{"id":"https://openalex.org/W2021045641","doi":"https://doi.org/10.1097/00043426-200401000-00012","title":"Radically Different Treatment Recommendations for Newly Diagnosed Neuroblastoma: Pitfalls in Assessment of Risk","display_name":"Radically Different Treatment Recommendations for Newly Diagnosed Neuroblastoma: Pitfalls in Assessment of Risk","publication_year":2003,"publication_date":"2003-12-24","ids":{"openalex":"https://openalex.org/W2021045641","doi":"https://doi.org/10.1097/00043426-200401000-00012","mag":"2021045641","pmid":"https://pubmed.ncbi.nlm.nih.gov/14707711"},"language":"en","primary_location":{"id":"doi:10.1097/00043426-200401000-00012","doi":"https://doi.org/10.1097/00043426-200401000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00043426-200401000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043729995","display_name":"Brian H. Kushner","orcid":"https://orcid.org/0000-0002-8916-0697","observed_orcids":["https://orcid.org/0000-0002-8916-0697"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian H. Kushner","raw_affiliation_strings":["Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. kushnerb@mskcc.org","the Departments of *Pediatrics and \u2020Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. kushnerb@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"the Departments of *Pediatrics and \u2020Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002140630","display_name":"Michael P. LaQuaglia","orcid":"https://orcid.org/0000-0002-7059-9851","observed_orcids":["https://orcid.org/0000-0002-7059-9851"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. LaQuaglia","raw_affiliation_strings":["the Departments of *Pediatrics and \u2020Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of *Pediatrics and \u2020Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034325765","display_name":"Kim Kramer","orcid":"https://orcid.org/0000-0002-3803-878X","observed_orcids":["https://orcid.org/0000-0002-3803-878X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kim Kramer","raw_affiliation_strings":["the Departments of *Pediatrics and \u2020Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of *Pediatrics and \u2020Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034081882","display_name":"Nai\u2010Kong V. Cheung","orcid":"https://orcid.org/0000-0001-6323-5171","observed_orcids":["https://orcid.org/0000-0001-6323-5171"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nai-Kong V. Cheung","raw_affiliation_strings":["the Departments of *Pediatrics and \u2020Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of *Pediatrics and \u2020Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034081882","https://openalex.org/A5034325765","https://openalex.org/A5043729995"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":1.0764,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.76925988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"26","issue":"1","first_page":"35","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inss","display_name":"INSS","score":0.906000018119812},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8999999761581421},{"id":"https://openalex.org/keywords/second-opinion","display_name":"second opinion","score":0.6359999775886536},{"id":"https://openalex.org/keywords/myeloablative-therapy","display_name":"myeloablative therapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.6060000061988831},{"id":"https://openalex.org/keywords/bone-marrow-involvement","display_name":"bone marrow involvement","score":0.5490000247955322},{"id":"https://openalex.org/keywords/spinal-metastases","display_name":"spinal metastases","score":0.43700000643730164},{"id":"https://openalex.org/keywords/retroperitoneal-mass","display_name":"retroperitoneal mass","score":0.6779999732971191},{"id":"https://openalex.org/keywords/low-risk-neuroblastoma","display_name":"low-risk neuroblastoma","score":0.550000011920929},{"id":"https://openalex.org/keywords/treatment-de-escalation","display_name":"treatment de-escalation","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9574199318885803},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.777338981628418},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6459273099899292},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5596482753753662},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46438607573509216},{"id":"https://openalex.org/C4441509","wikidata":"https://www.wikidata.org/wiki/Q6418787","display_name":"Multimodal therapy","level":2,"score":0.45571446418762207},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4425106346607208},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.44035714864730835},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.42990565299987793},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4175957143306732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2766941785812378},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23975032567977905},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006287","descriptor_name":"Health