{"id":"https://openalex.org/W2020945958","doi":"https://doi.org/10.1021/bc050295b","title":"A New Class of Gd-Based DO3A-Ethylamine-Derived Targeted Contrast Agents for MR and Optical Imaging","display_name":"A New Class of Gd-Based DO3A-Ethylamine-Derived Targeted Contrast Agents for MR and Optical Imaging","publication_year":2006,"publication_date":"2006-04-26","ids":{"openalex":"https://openalex.org/W2020945958","doi":"https://doi.org/10.1021/bc050295b","mag":"2020945958","pmid":"https://pubmed.ncbi.nlm.nih.gov/16704217"},"language":"en","primary_location":{"id":"doi:10.1021/bc050295b","doi":"https://doi.org/10.1021/bc050295b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc050295b","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081206696","display_name":"Anurag Mishra","orcid":"https://orcid.org/0000-0002-9917-3977","observed_orcids":["https://orcid.org/0000-0002-9917-3977"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Anurag Mishra","raw_affiliation_strings":["Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043482940","display_name":"Josef Pfeuffer","orcid":"https://orcid.org/0000-0001-9887-0458","observed_orcids":["https://orcid.org/0000-0001-9887-0458"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Josef Pfeuffer","raw_affiliation_strings":["Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051236860","display_name":"Ritu Mishra","orcid":"https://orcid.org/0000-0002-3581-5918","observed_orcids":["https://orcid.org/0000-0002-3581-5918"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Ritu Mishra","raw_affiliation_strings":["Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109288897","display_name":"J\u00f6rn Engelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"J\u00f6rn Engelmann","raw_affiliation_strings":["Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022699290","display_name":"Anil Kumar Mishra","orcid":"https://orcid.org/0000-0003-2523-9045","observed_orcids":["https://orcid.org/0000-0003-2523-9045","https://orcid.org/0000-0002-7451-4683","https://orcid.org/0000-0002-7467-9146"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Anil K. Mishra","raw_affiliation_strings":["Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210112925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054800712","display_name":"K\u01cemil U\u01e7urbil","orcid":"https://orcid.org/0000-0002-8475-9334","observed_orcids":["https://orcid.org/0000-0002-8475-9334"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Kamil Ugurbil","raw_affiliation_strings":["Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210112925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062035071","display_name":"Nikos K. Logothetis","orcid":"https://orcid.org/0000-0001-7728-4118","observed_orcids":["https://orcid.org/0000-0001-7728-4118","https://orcid.org/0009-0008-2284-6759"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210112925","display_name":"Max Planck Institute for Biological Cybernetics","ror":"https://ror.org/026nmvv73","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112925"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Nikos K. Logothetis","raw_affiliation_strings":["Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Physiology of Cognitive Processes and High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 T\u00fcbingen, Germany, Department of Radiopharmaceutical, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi 110054, India, and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210112925"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.9634,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.84844271,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"3","first_page":"773","last_page":"780"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10612","display_name":"Magnetism in coordination complexes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadolinium-based-contrast-agents","display_name":"gadolinium-based contrast agents","score":0.8169999718666077},{"id":"https://openalex.org/keywords/targeted-mri-contrast-agents","display_name":"targeted MRI contrast agents","score":0.7580000162124634},{"id":"https://openalex.org/keywords/optical-imaging-probes","display_name":"optical imaging probes","score":0.5640000104904175},{"id":"https://openalex.org/keywords/avidin-biotin-system","display_name":"avidin-biotin system","score":0.7049999833106995},{"id":"https://openalex.org/keywords/dual-modality-imaging","display_name":"dual-modality imaging","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.6299999952316284},{"id":"https://openalex.org/keywords/3t3-cells","display_name":"3T3 fibroblasts","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5680000185966492},{"id":"https://openalex.org/keywords/gadolinium-toxicity","display_name":"gadolinium