{"id":"https://openalex.org/W2020971663","doi":"https://doi.org/10.1073/pnas.93.25.14795","title":"Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy","display_name":"Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy","publication_year":1996,"publication_date":"1996-12-10","ids":{"openalex":"https://openalex.org/W2020971663","doi":"https://doi.org/10.1073/pnas.93.25.14795","mag":"2020971663","pmid":"https://pubmed.ncbi.nlm.nih.gov/8962134","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/26215"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.93.25.14795","doi":"https://doi.org/10.1073/pnas.93.25.14795","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.93.25.14795","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2020971663"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC26215/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048020071","display_name":"Guoxun Chen","orcid":"https://orcid.org/0000-0001-6226-4050","observed_orcids":["https://orcid.org/0000-0001-6226-4050"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoxun Chen","raw_affiliation_strings":["Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014910261","display_name":"Kazunori Koyama","orcid":"https://orcid.org/0000-0001-5803-0614","observed_orcids":["https://orcid.org/0000-0001-5803-0614"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazunori Koyama","raw_affiliation_strings":["Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"VA Medical Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xue Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Yuan","raw_affiliation_strings":["Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"VA Medical Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389574","display_name":"Young Lee","orcid":"https://orcid.org/0000-0002-7064-3146","observed_orcids":["https://orcid.org/0000-0002-7064-3146"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young Lee","raw_affiliation_strings":["Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111604406","display_name":"Yan-Ting Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan-Ting Zhou","raw_affiliation_strings":["Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"VA Medical Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044213015","display_name":"Robert Martin O'Doherty","orcid":"https://orcid.org/0000-0003-3031-4409","observed_orcids":["https://orcid.org/0000-0003-3031-4409"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert O\u2019Doherty","raw_affiliation_strings":["Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062992566","display_name":"Christopher B. Newgard","orcid":"https://orcid.org/0000-0002-1293-691X","observed_orcids":["https://orcid.org/0000-0002-1293-691X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher\u2009B. Newgard","raw_affiliation_strings":["Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109929922","display_name":"Roger H. Unger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger\u2009H. Unger","raw_affiliation_strings":["Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifford Laboratories for Diabetes Research, and Departments of\r Internal Medicine and Biochemistry, University of Texas\r Southwestern Medical Center, Dallas, TX 75235; and Veterans\r Affairs Medical Center, Dallas, TX 75216","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":8.8102,"has_fulltext":false,"cited_by_count":315,"citation_normalized_percentile":{"value":0.98074278,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"93","issue":"25","first_page":"14795","last_page":"14799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hyperleptinemia","display_name":"hyperleptinemia","score":0.8059999942779541},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.4959999918937683},{"id":"https://openalex.org/keywords/adipose-tissue-atrophy","display_name":"adipose tissue atrophy","score":0.6570000052452087},{"id":"https://openalex.org/keywords/lipoatrophy","display_name":"lipoatrophy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.8050000071525574},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.7620000243186951},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.7910000085830688},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9039999842643738},{"id":"https://openalex.org/keywords/plasma-triglycerides","display_name":"plasma triglycerides","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pair-feeding","display_name":"pair feeding","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8761821985244751},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8449740409851074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.835990309715271},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5089168548583984},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.49522271752357483},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4708050489425659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4659007489681244},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4317547678947449},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4312204122543335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3725665211677551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2505945861339569},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24178335070610046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10732930898666382}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.93.25.14795","doi":"https://doi.org/10.1073/pnas.93.25.14795","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.93.25.14795","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:8962134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8962134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:26215","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC26215/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:26215","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC26215/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3270822634","display_name":null,"funder_award_id":"DK0270037","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4267038666","display_name":"REGULATION OF THE HEPATIC NEGATIVE ACUTE PHASE RESPONSE","funder_award_id":"K08DK002700","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5996787255","display_name":null,"funder_award_id":"P50 H2598801","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8179475046","display_name":"The Glucoregulatory and Liporegulatory Peptide Hormones","funder_award_id":"R01DK002700","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000202452","display_name":null,"funder_award_id":"SMI 821-109","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000309019","display_name":null,"funder_award_id":"DK02700-37","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W988054948","https://openalex.org/W1496680932","https://openalex.org/W1996713062","https://openalex.org/W2002888717","https://openalex.org/W2006053538","https://openalex.org/W2007335266","https://openalex.org/W2012898950","https://openalex.org/W2013583119","https://openalex.org/W2014093920","https://openalex.org/W2015111081","https://openalex.org/W2016200465","https://openalex.org/W2028336115","https://openalex.org/W2036344921","https://openalex.org/W2049569798","https://openalex.org/W2060682066","https://openalex.org/W2082032640","https://openalex.org/W2087061260","https://openalex.org/W2090864647","https://openalex.org/W2102161788","https://openalex.org/W2130200187"],"related_works":["https://openalex.org/W2101131141","https://openalex.org/W1995998052","https://openalex.org/W2054500001","https://openalex.org/W2089726216","https://openalex.org/W2082724406","https://openalex.org/W2075353539","https://openalex.org/W2027141887","https://openalex.org/W2078679462","https://openalex.org/W2065011565","https://openalex.org/W1977104984"],"abstract_inverted_index":{"Sustained":[0],"hyperleptinemia":[1],"of":[2,110,147],"8":[3],"ng/ml":[4],"was":[5,65,136],"induced":[6],"for":[7,152],"28":[8],"days":[9],"in":[10,31,46,67,92,105,114,122,128,140],"normal":[11],"Wistar":[12],"rats":[13,26,72,77],"by":[14],"infusing":[15],"a":[16,28,54,148],"recombinant":[17,55],"adenovirus":[18],"containing":[19,57],"the":[20,40,58,75,106,115,141,145],"rat":[21],"leptin":[22],"cDNA":[23],"(AdCMV-leptin).":[24],"Hyperleptinemic":[25],"exhibited":[27],"30-50%":[29],"reduction":[30],"food":[32,123],"intake":[33,124],"and":[34,86,100,125,130],"gained":[35],"only":[36,139],"22":[37],"g":[38,45],"over":[39],"experimental":[41],"period":[42],"versus":[43,94],"115-132":[44],"control":[47,71],"animals":[48],"that":[49],"received":[50],"saline":[51],"infusions":[52],"or":[53],"virus":[56],"beta-galactosidase":[59],"gene":[60],"(AdCMV-beta":[61],"Gal).":[62],"Body":[63],"fat":[64,134],"absent":[66],"hyperleptinemic":[68,76,93,116,129],"rats,":[69],"whereas":[70],"pair-fed":[73,95,131],"to":[74],"retained":[78],"approximately":[79],"50%":[80],"body":[81],"fat.":[82],"Further,":[83],"plasma":[84],"triglycerides":[85],"insulin":[87,112],"levels":[88,102],"were":[89,103],"significantly":[90],"lower":[91],"controls,":[96],"while":[97],"fatty":[98],"acid":[99],"glucose":[101],"similar":[104],"two":[107],"groups,":[108],"suggestive":[109],"enhanced":[111],"sensitivity":[113],"animals.":[117],"Thus,":[118],"despite":[119],"equivalent":[120],"reductions":[121],"weight":[126],"gain":[127],"animals,":[132],"identifiable":[133],"tissue":[135],"completely":[137],"ablated":[138],"former":[142],"group,":[143],"raising":[144],"possibility":[146],"specific":[149],"lipoatrophic":[150],"activity":[151],"leptin.":[153]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}