Planning Guidelines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00043426-200401000-00012","doi":"https://doi.org/10.1097/00043426-200401000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00043426-200401000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},{"id":"pmid:14707711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14707711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric hematology/oncology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1610969327","https://openalex.org/W1810885877","https://openalex.org/W1899939340","https://openalex.org/W1909200755","https://openalex.org/W1943002254","https://openalex.org/W1956505774","https://openalex.org/W1959376412","https://openalex.org/W1969863577","https://openalex.org/W1970380630","https://openalex.org/W2002314852","https://openalex.org/W2036502860","https://openalex.org/W2093202549","https://openalex.org/W2096398040","https://openalex.org/W2101603147","https://openalex.org/W2130002311","https://openalex.org/W2157341748","https://openalex.org/W2291033035","https://openalex.org/W2327522594","https://openalex.org/W2415129127"],"related_works":["https://openalex.org/W2793376960","https://openalex.org/W4242436435","https://openalex.org/W4226143141","https://openalex.org/W2897692211","https://openalex.org/W1999846077","https://openalex.org/W2271226922","https://openalex.org/W4399215719","https://openalex.org/W2915044657","https://openalex.org/W3126515441","https://openalex.org/W2059586806"],"abstract_inverted_index":{"Neuroblastoma":[0,67],"risk":[1,42,218,226],"stratification":[2],"is":[3],"based":[4],"on":[5,51],"stage,":[6],"age,":[7],"and":[8,10,21,107,137,147,176,238,257],"biology":[9],"prescribes":[11],"surgery":[12,84],"for":[13,18,31,58,74],"low-risk":[14],"disease,":[15,20,156],"moderate-dose":[16],"chemotherapy":[17],"intermediate-risk":[19],"maximal":[22,75],"therapy":[23,120],"(including":[24],"myeloablative":[25],"treatment":[26],"with":[27,44,221,235,289],"stem":[28],"cell":[29],"transplantation)":[30],"high-risk":[32,283],"disease.":[33,201],"Four":[34],"cases":[35],"are":[36],"described":[37],"that":[38],"depict":[39],"pitfalls":[40],"in":[41,98,166,263,272],"assessment":[43],"potentially":[45],"far-reaching":[46],"consequences.":[47],"This":[48],"report":[49],"focuses":[50],"a":[52,195,232,264,270],"subset":[53],"of":[54,100,170,254],"four":[55,102,114],"patients":[56,115,279],"referred":[57],"second":[59,78],"opinions.":[60],"Stage":[61],"was":[62,96,145,184,211,250],"defined":[63],"by":[64],"the":[65,101,143,148,171,177,208,214],"International":[66],"Staging":[68],"System.":[69],"The":[70,252],"first":[71],"recommendations":[72],"were":[73,80,89,111],"therapy,":[76],"but":[77,104,161,198],"opinions":[79],"radically":[81],"different":[82],"(ie,":[83],"alone).":[85],"Ages":[86],"at":[87],"diagnosis":[88],"15":[90],"to":[91,127,190,205,224,274],"25":[92],"months.":[93],"Shimada":[94],"histopathology":[95],"unfavorable":[97,222,236],"three":[99],"patients,":[103],"chromosomal,":[105],"serum,":[106],"urine":[108],"prognostic":[109,276],"markers":[110],"favorable.":[112],"All":[113],"did":[116],"well":[117,288],"without":[118,157],"cytotoxic":[119,291],"(follow-up:":[121],"2":[122,153],"years":[123,129],"10":[124],"months":[125,131],"plus":[126],"4":[128,189,230],"8":[130],"plus).":[132],"Patient":[133,152,192,229],"1":[134],"had":[135,154,194,231],"abdominal":[136,209],"upper":[138],"thoracic/supraclavicular":[139],"masses":[140],"(stage":[141,219,227,244],"4);":[142],"former":[144],"resected":[146],"latter":[149,172],"spontaneously":[150],"regressed.":[151],"retroperitoneal":[155,196],"bone":[158,256,259],"marrow":[159,260],"involvement,":[160],"imaging":[162],"studies":[163],"showed":[164,173],"lesions":[165],"vertebral":[167],"bodies.":[168],"Biopsies":[169],"no":[174,199,290],"neuroblastoma":[175,266,284],"primary":[178],"tumor":[179,210],"(with":[180],"regional":[181],"lymph":[182,241],"nodes)":[183],"resected,":[185],"changing":[186,213],"stage":[187],"from":[188,216],"2B.":[191],"3":[193,220],"mass":[197],"distant":[200],"Though":[202],"initially":[203],"deemed":[204],"be":[206],"unresectable,":[207],"excised,":[212],"classification":[215],"high":[217],"histopathology)":[223],"low":[225],"1).":[228],"pelvic":[233],"mass,":[234],"histopathology,":[237],"bilateral":[239],"inguinal":[240],"node":[242],"involvement":[243,262],"3);":[245],"all":[246],"soft":[247],"tissue":[248],"disease":[249],"resected.":[251],"absence":[253],"cortical":[255],"extensive":[258],"metastatic":[261],"young":[265],"patient":[267],"should":[268],"cause":[269],"shift":[271],"attention":[273],"biologic":[275],"markers.":[277],"Some":[278],"classified":[280],"as":[281],"having":[282],"might":[285],"actually":[286],"do":[287],"therapy.":[292]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}