130],"when":[131],"ionized":[132],"are":[135],"estimated":[136],"from":[137,170],"total":[138],"plasma":[139],"values":[141],"acid-base":[143,147,164],"disorders.":[144],"metabolic":[146],"disorders,":[148,165],"adds":[152],"concentration.":[160,177],"compensated":[162],"respiratory":[163],"subtracts":[169]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}