{"id":"https://openalex.org/W2020954183","doi":"https://doi.org/10.1136/heartjnl-2013-304613.132","title":"GW24-e0815 The role of microRNA-29b in renal fibrosis induced by angiotensin II","display_name":"GW24-e0815 The role of microRNA-29b in renal fibrosis induced by angiotensin II","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2020954183","doi":"https://doi.org/10.1136/heartjnl-2013-304613.132","mag":"2020954183"},"language":"en","primary_location":{"id":"doi:10.1136/heartjnl-2013-304613.132","doi":"https://doi.org/10.1136/heartjnl-2013-304613.132","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2013-304613.132","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101945819","display_name":"Lijuan Song","orcid":"https://orcid.org/0000-0002-2441-2312","observed_orcids":["https://orcid.org/0000-0002-2441-2312"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]},{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Lijuan","raw_affiliation_strings":["The Affiliated Hospital of Hangzhou Normal University","The First Affiliated Hospital of Wenzhou Medical College","1The Affiliated Hospital of Hangzhou Normal University","2The First Affiliated Hospital of Wenzhou Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]},{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"1The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]},{"raw_affiliation_string":"2The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040467933","display_name":"Jialin Pan","orcid":"https://orcid.org/0000-0002-2701-4221","observed_orcids":["https://orcid.org/0000-0002-2701-4221"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jialin Pan","raw_affiliation_strings":["The First Affiliated Hospital of Wenzhou Medical College","2The First Affiliated Hospital of Wenzhou Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"2The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100639550","display_name":"Xinwei Zhang","orcid":"https://orcid.org/0000-0003-3325-5010","observed_orcids":["https://orcid.org/0000-0003-3325-5010"]},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinwei Zhang","raw_affiliation_strings":["The Affiliated Hospital of Hangzhou Normal University","1The Affiliated Hospital of Hangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]},{"raw_affiliation_string":"1The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091217057","display_name":"Xi Zhou","orcid":"https://orcid.org/0000-0002-9214-6028","observed_orcids":["https://orcid.org/0000-0002-9214-6028"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Zhou","raw_affiliation_strings":["The First Affiliated Hospital of Wenzhou Medical College","2The First Affiliated Hospital of Wenzhou Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"2The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100721854","display_name":"Xiaoyan Huang","orcid":"https://orcid.org/0000-0001-6306-6080","observed_orcids":["https://orcid.org/0000-0001-6306-6080"]},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Huang","raw_affiliation_strings":["The Affiliated Hospital of Hangzhou Normal University","1The Affiliated Hospital of Hangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]},{"raw_affiliation_string":"1The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063338851","display_name":"Guo\u2010qiang Lou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqiang Lou","raw_affiliation_strings":["The Affiliated Hospital of Hangzhou Normal University","1The Affiliated Hospital of Hangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]},{"raw_affiliation_string":"1The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101971401","display_name":"Deye Yang","orcid":"https://orcid.org/0000-0002-4797-3999","observed_orcids":["https://orcid.org/0000-0002-4797-3999"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]},{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deye Yang","raw_affiliation_strings":["The Affiliated Hospital of Hangzhou Normal University","The First Affiliated Hospital of Wenzhou Medical College","1The Affiliated Hospital of Hangzhou Normal University","2The First Affiliated Hospital of Wenzhou Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]},{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"1The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]},{"raw_affiliation_string":"2The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yang Deye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]},{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Deye","raw_affiliation_strings":["The Affiliated Hospital of Hangzhou Normal University","The First Affiliated Hospital of Wenzhou Medical College","1The Affiliated Hospital of Hangzhou Normal University","2The First Affiliated Hospital of Wenzhou Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]},{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"1The Affiliated Hospital of Hangzhou Normal University","institution_ids":["https://openalex.org/I4210103863"]},{"raw_affiliation_string":"2The First Affiliated Hospital of Wenzhou Medical