{"id":"https://openalex.org/W2020996799","doi":"https://doi.org/10.1016/j.bmcl.2013.02.027","title":"Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors","display_name":"Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors","publication_year":2013,"publication_date":"2013-02-14","ids":{"openalex":"https://openalex.org/W2020996799","doi":"https://doi.org/10.1016/j.bmcl.2013.02.027","mag":"2020996799","pmid":"https://pubmed.ncbi.nlm.nih.gov/23453843"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2013.02.027","doi":"https://doi.org/10.1016/j.bmcl.2013.02.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2013.02.027","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054145161","display_name":"Mohamed Elagawany","orcid":"https://orcid.org/0000-0002-1597-5324","observed_orcids":["https://orcid.org/0000-0002-1597-5324"]},"institutions":[{"id":"https://openalex.org/I154632036","display_name":"Misr University for Science and Technology","ror":"https://ror.org/05debfq75","country_code":"EG","type":"education","lineage":["https://openalex.org/I154632036"]},{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["EG","FR"],"is_corresponding":true,"raw_author_name":"Mohamed Elagawany","raw_affiliation_strings":["Laboratoire d'innovation th\u00e9rapeutique, UMR 7200, Facult\u00e9 de Pharmacie, Universit\u00e9 de Strasbourg, 74-route du Rhin, BP 60024, 67401 ILLKIRCH Cedex, France. alfath_tours@yahoo.com","Laboratoire d'innovation th\u00e9rapeutique, UMR 7200, Facult\u00e9 de Pharmacie, Universit\u00e9 de Strasbourg, 74-route du Rhin, BP 60024, 67401 ILLKIRCH Cedex, France","Organic Chemistry Department, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, 6th of the October, PO Box 77, Egypt","Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'innovation th\u00e9rapeutique, UMR 7200, Facult\u00e9 de Pharmacie, Universit\u00e9 de Strasbourg, 74-route du Rhin, BP 60024, 67401 ILLKIRCH Cedex, France. alfath_tours@yahoo.com","institution_ids":["https://openalex.org/I4210116974","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Laboratoire d'innovation th\u00e9rapeutique, UMR 7200, Facult\u00e9 de Pharmacie, Universit\u00e9 de Strasbourg, 74-route du Rhin, BP 60024, 67401 ILLKIRCH Cedex, France","institution_ids":["https://openalex.org/I4210116974","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Organic Chemistry Department, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, 6th of the October, PO Box 77, Egypt","institution_ids":["https://openalex.org/I154632036"]},{"raw_affiliation_string":"Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078045418","display_name":"Mohamed A. Ibrahim","orcid":"https://orcid.org/0000-0003-0257-860X","observed_orcids":["https://orcid.org/0000-0003-0257-860X"]},"institutions":[{"id":"https://openalex.org/I154632036","display_name":"Misr University for Science and Technology","ror":"https://ror.org/05debfq75","country_code":"EG","type":"education","lineage":["https://openalex.org/I154632036"]},{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["EG","FR"],"is_corresponding":false,"raw_author_name":"Mohamed A. Ibrahim","raw_affiliation_strings":["Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519, Egypt","Laboratoire d\u2019innovation th\u00e9rapeutique, UMR 7200, Facult\u00e9 de Pharmacie, Universit\u00e9 de Strasbourg, 74-route du Rhin, BP 60024, 67401 ILLKIRCH Cedex, France","Organic Chemistry Department, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, 6th of the October, PO Box 77, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519, Egypt","institution_ids":["https://openalex.org/I192398990"]},{"raw_affiliation_string":"Laboratoire d\u2019innovation th\u00e9rapeutique, UMR 7200, Facult\u00e9 de Pharmacie, Universit\u00e9 de Strasbourg, 74-route du Rhin, BP 60024, 67401 ILLKIRCH Cedex, France","institution_ids":["https://openalex.org/I4210116974","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Organic Chemistry Department, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, 6th of the October, PO Box 77, Egypt","institution_ids":["https://openalex.org/I154632036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082515316","display_name":"Hany E. A. Ahmed","orcid":"https://orcid.org/0000-0001-8898-8452","observed_orcids":["https://orcid.org/0000-0001-8898-8452"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]},{"id":"https://openalex.org/I23075662","display_name":"Taibah University","ror":"https://ror.org/01xv1nn60","country_code":"SA","type":"education","lineage":["https://openalex.org/I23075662"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Hany Emary Ali Ahmed","raw_affiliation_strings":["Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt","Pharmacognosy and Pharmaceutical Chemistry Department, Pharmacy College, Taibah University, Al-Madinaha Al-Munawaraha, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt","institution_ids":["https://openalex.org/I184834183"]},{"raw_affiliation_string":"Pharmacognosy and Pharmaceutical Chemistry Department, Pharmacy College, Taibah University, Al-Madinaha Al-Munawaraha, Saudi Arabia","institution_ids":["https://openalex.org/I23075662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005915201","display_name":"Abd-Allah Sh. El-Etrawy","orcid":"https://orcid.org/0000-0001-6160-798X","observed_orcids":["https://orcid.org/0000-0001-6160-798X"]},"institutions":[{"id":"https://openalex.org/I154632036","display_name":"Misr University for Science and Technology","ror":"https://ror.org/05debfq75","country_code":"EG","type":"education","lineage":["https://openalex.org/I154632036"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"A.Sh. El-Etrawy","raw_affiliation_strings":["Organic Chemistry Department, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, 6th of