{"id":"https://openalex.org/W2020989264","doi":"https://doi.org/10.1007/s10637-013-9942-y","title":"Phase I clinical and pharmacokinetic study of trabectedin and cisplatin given every three weeks in patients with advanced solid tumors","display_name":"Phase I clinical and pharmacokinetic study of trabectedin and cisplatin given every three weeks in patients with advanced solid tumors","publication_year":2013,"publication_date":"2013-03-06","ids":{"openalex":"https://openalex.org/W2020989264","doi":"https://doi.org/10.1007/s10637-013-9942-y","mag":"2020989264","pmid":"https://pubmed.ncbi.nlm.nih.gov/23467812"},"language":"en","primary_location":{"id":"doi:10.1007/s10637-013-9942-y","doi":"https://doi.org/10.1007/s10637-013-9942-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-013-9942-y","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086081284","display_name":"Cristiana Sessa","orcid":"https://orcid.org/0000-0001-8132-2527","observed_orcids":["https://orcid.org/0000-0001-8132-2527"]},"institutions":[{"id":"https://openalex.org/I4210095573","display_name":"Ospedale San Giovanni Bellinzona","ror":"https://ror.org/00mbsbt95","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095573"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Cristiana Sessa","raw_affiliation_strings":["Istituto Oncologico della Svizzera (IOSI), Ospedale San Giovanni, 6500, Bellinzona, Switzerland, Cristiana.Sessa@eoc.ch","Istituto Oncologico della Svizzera (IOSI), Ospedale San Giovanni, 6500, Bellinzona, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Oncologico della Svizzera (IOSI), Ospedale San Giovanni, 6500, Bellinzona, Switzerland, Cristiana.Sessa@eoc.ch","institution_ids":["https://openalex.org/I4210095573","https://openalex.org/I4404532900"]},{"raw_affiliation_string":"Istituto Oncologico della Svizzera (IOSI), Ospedale San Giovanni, 6500, Bellinzona, Switzerland","institution_ids":["https://openalex.org/I4210095573","https://openalex.org/I4404532900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071606172","display_name":"Gianluca Del Conte","orcid":"https://orcid.org/0000-0002-5066-5700","observed_orcids":["https://orcid.org/0000-0002-5066-5700"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Del Conte","raw_affiliation_strings":["Unit of New Drugs and Innovative Therapies, Department of Medical Oncology, San Raffaele Hospital, IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of New Drugs and Innovative Therapies, Department of Medical Oncology, San Raffaele Hospital, IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046897083","display_name":"Alexandre Christinat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095573","display_name":"Ospedale San Giovanni Bellinzona","ror":"https://ror.org/00mbsbt95","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095573"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexandre Christinat","raw_affiliation_strings":["Istituto Oncologico della Svizzera (IOSI), Ospedale San Giovanni, 6500, Bellinzona, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Oncologico della Svizzera (IOSI), Ospedale San Giovanni, 6500, Bellinzona, Switzerland","institution_ids":["https://openalex.org/I4210095573","https://openalex.org/I4404532900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025221164","display_name":"Sara Cresta","orcid":"https://orcid.org/0000-0002-6830-0662","observed_orcids":["https://orcid.org/0000-0002-6830-0662"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Cresta","raw_affiliation_strings":["Istituto Nazionale dei Tumori, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale dei Tumori, Milano, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083667929","display_name":"Antonella Perotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Perotti","raw_affiliation_strings":["Unit of New Drugs and Innovative Therapies, Department of Medical Oncology, San Raffaele Hospital, IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of New Drugs and Innovative Therapies, Department of Medical Oncology, San Raffaele Hospital, IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011883364","display_name":"Elisa Gallerani","orcid":"https://orcid.org/0000-0003-4051-0315","observed_orcids":["https://orcid.org/0000-0003-4051-0315"]},"institutions":[{"id":"https://openalex.org/I4210095573","display_name":"Ospedale San Giovanni Bellinzona","ror":"https://ror.org/00mbsbt95","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095573"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Elisa Gallerani","raw_affiliation_strings":["Istituto Oncologico della Svizzera (IOSI), Ospedale San Giovanni, 6500, Bellinzona, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Oncologico della Svizzera (IOSI), Ospedale San Giovanni, 6500, Bellinzona, Switzerland","institution_ids":["https://openalex.org/I4210095573","https://openalex.org/I4404532900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007422243","display_name":"Pilar Lardelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Lardelli","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048766168","display_name":"Carmen Maria Kahatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Kahatt","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048398150","display_name":"Vicente Alfaro","orcid":"https://orcid.org/0000-0002-0150-2390","observed_orcids":["https://orcid.org/0000-0002-0150-2390"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vicente Alfaro","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090502232","display_name":"Jorge Luis Iglesias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jorge