toxicity","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9682861566543579},{"id":"https://openalex.org/C2778678469","wikidata":"https://www.wikidata.org/wiki/Q411119","display_name":"Ethylamine","level":2,"score":0.9618205428123474},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.7008718252182007},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.49703124165534973},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.34859687089920044},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22422480583190918},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20190569758415222},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005021","descriptor_name":"Ethylamines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D005021","descriptor_name":"Ethylamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/bc050295b","doi":"https://doi.org/10.1021/bc050295b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc050295b","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:16704217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16704217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:312468","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/312468","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioconjugate Chemistry, v.17, 773-780 (2006)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_1791044","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0013-D219-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioconjugate Chemistry","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W107981457","https://openalex.org/W1964474031","https://openalex.org/W1971510744","https://openalex.org/W1984613175","https://openalex.org/W1989325815","https://openalex.org/W1995976462","https://openalex.org/W2005444217","https://openalex.org/W2022465964","https://openalex.org/W2024883068","https://openalex.org/W2025380280","https://openalex.org/W2033503179","https://openalex.org/W2038520392","https://openalex.org/W2057417855","https://openalex.org/W2079118100","https://openalex.org/W2095512576","https://openalex.org/W2119643174","https://openalex.org/W2120915161","https://openalex.org/W2150620038"],"related_works":["https://openalex.org/W2085426271","https://openalex.org/W7030388491","https://openalex.org/W3020192300","https://openalex.org/W2008230708","https://openalex.org/W4285678740","https://openalex.org/W2071023792","https://openalex.org/W2137200058","https://openalex.org/W2131538211","https://openalex.org/W1558402524","https://openalex.org/W7063968881"],"abstract_inverted_index":{"Synthetic":[0],"bifunctional":[1],"probes":[2,52],"based":[3],"on":[4,238],"[4,7-bis-carboxymethyl-10-(2-aminoethyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic":[5],"acid":[6],"(DO3A-ethylamine)":[7],"preloaded":[8],"with":[9,37,102,155,163,180,255,286],"gadolinium":[10],"were":[11,116],"prepared":[12],"for":[13,39,47,63,83,129,172,178,197],"applications":[14],"in":[15,230,245,261],"targeted":[16,48,64,276],"magnetic":[17],"resonance":[18],"imaging":[19,65],"(MRI)":[20],"and":[21,86,92,105,124,142,174,212,248],"optical":[22,87],"imaging.":[23,49,88],"A":[24,167],"convenient":[25],"route":[26],"of":[27,34,42,107,153,170,193,214],"synthesis":[28],"is":[29,75,269],"reported,":[30],"which":[31,79,99,274],"allowed":[32],"conjugation":[33,285],"this":[35],"probe":[36,72],"biomolecules":[38],"the":[40,54,151,164,183,252,256],"preparation":[41],"model":[43],"MR":[44,85,113,127,195,236],"contrast":[45,243,277],"agents":[46,278],"The":[50,70,89],"conjugated":[51],"have":[53],"following":[55],"interesting":[56],"properties:":[57],"GdDO3A-ethylamido-biotin":[58],"(Gd-9)":[59],"can":[60,80,100,279],"be":[61,81,280],"used":[62,82],"using":[66,121],"an":[67],"avidin-biotin":[68],"system.":[69],"fluorescent":[71],"GdDO3A-ethylthiourea-fluorescein":[73],"(Gd-12)":[74],"a":[76,95,191,220,226,242,270,283],"bimodal":[77],"compound,":[78,254],"both":[84,246],"precursors,":[90],"DO3A-ethylamidopropyl-maleimide":[91],"DO3A-ethyl-isothiocyanate":[93],"contain":[94],"highly":[96],"reactive":[97],"moiety,":[98],"interact":[101],"free":[103],"SH-terminals":[104],"N-terminals":[106],"biological":[108],"molecules,":[109],"respectively.":[110],"In":[111],"vitro":[112],"relaxivity":[114,128,160,168,196],"studies":[115,237],"performed":[117],"at":[118,132,157,190,207],"300":[119],"MHz":[120],"different":[122],"concentrations":[123],"chemical":[125],"environments.":[126],"ligand":[130,198],"Gd-9":[131,154],"pH":[133,158,208],"7.4,":[134,159],"r1":[135,173,200],"was":[136,144,188,201],"(3.32":[137],"+/-":[138,146,203],"0.03)":[139],"s(-1)":[140,148,205],"mM(-1)":[141,206],"r2":[143,179],"(5.02":[145],"0.14)":[147],"mM(-1).":[149],"For":[150],"mixture":[152],"avidin,":[156],"increased":[161],"linearly":[162],"avidin":[165],"concentration.":[166],"enhancement":[169,244],"45%":[171],"more":[175,259],"than":[176],"400%":[177],"respect":[181],"to":[182,233],"unbound":[184],"biotinylated":[185],"Gd3+":[186],"complex":[187],"found":[189],"ratio":[192],"4:1.":[194],"Gd-12,":[199],"(5.36":[202],"0.05)":[204],"7.4.":[209],"Fluorescence":[210],"microscopy":[211],"spectroscopy":[213],"Gd-12-labeled":[215],"3T3":[216],"mouse":[217],"fibroblasts":[218],"showed":[219],"concentration-dependent":[221],"intracellular":[222],"uptake,":[223],"accompanied":[224],"by":[225,251],"slight":[227],"dose-dependent":[228],"increase":[229],"toxicity":[231],"up":[232],"150":[234],"microM.":[235],"labeled":[239],"cells":[240],"indicated":[241],"T1-":[247],"T2-weighted":[249,262],"images":[250],"internalized":[253],"effect":[257],"being":[258],"pronounced":[260],"images.":[263],"Our":[264],"results":[265],"indicate":[266],"that":[267],"DO3A-ethylamine":[268],"multipurpose":[271],"precursor,":[272],"from":[273],"various":[275],"synthesized":[281],"after":[282],"single-step":[284],"organic/bioorganic":[287],"molecules.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}