{"id":"https://openalex.org/W2020982979","doi":"https://doi.org/10.1016/s1388-1981(02)00159-2","title":"Selective mutagenesis of lysyl residues leads to a stable and active form of delta 9 stearoyl-CoA desaturase","display_name":"Selective mutagenesis of lysyl residues leads to a stable and active form of delta 9 stearoyl-CoA desaturase","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W2020982979","doi":"https://doi.org/10.1016/s1388-1981(02)00159-2","mag":"2020982979","pmid":"https://pubmed.ncbi.nlm.nih.gov/12069848"},"language":"en","primary_location":{"id":"doi:10.1016/s1388-1981(02)00159-2","doi":"https://doi.org/10.1016/s1388-1981(02)00159-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1388-1981(02)00159-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037314002","display_name":"Hassan Mziaut","orcid":"https://orcid.org/0000-0002-1743-7933","observed_orcids":["https://orcid.org/0000-0002-1743-7933"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hassan Mziaut","raw_affiliation_strings":["Department of Biochemistry, University of Connecticut Health Center, Farmington 06030-3305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Connecticut Health Center, Farmington 06030-3305, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027003258","display_name":"George Korza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Korza","raw_affiliation_strings":["Department of Biochemistry, University of Connecticut Health Center, Farmington, CT 06030-3305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Connecticut Health Center, Farmington, CT 06030-3305, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070481491","display_name":"Abdellatif Benraiss","orcid":"https://orcid.org/0000-0002-0325-6234","observed_orcids":["https://orcid.org/0000-0002-0325-6234"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdellatif Benraiss","raw_affiliation_strings":["Departments of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009100025","display_name":"Juris Ozols","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Juris Ozols","raw_affiliation_strings":["Department of Biochemistry, University of Connecticut Health Center, Farmington, CT 06030-3305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Connecticut Health Center, Farmington, CT 06030-3305, USA","institution_ids":["https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009100025"],"corresponding_institution_ids":["https://openalex.org/I75929689"],"apc_list":{"value":3670,"currency":"USD","value_usd":3670},"apc_paid":null,"fwci":0.4634,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.49861076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"1583","issue":"1","first_page":"45","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.06759999692440033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase","display_name":"stearoyl-CoA desaturase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.7789999842643738},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-membrane-protein","display_name":"endoplasmic reticulum membrane protein","score":0.8960000276565552},{"id":"https://openalex.org/keywords/desaturase-activity","display_name":"desaturase activity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/gfp-reporter","display_name":"GFP reporter","score":0.43799999356269836},{"id":"https://openalex.org/keywords/mg132","display_name":"MG132","score":0.7599999904632568},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.6788880825042725},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6135545372962952},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5685350894927979},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5009031295776367},{"id":"https://openalex.org/C108305142","wikidata":"https://www.wikidata.org/wiki/Q3062286","display_name":"Heterologous expression","level":4,"score":0.4979112148284912},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49345675110816956},{"id":"https://openalex.org/C33161422","wikidata":"https://www.wikidata.org/wiki/Q5421712","display_name":"Expression vector","level":4,"score":0.475324422121048},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4707625210285187},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.45763519406318665},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.4575897455215454},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4536066949367523},{"id":"https://openalex.org/C2778506107","wikidata":"https://www.wikidata.org/wiki/Q3272916","display_name":"MG132","level":4,"score":0.4516439437866211},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.45078930258750916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4470495879650116},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.42863205075263977},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.42090409994125366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41716551780700684},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40774789452552795},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.30055731534957886},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24011242389678955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23252266645431519},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.21454724669456482},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2103341817855835}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013230","descriptor_name":"Stearoyl-CoA Desaturase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044943","descriptor_name":"Fatty Acid Desaturases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044943","descriptor_name":"Fatty Acid Desaturases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1388-1981(02)00159-2","doi":"https://doi.org/10.1016/s1388-1981(02)00159-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1388-1981(02)00159-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},{"id":"pmid:12069848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12069848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G737904702","display_name":"ISOLATION AND STRUCTURE OF MICROSOMAL MEMBRANE PROTEINS","funder_award_id":"R01GM026351","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1486904951","https://openalex.org/W1496897161","https://openalex.org/W1516929961","https://openalex.org/W1579774371","https://openalex.org/W1580725718","https://openalex.org/W1583341340","https://openalex.org/W1878535762","https://openalex.org/W1967457116","https://openalex.org/W1969460672","https://openalex.org/W1973639954","https://openalex.org/W1978315349","https://openalex.org/W1992856659","https://openalex.org/W2004465970","https://openalex.org/W2007263766","https://openalex.org/W2008744347","https://openalex.org/W2011907662","https://openalex.org/W2015357935","https://openalex.org/W2016777985","https://openalex.org/W2021842042","https://openalex.org/W2044005280","https://openalex.org/W2064627233","https://openalex.org/W2081499148","https://openalex.org/W2090122012","https://openalex.org/W2116967583","https://openalex.org/W2121781216","https://openalex.org/W2126843591","https://openalex.org/W2138009608","https://openalex.org/W2148010796","https://openalex.org/W2164985707","https://openalex.org/W2166987747","https://openalex.org/W2185694111","https://openalex.org/W4236777552"],"related_works":["https://openalex.org/W1516929961","https://openalex.org/W7099459133","https://openalex.org/W2024802425","https://openalex.org/W2116967583","https://openalex.org/W2097058674","https://openalex.org/W2079306618","https://openalex.org/W2148010796","https://openalex.org/W2052613838","https://openalex.org/W2794975867","https://openalex.org/W2341910871"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