L. Iglesias","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090638552","display_name":"Carlos Fern\u00e1ndez\u2010Teruel","orcid":"https://orcid.org/0000-0002-1473-2267","observed_orcids":["https://orcid.org/0000-0002-1473-2267"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Fern\u00e1ndez-Teruel","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058537459","display_name":"Luca Gianni","orcid":"https://orcid.org/0000-0002-2372-9625","observed_orcids":["https://orcid.org/0000-0002-2372-9625"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Gianni","raw_affiliation_strings":["Unit of New Drugs and Innovative Therapies, Department of Medical Oncology, San Raffaele Hospital, IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of New Drugs and Innovative Therapies, Department of Medical Oncology, San Raffaele Hospital, IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086081284"],"corresponding_institution_ids":["https://openalex.org/I4210095573","https://openalex.org/I4404532900"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":1.2097,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.76938686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"5","first_page":"1236","last_page":"1243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.2870999872684479,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.2870999872684479,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.26249998807907104,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.18160000443458557,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trabectedin","display_name":"trabectedin","score":1.0},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/advanced-solid-tumors","display_name":"advanced solid tumors","score":0.902999997138977},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9480000138282776},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/vomiting","display_name":"vomiting","score":0.49900001287460327},{"id":"https://openalex.org/keywords/recommended-dose","display_name":"recommended dose","score":0.7360000014305115},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/safety-profile","display_name":"safety profile","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2780752271","wikidata":"https://www.wikidata.org/wiki/Q2637746","display_name":"Trabectedin","level":4,"score":0.9775742888450623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.779910683631897},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6580442190170288},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5918264389038086},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5828414559364319},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5758565664291382},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5150160789489746},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48394349217414856},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.47267135977745056},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.45351874828338623},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3777053952217102},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.330608606338501},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27505841851234436},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.14532652497291565},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077606","descriptor_name":"Trabectedin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004149","descriptor_name":"Dioxoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004149","descriptor_name":"Dioxoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004149","descriptor_name":"Dioxoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10637-013-9942-y","doi":"https://doi.org/10.1007/s10637-013-9942-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-013-9942-y","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmid:23467812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23467812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320327811","display_name":"PharmaMar","ror":"https://ror.org/02h694m69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1966270249","https://openalex.org/W1980501396","https://openalex.org/W1987646951","https://openalex.org/W1999645826","https://openalex.org/W2003174619","https://openalex.org/W2018169190","https://openalex.org/W2037034361","https://openalex.org/W2037600788","https://openalex.org/W2060096874","https://openalex.org/W2062622745","https://openalex.org/W2065600610","https://openalex.org/W2067000923","https://openalex.org/W2086055140","https://openalex.org/W2107078868","https://openalex.org/W2108162771","https://openalex.org/W2108936162","https://openalex.org/W2110891275","https://openalex.org/W2115369099","https://openalex.org/W2117060150","https://openalex.org/W2123302336","https://openalex.org/W2125064537","https://openalex.org/W2127405377","https://openalex.org/W2130941707","https://openalex.org/W2139248078","https://openalex.org/W2147035647","https://openalex.org/W2153205088","https://openalex.org/W2153356964","https://openalex.org/W2153737617","https://openalex.org/W2156969792","https://openalex.org/W2157585376","https://openalex.org/W2157598836","https://openalex.org/W2168598691","https://openalex.org/W2187415274","https://openalex.org/W2561967435","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2037034361","https://openalex.org/W2062622745","https://openalex.org/W2272256978","https://openalex.org/W1988148939","https://openalex.org/W2164548254","https://openalex.org/W2156969792","https://openalex.org/W2024161443","https://openalex.org/W1988007458","https://openalex.org/W2257092426","https://openalex.org/W2224930545"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
