{"id":"https://openalex.org/W2020982033","doi":"https://doi.org/10.1155/2013/203168","title":"Impact of Standardized Allergen-RemovedRhus vernicifluaStokes Extract on Advanced Adenocarcinoma of the Ampulla of Vater: A Case Series","display_name":"Impact of Standardized Allergen-RemovedRhus vernicifluaStokes Extract on Advanced Adenocarcinoma of the Ampulla of Vater: A Case Series","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2020982033","doi":"https://doi.org/10.1155/2013/203168","mag":"2020982033","pmid":"https://pubmed.ncbi.nlm.nih.gov/23710214","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654714"},"language":"en","primary_location":{"id":"doi:10.1155/2013/203168","doi":"https://doi.org/10.1155/2013/203168","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/203168","pdf_url":"https://downloads.hindawi.com/journals/ecam/2013/203168.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/ecam/2013/203168.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112105865","display_name":"Won-Cheol Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woncheol Choi","raw_affiliation_strings":["Department of Medical Consilence, Graduate School, Jukjeon Campus, Dankook University, 152 Jukjeon-ro, Suji-gu, Yongin-si 448-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Consilence, Graduate School, Jukjeon Campus, Dankook University, 152 Jukjeon-ro, Suji-gu, Yongin-si 448-701, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069756184","display_name":"Soomin An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152252","display_name":"Kyung Hee University Hospital at Gangdong","ror":"https://ror.org/05x9xyq11","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210152252","https://openalex.org/I4405258385"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soomin An","raw_affiliation_strings":["Department of Clinical Oncology, Integrative Cancer Center, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Integrative Cancer Center, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210152252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021269021","display_name":"Eun\u2010Mi Kwon","orcid":"https://orcid.org/0000-0003-3871-8379","observed_orcids":["https://orcid.org/0000-0003-3871-8379"]},"institutions":[{"id":"https://openalex.org/I4210152252","display_name":"Kyung Hee University Hospital at Gangdong","ror":"https://ror.org/05x9xyq11","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210152252","https://openalex.org/I4405258385"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunmi Kwon","raw_affiliation_strings":["Department of Clinical Oncology, Integrative Cancer Center, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Integrative Cancer Center, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210152252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061211208","display_name":"Wan Kyu Eo","orcid":"https://orcid.org/0000-0002-9289-371X","observed_orcids":["https://orcid.org/0000-0002-9289-371X"]},"institutions":[{"id":"https://openalex.org/I4210152252","display_name":"Kyung Hee University Hospital at Gangdong","ror":"https://ror.org/05x9xyq11","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210152252","https://openalex.org/I4405258385"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wankyu Eo","raw_affiliation_strings":["Department of Hematology and Oncology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210152252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100405640","display_name":"Sang Hun Lee","orcid":"https://orcid.org/0000-0002-9538-446X","observed_orcids":["https://orcid.org/0000-0002-9538-446X"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sanghun Lee","raw_affiliation_strings":["Department of Medical Consilence, Graduate School, Jukjeon Campus, Dankook University, 152 Jukjeon-ro, Suji-gu, Yongin-si 448-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Consilence, Graduate School, Jukjeon Campus, Dankook University, 152 Jukjeon-ro, Suji-gu, Yongin-si 448-701, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100405640"],"corresponding_institution_ids":["https://openalex.org/I89015989"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":3.9399,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.92098186,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2013","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.45899999141693115,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.45899999141693115,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1542000025510788,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Medical Research and Treatments","score":0.11249999701976776,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhus-verniciflua","display_name":"Rhus verniciflua","score":0.8539999723434448},{"id":"https://openalex.org/keywords/ampullary-adenocarcinoma","display_name":"ampullary adenocarcinoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ampulla-of-vater","display_name":"ampulla of Vater","score":0.7960000038146973},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.5789999961853027},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.5239999890327454},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6899999976158142},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9810000061988831},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8792476654052734},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6468672752380371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5952749848365784},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5762208700180054},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.573041558265686},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5509249567985535},{"id":"https://openalex.org/C2780840399","wikidata":"https://www.wikidata.org/wiki/Q594066","display_name":"Ampulla of Vater","level":3,"score":0.5268957614898682},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3733948767185211},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3046042323112488},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16039210557937622}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1155/2013/203168","doi":"https://doi.org/10.1155/2013/203168","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/203168","pdf_url":"https://downloads.hindawi.com/journals/ecam/2013/203168.