the October, PO Box 77, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organic Chemistry Department, College of Pharmacy, Misr University for Science and Technology, Al-Motamayez District, 6th of the October, PO Box 77, Egypt","institution_ids":["https://openalex.org/I154632036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037180909","display_name":"Adel H. Ghiaty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Adel Ghiaty","raw_affiliation_strings":["Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083580285","display_name":"Zakaria K. Abdel\u2010Samii","orcid":"https://orcid.org/0000-0002-9088-414X","observed_orcids":["https://orcid.org/0000-0002-9088-414X"]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Zakaria K. Abdel-Samii","raw_affiliation_strings":["Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101626528","display_name":"Said A. El\u2010Feky","orcid":"https://orcid.org/0000-0003-0450-5949","observed_orcids":["https://orcid.org/0000-0003-0450-5949"]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Said A. El-Feky","raw_affiliation_strings":["Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039926688","display_name":"J\u00fcrgen Bajorath","orcid":"https://orcid.org/0000-0002-0557-5714","observed_orcids":["https://orcid.org/0000-0002-0557-5714"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Bajorath","raw_affiliation_strings":["Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, Dahlmannstr. 2, D-53113 Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, Dahlmannstr. 2, D-53113 Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5054145161"],"corresponding_institution_ids":["https://openalex.org/I154632036","https://openalex.org/I184834183","https://openalex.org/I4210116974","https://openalex.org/I68947357"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":1.786,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.82587417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"7","first_page":"2007","last_page":"2013"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyridazinone-derivatives","display_name":"pyridazinone derivatives","score":0.9940000176429749},{"id":"https://openalex.org/keywords/phthalazinone-derivatives","display_name":"phthalazinone derivatives","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-kinase-inhibitors","display_name":"protein kinase inhibitors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dyrk1a","display_name":"DYRK1A","score":0.847000002861023},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.8830000162124634},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7760000228881836},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.8349999785423279},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8787564039230347},{"id":"https://openalex.org/C2777736865","wikidata":"https://www.wikidata.org/wiki/Q17915111","display_name":"DYRK1A","level":3,"score":0.8666260242462158},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7473919987678528},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.5452171564102173},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.5444594025611877},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.5379137992858887},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5230984687805176},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.4889344274997711},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45551955699920654},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.45292723178863525},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.44969823956489563},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4387661814689636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4261387586593628},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.42372560501098633},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3695923388004303},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.36930662393569946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097603","descriptor_name":"Dyrk Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047389","descriptor_name":"Casein Kinase I","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047389","descriptor_name":"Casein Kinase I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2013.02.027","doi":"https://doi.org/10.1016/j.bmcl.2013.02.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2013.02.027","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:23453843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23453843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1515449698","https://openalex.org/W1964504843","https://openalex.org/W1966164508","https://openalex.org/W1970197612","https://openalex.org/W1989404928","https://openalex.org/W1995377960","https://openalex.org/W2003570263","https://openalex.org/W2019171844","https://openalex.org/W2028867134","https://openalex.org/W2030205108","https://openalex.org/W2030873096","https://openalex.org/W2034595626","https://openalex.org/W2048262770","https://openalex.org/W2049942764","https://openalex.org/W2065983808","https://openalex.org/W2072574664","https://openalex.org/W2077804275","https://openalex.org/W2082309242","https://openalex.org/W2084810833","https://openalex.org/W2096864392","https://openalex.org/W2140973257","https://openalex.org/W2154046401","https://openalex.org/W2166317851","https://openalex.org/W2951336635"],"related_works":["https://openalex.org/W2932918631","https://openalex.org/W2000341787","https://openalex.org/W2566987377","https://openalex.org/W2491033299","https://openalex.org/W3131095782","https://openalex.org/W2028697520","https://openalex.org/W2054228896","https://openalex.org/W2117905439","https://openalex.org/W4244146685","https://openalex.org/W3210278381"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}