College","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"99","issue":"Suppl 3","first_page":"A49.1","last_page":"A49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8202999830245972,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8202999830245972,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-29b","display_name":"miR-29b","score":0.9679999947547913},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":1.0},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8420000076293945},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8820000290870667},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8930000066757202},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/renal-tubular-epithelial-cells","display_name":"renal tubular epithelial cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/renal-interstitial-fibroblasts","display_name":"renal interstitial fibroblasts","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mirna-microarray","display_name":"miRNA microarray","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8742550611495972},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6645340919494629},{"id":"https://openalex.org/C2778577996","wikidata":"https://www.wikidata.org/wiki/Q2307492","display_name":"Renal cortex","level":3,"score":0.6212694048881531},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5672194361686707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5590980052947998},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5576778054237366},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5292032957077026},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5255576372146606},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5253305435180664},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.516676664352417},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43213385343551636},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35445883870124817},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09951624274253845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07189983129501343},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.055406391620635986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/heartjnl-2013-304613.132","doi":"https://doi.org/10.1136/heartjnl-2013-304613.132","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2013-304613.132","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2888603757","https://openalex.org/W2050945231","https://openalex.org/W2337900970","https://openalex.org/W2218522301","https://openalex.org/W2329767193","https://openalex.org/W2794147459","https://openalex.org/W7038082800","https://openalex.org/W3153269230","https://openalex.org/W2900759600","https://openalex.org/W6939451446"],"abstract_inverted_index":{"Objectives":[0],"Primary":[1],"study":[2,51],"have":[3],"demonstrated":[4,80],"that":[5,191],"the":[6,13,18,53,113,127,145],"Angiotensin":[7],"II":[8,35,111,161,180],"(Ang":[9],"II)":[10],"contents":[11],"and":[12,47,76,84,104,144,150,201],"its":[14],"receptor":[15],"density":[16],"in":[17,58,70,96,182,195,204],"kidney":[19],"of":[20,55,68,115,118,122,129,141,147,154,158,167,171,178,185,198],"young":[21,74,199],"spontaneously":[22],"hypertensive":[23],"rats":[24,32],"(SHR)":[25],"were":[26],"significantly":[27,125],"higher":[28],"than":[29],"age-matched":[30,77],"Wistar-Kyoto":[31],"(WKY).":[33],"Ang":[34,63,160,179,209],"has":[36],"been":[37],"shown":[38],"to":[39],"induce":[40],"renal":[41,59,71,100,106,196,205],"fibrosis,":[42],"including":[43],"Epithelial-Mesenchymal":[44],"Transition":[45],"(EMT)":[46],"tubulointerstitial":[48],"fibrosis.":[49],"This":[50],"investigated":[52],"role":[54],"microRNAs":[56],"(miRNAs)":[57],"fibrosis":[60,206],"induced":[61,207],"by":[62,81,86,94,120,169,208],"II.":[64,210],"Methods":[65],"Differential":[66],"expression":[67,114,128,146],"miRNAs":[69],"cortex":[72,197],"between":[73],"SHR":[75,200],"WKY":[78],"was":[79,92],"miRNA":[82],"microarray,":[83],"confirmed":[85],"real-time":[87],"PCR.":[88],"Results":[89],"The":[90],"miR-29b":[91,119,123,168,172,192],"down-regulated":[93,194],"48%":[95],"SHR.":[97],"In":[98],"NRK-52E":[99,142],"tubular":[101],"epithelial":[102],"cells":[103,143],"NRK-49F":[105,155],"interstitial":[107],"fibroblasts,":[108],"treatment":[109],"withAng":[110],"reduced":[112],"miR-29b.":[116],"Down-regulation":[117],"transfection":[121,170],"inhibitor":[124],"increased":[126],"transforming":[130],"growth":[131],"factor":[132],"(TGF-\u03b2),":[133],"\u03b1-smooth":[134],"muscle":[135],"actin":[136],"(\u03b1-SMA),":[137],"Collagen":[138],"(Col":[139],")":[140],"TGF-\u03b2,":[148],"Col":[149],"matrix":[151],"metalloproteinase-2":[152],"(MMP-2)":[153],"cells.":[156],"Treatment":[157,177],"10-7M":[159],"caused":[162],"similar":[163],"result,":[164],"while":[165],"up-regulation":[166],"mimics":[173],"24":[174],"hrs":[175],"before":[176],"resulted":[181],"obvious":[183],"down-regulation":[184],"these":[186],"genes.":[187],"Conclusions":[188],"We":[189],"conclude":[190],"is":[193],"may":[202],"participate":[203]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}