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2658340","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654714","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3654714","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654714","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evid Based Complement Alternat Med","raw_type":"Text"},{"id":"pmid:23710214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23710214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based complementary and alternative medicine : eCAM","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:48435732eb014abdbe25b6653f915fbb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/48435732eb014abdbe25b6653f915fbb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2013/203168","doi":"https://doi.org/10.1155/2013/203168","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/203168","pdf_url":"https://downloads.hindawi.com/journals/ecam/2013/203168.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020982033.pdf","grobid_xml":"https://content.openalex.org/works/W2020982033.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1514390757","https://openalex.org/W1558605356","https://openalex.org/W1967297296","https://openalex.org/W1980390240","https://openalex.org/W1989891308","https://openalex.org/W2008236710","https://openalex.org/W2016478463","https://openalex.org/W2020032281","https://openalex.org/W2023509608","https://openalex.org/W2034895966","https://openalex.org/W2045217572","https://openalex.org/W2047445609","https://openalex.org/W2053017034","https://openalex.org/W2059876951","https://openalex.org/W2062779027","https://openalex.org/W2066281382","https://openalex.org/W2067931817","https://openalex.org/W2095777948","https://openalex.org/W2097064129","https://openalex.org/W2113508412","https://openalex.org/W2117266502","https://openalex.org/W2120734711","https://openalex.org/W2129754451","https://openalex.org/W2134979720","https://openalex.org/W2136082633","https://openalex.org/W2150258520","https://openalex.org/W2151892458","https://openalex.org/W2153554788","https://openalex.org/W2157552285","https://openalex.org/W2166058984","https://openalex.org/W2167976980","https://openalex.org/W2352195579","https://openalex.org/W2417408094","https://openalex.org/W2797755486","https://openalex.org/W3158174091","https://openalex.org/W4233289436"],"related_works":["https://openalex.org/W7097218160","https://openalex.org/W1967405399","https://openalex.org/W2048542572","https://openalex.org/W2122180759","https://openalex.org/W2217706708","https://openalex.org/W3042067311","https://openalex.org/W3103310815","https://openalex.org/W2601422290","https://openalex.org/W3175179412","https://openalex.org/W2112574399"],"abstract_inverted_index":{"Background.":[0],"Adenocarcinoma":[1],"of":[2,5,41,98,188],"the":[3,22,38,85,90,102,155,167,186],"ampulla":[4],"Vater":[6],"(AAV)":[7],"is":[8],"a":[9,14],"rare":[10],"malignancy":[11],"that":[12],"has":[13,32],"better":[15],"prognosis":[16],"than":[17],"other":[18],"periampullary":[19],"cancers.":[20],"However,":[21],"standard":[23],"treatment":[24,169,187],"for":[25,49,84],"patients":[26,67,81,100,181],"with":[27,68,72,133,137,142,182],"relapsed":[28],"or":[29,51],"metastatic":[30,52],"AAV":[31,70,184],"not":[33],"been":[34],"established.":[35],"We":[36,88],"investigated":[37],"clinical":[39],"feasibility":[40],"standardized":[42,189],"allergen-removed":[43],"Rhus":[44],"verniciflua":[45],"stokes":[46],"(aRVS)":[47],"extract":[48,74,191],"advanced":[50,69,183],"AAV.":[53],"Patients":[54],"and":[55,94,140,154,173],"Methods.":[56],"From":[57],"July":[58],"2006":[59],"to":[60,122,166],"April":[61],"2011,":[62],"we":[63],"retrospectively":[64],"reviewed":[65],"all":[66],"treated":[71],"aRVS":[73,108,168,190],"alone.":[75],"After":[76],"applying":[77],"inclusion/exclusion":[78],"criteria,":[79],"12":[80],"were":[82,129,170],"eligible":[83],"final":[86],"analysis.":[87],"assessed":[89],"progression-free":[91],"survival":[92,96,177],"(PFS)":[93],"overall":[95],"(OS)":[97],"these":[99],"during":[101],"follow-up":[103],"period.":[104],"Results.":[105],"The":[106,117,145],"median":[107,146,156],"administration":[109],"period":[110],"was":[111,148,158,178],"147.0":[112],"days":[113],"(range:":[114,151,161],"72-601":[115],"days).":[116],"best":[118],"tumor":[119],"responses":[120],"according":[121],"Response":[123],"Evaluation":[124],"Criteria":[125],"in":[126,180],"Solid":[127],"Tumors":[128],"as":[130],"follows:":[131],"two":[132,136],"complete":[134],"response,":[135],"stable":[138],"disease,":[139],"eight":[141],"progressive":[143],"disease.":[144],"OS":[147],"15.1":[149],"months":[150,160],"4.9-25.1":[152],"months),":[153],"PFS":[157],"3.0":[159],"1.6-11.4":[162],"months).":[163],"Adverse":[164],"reactions":[165],"mostly":[171],"mild":[172],"self-limiting.":[174],"Conclusions.":[175],"Prolonged":[176],"observed":[179],"under":[185],"without":[192],"significant":[193],"adverse":[194],"effects.":[195]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}