{"id":"https://openalex.org/W2020952503","doi":"https://doi.org/10.1016/s0303-7207(01)00407-5","title":"The paradox of smooth muscle physiology","display_name":"The paradox of smooth muscle physiology","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2020952503","doi":"https://doi.org/10.1016/s0303-7207(01)00407-5","mag":"2020952503","pmid":"https://pubmed.ncbi.nlm.nih.gov/11377829"},"language":"en","primary_location":{"id":"doi:10.1016/s0303-7207(01)00407-5","doi":"https://doi.org/10.1016/s0303-7207(01)00407-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0303-7207(01)00407-5","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091484362","display_name":"David A. Woodrum","orcid":"https://orcid.org/0000-0002-5914-2420","observed_orcids":["https://orcid.org/0000-0002-5914-2420"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Woodrum","raw_affiliation_strings":["Institute for Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027359834","display_name":"Colleen Marie Brophy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Colleen M Brophy","raw_affiliation_strings":["Institute for Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA, USA","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027359834"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":0.5819,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.62943247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"177","issue":"1-2","first_page":"135","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6215999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6215999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.12849999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.9399999976158142},{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.8759999871253967},{"id":"https://openalex.org/keywords/smooth-muscle-relaxation","display_name":"smooth muscle relaxation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/myosin-light-chain-phosphorylation","display_name":"myosin light chain phosphorylation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cyclic-nucleotide-signaling","display_name":"cyclic nucleotide signaling","score":0.8610000014305115},{"id":"https://openalex.org/keywords/active-relaxation","display_name":"active relaxation","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.6560529470443726},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.6172332763671875},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5991301536560059},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.5632240772247314},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5549114346504211},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5422455072402954},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5241915583610535},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5218688249588013},{"id":"https://openalex.org/C127573956","wikidata":"https://www.wikidata.org/wiki/Q7821376","display_name":"Tonic (physiology)","level":2,"score":0.5183928608894348},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5141149163246155},{"id":"https://openalex.org/C2992204568","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle relaxation","level":2,"score":0.4499092400074005},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4405299127101898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43694204092025757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43378469347953796},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.41505166888237},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36183106899261475},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2805938720703125},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24429452419281006},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.23400604724884033}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009126","descriptor_name":"Muscle Relaxation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009712","descriptor_name":"Nucleotides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0303-7207(01)00407-5","doi":"https://doi.org/10.1016/s0303-7207(01)00407-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0303-7207(01)00407-5","pdf_url":null,"source":{"id":"https://openalex.org/S191044671","display_name":"Molecular and Cellular Endocrinology","issn_l":"0303-7207","issn":["0303-7207","1872-8057"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Endocrinology","raw_type":"journal-article"},{"id":"pmid:11377829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11377829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W11767146","https://openalex.org/W102592356","https://openalex.org/W110557356","https://openalex.org/W125983096","https://openalex.org/W261751860","https://openalex.org/W581127481","https://openalex.org/W1481540262","https://openalex.org/W1485534750","https://openalex.org/W1513598783","https://openalex.org/W1520395487","https://openalex.org/W1524337940","https://openalex.org/W1534588340","https://openalex.org/W1540426161","https://openalex.org/W1552489964","https://openalex.org/W1570227839","https://openalex.org/W1583134740","https://openalex.org/W1583351160","https://openalex.org/W1592758533","https://openalex.org/W1596707465","https://openalex.org/W1598363597","https://openalex.org/W1625449763","https://openalex.org/W1673058723","https://openalex.org/W1863186034","https://openalex.org/W1872922514","https://openalex.org/W1924060168","https://openalex.org/W1967269091","https://openalex.org/W1968613207","https://openalex.org/W1975638790","https://openalex.org/W1976462601","https://openalex.org/W1986338378","https://openalex.org/W1989427465","https://openalex.org/W1994717724","https://openalex.org/W1997464986","https://openalex.org/W1998006386","https://openalex.org/W2006557171","https://openalex.org/W2008907279","https://openalex.org/W2012790122","https://openalex.org/W2020592084","https://openalex.org/W2021100604","https://openalex.org/W2022868687","https://openalex.org/W2024134178","https://openalex.org/W2031065479","https://openalex.org/W2033395773","https://openalex.org/W2050779639","https://openalex.org/W2051109754","https://openalex.org/W2053141605","https://openalex.org/W2054659401","https://openalex.org/W2056399670","https://openalex.org/W2057510022","https://openalex.org/W2074501103","https://openalex.org/W2076059848","https://openalex.org/W2085220858","https://openalex.org/W2088976076","https://openalex.org/W2089818668","https://openalex.org/W2092994164","https://openalex.org/W2103294240","https://openalex.org/W2103387619","https://openalex.org/W2114883159","https://openalex.org/W2125487824","https://openalex.org/W2129282525","https://openalex.org/W2133183176","https://openalex.org/W2145834416","https://openalex.org/W2157138732","https://openalex.org/W2162754641","https://openalex.org/W2178203389","https://openalex.org/W2181033881","https://openalex.org/W2183882228","https://openalex.org/W2186370106","https://openalex.org/W2233299729","https://openalex.org/W2240613270","https://openalex.org/W2282933565","https://openalex.org/W2305092723","https://openalex.org/W2318818336","https://openalex.org/W2338909275","https://openalex.org/W2395031936","https://openalex.org/W2403932796","https://openalex.org/W2405362471","https://openalex.org/W2413964541","https://openalex.org/W2414720556","https://openalex.org/W2419169998","https://openalex.org/W2461910266","https://openalex.org/W2467982037","https://openalex.org/W2471652817","https://openalex.org/W2482397274","https://openalex.org/W2907410636","https://openalex.org/W2908162183","https://openalex.org/W4255552530","https://openalex.org/W6686342151","https://openalex.org/W6695599364","https://openalex.org/W6777062626"],"related_works":["https://openalex.org/W2089360269","https://openalex.org/W2066730987","https://openalex.org/W145582772","https://openalex.org/W2068670307","https://openalex.org/W2020527661","https://openalex.org/W1971500105","https://openalex.org/W1960319921","https://openalex.org/W2089818668","https://openalex.org/W2406357357","https://openalex.org/W2792073214"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}