{"id":"https://openalex.org/W2020977090","doi":"https://doi.org/10.1016/j.lfs.2012.03.005","title":"Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: Protective effect of 3-alkynyl selenophene","display_name":"Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: Protective effect of 3-alkynyl selenophene","publication_year":2012,"publication_date":"2012-03-28","ids":{"openalex":"https://openalex.org/W2020977090","doi":"https://doi.org/10.1016/j.lfs.2012.03.005","mag":"2020977090","pmid":"https://pubmed.ncbi.nlm.nih.gov/22483695"},"language":"en","primary_location":{"id":"doi:10.1016/j.lfs.2012.03.005","doi":"https://doi.org/10.1016/j.lfs.2012.03.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2012.03.005","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038329537","display_name":"Ethel Antunes Wilhelm","orcid":"https://orcid.org/0000-0002-2875-9962","observed_orcids":["https://orcid.org/0000-0002-2875-9962"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ethel Antunes Wilhelm","raw_affiliation_strings":["Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil","Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas Universidade Federal de Santa Maria Santa Maria CEP 97105-900 RS Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil","institution_ids":["https://openalex.org/I33501960"]},{"raw_affiliation_string":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas Universidade Federal de Santa Maria Santa Maria CEP 97105-900 RS Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110127471","display_name":"Ana Cristina Guerra Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Cristina Guerra Souza","raw_affiliation_strings":["Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012650363","display_name":"Bibiana Mozzaquatro Gai","orcid":"https://orcid.org/0000-0002-3523-3010","observed_orcids":["https://orcid.org/0000-0002-3523-3010"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bibiana Mozzaquatro Gai","raw_affiliation_strings":["Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017541809","display_name":"Pietro Maria Chagas","orcid":"https://orcid.org/0000-0003-4336-5264","observed_orcids":["https://orcid.org/0000-0003-4336-5264"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pietro M. Chagas","raw_affiliation_strings":["Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083400322","display_name":"Juliano A. Roehrs","orcid":"https://orcid.org/0000-0002-7744-8087","observed_orcids":["https://orcid.org/0000-0002-7744-8087"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliano Alex Roehrs","raw_affiliation_strings":["Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001474047","display_name":"Cristina Wayne Nogueira","orcid":"https://orcid.org/0000-0003-2950-3632","observed_orcids":["https://orcid.org/0000-0003-2950-3632"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Cristina Wayne Nogueira","raw_affiliation_strings":["Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil","institution_ids":["https://openalex.org/I33501960"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001474047"],"corresponding_institution_ids":["https://openalex.org/I33501960"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":1.3956,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.79750273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"90","issue":"17-18","first_page":"666","last_page":"672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/febrile-seizures","display_name":"febrile seizures","score":0.7929999828338623},{"id":"https://openalex.org/keywords/pentylenetetrazole","display_name":"pentylenetetrazole","score":0.925000011920929},{"id":"https://openalex.org/keywords/seizure-threshold","display_name":"seizure threshold","score":0.6000000238418579},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8209999799728394},{"id":"https://openalex.org/keywords/selenophene-derivatives","display_name":"selenophene derivatives","score":0.7429999709129333},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.9789999723434448},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.640999972820282},{"id":"https://openalex.org/keywords/long-term-memory","display_name":"long-term memory","score":0.6499999761581421},{"id":"https://openalex.org/keywords/pretreatment","display_name":"pretreatment","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.625659704208374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5712168216705322},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.5473811626434326},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5090696215629578},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4773814082145691},{"id":"https://openalex.org/C2778460930","wikidata":"https://www.wikidata.org/wiki/Q7447053","display_name":"Seizure threshold","level":4,"score":0.47002220153808594},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.466432124376297},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43866074085235596},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.41058409214019775},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.23394349217414856},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.127894788980484}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003292","descriptor_name":"Convulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003294","descriptor_name":"Seizures, Febrile","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003294","descriptor_name":"Seizures, Febrile","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003294","descriptor_name":"Seizures, Febrile","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010433","descriptor_name":"Pentylenetetrazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016566","descriptor_name":"Organoselenium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016566","descriptor_name":"Organoselenium Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lfs.2012.03.005","doi":"https://doi.org/10.1016/j.lfs.2012.03.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2012.03.005","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:22483695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22483695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322502","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","ror":"https://ror.org/05k49za97"},{"id":"https://openalex.org/F4320324336","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W587487219","https://openalex.org/W1576404822","https://openalex.org/W1871419233","https://openalex.org/W1976639286","https://openalex.org/W1978637210","https://openalex.org/W1984467164","https://openalex.org/W1987058334","https://openalex.org/W1995536650","https://openalex.org/W2000338817","https://openalex.org/W2006519483","https://openalex.org/W2009894419","https://openalex.org/W2013632767","https://openalex.org/W2018986911","https://openalex.org/W2027214667","https://openalex.org/W2032236869","https://openalex.org/W2038982079","https://openalex.org/W2043700628","https://openalex.org/W2045857933","https://openalex.org/W2055302244","https://openalex.org/W2064544053","https://openalex.org/W2066183672","https://openalex.org/W2067074086","https://openalex.org/W2067114364","https://openalex.org/W2067853282","https://openalex.org/W2070408656","https://openalex.org/W2077914126","https://openalex.org/W2077941638","https://openalex.org/W2079975349","https://openalex.org/W2080248115","https://openalex.org/W2083048709","https://openalex.org/W2083337256","https://openalex.org/W2090956034","https://openalex.org/W2092155494","https://openalex.org/W2096609436","https://openalex.org/W2102575851","https://openalex.org/W2103946141","https://openalex.org/W2148128786","https://openalex.org/W2150214268","https://openalex.org/W2151992582","https://openalex.org/W2326467418","https://openalex.org/W2417151066","https://openalex.org/W2418101836","https://openalex.org/W2912776256","https://openalex.org/W2952011141","https://openalex.org/W3030590294","https://openalex.org/W4231339551","https://openalex.org/W4285719527","https://openalex.org/W6816435331","https://openalex.org/W6834993098"],"related_works":["https://openalex.org/W7120741750","https://openalex.org/W1984467164","https://openalex.org/W2411711426","https://openalex.org/W2052317802","https://openalex.org/W3159343030","https://openalex.org/W2324741383","https://openalex.org/W2188573532","https://openalex.org/W2151932523","https://openalex.org/W1977440637","https://openalex.org/W4318918988"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}